1. Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study
- Author
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María C Baamonde Calzada, María L López Yepes, María A Juncos Tobarra, Laura Sahuquillo Frías, María C Zamorano Andrés, Patricia Esteban Torrella, Eloísa Urrechaga, Silvia Sánchez Fdez-Pacheco, María Núñez Gárate, Mercedes González Morales, Olaia Rodríguez-Fraga, Luis Sáenz, Natalia Sancho-Rodríguez, Sonia Pérez Sanmartín, Alfonso Pérez Martínez, María Gloria García Arévalo, Jose I Gutiérrez Revilla, Paloma Salas Gómez-Pablos, Amparo Galán Ortega, Laura Jiménez Añón, Aurelio Pons Castillo, Cristian Morales-Indiano, Elena Valera Nuñez, Laura Altimira Queral, Marina Vera, Alfonso L. Blázquez Manzanera, Jose Manuel Egea-Caparrós, Sara García Muñoz, Jose M Álamo, Patricia de la Hera Cagigal, Juan Adell Ruiz de León, Luciano Consuegra-Sánchez, Alicia Ruiz Ripa, Ruth González Tamayo, Luis García de Guadiana-Romualdo, Yolanda Pastor Murcia, Ana María Lourdes Padilla Jiménez, Vicente Ferrer Díaz de Brito Fernández, Amaia Fernández Uriarte, Ana M Hernando Holgado, Josep Miquel Bauça, Isabel Vírseda Chamorro, Luis Vicente Gutiérrez, Juan Antonio Vílchez, Martí Vila Pérez, Jorge Férriz Vivancos, María Arnaldos Carrillo, Álex Larruzea, Daniel Morell-García, Cristina Acevedo Alcaraz, María José Alcaide Martín, Elisa Nuez-Zaragoza, Cristina Ruiz Iruela, Iria Cebreiros López, Magdalena Canalda Campás, Vicente Aguadero, Irene Gutiérrez Garcia, María del Carmen Lorenzo-Lozano, and José Pedregosa Díaz
- Subjects
Male ,Clinical Biochemistry ,030204 cardiovascular system & hematology ,Biochemistry ,Severity of Illness Index ,SARS‐CoV‐2 ,0302 clinical medicine ,Troponin I ,Odds Ratio ,myocardial injury ,030212 general & internal medicine ,Aged, 80 and over ,biology ,Troponin T ,General Medicine ,Middle Aged ,Systemic Inflammatory Response Syndrome ,Cardiology ,Female ,Original Article ,Cardiomyopathies ,cardiac troponin T ,medicine.medical_specialty ,Cardiac troponin ,Coronavirus disease 2019 (COVID-19) ,cardiac troponin I ,macromolecular substances ,03 medical and health sciences ,COVID‐19 ,Internal medicine ,Severity of illness ,medicine ,Humans ,Mortality ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,COVID-19 ,Retrospective cohort study ,Odds ratio ,Original Articles ,Pneumonia ,Troponin ,biology.protein ,prognosis ,business ,Biomarkers - Abstract
BACKGROUND: Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. METHODS: This is a multicentre, retrospective observational study enrolling patients with laboratory-confirmed COVID-19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex-specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty-day mortality was defined as endpoint. RESULTS: A total of 1280 COVID-19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut-off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex-specific cut-off was used. This prevalence was significantly higher (42.9% vs 21.9%; P
- Published
- 2021