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3 results on '"Diego Delle, Rose"'

1. Whole genome sequencing of carbapenem-resistant

Author

Carla, Fontana, Silvia, Angeletti, Walter, Mirandola, Eleonora, Cella, Lai, Alessia, Gianguglielmo, Zehender, Marco, Favaro, Davide, Leoni, Diego Delle, Rose, Giovanni, Gherardi, Lucia De, Florio, Marco, Salemi, Massimo, Andreoni, Loredana, Sarmati, and Massimo, Ciccozzi

Subjects
Adult, Aged, 80 and over, Male, Molecular Epidemiology, Whole Genome Sequencing, Bacteremia, Middle Aged, beta-Lactam Resistance, beta-Lactamases, Anti-Bacterial Agents, Disease Outbreaks, Klebsiella Infections, Evolution, Molecular, Klebsiella pneumoniae, Young Adult, Carbapenem-Resistant Enterobacteriaceae, Bacterial Proteins, Carbapenems, Humans, Female, Genome, Bacterial, Phylogeny, Aged, Multilocus Sequence Typing
Published
2020

2. An in-depth analysis of nosocomial bloodstream infections due to Gram-negative bacilli: clinical features, microbiological characteristics and predictors of mortality in a 1 year, prospective study in a large tertiary care Italian hospital

Author

Carla Fontana, Diego Delle Rose, Davide Leoni, Anna Altieri, Raffaella Cerretti, Silvia Minelli, Massimo Andreoni, Patrizio Pezzotti, Loredana Sarmati, and Benedetta Mariotti

Subjects
0301 basic medicine, Microbiology (medical), Adult, Male, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, characteristics, 030106 microbiology, Gram negative, Bacteremia, Tertiary care, Hospitals, University, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Bloodstream infections, mortality, nosocomial, predictors, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Aged, Cross Infection, General Immunology and Microbiology, business.industry, Incidence, General Medicine, Gram negative bacilli, Middle Aged, bacterial infections and mycoses, Survival Analysis, Infectious Diseases, Treatment Outcome, Italy, Female, business, Gram-Negative Bacterial Infections
Abstract

Bloodstream infections (BSI) due to Gram negative bacilli (GNB) represent a major concern among nosocomial infections, since they are noticeably associated with a high mortality rates, increase of healthcare costs and prolongation of hospital stay.Over a 12-month period (2014-2015) all the adult patients admitted to a university-based Italian hospital were monitored for development of BSIs due to GNB. Multiple logistics regression models were performed to assess the impact of patients' risk factors on the in-hospital and 14-day mortality.During the study period 208 patients were diagnosed with at least a BSI due to a Gram negative species for an incidence rate of 12.8 cases/1,000 admissions (95%CI: 11.2-14.7). Multivariate analyses showed that multiple organ dysfunctions along with immune deficit and inadequate therapy in the first 48hrs were associated with a higher risk of death.A thorough evaluation of both immune status and organ dysfunction at the onset of septic events, along with adequate antimicrobial therapy appear to be the most reliable factors in predicting the outcome in these infections. SOFA score can be efficaciously substituted to the single organ dysfunctions analysis in predicting mortality after these events.

Published
2018

3. Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients. a 1-year, large, prospective surveillance study in 5 Italian hospitals

Author

Silvia Natoli, Giorgia Citterio, Monica Rocco, Marcello Meledandri, Stefano Boros, Grazia Prignano, Maria Teresa Gallo, Marco Favaro, Loredana Sarmati, Sabina Gini, Massimo Andreoni, Mario D'Ambrosio, G. P. Testore, Pasquale Sordillo, Francesca Leonardis, Giovanni Rezza, Roberta Caccese, Diego Delle Rose, Carlotta Cerva, Tiziana Franci, Maria Grazia Celeste, and Carla Fontana

Subjects
Male, medicine.medical_specialty, Pediatrics, Epidemiology, bloodstream infections, intensive care unit, klebsiella pneumoniae, microbiology, mortality, predictors, infectious diseases, public health, environmental and occupational health, epidemiology, health policy, Rome, Settore MED/41 - Anestesiologia, Bacteremia, Microbiology, law.invention, Bloodstream infections, Intensive care unit, Klebsiella pneumoniae, Mortality, Predictors, Risk Factors, law, Internal medicine, medicine, Humans, Prospective Studies, Simplified Acute Physiology Score, Aged, Univariate analysis, business.industry, Incidence, Health Policy, Incidence (epidemiology), Mortality rate, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, Hospitals, Intensive Care Units, Infectious Diseases, SAPS II, Epidemiological Monitoring, Female, business
Abstract

Background Bloodstream infections (BSIs) from multidrug-resistant (MDR) bacteria cause morbidity and mortality in intensive care unit (ICU) patients worldwide. This study investigated the incidence of BSIs in 5 adult general ICUs in Rome, Italy, and evaluated the mortality rate and risk factors associated with these infections. Methods Over a 12-month period, 1,318 patients were enrolled. Demographic characteristics, Simplified Acute Physiology Score II (SAPS II), comorbidities, and BSI isolate data were collected. After stratification for the outcome, statistical analysis was performed to assess the impact of patient risk factors on in-hospital mortality. Results There were 324 BSIs in 175 patients recorded, with an in-hospital mortality rate of 46%. Univariate analysis revealed that SAPS II, cardiac comorbidity, and Klebsiella pneumoniae BSI were significantly associated with a higher risk of death. Having a K pneumoniae BSI and cardiac illness at admission were both confirmed to be associated with death by multivariate analysis ( P = .0162 and P = .0158, respectively). Most of the K pneumoniae isolates showed high resistance rates to carbapenems. Conclusion BSIs caused by K pneumoniae and cardiovascular comorbidity in ICU patients are associated with a higher risk of death. Thorough surveillance for MDR pathogens and stratification of the patients' risk on admission into the ICU are key to improving the outcomes of these infections.

Published
2015

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