Search

Your search keyword '"Carrai, V"' showing total 4 results
Start Over Author "Carrai, V" Topic female
4 results on '"Carrai, V"'

1. Predicting the probability of Gaucher disease in subjects with splenomegaly and thrombocytopenia

Author

Motta I, Consonni D, Stroppiano M, Benedetto C, Cassinerio E, Tappino B, Ranalli P, Borin L, Facchini L, Patriarca A, Barcellini W, Lanza F, Filocamo M, Cappellini MD, Farina F, Codeluppi K, Rivolti E, Simonetti F, Lunghi F, Perrone T, Sgherza N, Carrai V, Cafro AM, Cairoli R, Amendola A, Trabacchi E, Vallisa D, Burgo I, Federici AB, Carbone C, D’Adda M, Mannina D, Di Giacomo V, Lupparelli G, Lombardo A., Motta, I, Consonni, D, Stroppiano, M, Benedetto, C, Cassinerio, E, Tappino, B, Ranalli, P, Borin, L, Facchini, L, Patriarca, A, Barcellini, W, Lanza, F, Filocamo, M, Cappellini, M, Farina, F, Codeluppi, K, Rivolti, E, Simonetti, F, Lunghi, F, Perrone, T, Sgherza, N, Carrai, V, Cafro, A, Cairoli, R, Amendola, A, Trabacchi, E, Vallisa, D, Burgo, I, Federici, A, Carbone, C, D’Adda, M, Mannina, D, Di Giacomo, V, Lupparelli, G, and Lombardo, A

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Science, Population, Diseases, Disease, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Hematologist, education, education.field_of_study, Gaucher Disease, Multidisciplinary, biology, Transferrin saturation, business.industry, beta-Glucosidase, Middle Aged, Thrombocytopenia, Dried blood spot, Algorithm, Ferritin, Multicenter study, 030220 oncology & carcinogenesis, Splenomegaly, biology.protein, Medicine, Female, business, Haematological diseases, Algorithms, Human, 030215 immunology
Abstract

Hematologists are frequently involved in the diagnostic pathway of Gaucher disease type 1 (GD1) patients since they present several hematological signs. However, GD1 is mainly underdiagnosed because of a lack of awareness. In this multicenter study, we combine the use of a diagnostic algorithm with a simple test (β-glucosidase activity on Dried Blood Spot) in order to facilitate the diagnosis in a population presenting to the hematologist with splenomegaly and/or thrombocytopenia associated with other hematological signs. In this high-risk population, the prevalence of GD1 is 3.3%. We propose an equation that predicts the probability of having GD1 according to three parameters that are routinely evaluated: platelet count, ferritin, and transferrin saturation.

Published
2021

2. Immunohistochemistry applied to the study of bone marrow Gaucher's cells: a case report

Author

Alterini, R., Rigacci, L., Stefanacci, S., Innocenti, F., VALERIA SANTINI, Carrai, V., and Rossi Ferrini, P.

Subjects
Adult, Immunoglobulin kappa-Chains, Gaucher Disease, Immunoglobulin M, Antigens, CD, Humans, Bone Marrow Cells, Bone Marrow Examination, Female, Immunohistochemistry
Abstract

Gaucher's disease is frequently associated with immunologic abnormalities, e.g. hypergammaglobulinemia, polyclonal gammopathy and benign monoclonal gammopathy. A patient with Gaucher's disease and a selective accumulation of IgM k in Gaucher's cells without serum monoclonal gammopathies is described. The selective accumulation is detected by immunohistochemistry analysis performed on cryostat bone marrow biopsies.

Published
1999

3. Real-world use of thrombopoietin receptor agonists in elderly patients with primary immune thrombocytopenia

Author

Wilma Barcellini, Michele Cavo, Emanuele Sutto, Francesca Palandri, Andrea Patriarca, Daniela Bartoletti, Erminia Baldacci, Gaetano Giuffrida, Francesco Zaja, Monica Carpenedo, Ugo Consoli, Antonietta Ferretti, Federico Chiurazzi, Daniela Nicolosi, Elena Rivolti, Giuseppe Auteri, Esther Oliva, Maria Gabriella Mazzucconi, Elisa Lucchini, Silvia Cantoni, Giuseppe Carli, Valerio De Stefano, Nicola Vianelli, Giovanni Caocci, Francesco Rodeghiero, Elena Rossi, Valentina Carrai, Alessandra Borchiellini, Marco Ruggeri, Palandri, F, Rossi, E, Bartoletti, D, Ferretti, A, Ruggeri, M, Lucchini, E, Carrai, V, Barcellini, W, Patriarca, A, Rivolti, E, Consoli, U, Cantoni, S, Oliva, En, Chiurazzi, F, Caocci, G, Giuffrida, G, Borchiellini, A, Auteri, G, Baldacci, E, Carli, G, Nicolosi, D, Sutto, E, Carpenedo, M, Cavo, M, Mazzucconi, Mg, Zaja, F, De Stefano, V, Rodeghiero, F, Vianelli, N., Palandri F., Rossi E., Bartoletti D., Ferretti A., Ruggeri M., Lucchini E., Carrai V., Barcellini W., Patriarca A., Rivolti E., Consoli U., Cantoni S., Oliva E.N., Chiurazzi F., Caocci G., Giuffrida G., Borchiellini A., Auteri G., Baldacci E., Carli G., Nicolosi D., Sutto E., Carpenedo M., Cavo M., Mazzucconi M.G., Zaja F., De Stefano V., Rodeghiero F., and Vianelli N.

Subjects
Male, Receptors, Fc, Biochemistry, Gastroenterology, Benzoates, chemistry.chemical_compound, Older patients, Romiplostim, Retrospective Studie, Hydrazine, Medicine, Platelet, Aged, 80 and over, Hematology, Middle Aged, Thrombosis, Hydrazines, Thrombopoietin, Idiopathic Thrombocytopenic Purpura, Eltrombopag, Female, Receptors, Thrombopoietin, medicine.drug, Human, Thrombopoietin Receptor Agonists, medicine.medical_specialty, Immune Thrombocytopenia, Recombinant Fusion Proteins, Immunology, Hemorrhage, Follow-Up Studie, Benzoate, Internal medicine, Humans, Retrospective Studies, Aged, Purpura, Thrombocytopenic, Idiopathic, business.industry, Cell Biology, medicine.disease, Immune thrombocytopenia, Settore MED/15 - MALATTIE DEL SANGUE, chemistry, Pyrazole, Pyrazoles, business, Fibrinolytic agent, Follow-Up Studies, Recombinant Fusion Protein
Abstract

The efficacy and safety of thrombopoietin receptor agonists (TRAs) in older patients with primary immune thrombocytopenia (ITP) are unknown. We investigated TRA response and switch, thrombotic/hemorrhagic risk, and sustained responses off-treatment (SROTs) in 384 patients with ITP aged ≥60 years. After 3 months, 82.5% and 74.3% of eltrombopag- and romiplostim-treated patients, respectively, achieved a response; 66.7% maintained the response (median follow-up, 2.7 years). Eighty-five (22.2%) patients switched to the alternative TRA; although no cross-toxicity was observed, 83.3% of resistant patients had a response after the switch. Thirty-four major thromboses (3 fatal) and 14 major hemorrhages (none fatal) occurred in 18 and 10 patients, respectively, while on TRAs and were associated with thrombosis history (subdistribution hazard ratio, 2.04, P = .05) and platelet count

Published
2021

4. Alternate use of thrombopoietin receptor agonists in adult primary immune thrombocytopenia patients: A retrospective collaborative survey from Italian hematology centers

Author

Angela Maria Ciminello, Giorgina Specchia, Fabrizio Pane, Silvia Cantoni, Roberto Cairoli, Felicetto Ferrara, Erminia Baldacci, Francesco Zaja, Ugo Consoli, Alessandra Ricco, Andrea Artoni, Monica Carpenedo, Valerio De Stefano, Michele Nichelatti, Mariella D'Adda, Nicola Vianelli, Francesco Rodeghiero, Elena Rossi, Wilma Barcellini, Valentina Carrai, Andrea Visentin, Maria Gabriella Mazzucconi, Marco Ruggeri, Domenica Caramazza, Cantoni, Silvia, Carpenedo, Monica, Mazzucconi, Maria Gabriella, DE STEFANO, Valerio Flavio, Carrai, Valentina, Ruggeri, Marco, Specchia, Giorgina, Vianelli, Nicola, Pane, Fabrizio, Consoli, Ugo, Artoni, Andrea, Zaja, Francesco, D'Adda, Mariella, Visentin, Andrea, Ferrara, Felicetto, Barcellini, Wilma, Caramazza, Domenica, Baldacci, Erminia, Rossi, Elena, Ricco, Alessandra, Ciminello, Angela, Rodeghiero, Francesco, Nichelatti, Michele, Cairoli, Roberto, Cantoni, S, Carpenedo, M, Mazzucconi, M, De Stefano, V, Carrai, V, Ruggeri, M, Specchia, G, Vianelli, N, Pane, F, Consoli, U, Artoni, A, Zaja, F, D'Adda, M, Visentin, A, Ferrara, F, Barcellini, W, Caramazza, D, Baldacci, E, Rossi, E, Ricco, A, Ciminello, A, Rodeghiero, F, Nichelatti, M, Cairoli, R, and De Stefano, Valerio

Subjects
Adolescent, Adult, Aged, 80 and over, Female, Humans, Italy, Male, Middle Aged, Purpura, Thrombocytopenic, Idiopathic, Receptors, Thrombopoietin, Retrospective Studies, Surveys and Questionnaires, Young Adult, Hematology, Aged, 80 and over, Purpura, Thrombocytopenic, Idiopathic, Receptors, Thrombopoietin, Thrombopoietin receptor agonists, chemistry.chemical_compound, 0302 clinical medicine, Retrospective Studie, Surveys and Questionnaire, Young adult, Thrombopoietin receptor agonists, Immune thrombocytopenia, immune thrombocytopenia, 030220 oncology & carcinogenesis, Receptor, medicine.drug, Human, medicine.medical_specialty, Thrombopoietin Receptor Agonists, Eltrombopag, 03 medical and health sciences, Internal medicine, medicine, Adverse effect, Romiplostim, business.industry, Retrospective cohort study, Immune thrombocytopenia, Settore MED/15 - MALATTIE DEL SANGUE, chemistry, Immunology, ITP, business, 030215 immunology
Abstract

Sequential use of the TPO-RAs romiplostim and eltrombopag in ITP patients failing either agent was retrospectively evaluated to assess efficacy and impact of clinical characteristics on outcome. Patients were grouped into 5 categories: efficacy issues: 1st TPO-RA failure; loss of response; non-efficacy issues: platelet fluctuations; patient's preference; adverse event development. Either one TPO-RA sequence was analyzed at 3 month and at last follow-up. 106/546 patients on TPO-RA underwent switch and 65% achieved, regained or maintained a short- term response independent of switch sequence, gender or age; lower response rates were associated with lines of previous therapy; disease duration lowers probability to respond. Clinically, patients switched for efficacy issue did not differ from those switched for non-efficacy issues. Response was achieved/regained in 57.8% of patients switched for efficacy issues, the lowest response rates were observed in non-responders to 1st TPO-RA; 80% of patients switched for non-efficacy issues maintained a response. Platelet fluctuation resolved in 44.4%. Of the 49 patients evaluable for long-term outcome, 27 were in response on therapy; 16 discontinued the TPO-RA for reasons other than efficacy, while only 6 were non responders. We confirm the efficacy of TPO-RA switch; once achieved, response to the 2nd TPO-RA seems durable.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results