1. Oxidative Stress and Menopausal Status: The Coronary Artery Risk Development in Young Adults Cohort Study
- Author
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Amir S. Heravi, Erin D. Michos, Di Zhao, Bharath Ambale-Venkatesh, Henrique Doria De Vasconcellos, Donald Lloyd-Jones, Pamela J. Schreiner, Jared P. Reis, Colin Wu, Cora E. Lewis, James M. Shikany, Stephen Sidney, Eliseo Guallar, Chiadi E. Ndumele, Pamela Ouyang, Ron C. Hoogeveen, Joao A.C. Lima, Dhananjay Vaidya, and Wendy S. Post
- Subjects
Cohort Studies ,Oxidative Stress ,Young Adult ,Cardiovascular Diseases ,Creatinine ,Humans ,Female ,General Medicine ,Original Articles ,Menopause ,Coronary Vessels ,Aged - Abstract
BACKGROUND: Low endogenous estrogen concentrations after menopause may contribute to higher oxidative stress and greater cardiovascular disease (CVD) risk. However, differences in oxidative stress between similarly aged premenopausal and postmenopausal women are not well-characterized on a population level. We hypothesized that urinary isoprostane concentrations, a standard measure of systemic oxidative stress, are higher in women who have undergone menopause compared to premenopausal women. METHODS AND RESULTS: We examined differences in urinary 8-isoprostane (iPF(2α)-III) and 2,3-dinor-8-isoprostane (iPF(2α)-III-M) indexed to urinary creatinine between 279 postmenopausal and 196 premenopausal women in the Coronary Artery Risk Development in Young Adults (CARDIA) study, using linear regression with progressive adjustment for sociodemographic factors and traditional CVD risk factors. Unadjusted iPF(2α)-III-M concentrations were higher among postmenopausal compared to premenopausal women (Median [25th, 75th percentile]: 1762 [1178, 2974] vs. 1535 [1067, 2462] ng/g creatinine; p = 0.01). Menopause was associated with 25.5% higher iPF(2α)-III-M (95% confidence interval [6.5–47.9]) adjusted for age, race, college education, and field center. Further adjustments for tobacco use (21.2% [2.9–42.6]) and then CVD risk factors (18.8% [0.1–39.6]) led to additional partial attenuation. Menopause was associated with higher iPF(2α)-III in Black but not White women. CONCLUSIONS: We conclude that postmenopausal women had higher oxidative stress, which may contribute to greater CVD risk. ClinicalTrials.gov Identifier: NCT00005130.
- Published
- 2023