1. Retransfusion acidosis after haemorrhagic hypotension in dogs
- Author
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G. Szántó, E. Vándor, and L. Takács
- Subjects
Male ,Partial Pressure ,Bicarbonate ,Potassium ,Plasma Substitutes ,chemistry.chemical_element ,Blood Pressure ,Hemorrhage ,Hepatic Veins ,Low molecular weight dextran ,chemistry.chemical_compound ,Dogs ,Animals ,Medicine ,Blood Transfusion ,Pyruvates ,General Environmental Science ,Acidosis ,Acid-Base Equilibrium ,Blood Volume ,Portal Vein ,business.industry ,Shed blood ,Dextrans ,Carbon Dioxide ,Femoral Vein ,Hydrogen-Ion Concentration ,Oxygen ,Bicarbonates ,Blood ,Dextran ,chemistry ,Anesthesia ,Lactates ,General Earth and Planetary Sciences ,Female ,Hypotension ,medicine.symptom ,business - Abstract
Summary Anaesthetized dogs subjected to severe haemorrhagic hypotension followed by spontaneous uptake of 30 per cent of the shed blood were studied. One group was then transfused with blood, another with low molecular weight dextran, and a third with Locke's solution. During the hypotensive phase, the arterial p H, standard bicarbonate, buffer base and Pco 2 fell, while the lactate, pyruvate, and potassium values rose. Within half a minute of retransfusion, the p H decreased further but the Pco 2 rose to normal or higher values. The greatest fall in p H occurred in the dextran group, but the p H of dextran is lower than that of the reinfused blood or Locke's solution. The fall in p H and rise in Pco 2 after retransfusion occur with unchanged lactate levels and so cannot be attributed to ‘washout’ of lactate from the tissues.
- Published
- 1974