1. Clinical and Molecular Characterization of Panton–Valentine Leukocidin-Positive InvasiveStaphylococcus aureusInfections in Korea
- Author
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Jeong Su Park, Shinwon Lee, Ji Hwan Bang, Eun Ju Choo, Jeong-Hwan Hwang, Hong Bin Kim, Eu Suk Kim, Chisook Moon, Yoonseon Park, Hee Jung Choi, Kyung-Hwa Park, Eun Jung Lee, Myoung Don Oh, Kyoung Ho Song, Young Keun Kim, Min Hyok Jeon, Pyoeng Gyun Choe, Kye-Hyung Kim, Kyoung Un Park, and Hwang Jm
- Subjects
Adult ,Male ,Methicillin-Resistant Staphylococcus aureus ,Microbiology (medical) ,Adolescent ,Virulence Factors ,Bacterial Toxins ,Immunology ,Leukocidin ,Exotoxins ,Virulence ,Microbial Sensitivity Tests ,medicine.disease_cause ,Microbiology ,Young Adult ,03 medical and health sciences ,Leukocidins ,Republic of Korea ,Prevalence ,medicine ,Humans ,skin and connective tissue diseases ,Aged ,030304 developmental biology ,Aged, 80 and over ,Pharmacology ,Cross Infection ,Molecular Epidemiology ,0303 health sciences ,Molecular epidemiology ,030306 microbiology ,business.industry ,Middle Aged ,Staphylococcal Infections ,respiratory system ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,Anti-Bacterial Agents ,Community-Acquired Infections ,Staphylococcus aureus ,bacteria ,Female ,Staphylococcus aureus infections ,Panton–Valentine leukocidin ,business ,Multilocus Sequence Typing - Abstract
Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea.A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone.ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.
- Published
- 2019