1. Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
- Author
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Sato Ashida, Dina Eliezer, Donald W. Hadley, Yonit A. Addissie, Laura M. Koehly, and Andrea F. Goergen
- Subjects
Adult ,Male ,Health Knowledge, Attitudes, Practice ,Heterozygote ,medicine.medical_specialty ,Genetic testing ,Colorectal cancer ,Cross-sectional study ,Science ,MEDLINE ,Colonoscopy ,Article ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Health care ,medicine ,Humans ,Family ,Genetic Predisposition to Disease ,Cancer genetics ,Preventive medicine ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,United States ,Lynch syndrome ,Colon cancer ,Risk perception ,Cross-Sectional Studies ,030220 oncology & carcinogenesis ,Family medicine ,Colonic Neoplasms ,Mutation ,Medicine ,Female ,030211 gastroenterology & hepatology ,business - Abstract
Cascade genetic testing provides a method to appropriately focus colonoscopy use in families with Lynch syndrome (LS). However, research suggests that up to two-thirds at risk to inherit LS don’t participate. Within the United States, no studies have assessed colonoscopy use within this elusive and high-risk subset. We set forth to (1) document colonoscopy use within those not undergoing genetic testing (NGT) and (2) identify factors associated with completing colonoscopy. Data came from a cross sectional survey of families with molecularly confirmed LS. One hundred seventy-six (176) adults participated; 47 of unknown variant status and 129 with variant status known (59 carriers/70 non-carriers). Despite a high level of awareness of LS (85%) and identical recommendations for colonoscopy, NGT reported significantly lower use of colonoscopy than carriers (47% vs. 73%; p = 0.003). Our results show that perceived risk to develop colon cancer (AOR = 1.99, p p Trial Registration Clinical Trials.gov Identifier: NCT00004210.
- Published
- 2020