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Your search keyword '"Chi-Ming, Su"' showing total 2 results
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2 results on '"Chi-Ming, Su"'

1. De Novo incontinentia pigmenti in female twins

Author

Pen-Hua, Su, Jia-Yuh, Chen, Ju-Shan, Yu, Chi-Ming, Su, Tzu-Ching, Huang, and Suh-Jen, Chen

Subjects
Male, Mutation, Infant, Newborn, Twins, Humans, Female, Genetic Diseases, X-Linked, Incontinentia Pigmenti, Carrier Proteins, Polymerase Chain Reaction, Infant, Premature, I-kappa B Kinase, Pedigree
Abstract

The cutaneous lesions of incontinentia pigmenti classically evolve in stages, beginning with erythematous vesicular rash and bullae, followed by verrucose lesions, with an eventual macular pattern of splashed or whorled hyperpigmentation. We describe female twins presenting with the classic form of cutaneous expression. Ophthalmologic examination revealed abnormal vascular proliferations in the peripheral retinas in twin B. Several studies have confirmed linkage of familial incontinentia pigmenti to chromosome Xq28, with the factor VIII gene in Xq28 identified as the locus for incontinentia pigmenti. Two-hundred kilobases proximal to this locus, the gene for NEMO (NF-kappaB essential modulator)/IKKgamma (I kappaB kinase-gamma) has been mapped. We describe herein female twins with incontinentia pigmenti caused by a de novo mutation of this locus, as demonstrated by diagnostic polymerase chain reaction.

Published
2004

2. Comparison of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants

Author

Jia-Yuh Chen, Chi-Ming Su, Pen-Hua Su, Hong-Shen Lee, and Tzu-Ching Huang

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_treatment, Indomethacin, Renal function, Ibuprofen, Infant, Premature, Diseases, chemistry.chemical_compound, Ductus arteriosus, Medicine, Humans, Cyclooxygenase Inhibitors, Infusions, Intravenous, Blood urea nitrogen, Ductus Arteriosus, Patent, Mechanical ventilation, Creatinine, Respiratory Distress Syndrome, Newborn, Respiratory distress, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Infant, Newborn, Gestational age, medicine.anatomical_structure, chemistry, Anesthesia, Pediatrics, Perinatology and Child Health, Female, business, medicine.drug
Abstract

Background: Patent ductus arteriosus (PDA) is commonly found in very low-birthweight (VLBW) infants. The presence of respiratory distress syndrome (RDS) is also associated with increased frequency of significant PDA. Intravenous indomethacin has been used to treat and to prevent PDA in premature infants since 1976. However, concern remains regarding the safety of indomethacin, which affects renal, gastrointestinal and cerebral perfusion. Intravenous ibuprofen has recently been used to treat and to prevent PDA premature infants with PDA without reducing cerebral blood flow or affecting intestinal or renal hemodynamics. The aim of the present study is to compare intravenous ibuprofen and indomethacin with regard to efficacy and safety for the early treatment of PDA in preterm infants. Methods: A total of 63 preterm infants with RDS who had a birthweight of ≤1500 g and gestational age of ≤32 weeks, were enrolled in the present study. All patients were treated with nasal continuous positive airway pressure with additional oxygen supply in inspired air>30%, or with mechanical ventilation. The patients’ serum platelet counts were>100 000/uL, and serum creatinine values were

Published
2003

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