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1. Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV

Author

Henrich, Timothy J, Bosch, Ronald J, Godfrey, Catherine, Mar, Hanna, Nair, Apsara, Keefer, Michael, Fichtenbaum, Carl, Moisi, Daniela, Clagett, Brian, Buck, Amanda M, Deitchman, Amelia N, Aweeka, Francesca, Li, Jonathan Z, Kuritzkes, Daniel R, Lederman, Michael M, Hsue, Priscilla Y, Deeks, Steven G, Team, the ACTG A5337, Campbell, Danielle, Cutler, Corey, Dorosh, Michael, Ha, Belinda, Hawkins, Elizabeth, Hensel, Christopher, Khairalla, Nayri, Knowles, Kevin, Lee, Sulggi A, Pedersen, Susan, Ritz, Justin, Ryder, Dylan, Sekaly, Rafick, Shugarts, David L, Straub, Becky, and Zolopa, Andrew

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Sexually Transmitted Infections, HIV/AIDS, Infectious Diseases, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Humans, HIV Infections, HIV-1, CD8-Positive T-Lymphocytes, CD4-Positive T-Lymphocytes, DNA, Viral, Sirolimus, Male, Female, Adult, Middle Aged, Immune Checkpoint Proteins, Cell Cycle, Programmed Cell Death 1 Receptor, ACTG A5337 Team, HIV curative strategies, HIV immunology, HIV persistence, HIV reservoirs, antiproliferative medications, immunotherapy, intact proviral HIV-1 DNA, mTOR inhibition, sirolimus, Biomedical and clinical sciences
Abstract

Key HIV cure strategies involve reversing immune dysfunction and limiting the proliferation of infected T cells. We evaluate the safety of sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in people with HIV (PWH) and study the impact of sirolimus on HIV-1 reservoir size and HIV-1-specific immunity in a single-arm study of 20 weeks of treatment in PWH on antiretroviral therapy (ART). Sirolimus treatment does not impact HIV-1-specific CD8 T cell responses but leads to a significant decrease in CD4+ T cell-associated HIV-1 DNA levels at 20 weeks of therapy in the primary efficacy population (n = 16; 31% decline, p = 0.008). This decline persists for at least 12 weeks following cessation of the study drug. Sirolimus treatment also leads to a significant reduction in CD4+ T cell cycling and PD-1 expression on CD8+ lymphocytes. These data suggest that homeostatic proliferation of infected cells, an important mechanism for HIV persistence, is an intriguing therapeutic target.

Published
2024

2. Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Author

Peluso, Michael J, Ryder, Dylan, Flavell, Robert R, Wang, Yingbing, Levi, Jelena, LaFranchi, Brian H, Deveau, Tyler-Marie, Buck, Amanda M, Munter, Sadie E, Asare, Kofi A, Aslam, Maya, Koch, Walter, Szabo, Gyula, Hoh, Rebecca, Deswal, Monika, Rodriguez, Antonio E, Buitrago, Melissa, Tai, Viva, Shrestha, Uttam, Lu, Scott, Goldberg, Sarah A, Dalhuisen, Thomas, Vasquez, Joshua J, Durstenfeld, Matthew S, Hsue, Priscilla Y, Kelly, J Daniel, Kumar, Nitasha, Martin, Jeffrey N, Gambhir, Aruna, Somsouk, Ma, Seo, Youngho, Deeks, Steven G, Laszik, Zoltan G, VanBrocklin, Henry F, and Henrich, Timothy J

Subjects
Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Clinical Research, Coronaviruses, Lung, Emerging Infectious Diseases, Humans, COVID-19, RNA, Viral, SARS-CoV-2, T-Lymphocytes, Male, Middle Aged, Female, Lymphocyte Activation, Positron-Emission Tomography, Adult, Aged, Time Factors, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

The mechanisms of postacute medical conditions and unexplained symptoms after SARS-CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence that viral persistence, immune dysregulation, and T cell dysfunction may play major roles. We performed whole-body positron emission tomography imaging in a well-characterized cohort of 24 participants at time points ranging from 27 to 910 days after acute SARS-CoV-2 infection using the radiopharmaceutical agent [18F]F-AraG, a selective tracer that allows for anatomical quantitation of activated T lymphocytes. Tracer uptake in the postacute COVID-19 group, which included those with and without continuing symptoms, was higher compared with prepandemic controls in many regions, including the brain stem, spinal cord, bone marrow, nasopharyngeal and hilar lymphoid tissue, cardiopulmonary tissues, and gut wall. T cell activation in the spinal cord and gut wall was associated with the presence of LC symptoms. In addition, tracer uptake in lung tissue was higher in those with persistent pulmonary symptoms specifically. Increased T cell activation in these tissues was also observed in many individuals without LC. Given the high [18F]F-AraG uptake detected in the gut, we obtained colorectal tissue for in situ hybridization of SARS-CoV-2 RNA and immunohistochemical studies in a subset of five participants with LC symptoms. We identified intracellular SARS-CoV-2 single-stranded spike protein-encoding RNA in rectosigmoid lamina propria tissue in all five participants and double-stranded spike protein-encoding RNA in three participants up to 676 days after initial COVID-19, suggesting that tissue viral persistence could be associated with long-term immunologic perturbations.

Published
2024

3. Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial.

Author

Jacobs, Tom, Mumbiro, Vivian, Cassia, Uneisse, Zimba, Kevin, Nalwanga, Damalie, Ballesteros, Alvaro, Domínguez-Rodríguez, Sara, Tagarro, Alfredo, Madrid, Lola, Mutata, Constantine, Chitsamatanga, Moses, Bwakura-Dangarembizi, Mutsa, Passanduca, Alfeu, Buck, W, Nduna, Bwendo, Chabala, Chishala, Najjingo, Elizabeth, Musiime, Victor, Moraleda, Cinta, Colbers, Angela, Mujuru, Hilda, Rojo, Pablo, and Burger, David

Subjects
HIV, dolutegravir, drug–drug interaction, infants, rifampicin, Female, Humans, Infant, Male, Heterocyclic Compounds, 3-Ring, HIV, HIV Infections, Oxazines, Piperazines, Pyridones, Rifampin
Abstract

BACKGROUND: We evaluated dolutegravir pharmacokinetics in infants with human immunodeficiency virus (HIV) receiving dolutegravir twice daily (BID) with rifampicin-based tuberculosis (TB) treatment compared with once daily (OD) without rifampicin. METHODS: Infants with HIV aged 1-12 months, weighing ≥3 kg, and receiving dolutegravir BID with rifampicin or OD without rifampicin were eligible. Six blood samples were taken over 12 (BID) or 24 hours (OD). Dolutegravir pharmacokinetic parameters, HIV viral load (VL) data, and adverse events (AEs) were reported. RESULTS: Twenty-seven of 30 enrolled infants had evaluable pharmacokinetic curves. The median (interquartile range) age was 7.1 months (6.1-9.9), weight was 6.3 kg (5.6-7.2), 21 (78%) received rifampicin, and 11 (41%) were female. Geometric mean ratios comparing dolutegravir BID with rifampicin versus OD without rifampicin were area under curve (AUC)0-24h 0.91 (95% confidence interval, .59-1.42), Ctrough 0.95 (0.57-1.59), Cmax 0.87 (0.57-1.33). One infant (5%) receiving rifampicin versus none without rifampicin had dolutegravir Ctrough

Published
2024

4. Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change

Author

Jacobs, Tom G, Mumbiro, Vivian, Chitsamatanga, Moses, Namuziya, Natasha, Passanduca, Alfeu, Domínguez-Rodríguez, Sara, Tagarro, Alfredo, Nathoo, Kusum J, Nduna, Bwendo, Ballesteros, Alvaro, Madrid, Lola, Mujuru, Hilda A, Chabala, Chishala, Buck, W Chris, Rojo, Pablo, Burger, David M, Moraleda, Cinta, and Colbers, Angela

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, HIV/AIDS, Infectious Diseases, Clinical Research, Clinical Trials and Supportive Activities, Pediatric AIDS, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Male, Infant, Humans, Child, Female, Lopinavir, Ritonavir, Rifampin, HIV Infections, Anti-HIV Agents, HIV Protease Inhibitors, lopinavir, infants, rifampin, HIV, tuberculosis, drug-drug interaction, EMPIRICAL Clinical Trial Group, Public Health and Health Services, Virology, Clinical sciences, Epidemiology, Public health
Abstract

BackgroundAlthough super-boosted lopinavir/ritonavir (LPV/r; ratio 4:4 instead of 4:1) is recommended for infants living with HIV and receiving concomitant rifampicin, in clinical practice, many different LPV/r dosing strategies are applied due to poor availability of pediatric separate ritonavir formulations needed to superboost. We evaluated LPV pharmacokinetics in infants with HIV receiving LPV/r dosed according to local guidelines in various sub-Saharan African countries with or without rifampicin-based tuberculosis (TB) treatment.MethodsThis was a 2-arm pharmacokinetic substudy nested within the EMPIRICAL trial (#NCT03915366). Infants aged 1-12 months recruited into the main study were administered LPV/r according to local guidelines and drug availability either with or without rifampicin-based TB treatment; during rifampicin cotreatment, they received double-dosed (ratio 8:2) or semisuperboosted LPV/r (adding a ritonavir 100 mg crushed tablet to the evening LPV/r dose). Six blood samples were taken over 12 hours after intake of LPV/r.ResultsIn total, 14/16 included infants had evaluable pharmacokinetic curves; 9/14 had rifampicin cotreatment (5 received double-dosed and 4 semisuperboosted LPV/r). The median (IQR) age was 6.4 months (5.4-9.8), weight 6.0 kg (5.2-6.8), and 10/14 were male. Of those receiving rifampicin, 6/9 infants (67%) had LPV Ctrough

Published
2023

5. Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021.

Author

Osório, Dulce, Liasse, Suraia, Cassia, Uneisse, Sidat, Muhammad, Taunde, Sérgio, Mate, Belarmina, Pambo, Elcídio, Mazivila, Otília, Elias, Beatriz, Lorenzoni, Cesaltina, and Buck, Chris

Subjects
COVID-19, Mozambique, SARS-CoV-2, hospitalization, infant, Female, Humans, Infant, Child, COVID-19, SARS-CoV-2, Retrospective Studies, Pandemics, Mozambique, Oxygen
Abstract

INTRODUCTION: during the second wave of the COVID-19 pandemic in Mozambique, there was a surge in pediatric hospitalizations at a time when there was relatively little evidence, but significant concern about clinical outcomes in African children, particularly in higher-risk infants requiring, and health system capacity to respond. METHODS: a retrospective cohort study was conducted for patients 1-12 months of age admitted to the Breastfeeding ward at Hospital Central de Maputo from January-February 2021. All had routine SARS-CoV-2 PCR testing performed. For patients with positive results, hospital charts were retrospectively reviewed. Descriptive analyses were performed. RESULTS: of 209 patients that had SARS-CoV-2 PCR testing performed, 102 (48.8%) received results, of which 37 (36.3%) were positive. Positive results were received prior to discharge for 14 patients (37.8%). Median duration of hospitalization was 3 days. There were two deaths in COVID-positive patients (5.4%), both with complex comorbidities. For the 35 COVID-19 positive patients whose charts were located, the principal admission diagnosis was respiratory for 22 (62.9%), and 14 (40.0%) had oxygen saturation 12.0 x 103cells/mL in 10 patients (28.6%) and the most common abnormal finding on chest radiograph was peribronchial thickening (38.5% of patients with results). Oxygen therapy was needed for 20 patients (57.1%). CONCLUSION: the majority of infants with COVID-19 had a mild, short-duration respiratory illness that did not exceed ward capacity for care, including oxygen treatment. Laboratory capacity for PCR testing was overwhelmed, delaying the return of results and complicating inpatient infection control measures.

Published
2023

6. Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci

Author

DeVries, Amber A, Dennis, Joe, Tyrer, Jonathan P, Peng, Pei-Chen, Coetzee, Simon G, Reyes, Alberto L, Plummer, Jasmine T, Davis, Brian D, Chen, Stephanie S, Dezem, Felipe Segato, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia N, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Berchuck, Andrew, Bogdanova, Natalia V, Bogdanova-Markov, Nadja, Brenton, James D, Butzow, Ralf, Campbell, Ian, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Cook, Linda S, DeFazio, Anna, Doherty, Jennifer A, Dörk, Thilo, Eccles, Diana M, Eliassen, A Heather, Fasching, Peter A, Fortner, Renée T, Giles, Graham G, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Webb, P, DeFazio, A, Friedlander, M, Obermair, A, Grant, P, Nagle, C, Beesley, V, Chevenix-Trench, G, Bowtell, D, Blomfield, P, Brand, A, Davis, A, Leung, Y, Nicklin, J, Quinn, M, Livingstone, K, O'Neill, H, Williams, M, Black, A, Hadley, A, Glasgow, A, Garrett, A, Rao, A, Shannon, C, Steer, C, Allen, D, Neesham, D, Otton, G, Au-Yeung, G, Goss, G, Wain, G, Gard, G, Robertson, G, Lombard, J, Tan, J, McNeilage, J, Power, J, Coward, J, Miller, J, Carter, J, Lamont, J, Wong, KM, Reid, K, Perrin, L, Milishkin, L, Nascimento, M, Buck, M, Bunting, M, Harrison, M, Chetty, N, Hacker, N, McNally, O, Harnett, P, Beale, P, Awad, R, Mohan, R, Farrell, R, McIntosh, R, Rome, R, Sayer, R, Houghton, R, Hogg, R, Land, R, Baron-Hay, S, and Paramasivum, S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Human Genome, Genetic Testing, Clinical Research, Ovarian Cancer, Rare Diseases, Prevention, Women's Health, Cancer, Genetics, 2.1 Biological and endogenous factors, Female, Humans, Carcinoma, Ovarian Epithelial, Genome-Wide Association Study, Alleles, DNA Copy Number Variations, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Ovarian Neoplasms, OPAL Study Group, AOCS Group, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundKnown risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort.MethodsSingle nucleotide polymorphism array data from 13 071 EOC cases and 17 306 controls of White European ancestry were used to identify CNVs associated with EOC risk using a rare admixture maximum likelihood test for gene burden and a by-probe ratio test. We performed enrichment analysis of CNVs at known EOC risk loci and functional biofeatures in ovarian cancer-related cell types.ResultsWe identified statistically significant risk associations with CNVs at known EOC risk genes; BRCA1 (PEOC = 1.60E-21; OREOC = 8.24), RAD51C (Phigh-grade serous ovarian cancer [HGSOC] = 5.5E-4; odds ratio [OR]HGSOC = 5.74 del), and BRCA2 (PHGSOC = 7.0E-4; ORHGSOC = 3.31 deletion). Four suggestive associations (P

Published
2022

7. Sperm epigenetic clock associates with pregnancy outcomes in the general population.

Author

Pilsner, J Richard, Saddiki, Hachem, Whitcomb, Brian W, Suvorov, Alexander, Buck Louis, Germaine M, Mumford, Sunni L, Schisterman, Enrique F, Oluwayiose, Oladele A, and Balzer, Laura B

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Prevention, Aging, Clinical Research, Contraception/Reproduction, Reproductive health and childbirth, Child, Epigenesis, Genetic, Female, Humans, Male, Pregnancy, Pregnancy Outcome, Prospective Studies, Semen, Spermatozoa, Time-to-Pregnancy, sperm epigenetic clock, aging, methylation, infertility, pregnancy, machine learning, Medical and Health Sciences, Studies in Human Society, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

Study questionIs sperm epigenetic aging (SEA) associated with probability of pregnancy among couples in the general population?Summary answerWe observed a 17% lower cumulative probability at 12 months for couples with male partners in the older compared to the younger SEA categories.What is known alreadyThe strong relation between chronological age and DNA methylation profiles has enabled the estimation of biological age as epigenetic 'clock' metrics in most somatic tissue. Such clocks in male germ cells are less developed and lack clinical relevance in terms of their utility to predict reproductive outcomes.Study design, size, durationThis was a population-based prospective cohort study of couples discontinuing contraception to become pregnant recruited from 16 US counties from 2005 to 2009 and followed for up to 12 months.Participants/materials, setting, methodsSperm DNA methylation from 379 semen samples was assessed via a beadchip array. A state-of-the-art ensemble machine learning algorithm was employed to predict age from the sperm DNA methylation data. SEA was estimated from clocks derived from individual CpGs (SEACpG) and differentially methylated regions (SEADMR). Probability of pregnancy within 1 year was compared by SEA, and discrete-time proportional hazards models were used to evaluate the relations with time-to-pregnancy (TTP) with adjustment for covariates.Main results and the role of chanceOur SEACpG clock had the highest predictive performance with correlation between chronological and predicted age (r = 0.91). In adjusted discrete Cox models, SEACpG was negatively associated with TTP (fecundability odds ratios (FORs)=0.83; 95% CI: 0.76, 0.90; P = 1.2×10-5), indicating a longer TTP with advanced SEACpG. For subsequent birth outcomes, advanced SEACpG was associated with shorter gestational age (n = 192; -2.13 days; 95% CI: -3.67, -0.59; P = 0.007). Current smokers also displayed advanced SEACpG (P

Published
2022

8. Head-to-head intra-individual comparison of biodistribution and tumor uptake of 68Ga-FAPI and 18F-FDG PET/CT in cancer patients

Author

Giesel, Frederik L, Kratochwil, Clemens, Schlittenhardt, Joel, Dendl, Katharina, Eiber, Matthias, Staudinger, Fabian, Kessler, Lukas, Fendler, Wolfgang P, Lindner, Thomas, Koerber, Stefan A, Cardinale, Jens, Sennung, David, Roehrich, Manuel, Debus, Juergen, Sathekge, Mike, Haberkorn, Uwe, Calais, Jeremie, Serfling, Sebastian, and Buck, Andreas L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Research, Biomedical Imaging, Female, Fluorodeoxyglucose F18, Gallium Radioisotopes, Humans, Male, Middle Aged, Neoplasms, Positron Emission Tomography Computed Tomography, Retrospective Studies, Tissue Distribution, FAPI PET, CT, FDG PET, Cancer-associated fibroblast, Various cancer diseases, FAPI PET/CT, FDG PET/CT, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

PurposeFAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The purpose of this study is the head-to-head intra-individual comparison of 68Ga-FAPI versus standard-of-care 18F-FDG in PET/CT in organ biodistribution and tumor uptake in patients with various cancers.Material and methodsThis international retrospective multicenter analysis included PET/CT data from 71 patients from 6 centers who underwent both 68Ga-FAPI and 18F-FDG PET/CT within a median time interval of 10 days (range 1-89 days). Volumes of interest (VOIs) were manually drawn in normal organs and tumor lesions to quantify tracer uptake by SUVmax and SUVmean. Furthermore, tumor-to-background ratios (TBR) were generated (SUVmax tumor/ SUVmax organ).ResultsA total of 71 patients were studied of, which 28 were female and 43 male (median age 60). In 41 of 71 patients, the primary tumor was present. Forty-three of 71 patients exhibited 162 metastatic lesions. 68Ga-FAPI uptake in primary tumors and metastases was comparable to 18F-FDG in most cases. The SUVmax was significantly lower for 68Ga-FAPI than 18F-FDG in background tissues such as the brain, oral mucosa, myocardium, blood pool, liver, pancreas, and colon. Thus, 68Ga-FAPI TBRs were significantly higher than 18F-FDG TBRs in some sites, including liver and bone metastases.ConclusionQuantitative tumor uptake is comparable between 68Ga-FAPI and 18F-FDG, but lower background uptake in most normal organs results in equal or higher TBRs for 68Ga-FAPI. Thus, 68Ga-FAPI PET/CT may yield improved diagnostic information in various cancers and especially in tumor locations with high physiological 18F-FDG uptake.

Published
2021

9. Extrathymic Aire-expressing cells support maternal-fetal tolerance

Author

Gillis-Buck, Eva, Miller, Haleigh, Sirota, Marina, Sanders, Stephan J, Ntranos, Vasilis, Anderson, Mark S, Gardner, James M, and MacKenzie, Tippi C

Subjects
Pediatric, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, 1.1 Normal biological development and functioning, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Animals, Epithelial Cells, Female, Fetal Growth Retardation, Fetus, Immune Tolerance, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Placenta, Pregnancy, Thymus Gland, Transcription Factors
Abstract

Healthy pregnancy requires tolerance to fetal alloantigens as well as syngeneic embryonic and placental antigens. Given the importance of the autoimmune regulator (Aire) gene in self-tolerance, we investigated the role of Aire-expressing cells in maternal-fetal tolerance. We report that maternal ablation of Aire-expressing (Aire +) cells during early mouse pregnancy caused intrauterine growth restriction (IUGR) in both allogeneic and syngeneic pregnancies. This phenotype is immune mediated, as IUGR was rescued in Rag1-deficient mice, and involved a memory response, demonstrated by recurrence of severe IUGR in second pregnancies. Single-cell RNA sequencing demonstrated that Aire + cell depletion in pregnancy results in expansion of activated T cells, particularly T follicular helper cells. Unexpectedly, selective ablation of either Aire-expressing medullary thymic epithelial cells or extrathymic Aire-expressing cells (eTACs) mapped the IUGR phenotype exclusively to eTACs. Thus, we report a previously undescribed mechanism for the maintenance of maternal-fetal immune homeostasis and demonstrate that eTACs protect the conceptus from immune-mediated IUGR.

Published
2021

10. Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration

Author

Buck, Silas A, Steinkellner, Thomas, Aslanoglou, Despoina, Villeneuve, Michael, Bhatte, Sai H, Childers, Victoria C, Rubin, Sophie A, De Miranda, Briana R, O'Leary, Emma I, Neureiter, Elizabeth G, Fogle, Keri J, Palladino, Michael J, Logan, Ryan W, Glausier, Jill R, Fish, Kenneth N, Lewis, David A, Greenamyre, J Timothy, McCabe, Brian D, Cheetham, Claire EJ, Hnasko, Thomas S, and Freyberg, Zachary

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Basic Behavioral and Social Science, Neurosciences, Aging, Neurodegenerative, Behavioral and Social Science, Neurological, Animals, Cell Survival, Dopaminergic Neurons, Drosophila, Drosophila Proteins, Female, Humans, Locomotion, Male, Mice, Rats, Sex Characteristics, Vesicular Glutamate Transport Proteins, aging, dopamine, neurodegeneration, vesicular glutamate transporter, Drosophila, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Age is the greatest risk factor for Parkinson's disease (PD) which causes progressive loss of dopamine (DA) neurons, with males at greater risk than females. Intriguingly, some DA neurons are more resilient to degeneration than others. Increasing evidence suggests that vesicular glutamate transporter (VGLUT) expression in DA neurons plays a role in this selective vulnerability. We investigated the role of DA neuron VGLUT in sex- and age-related differences in DA neuron vulnerability using the genetically tractable Drosophila model. We found sex differences in age-related DA neurodegeneration and its associated locomotor behavior, where males exhibit significantly greater decreases in both DA neuron number and locomotion during aging compared with females. We discovered that dynamic changes in DA neuron VGLUT expression mediate these age- and sex-related differences, as a potential compensatory mechanism for diminished DA neurotransmission during aging. Importantly, female Drosophila possess higher levels of VGLUT expression in DA neurons compared with males, and this finding is conserved across flies, rodents, and humans. Moreover, we showed that diminishing VGLUT expression in DA neurons eliminates females' greater resilience to DA neuron loss across aging. This offers a new mechanism for sex differences in selective DA neuron vulnerability to age-related DA neurodegeneration. Finally, in mice, we showed that the ability of DA neurons to achieve optimal control over VGLUT expression is essential for DA neuron survival. These findings lay the groundwork for the manipulation of DA neuron VGLUT expression as a novel therapeutic strategy to boost DA neuron resilience to age- and PD-related neurodegeneration.

Published
2021

11. Inpatient Point-of-Care HIV Early Infant Diagnosis in Mozambique to Improve Case Identification and Linkage to Antiretroviral Therapy

Author

Matsinhe, Mércia, Bollinger, Timothy, Lee, Nilza, Loquiha, Osvaldo, Meggi, Bindiya, Mabunda, Nédio, Mudenyanga, Chishamiso, Mutsaka, Dadirayi, Florêncio, Marcelina, Mucaringua, Aurora, Macassa, Eugénia, Seni, Amir, Jani, Ilesh, and Buck, W Chris

Subjects
Health Services and Systems, Public Health, Health Sciences, Pediatric, Prevention, Infectious Diseases, Patient Safety, Clinical Research, HIV/AIDS, Health Services, Good Health and Well Being, Child, Female, HIV Infections, Humans, Infant, Infectious Disease Transmission, Vertical, Inpatients, Mozambique, Point-of-Care Systems, Retrospective Studies, Health services and systems, Public health
Abstract

IntroductionNovel approaches to case identification and linkage to antiretroviral therapy (ART) are needed to close gaps in early infant diagnosis (EID) of HIV. Point-of-care (POC) EID is a recent innovation that eliminates the long turnaround times of conventional EID that limit patient management in the inpatient setting. The initial deployment of POC EID in Mozambique focused primarily on outpatient clinics; however, 2 high-volume tier-4 pediatric referral hospitals were also included.MethodsTo assess the impact of inpatient POC EID, a retrospective review of testing and care data from Hospital Central de Beira (HCB) and Hospital Central de Maputo (HCM) was performed for the period September 2017 to July 2018, with comparison to the 8-month pre-POC period when dried blood spots were used for conventional EID.ResultsMonthly testing volume increased from 8.5 tests pre-POC to 17.6 tests with POC (P

Published
2021

12. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Author

Whitman, Jeffrey D, Hiatt, Joseph, Mowery, Cody T, Shy, Brian R, Yu, Ruby, Yamamoto, Tori N, Rathore, Ujjwal, Goldgof, Gregory M, Whitty, Caroline, Woo, Jonathan M, Gallman, Antonia E, Miller, Tyler E, Levine, Andrew G, Nguyen, David N, Bapat, Sagar P, Balcerek, Joanna, Bylsma, Sophia A, Lyons, Ana M, Li, Stacy, Wong, Allison Wai-yi, Gillis-Buck, Eva Mae, Steinhart, Zachary B, Lee, Youjin, Apathy, Ryan, Lipke, Mitchell J, Smith, Jennifer Anne, Zheng, Tina, Boothby, Ian C, Isaza, Erin, Chan, Jackie, Acenas, Dante D, Lee, Jinwoo, Macrae, Trisha A, Kyaw, Than S, Wu, David, Ng, Dianna L, Gu, Wei, York, Vanessa A, Eskandarian, Haig Alexander, Callaway, Perri C, Warrier, Lakshmi, Moreno, Mary E, Levan, Justine, Torres, Leonel, Farrington, Lila A, Loudermilk, Rita P, Koshal, Kanishka, Zorn, Kelsey C, Garcia-Beltran, Wilfredo F, Yang, Diane, Astudillo, Michael G, Bernstein, Bradley E, Gelfand, Jeffrey A, Ryan, Edward T, Charles, Richelle C, Iafrate, A John, Lennerz, Jochen K, Miller, Steve, Chiu, Charles Y, Stramer, Susan L, Wilson, Michael R, Manglik, Aashish, Ye, Chun Jimmie, Krogan, Nevan J, Anderson, Mark S, Cyster, Jason G, Ernst, Joel D, Wu, Alan HB, Lynch, Kara L, Bern, Caryn, Hsu, Patrick D, and Marson, Alexander

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Biodefense, Pneumonia & Influenza, Prevention, Clinical Research, Infectious Diseases, Lung, Vaccine Related, Pneumonia, Emerging Infectious Diseases, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 4.2 Evaluation of markers and technologies, Infection, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Antibodies, Viral, Betacoronavirus, Biotechnology, COVID-19, COVID-19 Testing, Chromatography, Affinity, Clinical Laboratory Techniques, Coronavirus Infections, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G, Immunoglobulin M, Male, Middle Aged, Pandemics, Pneumonia, Viral, Point-of-Care Testing, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Sensitivity and Specificity, Young Adult
Abstract

Appropriate use and interpretation of serological tests for assessments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure, infection and potential immunity require accurate data on assay performance. We conducted a head-to-head evaluation of ten point-of-care-style lateral flow assays (LFAs) and two laboratory-based enzyme-linked immunosorbent assays to detect anti-SARS-CoV-2 IgM and IgG antibodies in 5-d time intervals from symptom onset and studied the specificity of each assay in pre-coronavirus disease 2019 specimens. The percent of seropositive individuals increased with time, peaking in the latest time interval tested (>20 d after symptom onset). Test specificity ranged from 84.3% to 100.0% and was predominantly affected by variability in IgM results. LFA specificity could be increased by considering weak bands as negative, but this decreased detection of antibodies (sensitivity) in a subset of SARS-CoV-2 real-time PCR-positive cases. Our results underline the importance of seropositivity threshold determination and reader training for reliable LFA deployment. Although there was no standout serological assay, four tests achieved more than 80% positivity at later time points tested and more than 95% specificity.

Published
2020

13. Discordant retention of HIV-infected mothers and children

Author

Nhampossa, Tacilta, Fernandez, Sheila, Augusto, Orvalho, Fuente-Soro, Laura, Maculuve, SÓ nia, Bernardo, Edson, Saura, Anna, Casellas, Aina, Gonzalez, Raquel, Ruperez, Maria, Karajeans, Esmeralda, Vaz, Paula, Menendez, Clara, Buck, W Chris, Naniche, Denise, and Lopez-Varela, Elisa

Subjects
Pediatric, Pediatric AIDS, Clinical Research, Infectious Diseases, HIV/AIDS, Infection, Good Health and Well Being, Adult, Anti-HIV Agents, Child, Child, Preschool, Cohort Studies, Family Practice, Female, HIV Infections, Humans, Infant, Infant, Newborn, Lost to Follow-Up, Male, Mothers, Mozambique, Patient Compliance, ART, children, family, HIV, lost to follow up, retention, Clinical Sciences, Arthritis & Rheumatology
Abstract

It is often assumed that children and their caregivers either stay in care together or discontinue together, but data is lacking on caregiver-child retention concordance. We sought to describe the pattern of care among a cohort of human immunodeficiency virus (HIV) infected children and mothers enrolled in care at the Manhiça District Hospital (MDH).This was a retrospective review of routine HIV clinical data collected under a larger prospective HIV cohort study at MDH. Children enrolling HIV care from January 2013 to November 2016 were identified and matched to their mother's HIV clinical data. Retention in care for mothers and children was assessed at 24 months after the child's enrolment. Multinomial logistic regression was performed to evaluate variables associated with retention discordance.For the 351 mother-child pairs included in the study, only 39% of mothers had concordant care status at baseline (23% already active in care, 16% initiated care concurrently with their children). At 24-months follow up, a total of 108 (31%) mother-child pairs were concordantly retained in care, 88 (26%) pairs were concordantly lost to follow up (LTFU), and 149 (43%) had discordant retention. Pairs with concurrent registration had a higher probability of being concordantly retained in care. Children who presented with advanced clinical or immunological stage had increased probability of being concordantly LTFU.High rates of LTFU as well as high proportions of discordant retention among mother-child pairs were found. Prioritization of a family-based care model that has the potential to improve retention for children and caregivers is recommended.

Published
2020

14. Quality of life assessments in a cohort of Mozambican children with sickle cell disease

Author

Issa, Faiaz, Dang, Brian Norman, Buck, W Chris, Chicumbe, Sérgio, Nicolau, Nelsa, Virate, Chana, Cassamo, Naya, Dias, Angelina, and Amodo, Faizana

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Chronic Pain, Pain Research, Mind and Body, Behavioral and Social Science, Sickle Cell Disease, Rare Diseases, Pediatric, Hematology, Clinical Research, 7.1 Individual care needs, Management of diseases and conditions, Good Health and Well Being, Adolescent, Analgesics, Opioid, Anemia, Sickle Cell, Caregivers, Child, Child, Preschool, Cohort Studies, Female, Health Services Accessibility, Humans, Hydroxyurea, Male, Mozambique, Pain, Pain Management, Quality of Life, Social Support, Surveys and Questionnaires, Sickle cell disease, quality of life, hydroxyurea, children, pediatrics, Clinical sciences, Health services and systems, Public health
Abstract

Introductionsickle cell disease (SCD) has significant pediatric morbidity and mortality in sub-Saharan Africa, where access to therapies such as hydroxyurea and opioids is often limited. Poor disease control and Pain management adversely affects the well-being and mental health of affected children. Questionnaires have been utilized in other regions to report the quality of life (QOL) in children with SCD, but assessments from Africa are lacking.Methodschildren age 2-14 years with SCD presenting for routine outpatient consultations at Hospital Central de Maputo from June-August 2017 were offered participation. After informed consent, the Pediatric QOL Inventory (PedsQL) SCD Module was administered to all caregivers and children > 5 years. Responses were scored from 0-100, with higher scores representing better QOL.Resultsa total of 14 children were included, with six (43%), four (29%), two (14%), and two (14%) from the age groups of 2-4, 5-7, 8-12, and 13-14 years, respectively. Mean overall patient QOL was 65.3 and 56.0 in child and caregiver respondents. In patients > 5 years, the difference in mean overall QOL for those on/not on hydroxyurea was 0.6 (66.5-64.9) in child respondents and 15.8 (68.4-52.6) in caregiver respondents. Domains related to worry/emotions and communication scored lower in QOL than Pain-related domains for both patient and caregiver respondents.ConclusionSCD has a negative impact on QOL as reported by this cohort of Mozambican pediatric patients and caregivers, with Pain being less of a concern than emotional and interpersonal issues. A comprehensive, child-focused care approach with robust psychosocial support is needed.

Published
2020

15. Epidemiology of Disease and Mortality From a PICU in Mozambique*

Author

Punchak, Maria, Hall, Kaitlin, Seni, Amir, Buck, W Chris, DeUgarte, Daniel A, Hartford, Emily, Kelly, Robert B, and Muando, Valéria I

Subjects
Public Health, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Infectious Diseases, Patient Safety, Hematology, Clinical Research, Sepsis, Physical Injury - Accidents and Adverse Effects, 8.1 Organisation and delivery of services, Health and social care services research, Infection, Good Health and Well Being, Adolescent, Cause of Death, Child, Child Mortality, Child, Preschool, Critical Care, Female, HIV Infections, Hospital Mortality, Humans, Infant, Infant, Newborn, Intensive Care Units, Pediatric, Length of Stay, Malaria, Male, Mozambique, Poverty, Retrospective Studies, burns, human immunodeficiency virus, malaria, pediatric, sepsis, trauma, Nursing, Paediatrics and Reproductive Medicine, Pediatrics, Clinical sciences, Paediatrics
Abstract

ObjectivesDelivery of pediatric critical care in low-income countries is limited by a lack of infrastructure, resources, and providers. Few studies have analyzed the epidemiology of disease associated with a PICU in a low-income country. The aim of this study was to document the primary diagnoses and the associated mortality rates of patients presenting to a tertiary PICU in Mozambique in order to formulate quality improvement projects through an international academic partnership. We hypothesized that the PICU mortality rate would be high and that sepsis would be a common cause of death.DesignRetrospective, observational study.SettingTertiary academic PICU.PatientsAll admitted PICU patients.InterventionsAll available data collection forms containing demographic and clinical data of patients admitted to the PICU at Hospital Central de Maputo, Mozambique from January 2013 to December 2013 were analyzed retrospectively.Measurements and main resultsThe patient median age was 2 years (57% male). The most common primary diagnoses were malaria (22%), sepsis (18%), respiratory tract infections (12%), and trauma (6%). The mortality rate was 25%. Mortality rates were highest among patients with sepsis (59%), encephalopathy (56%), noninfectious CNS pathologies (33%), neoplastic diseases (33%), meningitis/encephalitis (29%), burns (26%), and cardiovascular pathologies (26%). The median length of PICU stay was 2 days. HIV exposure/infection had a nonstatistically significant association with mortality. Patients admitted for burns had the highest median length of PICU stay (4 d). Most trauma admissions were male (75%), and approximately half of all trauma admissions had an associated head injury (55%).ConclusionsInfectious disease and trauma were highly represented in this Mozambican PICU, and overall mortality was high compared with high-income countries. With this knowledge, targeted collaborative projects in Mozambique can now be created and modified. Further research is needed to monitor the potential benefits of such interventions.

Published
2018

16. Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo

Author

Buck, Amanda KW, Groszek, Joseph J, Colvin, Daniel C, Keller, Sara B, Kensinger, Clark, Forbes, Rachel, Karp, Seth, Williams, Phillip, Roy, Shuvo, and Fissell, William H

Subjects
Fluid Mechanics and Thermal Engineering, Engineering, Biomedical Engineering, Clinical Research, Assistive Technology, Bioengineering, Hematology, Cardiovascular, Animals, Computer Simulation, Dogs, Equipment Design, Female, Hemodynamics, Hemofiltration, Hydrodynamics, Kidneys, Artificial, Platelet Activation, Stress, Mechanical, Thrombosis, hemofilter, hemodynamics, thrombogenicity, bioartificial kidney, Biomedical engineering
Abstract

A major challenge in developing blood-contacting medical devices is mitigating thrombogenicity of an intravascular device. Thrombi may interfere with device function or embolize from the device to occlude distant vascular beds with catastrophic consequences. Chemical interactions between plasma proteins and bioengineered surface occur at the nanometer scale; however, continuum models of blood predict local shear stresses that lead to platelet activation or aggregation and thrombosis. Here, an iterative approach to blood flow path design incorporating in silico, in vitro, and in vivo experiments predicted the occurrence and location of thrombi in an implantable hemofilter. Low wall shear stress (WSS) regions identified by computational fluid dynamics (CFD) predicted clot formation in vivo. Revised designs based on CFD demonstrated superior performance, illustrating the importance of a multipronged approach for a successful design process.

Published
2018

17. Most Frequently Reported Prescription Medications and Supplements in Couples Planning Pregnancy: The LIFE Study

Author

Palmsten, Kristin, Flores, Katrina F, Chambers, Christina D, Weiss, Lauren A, Sundaram, Rajeshwari, and Buck Louis, Germaine M

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Trials and Supportive Activities, Clinical Research, Infertility, Contraception/Reproduction, Reproductive health and childbirth, Adult, Dietary Supplements, Female, Fertilization, Humans, Male, Nonprescription Drugs, Preconception Care, Pregnancy, Prescription Drugs, Prospective Studies, dietary supplements, fecundity, fertility, medication, preconception care, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Reproductive medicine, Midwifery
Abstract

ObjectiveTo identify frequently reported prescription medications and supplements among couples planning pregnancy because there is a lack of descriptive information on these agents in women and men who are trying to conceive.MethodsFive hundred one couples enrolled in the Longitudinal Study of Infertility and the Environment, which took place between 2005 and 2009. Participants reported prescription medications as well as prescription and over-the-counter supplements used through interviews at study enrollment and through daily dairies during the 12-month follow-up. We identified prescription medications and supplements prospectively reported by ≥1% of women and men at baseline and from daily journal information grouped into 3-month preconception follow-up intervals while couples tried for pregnancy.ResultsThe 5 most reported prescription medications among women were levothyroxine (5.8%), cetirizine (2.6%), fluticasone (2.4%), escitalopram (1.8%), and fluoxetine (1.8%) and for men were lisinopril (2.0%), mometasone (2.0%), fexofenadine (1.8%), atorvastatin (1.6%), and montelukast (1.6%). The most reported supplements were multivitamins (63.3%, 43.5%) and fish oil (13.2%, 9.4%) for women and men, respectively, and prenatal vitamins (22.0%) for women. For women during the first 3 months of follow-up, prenatal vitamins (6.0%) and antibiotics (1.2%-2.6%) were among the most frequently started medications. During the next 3 months, clomiphene (4.5%) was the most frequently initiated medication.ConclusionsCouples trying for pregnancy reported a variety of prescription medications and supplements, and they differed by gender. Preconception guidance should address medication and supplement use to avoid potential exposures associated with adverse reproductive and perinatal outcomes.

Published
2018

18. Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice

Author

Laura L. Giacometti, Lauren A. Buck, and Jacqueline M. Barker

Subjects
Progesterone, Estrous cycle, Reinstatement, Reward seeking, Stress, Female, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Women are more vulnerable to stress-induced craving, which may be associated with increased vulnerability to relapse. Susceptibility to stress-induced craving also appears to be modulated by the menstrual cycle and is negatively correlated with circulating progesterone levels in women. However, the factors that contribute to relapse vulnerability are poorly characterized in female animals. In this study, we assessed whether chronic ethanol exposure, estrous cycle, or exogenous progesterone administration modulated vulnerability to stress-induced reinstatement. To model ethanol dependence, adult female C57Bl/6J mice underwent chronic intermittent ethanol (CIE) exposure via vapor inhalation. Seventy-two hours after the final ethanol exposure, food-restricted mice began training in a conditioned place preference paradigm (CPP) for a food reward, followed by extinction training. Mice were then subjected to forced swim stress and assessed for reinstatement of their preference for the reward-paired chamber. CIE did not affect stress-induced reinstatement. However, stress-induced reinstatement was attenuated during the diestrus phase, when endogenous levels of progesterone peak in female mice. Further, administration of exogenous progesterone mimicked the attenuated reinstatement observed in diestrus. These findings indicate that circulating hormone levels modulate susceptibility to relapse-like behaviors and implicate progesterone as a potential target for treating stress-induced relapse in women.

Published
2022
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19. Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish

Author

Yan, Yi‐Lin, Desvignes, Thomas, Bremiller, Ruth, Wilson, Catherine, Dillon, Danielle, High, Samantha, Draper, Bruce, Buck, Charles Loren, and Postlethwait, John

Subjects
Biochemistry and Cell Biology, Genetics, Biological Sciences, Infertility, Contraception/Reproduction, Rare Diseases, Estrogen, Underpinning research, 1.1 Normal biological development and functioning, Reproductive health and childbirth, Adult Stem Cells, Animals, Female, Gene Expression Regulation, Developmental, Gonads, Humans, Male, Ovarian Follicle, Polycystic Ovary Syndrome, Transforming Growth Factor beta, Zebrafish Proteins, BMP15, GDF9, Sertoli cells, TGFβ, gonad development, gonadal soma germ cell interaction, granulosa cells, insulin signaling, oogenesis, ovarian follicle, polycystic ovarian syndrome, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology, Bioinformatics and computational biology, Evolutionary biology
Abstract

BackgroundAberrant signaling between germ cells and somatic cells can lead to reproductive disease and depends on diffusible signals, including transforming growth factor-beta (TGFB) -family proteins. The TGFB-family protein Gsdf (gonadal soma derived factor) controls sex determination in some fish and is a candidate for mediating germ cell/soma signaling.ResultsZebrafish expressed gsdf in somatic cells of bipotential gonads and expression continued in ovarian granulosa cells and testicular Sertoli cells. Homozygous gsdf knockout mutants delayed leaving the bipotential gonad state, but then became a male or a female. Mutant females ovulated a few oocytes, then became sterile, accumulating immature follicles. Female mutants stored excess lipid and down-regulated aromatase, gata4, insulin receptor, estrogen receptor, and genes for lipid metabolism, vitellogenin, and steroid biosynthesis. Mutant females contained less estrogen and more androgen than wild-types. Mutant males were fertile. Genomic analysis suggests that Gsdf, Bmp15, and Gdf9, originated as paralogs in vertebrate genome duplication events.ConclusionsIn zebrafish, gsdf regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra-ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS), suggesting a role for a related TGFB signaling molecule in the etiology of PCOS. Developmental Dynamics 246:925-945, 2017. © 2017 Wiley Periodicals, Inc.

Published
2017

20. Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Coleman, Robert L, Oza, Amit M, Lorusso, Domenica, Aghajanian, Carol, Oaknin, Ana, Dean, Andrew, Colombo, Nicoletta, Weberpals, Johanne I, Clamp, Andrew, Scambia, Giovanni, Leary, Alexandra, Holloway, Robert W, Gancedo, Margarita Amenedo, Fong, Peter C, Goh, Jeffrey C, O'Malley, David M, Armstrong, Deborah K, Garcia-Donas, Jesus, Swisher, Elizabeth M, Floquet, Anne, Konecny, Gottfried E, McNeish, Iain A, Scott, Clare L, Cameron, Terri, Maloney, Lara, Isaacson, Jeff, Goble, Sandra, Grace, Caroline, Harding, Thomas C, Raponi, Mitch, Sun, James, Lin, Kevin K, Giordano, Heidi, Ledermann, Jonathan A, investigators, ARIEL3, Buck, M, Dean, A, Friedlander, ML, Goh, JC, Harnett, P, Kichenadasse, G, Scott, CL, Denys, H, Dirix, L, Vergote, I, Elit, L, Ghatage, P, Oza, AM, Plante, M, Provencher, D, Weberpals, JI, Welch, S, Floquet, A, Gladieff, L, Joly, F, Leary, A, Lortholary, A, Lotz, J, Medioni, J, Tredan, O, You, B, El-Balat, A, Hänle, C, Krabisch, P, Neunhöffer, T, Pölcher, M, Wimberger, P, Amit, A, Kovel, S, Leviov, M, Safra, T, Shapira-Frommer, R, Stemmer, S, Bologna, A, Colombo, N, Lorusso, D, Pignata, S, Sabbatini, RF, Scambia, G, Tamberi, S, Zamagni, C, Fong, PC, O'Donnell, A, Gancedo, M Amenedo, Herraez, A Casado, Garcia-Donas, J, Guerra, EM, Oaknin, A, Palacio, I, Romero, I, Sanchez, A, Banerjee, SN, Clamp, A, Drew, Y, Gabra, HG, Jackson, D, Ledermann, JA, McNeish, IA, Parkinson, C, and Powell, M

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Orphan Drug, Clinical Research, Cancer, Genetics, Clinical Trials and Supportive Activities, Ovarian Cancer, Rare Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, 6.2 Cellular and gene therapies, Aged, Disease-Free Survival, Double-Blind Method, Female, Follow-Up Studies, Humans, Indoles, Internationality, Maintenance Chemotherapy, Middle Aged, Molecular Targeted Therapy, Neoplasm Recurrence, Local, Ovarian Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Risk Assessment, Survival Rate, Treatment Outcome, ARIEL3 investigators, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundRucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma.MethodsIn this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients from 87 hospitals and cancer centres across 11 countries. Eligible patients were aged 18 years or older, had a platinum-sensitive, high-grade serous or endometrioid ovarian, primary peritoneal, or fallopian tube carcinoma, had received at least two previous platinum-based chemotherapy regimens, had achieved complete or partial response to their last platinum-based regimen, had a cancer antigen 125 concentration of less than the upper limit of normal, had a performance status of 0-1, and had adequate organ function. Patients were ineligible if they had symptomatic or untreated central nervous system metastases, had received anticancer therapy 14 days or fewer before starting the study, or had received previous treatment with a poly(ADP-ribose) polymerase inhibitor. We randomly allocated patients 2:1 to receive oral rucaparib 600 mg twice daily or placebo in 28 day cycles using a computer-generated sequence (block size of six, stratified by homologous recombination repair gene mutation status, progression-free interval after the penultimate platinum-based regimen, and best response to the most recent platinum-based regimen). Patients, investigators, site staff, assessors, and the funder were masked to assignments. The primary outcome was investigator-assessed progression-free survival evaluated with use of an ordered step-down procedure for three nested cohorts: patients with BRCA mutations (carcinoma associated with deleterious germline or somatic BRCA mutations), patients with homologous recombination deficiencies (BRCA mutant or BRCA wild-type and high loss of heterozygosity), and the intention-to-treat population, assessed at screening and every 12 weeks thereafter. This trial is registered with ClinicalTrials.gov, number NCT01968213; enrolment is complete.FindingsBetween April 7, 2014, and July 19, 2016, we randomly allocated 564 patients: 375 (66%) to rucaparib and 189 (34%) to placebo. Median progression-free survival in patients with a BRCA-mutant carcinoma was 16·6 months (95% CI 13·4-22·9; 130 [35%] patients) in the rucaparib group versus 5·4 months (3·4-6·7; 66 [35%] patients) in the placebo group (hazard ratio 0·23 [95% CI 0·16-0·34]; p

Published
2017

21. Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid.

Author

Düwel, Stephan, Hundshammer, Christian, Gersch, Malte, Feuerecker, Benedikt, Steiger, Katja, Buck, Achim, Walch, Axel, Haase, Axel, Glaser, Steffen J, Schwaiger, Markus, and Schilling, Franz

Subjects
Kidney, Hela Cells, Animals, Humans, Rats, Mammary Neoplasms, Animal, Carbon Isotopes, Furans, Contrast Media, Magnetic Resonance Imaging, Staining and Labeling, Injections, Subcutaneous, Hydrogen-Ion Concentration, Female, Urinary Bladder, MCF-7 Cells, HeLa Cells, Mammary Neoplasms, Animal, Injections, Subcutaneous
Abstract

Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that 13C-labelled zymonic acid (ZA) can be used as hyperpolarized magnetic resonance pH imaging sensor. ZA is synthesized from [1-13C]pyruvic acid and its 13C resonance frequencies shift up to 3.0 p.p.m. per pH unit in the physiological pH range. The long lifetime of the hyperpolarized signal enhancement enables monitoring of pH, independent of concentration, temperature, ionic strength and protein concentration. We show in vivo pH maps within rat kidneys and subcutaneously inoculated tumours derived from a mammary adenocarcinoma cell line and characterize ZA as non-toxic compound predominantly present in the extracellular space. We suggest that ZA represents a reliable and non-invasive extracellular imaging sensor to localize and quantify pH, with the potential to improve understanding, diagnosis and therapy of diseases characterized by aberrant acid-base balance.

Published
2017

22. Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses

Author

Nguyen, Khang D, Lee, Eunice E, Yue, Yangbo, Stork, Jiri, Pock, Lumir, North, Jeffrey P, Vandergriff, Travis, Cockerell, Clay, Hosler, Gregory A, Pastrana, Diana V, Buck, Christopher B, and Wang, Richard C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Emerging Infectious Diseases, Infection, Skin, Adult, Antigens, Viral, Tumor, Biopsy, Capsid Proteins, Case-Control Studies, Female, Humans, Keratinocytes, Keratosis, Male, Middle Aged, Polyomavirus, Polyomavirus Infections, Pruritus, Retrospective Studies, Viral Load, dyskeratosis, HIV/AIDS, human polyomavirus 6, human polyomavirus 7, immunosuppression, organ transplantation, parakeratosis, polyomavirus, pruritus, Dermatology & Venereal Diseases, Clinical sciences
Abstract

BackgroundHuman polyomavirus (HPyV)6 and HPyV7 are shed chronically from human skin. HPyV7, but not HPyV6, has been linked to a pruritic skin eruption of immunosuppression.ObjectiveWe determined whether biopsy specimens showing a characteristic pattern of dyskeratosis and parakeratosis might be associated with polyomavirus infection.MethodsWe screened biopsy specimens showing "peacock plumage" histology by polymerase chain reaction for HPyVs. Cases positive for HPyV6 or HPyV7 were then analyzed by immunohistochemistry, electron microscopy, immunofluorescence, quantitative polymerase chain reaction, and complete sequencing, including unbiased, next-generation sequencing.ResultsWe identified 3 additional cases of HPyV6 or HPyV7 skin infections. Expression of T antigen and viral capsid was abundant in lesional skin. Dual immunofluorescence staining experiments confirmed that HPyV7 primarily infects keratinocytes. High viral loads in lesional skin compared with normal-appearing skin and the identification of intact virions by both electron microscopy and next-generation sequencing support a role for active viral infections in these skin diseases.LimitationThis was a small case series of archived materials.ConclusionWe have found that HPyV6 and HPyV7 are associated with rare, pruritic skin eruptions with a distinctive histologic pattern and describe this entity as "HPyV6- and HPyV7-associated pruritic and dyskeratotic dermatoses."

Published
2017

23. Integrated genomic and molecular characterization of cervical cancer.

Author

Cancer Genome Atlas Research Network, Albert Einstein College of Medicine, Analytical Biological Services, Barretos Cancer Hospital, Baylor College of Medicine, Beckman Research Institute of City of Hope, Buck Institute for Research on Aging, Canada's Michael Smith Genome Sciences Centre, Harvard Medical School, Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services, HudsonAlpha Institute for Biotechnology, ILSbio, LLC, Indiana University School of Medicine, Institute of Human Virology, Institute for Systems Biology, International Genomics Consortium, Leidos Biomedical, Massachusetts General Hospital, McDonnell Genome Institute at Washington University, Medical College of Wisconsin, Medical University of South Carolina, Memorial Sloan Kettering Cancer Center, Montefiore Medical Center, NantOmics, National Cancer Institute, National Hospital, Abuja, Nigeria, National Human Genome Research Institute, National Institute of Environmental Health Sciences, National Institute on Deafness &Other Communication Disorders, Ontario Tumour Bank, London Health Sciences Centre, Ontario Tumour Bank, Ontario Institute for Cancer Research, Ontario Tumour Bank, The Ottawa Hospital, Oregon Health &Science University, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, SRA International, St Joseph's Candler Health System, Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University, Research Institute at Nationwide Children's Hospital, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, University of Bergen, University of Texas MD Anderson Cancer Center, University of Abuja Teaching Hospital, University of Alabama at Birmingham, University of California, Irvine, University of California Santa Cruz, University of Kansas Medical Center, University of Lausanne, University of New Mexico Health Sciences Center, University of North Carolina at Chapel Hill, University of Oklahoma Health Sciences Center, University of Pittsburgh, University of São Paulo, Ribeir ão Preto Medical School, University of Southern California, University of Washington, University of Wisconsin School of Medicine &Public Health, Van Andel Research Institute, and Washington University in St Louis

Subjects
Cancer Genome Atlas Research Network, Albert Einstein College of Medicine, Analytical Biological Services, Barretos Cancer Hospital, Baylor College of Medicine, Beckman Research Institute of City of Hope, Buck Institute for Research on Aging, Canada's Michael Smith Genome Sciences Centre, Harvard Medical School, Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services, HudsonAlpha Institute for Biotechnology, ILSbio, LLC, Indiana University School of Medicine, Institute of Human Virology, Institute for Systems Biology, International Genomics Consortium, Leidos Biomedical, Massachusetts General Hospital, McDonnell Genome Institute at Washington University, Medical College of Wisconsin, Medical University of South Carolina, Memorial Sloan Kettering Cancer Center, Montefiore Medical Center, NantOmics, National Cancer Institute, National Hospital, Abuja, Nigeria, National Human Genome Research Institute, National Institute of Environmental Health Sciences, National Institute on Deafness &Other Communication Disorders, Ontario Tumour Bank, London Health Sciences Centre, Ontario Tumour Bank, Ontario Institute for Cancer Research, Ontario Tumour Bank, The Ottawa Hospital, Oregon Health &Science University, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, SRA International, St Joseph's Candler Health System, Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University, Research Institute at Nationwide Children's Hospital, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, University of Bergen, University of Texas MD Anderson Cancer Center, University of Abuja Teaching Hospital, University of Alabama at Birmingham, University of California, Irvine, University of California Santa Cruz, University of Kansas Medical Center, University of Lausanne, University of New Mexico Health Sciences Center, University of North Carolina at Chapel Hill, University of Oklahoma Health Sciences Center, University of Pittsburgh, University of São Paulo, Ribeir ão Preto Medical School, University of Southern California, University of Washington, University of Wisconsin School of Medicine &Public Health, Van Andel Research Institute, Washington University in St Louis, Humans, Adenocarcinoma, Carcinoma, Squamous Cell, Protein-Serine-Threonine Kinases, Mitogen-Activated Protein Kinase Kinases, Receptor, erbB-3, DNA-Binding Proteins, Receptors, Transforming Growth Factor beta, Nuclear Proteins, Transcription Factors, HLA-A Antigens, Proteomics, Genomics, Virus Integration, Signal Transduction, Mutation, Uterine Cervical Neoplasms, Female, Proto-Oncogene Proteins p21(ras), PTEN Phosphohydrolase, Human papillomavirus 16, Keratins, Caspase 8, Phosphatidylinositol 3-Kinases, Molecular Targeted Therapy, Programmed Cell Death 1 Ligand 2 Protein, RNA, Long Noncoding, APOBEC-1 Deaminase, B7-H1 Antigen, Receptor, Transforming Growth Factor-beta Type II, Receptor, ErbB-3, Biotechnology, Clinical Research, Human Genome, Cancer, Sexually Transmitted Infections, Cervical Cancer, Genetics, 2.1 Biological and endogenous factors, General Science & Technology
Abstract

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers.

Published
2017

24. The LGBTQI health forum: an innovative interprofessional initiative to support curriculum reform.

Author

Braun, Hannan M, Ramirez, David, Zahner, Greg J, Gillis-Buck, Eva Mae, Sheriff, Heather, and Ferrone, Marcus

Subjects
Humans, Curriculum, Education, Professional, California, Female, Male, Sexual and Gender Minorities, LGBT, cultural competence, disparity, diversity, interprofessional education, syllabus, Public Health and Health Services, Specialist Studies in Education
Abstract

Lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) individuals continue to face barriers to accessing appropriate and comprehensive healthcare. Compounding this problem, healthcare trainees report few training opportunities and low levels of preparedness to care for LGBTQI patients. In 2009, an interprofessional group of students and a faculty advisor at the University of California, San Francisco, developed a novel student-organized LGBTQI Health Forum for medical, dental, pharmacy, nursing, and physical therapy students to deliver LGBTQI health content that was otherwise absent from the formal curriculum. This elective course has evolved based upon participant feedback, emerging educational strategies, and the existing curricula infrastructure at our institution. After eight years of growth, this 10-contact hour weekend elective attracts over 250 participants each year. Plenary sessions deliver foundational terminology and skills to all attendees. Learners then select breakout sessions to attend, allowing for an individualized curriculum based upon specific interests and knowledge gaps. Breakout session topics prioritize traditionally underrepresented aspects of LGBTQI health in professional school curricula. This Forum serves as a model in which to supplement LGBTQI content into existing school curricula and offers an opportunity for interprofessional education. Next steps include conducting a formal evaluation of the curriculum, expanding our performance-based assessments, and potentially implementing a continuing education program for licensed practitioners. With a core group of interprofessional student organizers and a faculty champion, other institutions may view this course architecture as a potential way to offer learners not only LGBTQI content, but other underrepresented subjects into their own educational programs.

Published
2017

25. Hospital admissions from a pediatric HIV care and treatment program in Malawi

Author

Nosek, Carl A, Buck, W Chris, Caviness, Alison C, Foust, Abbie, Nyondo, Yewo, Bottomani, Madalitso, and Kazembe, Peter N

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Health Services, HIV/AIDS, Pediatric Cancer, Pediatric, Prevention, Pediatric Research Initiative, Cancer, Pediatric AIDS, Clinical Research, Infection, Good Health and Well Being, Zero Hunger, Adolescent, Child, Child, Preschool, Early Diagnosis, Female, HIV Infections, Health Services Accessibility, Hospitalization, Humans, Infant, Infant, Newborn, Malawi, Male, Retrospective Studies, HIV, Admission, Paediatrics and Reproductive Medicine, Pediatrics, Paediatrics, Midwifery
Abstract

BackgroundThe scale up of pediatric antiretroviral treatment programs across Sub-Saharan Africa over the last decade has brought increasing numbers of children into HIV care. This patient population requiring life-long care presents new challenges in the outpatient and inpatient settings. We sought to describe hospitalizations from a large pediatric HIV treatment facility to better understand the scope of the situation and identify areas for improved care delivery.MethodsWe conducted a retrospective case series of all HIV-infected and exposed patients

Published
2016

26. Dichorionic twin trajectories: the NICHD Fetal Growth Studies

Author

Grantz, Katherine L, Grewal, Jagteshwar, Albert, Paul S, Wapner, Ronald, D’Alton, Mary E, Sciscione, Anthony, Grobman, William A, Wing, Deborah A, Owen, John, Newman, Roger B, Chien, Edward K, Gore-Langton, Robert E, Kim, Sungduk, Zhang, Cuilin, Louis, Germaine M Buck, and Hediger, Mary L

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Pediatric, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Biomedical Imaging, Reproductive health and childbirth, Adult, Female, Fetal Development, Humans, Male, Maternal Age, National Institute of Child Health and Human Development (U.S.), Pregnancy, Pregnancy, Twin, Prospective Studies, Reference Values, Twins, Dizygotic, Ultrasonography, Prenatal, United States, Young Adult, dichorionic, estimated fetal weight, fetal growth, twin, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

BackgroundSystematic evaluation and estimation of growth trajectories in twins require ultrasound measurements across gestation that are performed in controlled clinical settings. Currently, there are few such data for contemporary populations. There is also controversy about whether twin fetal growth should be evaluated with the use of the same benchmarks as singleton growth.ObjectivesOur objective was to define the trajectory of fetal growth in dichorionic twins empirically using longitudinal 2-dimensional ultrasonography and to compare the fetal growth trajectories for dichorionic twins with those based on a growth standard that was developed by our group for singletons.Study designA prospective cohort of 171 women with twin gestations was recruited from 8 US sites from 2012-2013. After an initial sonogram at 11 weeks 0 days-13 weeks 6 days of gestation during which dichorionicity was confirmed, women were assigned randomly to 1 of 2 serial ultrasonography schedules. Growth curves and percentiles were estimated with the use of linear mixed models with cubic splines. Percentiles were compared statistically at each gestational week between the twins and 1731 singletons, after adjustment for maternal age, race/ethnicity, height, weight, parity, employment, marital status, insurance, income, education, and infant sex. Linear mixed models were used to test for overall differences between the twin and singleton trajectories with the use of likelihood ratio tests of interaction terms between spline mean structure terms and twin-singleton indicator variables. Singleton standards were weighted to correspond to the distribution of maternal race in twins. For those ultrasound measurements in which there were significant global tests for differences between twins and singletons, we tested for week-specific differences using Wald tests that were computed at each gestational age. In a separate analysis, we evaluated the degree of reclassification in small for gestational age, which was defined as

Published
2016

27. Seroprevalence of CMV, HSV-2 and HBV among HIV-Infected Malawian Children: A Cross-sectional Survey

Author

Varo, Rosauro, Buck, W Chris, Kazembe, Peter N, Phiri, Sam, Andrianarimanana, Diavolana, and Weigel, Ralf

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Infectious Diseases, Hepatitis, Digestive Diseases, Liver Disease, Chronic Liver Disease and Cirrhosis, Pediatric, HIV/AIDS, Sexually Transmitted Infections, Clinical Research, Hepatitis - B, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Adolescent, Antibodies, Viral, Biomarkers, Child, Child, Preschool, Coinfection, Cross-Sectional Studies, Cytomegalovirus, Cytomegalovirus Infections, DNA, Viral, Female, HIV Infections, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Herpes Simplex, Herpesvirus 2, Human, Humans, Immunoglobulin G, Immunoglobulin M, Malawi, Male, Prevalence, Seroepidemiologic Studies, viral co-infections, HIV, children, CMV, HSV-2, HBV, Paediatrics and Reproductive Medicine, Pediatrics, Paediatrics
Abstract

BackgroundLittle is known about viral co-infections in African human immunodeficiency virus (HIV)-infected children. We examined the prevalence of seromarkers for cytomegalovirus (CMV), herpes simplex virus type 2 (HSV-2) and hepatitis B virus (HBV) infections among HIV-infected, antiretroviral treatment (ART)-naïve children in Lilongwe, Malawi.MethodsNinety-one serum samples were tested for IgG and IgM antibodies to CMV, and IgG antibodies to HSV-2 and hepatitis B surface antigen (HBsAg). Baseline demographic, clinical and laboratory data were abstracted from electronic records.ResultsCMV IgG was the most common positive result in all age groups (in 73% of children

Published
2016

28. Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women

Author

Chen, Liwei, Li, Shanshan, He, Chunyan, Zhu, Yeyi, Louis, Germaine M Buck, Yeung, Edwina, Hu, Frank B, and Zhang, Cuilin

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Health Sciences, Pediatric, Clinical Research, Prevention, Diabetes, Perinatal Period - Conditions Originating in Perinatal Period, Obesity, Reproductive health and childbirth, Adiposity, Adult, Age Factors, Diabetes, Gestational, Female, Humans, Menarche, Odds Ratio, Pregnancy, Prospective Studies, Risk Factors, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveTo examine the association between age at menarche and risk of gestational diabetes mellitus (GDM).Research design and methodsA prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II.ResultsThe adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95-1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1% (P = 0.0007) of the association was mediated through prepregnancy BMI.ConclusionsThese findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

Published
2016

29. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY)

Author

Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Abdelaziz, Mohamed Abdelfattah, Bushra Abdelqader, Audrey Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Ajibode Abdulakeem, Rezan Abdul-Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andres Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Lawrence Addai-Boampong, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Shanti A Adhikari, Rina Adhikary, Adhikarla Aditya, Patience Adjepong, Gabrielle Adkins, Adnan Adnan, Marguerite Adriaanse, John Aeron-Thomas, Debbie Affleck, Carmel Afnan, Muhammad Afridi, Patricia Afrim, Felicia Akua Afriyie, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Laura Aguilar Jimenez, Jacqueline Afrakomah Agyekum, Kwame Agyen, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana G Ahmed, Syed Ahmed, Syed H Ahmed, Roa Ahmed Ali, Bilal Ahmed Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, Christine Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al-Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki Alatzoglou, Paul Albert, Albertus Albertus, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John Alexander, Peter D G Alexander, Julyan Al-fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al-Hity, Ali Ali, Amanda Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed Ali, Mohammad Ali, Muhammad S Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Syed Ali, Emilio Aliberti, Jade Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Abdullah Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Tania Allen, Abiola Alli, Kathryn Allison, Bethan Allman, Helen K Allsop, Lynne Allsop, David Allsup, Amal F T Almahroos, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al-Shahi Salman, Warkaq Al-Shamkhani, Fadia Alsheikh, Bashar Al-Sheklly, Sara Altaf, Amanda Alty, Mary Alvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Amel Amelia Ganefianty, Katharine Ames, Maria R Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Badshah Amit, Amjad Amjad, Neelma Amjad, James Amoah-Dankwa, Victoria Amosun, Muhammad Amsal, Khaled Amsha, John Amuasi, Noelia Amutio Martin, Pugh Amy, Ann Anada, Atul Anand, Samantha Anandappa, Satya D Anantapatnaikuni, Ellen Anderson, Julie Anderson, Laura Anderson, Marina Anderson, Michelle Anderson, Nicola Anderson, Rachel Anderson, Rebecca Anderson, Rory Anderson, Samantha Anderson, Wendy Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Joyann Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Louise Anning, Maldwyn Ansah, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Varghese Anu, Muhammad Anwar, Elena Apetri, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia F Aquino, Bianca Araba, Samuel Aransiola, Mariana Araujo, Ann Archer, Denise Archer, Samuel Archer, Simon Archer, Daniele Arcoria, Christian Ardley, Ana-Maria Arias, Oluwatoyin Aribike, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Jennifer Armistead, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Wendy Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Andrew Arnott, Dhawal Arora, Kavan Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Armena Arumaithurai, Ayush Arya, Rita Arya, Diptesh Aryal, Denisa Asandei, Adeeba Asghar, Malik Asghar, Arif Ashab, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Samuel Ashcroft, Georgia Asher, Zakariya Ashfak, Ayesha Ashfaq, Abdul Ashish, Dawn Ashley, Sally Ashman-Flavell, Sundar Ashok, Abd-El-Aziz Ashour, Muhammad Z Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Fiona J Ashworth, Rebecca Ashworth, Arshia Aslam, I Aslam, Suhail Aslam, Laura Aslett, Harshini Asogan, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain, Deborah Athorne, Billie Atkins, Christopher Atkins, Stacey Atkins, John Atkinson, Vicki Atkinson, Abolaji Atomode, Brygitta Atraskiewicz, Abdul A Attia, Eva Attubato, Marie Attwood, Paula Aubrey, Zoltan Auer, Avinash Aujayeb, Aye Chan Thar Aung, Hnin Aung, Hnin Wint Wint Aung, Ko Ko Aung, Kyaw Thu Aung, Nwe Aung, Yin Aung, Zaw Myo Aung, Emily Austin, Karen Austin, Abdusshakur Auwal, Malcolm Avari, Miriam Avery, Nicholas Aveyard, Joanne Avis, Georgina Aviss, Cristina Avram, Paula Avram, Abuzar Awadelkareem, Gabriel Awadzi, Mahmoud Awaly, Atia Awan, Aszad Aya, Eman Ayaz, John Maximilian Ayerh, Amanda Ayers, Jawwad Azam, Ahmed Azeem, Mohammed Azharuddin, Ammar Aziz, Ghazala Aziz, Imran Aziz, N Aziz, Ali Azkoul, Ashaari Azman Shah, Giada Azzopardi, Hocine Azzoug, Fiyinfoluwa Babatunde, Melvin Babi, Babiker Babiker, Gayna Babington, Matthew Babirecki, Marta Babores, Adetona O Babs-Osibodu, Sammy Bacciarelli, Roudi Bachar, Michel-Elie Bachour, Alisjahbana Bachti, Gina Bacon, Jenny Bacon, Bibi Badal, Aysha Badat, Maryuma Bader, Gurpreet R Badhan, Shreya Badhrinarayanan, Joseph P Bae, Alice Baggaley, Amy Baggott, Graham Bagley, Dinesh Bagmane, Lynsey Bagshaw, Kasra Bahadori, Angela Bailey, James Bailey, Katie Bailey, Lindsey Bailey, Liz Bailey, Lucy Bailey, Maria A Bailey, Morgan Bailey, Pippa Bailey, Sarah Bailey, Hamish Baillie, J Kenneth Baillie, Jennifer Bain, Vikram Bains, David Baird, Eilidh Baird, Kevin Baird, Susan Baird, Tracy Baird, Yolanda Baird, Aiysha Bajandouh, Danielle C Baker, Evelyn Baker, Johanne Baker, Josephine Baker, Kenneth Baker, Mark Baker, Rebecca Baker, Terri-Anne Baker, Victoria Baker, Hugh Bakere, Nawar Bakerly, Michelle Baker-Moffatt, Ameet Bakhai, Nauman Bakhtiar, Panos Bakoulas, Dhanalakshmi Bakthavatsalam, Niranjan Balachandran, Andrea Balan, Prasath Balasingam, Theodosios Balaskas, Madhu Balasubramaniam, Nicola Balatoni, Alison Balcombe, Alexander Baldwin, Ashley Baldwin, Caron Baldwin, Danielle Baldwin, Fiona Baldwin, Rebekah Baldwin-Jones, Nichola Bale, James Balfour, Matthew Ball, Robert Ball, K Ballard, Ismael Balluz, Craig Balmforth, Emese Balogh, Abeir Baltmr, Amir Baluwala, Gabby Bambridge, Alasdair Bamford, Amy Bamford, Peter Bamford, Adefunke Bamgboye, Elizabeth Bancroft, Hollie Bancroft, Joyce Banda, Krishna Bandaru, Srini Bandi, Nageswar Bandla, Somaditya Bandyopadhyam, Amit Banerjee, Ritwik Banerjee, Santosh Baniya, Omar Bani-Saad, Harrison Banks, Luke Banks, Paul Banks, Claudia Bann, Helen Bannister, Oliver Bannister, Laura Banton, Tran Bao, Mariamma Baptist, Tanya Baqai, Ananya M Baral, Sharad Chandra Baral, Desislava Baramova, Russel Barber, Emma Barbon, Monica Barbosa, Jamie Barbour, Alexander Barclay, Amanda Barclay, Claire Barclay, George Bardsley, Stephanie Bareford, Shahedal Bari, Morris Barimbing, Amy Barker, Debbie Barker, Erandi Barker, Helen Barker, Joseph Barker, Leon Barker, Lesley Barker, Oliver Barker, Kerry Barker-Williams, Sinha Barkha, Juliana Barla, Gavin Barlow, Richard Barlow, Valerie Barlow, James Barnacle, Alex Barnard, Debi Barnes, Nicky Barnes, Rory Barnes, Theresa Barnes, Calum Barnetson, Amy Barnett, Ashton Barnett-Vanes, Prince Gyenti Barning, William Barnsley, Andrew Barr, David Barr, James Barr, Charlotte Barr, Nina Barratt, Shaney Barratt, Manuella Barrera, Amy Barrett, Fiona Barrett, Jessica Barrett, Sue Barrett, Esther Barrow, Jazz Bartholomew, Claire Bartlett, Georgina Bartlett, James Bartlett, Louise Bartlett, Shauna Bartley, Sandra Bartolmeu-Pires, Anna Barton, Greg Barton, Jill Barton, Lorna Barton, Rachael Barton, Rosaleen Baruah, Sonia Baryschpolec, Hannah Bashir, Archana Bashyal, Betsy Basker, Sudha Basnet, Buddha Basnyat, Ayten Basoglu, Alexander Basran, John Bassett, G Bassett, Chris Bassford, Bengisu Bassoy, Victoria Bastion, Anup Bastola, Anupam Basumatary, Precious Basvi, Jireh A Batac, Vipula R Bataduwaarachchi, Tristan Bate, Harry J Bateman, Kathryn Bateman, Vhairi Bateman, Eleanor Bates, Hayley Bates, Michelle Bates, Simon Bates, Sally Batham, Ana Batista, Amit Batla, Dushyant Batra, Harry Batty, Thomas Batty, Alice Batty, Miranda Baum, Rachel Baumber, Carina Bautista, Fareha Bawa, Tanveer Bawa, Fatima S Bawani, Simon Bax, Matt Baxter, Nicola Baxter, Zachary Baxter, Hannah Bayes, Lee-Ann Bayo, Farid Bazari, Rohit Bazaz, Ahmad Bazli, Laura Beacham, Wendy Beadles, Kirsten Beadon, Philip Beak, Andy Beale, Kathy Beard, Jack Bearpark, Alanna Beasley, Sandee Beattie, Karen Beaumont, Dawn Beaumont-Jewell, Theresa Beaver, Sarah Beavis, Christy Beazley, Sarah Beck, Virginia Beckett, Rosie Beckitt, Sarah Beckley, Heidi Beddall, Seonaid Beddows, Deborah Beeby, Sophia Beeby, Gail Beech, Michelle Beecroft, Nigel Beer, Sally Beer, Jane Beety, Gabriela Bega, Alison Begg, Susan Begg, Sara Beghini, Ayesha Begum, Salman Begum, Selina Begum, Teresa Behan, Roya Behrouzi, Jon Beishon, Claire Beith, James Belcher, Holly Belfield, Katherine Belfield, Ajay Belgaumkar, Dina Bell, Gareth Bell, Gillian Bell, Jessica Bell, Lauren Bell, Louise Bell, Nicholas Bell, Pippa Bell, Stephanie Bell, Jennifer Bellamu, Mary Bellamy, Tammy Bellamy, Arianna Bellini, Amanda Bellis, Fionn Bellis, Lesley Bendall, Naveena Benesh, Nicola Benetti, Leonie Benham, Guy Benison-Horner, Sarah Benkenstein, Tracey Benn, Ann Bennett, Caroline Bennett, Denise Bennett, Gillian Bennett, Kaytie Bennett, Kristopher Bennett, Lorraine Bennett, Miriam R Bennett, Sara Bennett, Karen Bennion, Gautham Benoy, Vivienne Benson, Andrew Bentley, James Bentley, Ian Benton, Eva Beranova, Matthew Beresford, Colin Bergin, Malin Bergstrom, Jolanta Bernatoniene, Thomas Berriman, Zoe Berry, Frida Best, Kimberley Best, Ans-Mari Bester, Yvonne Beuvink, Emily Bevan, Sarah Bevins, Tom Bewick, Andrew Bexley, Sonay Beyatli, Fenella Beynon, Arjun Bhadi, Sanjay Bhagani, Shiv Bhakta, Rekha Bhalla, Khushpreet Bhandal, Kulbinder Bhandal, Ashwin Bhandari, Lila Nath Bhandari, Sangam Bhandari, Jennifer Bhanich Supapol, Aashutosh Bhanot, Ravina Bhanot, Swati Bhasin, Abdul Bhat, Prashanth Bhat, Rahul Bhatnagar, Karan Bhatt, Janki Bhayani, Deepika Bhojwani, Parminder Bhuie, M S Bhuiyan, Salimuzzaman Bhuiyan, Anna Bibby, Fatima Bibi, Naheeda Bibi, Salma Bibi, Tihana Bicanic, Sarah Bidgood, Julie Bigg, Sarah Biggs, Alphonsa Biju, Andras Bikov, Sophie Billingham, Jessica Billings, Prof Binh, Alice Binns, Muhammad BinRofaie, Oliver Bintcliffe, Catherine Birch, Janine Birch, Jenny Birch, Katherine Birchall, Sam Bird, Sumedha Bird, Sarah Bird, Mark Birt, Claire Bishop, Kilanalei Bishop, Linda Bishop, Lisa Bishop, Karen Bisnauthsing, Nibedan Biswas, Mustapha Bittaye, Sahar Biuk, Karen Blachford, Ethel Black, Helen Black, Karen Black, Mairead Black, Polly Black, Virginia Black, Hayley Blackgrove, Bethan Blackledge, Joanne Blackler, Samantha Blackley, Helen Blackman, Caroline Blackstock, Cameron Blair, Francesca Blakemore, Helen Blamey, Alison Bland, Sujata Blane, Simon Blankley, Parry Blaxill, Katie Blaylock, Jane Blazeby, Natalie Blencowe, Ben Bloom, Jack Bloomfield, Angela Bloss, Alex Blowers, Samuel Blows, Hannah Bloxham, Susan Blrd, Louise Blundell, Andrew Blunsum, Mark Blunt, Tadhg Blunt, Ian Blyth, Kevin Blyth, Andrew Blythe, Karen Blythe, Kwabena Appiah Boahen, Marilyn Boampoaa, Sarah Board, Boniface Bobie, Karen Bobruk, Pritesh N Bodalia, Neena Bodasing, Marianne Boden, Tanya Bodenham, Gabriele Boehmer, Marta Boffito, Katherine Bohanan, Kristyna Bohmova, Niamh Bohnacker, Sumit Bokhandi, Maria Bokhar, Saba Bokhari, Sakina Bokhari, Syed O Bokhari, Idan Bokobza, Ambrose Boles, Clare Bolger, Candice Bonaconsa, Charlotte Bond, Helena Bond, Stuart Bond, Thomas Bond, Alice Bone, Georgia Boniface, Joseph Bonney, Lizzy Bonney, Lauren Booker, Sarah Boot, Matthew Boothroyd, Joanne Borbone, Naomi Borman, Samantha Bosence, Kirsty Bostock, Neil Botting, Fiona Bottrill, Hannah Bouattia, Laura Bough, Hayley Boughton, Zoe Boult, Tarek Boumrah, Miriam Bourke, Stephen Bourke, Michelle Bourne, Rachel Bousfield, Lucy Boustred, Alexandra Bowes, Amy Bowes, Philip Bowker, Tabitha Bowker, Helen Bowler, Louise Bowman, Simon Bowman, Rachel Bowmer, Angie Bowring, Helen Bowyer, Aileen Boyd, Jenny Boyd, Laura Boyd, Nicola Boyer, Namoi Boyle, Pauline Boyle, Rosalind Boyle, Louise Boyles, Leanna Brace, Abbey Bracken, Jodie Bradder, Clare J Bradley, Pamela Bradley, Patrick Bradley, Paul Bradley, Joanne Bradley-Potts, Lynne Bradshaw, Zena Bradshaw, Clare Brady, Rebecca Brady, Shirin Brady, Pedro Braga Sardo, Denise Braganza, Megan Braithwaite, Susan Brammer, Marie Branch, Thomas Brankin-Frisby, Jamie Brannigan, Sophie Brattan, Fiona Bray, Nancy Bray, Manny Brazil, Lucy Brear, Tracy Brear, Stephen Brearey, Laura Bremner, Morwenna Brend, Carolin Bresges, Catherine Bressington, Giovanna Bretland, Chris Brewer, Michael Bridgett, Gavin Bridgwood, Sara Brigham, John Bright, Christopher Brightling, Tracey Brigstock, Lutece Brimfield, Philip Brinksman, Elaine Brinkworth, Robin Brittain-Long, Vianne Britten, Hannah Britton, Lauren Broad, Sarah Broadhead, Rosie Broadhurst, Andrew Broadley, Marie Broadway, Christopher Brockelsby, Megan Brocken, Tomos Brockley, Mary Brodsky, Fiona Brogan, Liz Brohan, Felicity Brokke, Jacob Brolly, David Bromley, Hannah Brooke-Ball, Verity Brooker, Matthew Brookes, Deirdre Brooking, Alison Brooks, Daniel Brooks, Jolene Brooks, Karen Brooks, Nicole Brooks, Philip Brooks, Rachel Brooks, Samuel Brooks, Sophie Brooks, Malcolm Broom, Natalie Broomhead, Chloe Broughton, Nathaniel Broughton, Matt Brouns, Alison Brown, Ammani Brown, Andrew Brown, Ashley Brown, Caitlin Brown, Carly Brown, Catrin Brown, Ellen Brown, Heather Brown, Janet Brown, Jo Brown, Louise Brown, Niall Brown, Nicola Brown, Pauline Brown, Richard Brown, Robert Brown, Steven Brown, Tom Brown, Bria Browne, Charlotte Browne, Duncan Browne, Mitchell Browne, Stephen Brownlee, Alba Brraka, Johanna Bruce, Michelle Bruce, Wojciech Brudlo, Andrei Brunchi, Nigel Brunskill, Alan Brunton, Margaret Brunton, Meera Bryant, Emma Bryden, Hannah Brzezicki, April Buazon, Maya H Buch, Ruaridh Buchan, Ruaridh Buchanan, Danielle Buche, Amanda Buck, Lisa Buck, Matthew Buckland, Clare Buckley, Laura Buckley, Philip Buckley, Sarah Buckley, Carol Buckman, Alex Budds, George Bugg, Ramadan Bujazia, Marwan Bukhari, Shanze Bukhari, Richard Bulbulia, Alex Bull, Damian Bull, Kate Bull, Rhian Bull, Thomas Bull, Emily Bullock, Susan Bullock, Naomi Bulteel, Kasun Bumunarachchi, Roneleeh Bungue-Tuble, Oliver Burbidge, Caroline Burchett, Dorota Burda, Christy Burden, Thomas G Burden, Mika Burgess, Richard Burgess, Sophia Burgess, Erlina Burhan, Hasan Burhan, Hannah Burke, Kerry Burke, Adrian Burman, Sara Burnard, Caroline Burnett, Sharon Burnett, Amy Burns, Collette Burns, James Burns, Karen Burns, Kiki Burns, Daniel Burrage, Kate Burrows, Claire Burston, Anna Burton, Ben Burton, Fiona Burton, Helen Burton, Matthew Burton, Mannaria Butar butar, Deborah Butcher, Aaron Butler, Emily Butler, Jessica Butler, Joanne Butler, Joshua Butler, Peter Butler, Susan Butler, Jenny Butler, Al-Tahoor Butt, Massawer Butt, Mohammad M Butt, Caryl Butterworth, Nicola Butterworth-Cowin, Robert Buttery, Tom Buttle, Heather Button, Daniel Buttress, Hannah Bye, Jane Byrne, Wendy Byrne, Victoria Byrne-Watts, Amanda Cabandugama, Luisa Cabrero, Simone Caddy, Ruth Cade, Anthony Cadwgan, Zhen Cahilog, Ajeng Cahyareny, Donna Cairney, James Calderwood, Darren Caldow, Emily Cale, Giorgio Calisti, Debbie Callaghan, Jennifer Callaghan, Claire Callens, Donaldson Callum, Caroline Calver, Melissa Cambell-Kelly, Tracey Camburn, David R Cameron, Eleanor Cameron, Fraser Cameron, Sheena Cameron, Christian Camm, Renee F D Cammack, Alison Campbell, Amy Campbell, Barbara Campbell, Bridget Campbell, Debbie Campbell, Helen Campbell, Hilary Campbell, Jonathan Campbell, Karen Campbell, Marion Campbell, Mark Campbell, Rachael Campbell, Robyn Campbell, Wynny Campbell, Quentin Campbell Hewson, Julie Camsooksai, Lisa Canclini, Shaula M Candido, Janie Candlish, Cielito Caneja, Alexandra Cann, Johnathon Cann, Ruby Cannan, Abigail Cannon, Emma Cannon, Michael Cannon, Petra Cannon, Vivienne Cannons, Ebnier Canonizado, Jane Cantliff, Ben Caplin, Santino Capocci, Noemi Caponi, Angelika Capp, Richard Capstick, Thomas Capstick, Catalin Caraenache, Aimee Card, Mary Cardwell, Charles Carey, Rachel Carey, Simon Carley, Ffion Carlin, Tammy Carlin, Samantha Carmichael, Margaret Carmody, Mandy Carnahan, Charlotte Caroline, Jodi Carpenter, Sharon Carr, Anna Carrasco, Zoe Carrington, Amy Carroll, Anne Carroll, Paul Carroll, Rachel Carson, Cindy Cart, Emma Carter, Jonathan Carter, Michael Carter, Natasha Carter, Paul Carter, Penny Carter, Douglas Cartwright, Jo-Anne Cartwright, Claire Carty, Lotoyah Carty, Jaime Carungcong, Charlotte Carver, Emma Carver, Rachel Carver, Susan Casey, Annie Cassells, Teresa Castiello, Gail Castle, Bridget Castles, Melanie Caswell, Ana Maria Catana, Heidi Cate, Anelise Catelan Zborowski, Susanne Cathcart, Katrina Cathie, Darwin Catibog, Christine Catley, Laura Catlow, Matthew Caudwell, Anna Cavazza, Ashleigh Cave, Luke Cave, Simon Cavinato, Frianne Cawa, Kathryn Cawley, Chloe Caws, Kay Cawthorne, Hankins Cendl, Hannah Century, Jeva Cernova, Mansur Cesay, Ed Cetti, Stephanie Chabane, Manish Chablani, Cathleen Chabo, Cyril J Chacko, David Chadwick, Julie Chadwick, Robert Chadwick, Ela Chakkarapani, Arup Chakraborty, Mallinath Chakraborty, Mollika Chakravorty, Petya Chalakova, Bimal Sharma Chalise, James Chalmers, Richard Chalmers, Georgina Chamberlain, Sarah Chamberlain, Emma Chambers, Jonathan Chambers, Lucy Chambers, Naomi Chambers, Alex Chan, Carmen Chan, Cheuk Chan, Evelyn Chan, Jay Marie Chan, Kawai Chan, Kayen Chan, Kimberley Chan, Ping Chan, Rebekah (Pui-Ching) Chan, Xin H S Chan, Chris Chandler, Heidi Chandler, Kim J Chandler, Stuart Chandler, Zoe Chandler, Sumit Chandra, Navin Chandran, Badrinathan Chandrasekaran, Yvonne Chang, Ho Quang Chanh, Grace Chaplin, Josephine Chaplin, Graeme Chapman, John Chapman, Katie Chapman, Laura Chapman, Lianne Chapman, Matthew Chapman, Polly Chapman, Timothy Chapman, Lucy Chappell, Amanda Charalambou, Bethan Charles, Dianne Charlton, Sam Charlton, Kevin Chatar, Calvin Chatha, Debra Chatterton, Ritesh Chaube, Muhammad Y N Chaudhary, Netra B Chaudhary, Iram Chaudhry, Zain Chaudhry, Nazia Chaudhuri, Muhammad Chaudhury, Anoop Chauhan, Ruchi S Chauhan, Alexander Chavasse, Nicola Chavasse, Vipal Chawla, Lindsay Cheater, James Cheaveau, Charlotte Cheeld, Michelle Cheeseman, Fang Chen, Hui Min Chen, Terence Chen, Floria Cheng, Lok Yin Cheng, Zhihang Cheng, Helen Chenoweth, Chun How Cheong, Shiney Cherian, Mary Cherrie, Helen Cheshire, Chee Kay Cheung, Elaine Cheung, Kayan Cheung, Michelle Cheung, Claire Cheyne, Swati Chhabra, Wei Ling Chia, Eric Chiang, Angela Chiapparino, Rosavic Chicano, Moses Chikungwa, Zviedzo A Chikwanha, Gemma Chilcott, Sam Chilcott, Alison Chilvers, Phillipa Chimbo, KokWai Chin, Wen Jie Chin, Rumbidzai Chineka, Amol Chingale, Ezomike Chinonso, Chloe Chin-Saad, Margaret Chirgwin, Heather Chisem, Claire Chisenga, Catherine Chisholm, Ben Chisnall, Carolyn Chiswick, Sunder Chita, Nihil Chitalia, Matthew Chiu, Laura Chiverton, Brenda Chivima, Catherine Chmiel, Soha Choi, Willy Choon Kon Yune, Meena Chopra, Michelle Chopra, Vandana Choudhary, Omur Choudhury, Sarah Choudhury, Bing-Lun Chow, Mahibbur Chowdhury, Shahid Chowdhury, Angela Chrisopoulou, Victoria Christenssen, Peter Christian, Alexander Christides, Fiona Christie, Daniel Christmas, Georgios Christoforou, Thereza Christopherson, Anna Christou, Mark Christy, Paris Chrysostomou, Yunli Chua, Dip Chudgar, Richard Chudleigh, Srikanth Chukkambotla, Michael E Chukwu, Izu Chukwulobelu, Chi Yee Chung, Elaine Church, Sara R Church, David Churchill, Nicole Cianci, Paola Cicconi, Paola Cinardo, Zdenka Cipinova, Bessie Cipriano, Sarah Clamp, Bridget Clancy, Melanie Clapham, Edel Clare, Sarbjit Clare, Andrew Clark, Charlotte Clark, Diane Clark, Emma Clark, Felicity Clark, Gabrielle Clark, James Clark, Julia Clark, Katherine Clark, Kaylea Clark, Louise Clark, Lucy Clark, Martyn Clark, Matthew Clark, Nicola Clark, Patricia Clark, Richard Clark, Thomas Clark, Tonia Clark, Zoe Clark, Alison Clarke, Andrea Clarke, Jude Clarke, Paul Clarke, Robert Clarke, Roseanne Clarke, 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Collier, Terry Collingwood, Paul Collini, Emma Collins, Jaimie Collins, Joanne Collins, Kayleigh Collins, Megan Collins, Nicola Collins, Sally Collins, Vicky Collins, Andrew Collinson, Bernadette Collinson, Jennifer Collinson, Matthew Collis, Madeleine Colmar, Hayley E Colton, James Colton, Katie Colville, Carolyn Colvin, Edward Combes, David Comer, Alison Comerford, Dónal Concannon, Alison Condliffe, Robin Condliffe, Emma Connell, Lynne Connell, Natalie Connell, Karen Connelly, Gavin Connolly, Emma Connor, Antonia Conroy, Kevin Conroy, Veronica Conteh, Rory Convery, Francesca Conway, Grainne Conway, Rhiannon Conway, Robert Conway, Jo-Anna Conyngham, Amanda Cook, Amber Cook, Colette Cook, Eloise Cook, Gemma Cook, Helen Cook, Julie Cook, Martin Cook, Sarah Cook, Danielle Cooke, Graham Cooke, Hannah Cooke, Justin Cooke, Katrina Cooke, Tim Cooke, Vikki Cooke, Adele Cooper, Chris Cooper, David Cooper, Helen Cooper, Jamie Cooper, Lauren Cooper, Nick Cooper, Rowena Cooper, Samantha Cooray, Thomas Cope, Sinead Corbet, Carolyn Corbett, Ailsa Corbishley, John Corcoran, Chris Cordell, Jessica Cordle, Alasdair Corfield, John Corless, Alison Corlett, Joe Cornwell, Michael Cornwell, Diana Corogeanu, Aisling Corr, Mirella Corredera, Ruth Corrigan, P Corry, Rita Corser, Jon Cort, Denise Cosgrove, Tracey Cosier, Patricia Costa, Telma Costa, Charlie Coston, Susannah Cotgrove, Zoe Coton, Lisa-Jayne Cottam, Rhiannon Cotter, Donna Cotterill, Caroline Cotton, George Couch, Martina Coulding, Andrew Coull, David Counsell, David Counter, Cherry Coupland, Ellie Courtney, Julia Courtney, Rebecca Cousins, Amanda J Coutts, Alexander Cowan, Elena Cowan, Richard Cowan, Richard Cowell, Louise Cowen, Steve Cowman, Amanda Cowton, Ellie Cox, Emma Cox, Giles Cox, Helen Cox, Karina Cox, Miriam Cox, Karen Coy, Andrea Cradduck-Bamford, Hannah Craig, Jayne Craig, John Craig, Victoria Craig, Felicity Craighead, Matthew Cramp, Hayley Cranston, Sheetal S Crasta, Jacolene Crause, Angie Crawford, Emma Crawford, Isobel Crawford, Sarah Crawshaw, Ben Creagh-Brown, Andrew Creamer, Amanda Creaser-Myers, Joanne Cremona, Saveria Cremona, Anna Crepet, Janet Cresswell, Mark Cribb, Charles Crichton, Declan Crilly, Lauren Crisp, Nikki Crisp, Dominic Crocombe, Maria Croft, Jennifer Crooks, Harriet Crosby, Elizabeth Cross, Tim Cross, Amy Crothers, Stephen Crotty, Susan Crouch, Madeleine Crow, Amanda Crowder, Kate Crowley, Teresa Crowley, Rebecca Croysdill, Callum Cruickshank, Conor Cruickshank, Irena Cruickshank, James Cruise, Carina Cruz, Trino Cruz Cervera, Dominic Cryans, Guanguo Cui, Helen Cui, Lorraine Cullen, Gillian Cummings-Fosong, Victoria Cunliffe, Neil Cunningham, Nicola Cunningham, Jason Cupitt, Hollie Curgenven, Gerens Curnow, David Curran, Simon Curran, Craig Currie, Jacqueline Currie, Scarlett Currie, Susan Currie, Susie Currie, Jonathan Curtis, Katrina Curtis, Matthew Curtis, Olivia Curtis, Thomas Curtis, Rebecca Cuthbertson, Jennifer Cuthill, Sean Cutler, Sarah Cutts, Marta 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Souza, Anthony De Soyza, Natasha de Vere, Johannes de Vos, Bethan Deacon, Sharon Dealing, Anna Dean, Julie Dean, Katrina Dean, Stephen Dean, Tessa Dean, Jill Deane, James Dear, Effie Dearden, Catherine Deas, Samuel Debbie, Gabor Debreceni, Vashist Deelchand, Matthew Deeley, Joanne Deery, Emmanuel Defever, Manuela Del Forno, Arnold Dela Rosa, Gonzalo De-La-Cedra, Amanda Dell, Carrie Demetriou, David DeMets, Jane Democratis, Jacqueline Denham, Emmanuelle Denis, Laura Denley, Craig Denmade, Alexandra Dent, Kathy Dent, Martin Dent, Elise Denton, Tom Denwood, Nishigandh Deole, Darshita Depala, Maria Depante, Susan Dermody, Amisha Desai, Asmita Desai, Purav Desai, Sanjeev Deshpande, Vai Deshpande, Sirjana Devkota, Usha Devkota, Debbie Devonport, Matthew Devonport, Prakash Dey, Vishal Dey, Rogin Deylami, Kevin Dhaliwal, Sundip Dhani, Amandeep Dhanoa, Mili Dhar, Ankush Dhariwal, Dawpadee Dharmasena, Devesh Dhasmana, Ekanjali Dhillon, Reiss Dhillon, Syra Dhillon, Meghnath Dhimal, Dipali Dhiru, Trupti Dhorajiwala, Priya Dias, Stephanie Diaz, Kayleigh Diaz-Pratt, Mohammed Dibas, Debbie Dickerson, Pamela Dicks, Matt Dickson, Stuart Dickson, J Digby, Ronneil Digpal, Sean Dillane, Sarah Diment, Paul Dimitri, Georgios Dimitriadis, Sajeel Din, Thai H Dinh, Thi T T Dinh, Alex Dipper, Sabiq Dipro, Laura Dirmantaite, Lorelle Dismore, Lisa Ditchfield, Sarah Diver, Lavanya Diwakar, Preeti Diwan, Caroline Dixon, Giles Dixon, Kate Dixon, Brice Djeugam, Sipho Dlamini, Petr Dlouhy, Andrea D'Mello, Paul Dmitri, Thi Tien Do, Laurence Dobbie, Marinela Dobranszky Oroian, Charlotte Dobson, Lee Dobson, Marie Docherty, David Dockrell, Jacqueline Dodd, James Dodd, Jackie Dodds, Rebecca Dodds, Steve Dodds, Richi Dogra, Conor Doherty, Erin Doherty, Warren Doherty, Yumiko Doi, Iain Doig, Eleanor Doke, Daniel Dolan, Mark Dolman, Rozzie Dolman, Lisa Donald, Katie Donald, Callum Donaldson, Christopher Donaldson, Denise Donaldson, Gillian Donaldson, Kate Donaldson, Phu Khiem Dong, Martha Donkor, Sinead Donlon, Joanne Donnachie, Eilish Donnelly, Ronan Donnelly, Phil Donnison, Aravindhan Donohoe, Gemma Donohoe, Bryan Donohue, Emma Dooks, Reece J Doonan, Rogier Van Doorn, Grainne Doran, Rachael Dore, Kane Dorey, Sharon Dorgan, Kataryna Dos Santos, Moonira Dosani, Davinder Dosanjh, Paula Dospinescu, Isabelle Doss, Theonymfi Doudouliaki, Andrew Dougherty, Jill Doughty, Katie Douglas, Jonathan Douse, Allyn Dow, Lucy Dowden, Michelle Dower, Sud Dowling, Nicola Downer, Charlotte Downes, Rob Downes, Thomas Downes, Damian Downey, Robert Downey, Caroline Downing, Louise Downs, Simon Dowson, Cornel Dragan, Cristina Dragos, Maire Drain, Chelsea Drake, Victoria Drew, Olivia Drewett, Anthony Drexel, Celine Driscoll, Helena Drogan, Odysseas Drosos, Graham Drummond, Katie Drury, Kay Druryk, Ronald Druyeh, Jack Dryburgh-Jones, Simon Drysdale, An Du Thinh, Hazel Dube, Judith Dube, Stephen Duberley, Paige K Duckenfield, Hayley Duckles-Leech, Nicola Duff, Emma Duffield, Heather Duffy, Helen Duffy, 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Patrick Easton, Ruth Eatough, Oluwadamilola Ebigbola, Martin Ebon, Alison Eccles, Sinan Eccles, Chloe Eddings, Michael Eddleston, Maureen Edgar, Katharine Edgerley, Nicholas Edmond, Mary Edmondson, Tracy Edmunds, Abby Edwards, Alexandra Edwards, Catherine Edwards, Joy Edwards, Kennedy Edwards, Mandy Edwards, Martin Edwards, Sophie Edwards, Jenny Eedle, Aline Eggink, Dawn Egginton, Sam Eggleston, Loveth Ehiorobo, Sarah Eisen, Ugochukwu Ekeowa, Mohamed Ekoi, Ayomide Ekunola, Soha El Behery, Nagla Elashhar, Lisa Elawamy, Mohamed Elbeshy, Kate El-Bouzidi, Jennifer Elder, Mohammed El-Din, Emma Eldridge, Diana Eleanor, Uchenna Elenwa, Ibrahim Eletu, Eman Elfar, Mayy Magdy Elgamal, Amr Elgohary, Mohamed A A Elhadi, Stellios Elia, Jennifer Elias, Tania Elias, Nadia Elkaram, Andrew V Elkins, Julie Ellam, Nikki Ellard, Laura N Ellerton, Lucy Elliot, Amy Elliott, Fiona Elliott, Kerry Elliott, Scott Elliott, Sian Elliott, Annie Ellis, Christine Ellis, Kaytie Ellis, Leila Ellis, Rupert Ellis, Tak-Yan Ellis, Yvette Ellis, Alison C Ellwood, Rahma Elmahdi, Einas Elmahi, Hannah-May Elmasry, Mohammed El-Naggar, Najla Elndari, Omer Elneima, Mohamed Elokl, Ahmed Elradi, Mohamed Elsaadany, Mohammed A S A Elsayed, Sally El-Sayeh, Hana El-Sbahi, Mohammad Elsebaei, Tarek Elsefi, Karim El-Shakankery, Alguili Elsheikh, Hosni El-Taweel, Sarah Elyoussfi, Jonathan Emberey, Jonathan R Emberson, John Emberton, Anna Emery, Julian Emmanuel, Ingrid Emmerson, Michael Emms, Florence Emond, Marieke Emonts, Nicu Enachi, Dickson Enenche, Angila Engden, Katy English, Emma Entwistle, Hene Enyi, Marios Erotocritou, Peter Eskander, Hanif Esmail, Fatheha Essa, Brynach Evans, Chris Evans, Debra Evans, E Evans, Emrys Evans, Gail Evans, Gareth Evans, Isabel Evans, Jack Evans, Jacqueline Evans, Jennifer Evans, John Evans, Jolanta Evans, Lisa Evans, Lynn Evans, Mim Evans, Morgan Evans, Ranoromanana Evans, Sharon Evans, Sian Evans, Teriann Evans, Tomos Evans, Caroline Everden, Serenydd Everden, Lynette Every, Hayley Evison, Lynsey Evison, Chiamaka Ezenduka, Jacqueline Faccenda, Leila Fahel, Youstina Fahmay, Ian Fairbairn, Sara Fairbairn, Terry Fairbairn, Andy Fairclough, Louise Fairlie, Mark Fairweather, Anne Fajardo, Naomi Falcone, Euan Falconer, John Fallon, Andrea Fallow, David Faluyi, Victoria Fancois, Ayaan Farah, Muna Farah, Qayyum Farah, Nowin Z Fard, Leila Fares, Amr Farg, Adam Farmer, Katie Farmer, Toni Farmery, Samantha Farnworth, Faiyaz Farook, Hadia Farooq, Sidrah Farooq, Fiona Farquhar, Holly Farr, Aaron Farrell, Barbara Farrell, Fayed Farrukh, James Farthing, Syeda Farzana, Rahmatu Fasina, Azam Fatemi, Mina Fatemi, Suman Fathima, Nibah Fatimah, Maria Faulkner, Saul N Faust, Clair Favager, Joe Fawke, Sinmidele Fawohunre, Abul Fazal, Aisthath Fazleen, Simon Fearby, Connie Fearnley, Alex Feben, Federico Fedel, Daria Fedorova, Christopher Fegan, Mae Felongo, Lynsey Felton, Tim Felton, Kate Fenlon, Andrea Fenn, Ruth Fennelly, Isabelle Fenner, Ciara Fenton, Melisa Fenton, Gloria Ferenando, Cameron Ferguson, Jenny Ferguson, Kathryn Ferguson, Katie Ferguson, Susan Ferguson, Susie Ferguson, Victoria Ferguson, Denzil Fernandes, Candida Fernandez, Eduardo Fernandez, Maria Fernandez, Sonia Fernandez Lopez, Jaime Fernandez Roman, Callum J Fernando, Jessica Fernando, Ahmed Feroz, Pietro Ferranti, Thais Ferrari, Eleanor Ferrelly, Alexandra Ferrera, Emma Ferriman, Sheldon Ferron, Nicholas Fethers, Ben Field, Janet Field, Rebecca Field, Karen Fielder, Lindsey Fieldhouse, Andra Fielding, Julie Fielding, Sarah Fielding, Asma Fikree, Santos Filipa, Sarah A Filson, Shona Finan, Sarah Finbow, Deborah J Finch, Joanne Finch, Laurie Finch, Simon Finch, Spencer Finch, Natalie Fineman, Jim Finlayson, Lauren Finlayson, Adam Finn, Joanne Finn, Dylan Finnerty, Clare Finney, Deborah Finucane, Sofia Fiouni, Jo Fiquet, Promise Firi, James Fisher, Neil Fisher, Daniel Fishman, Krystofer Fishwick, Carolyn Fitton, Felicity Fitzgerald, Fiona Fitzgerald, Karen Fitzjohn, Jan Flaherty, Michael Flanagan, Charles Flanders, Nikolaos Flaris, Gail Fleming, Julie Fleming, Lucy Fleming, Paul Fleming, William Flesher, Alison Fletcher, Anna Fletcher, Jonathan Fletcher, Lucy Fletcher, Simon Fletcher, Sophie Fletcher, Fiona Flett, Karen Flewitt, Sarah Flockhart, Christopher Flood, Ian Floodgate, Jonathan Flor, Vincent Florence, Mary Flowerdew, Sharon Floyd, Margaret J Flynn, Rachel Flynn, Claire Foden, Adama Fofana, Georgina Fogarty, Paul Foley, Linda Folkes, Tracey Fong, Daniela M Font, Aiwyne Foo, Jane Foo, Andrew Foot, Helen R Foot, Jayne Foot, Jane Forbes, Amber Ford, Jamie Ford, Imogen Fordham, Jennifer Foreman, Matthew Forester, Mohammad Forkan, Caroline Fornolles, Adam Forrest, Ellie Forsey, Miranda Forsey, Thomas Forshall, Elliot Forster, Abigail Forsyth, Julian Forton, Conrad Foster, Emily Foster, Joseph Foster, Rachel A Foster, Tracy Foster, Angela Foulds, Ian Foulds, Folakemi Fowe, Natasha Fowkes, Emily Fowler, Robert Fowler, Stephen Fowler, Amy Fox, Claire Fox, Heather Fox, Jonathan Fox, Laura Fox, Lauren Fox, Natalie Fox, Olivia Fox, Simon Fox, Sarah-Jane Foxton, Eva Fraile, Rebecca Frake, Alex Francioni, Olesya Francis, Rebecca Francis, Sarah Francis, Theodora Francis-Bacon, Helen Frankland, Jessica Franklin, Siobhan Franklin, Catherine Fraser, Andi Fratila, Sharon Frayling, Martyn Fredlund, Anna Freeman, Carol Freeman, Elaine Freeman, Hannah Freeman, Nicola Freeman, Clare Freer, Eleanor French, Thomas French, Karen Freshwater, Matthew Frise, Renate Fromson, Adam Frosh, John Frost, Victoria Frost, Oliver Froud, Rachel Frowd, Arun Fryatt, Andrzej Frygier, Bridget Fuller, Liz Fuller, Lucy Fuller, Tracy Fuller, Duncan Fullerton, Carrie Fung, Gayle Fung, Sarah Funnell, John Furness, Andrew Fyfe, Nytianandan G, Elizabeth Gabbitas, Claire Gabriel, Zoë Gabriel, Hadiza Gachi, Sophie Gaffarena, Sarah Gage, Joshua Gahir, Sarveen Gajebasia, Katarzyna Gajewska-Knapik, Babita Gajmer, Zacharoula Galani, Christopher Gale, Hugo Gale, Linda Gale, Rebecca Gale, Swetha Gali, Bernadette Gallagher, Jude Gallagher, Rosie Gallagher, William Gallagher, Feroze Gallam, Joanne Galliford, Catherine Galloway, Chris Galloway, Emma Galloway, Jacqui Galloway, James Galloway, Anna Galvin, Victoria Galvis, Gareth Gamble, Laura Gamble, Liz Gamble, Brian Gammon, Chien N Gan, Muhammad B Ganaie, Jaikumar Ganapathi, Ramesh Ganapathy, Kaminiben Gandhi, Sarah Gandhi, Usha Ganesh, Thenugan Ganeshanathan, Saibal Ganguly, Abrar Gani, Pauline Ganley, Ukraina Garcia, Emma-James Garden, Antoni D Gardener, Emma Gardiner, Michael Gardiner, Phil Gardiner, Siobhan Gardiner, Caroline Gardiner-Hill, Jonathan Gardner, Louis Gardner, Mark Garfield, Atul Garg, Isha Garg, Nathan Garlick, Daniel Garner, Justin Garner, Lucie Garner, Zoe Garner, Rosaline Garr, Kathryn A Garrero, Manisha Gartaula, Florence Garty, Rachel Gascoyne, Hyeriju Gashau, Aoife Gatenby, Erin Gaughan, Alok Gaurav, Mariana Gavrila, Jane Gaylard, Sophie Gayle, Catherine Geddie, Ian Gedge, Sarah Gee, Fartuun Geele, Kalaichelvi Geerthan, Minnie Gellamucho, Karzan Gelly, Leila Gelmon, Sandra Gelves-Zapata, Gemma Genato, Neal Gent, Susan Gent, Natalie Geoghegan, Aparna George, Bini George, Sam George, Susan George, Tina George, Valerie P George, Simon Georges, Domonique Georgiou, Peter Gerard, Leigh Gerdes, Louise Germain, Helen Gerrish, Abel Getachew, Louise Gethin, Siobhan Gettings, Hisham Ghanayem, Bijan Ghavami Kia, Shaista Ghazal, Anca Gherman, Alison Ghosh, Dipansu Ghosh, Justin Ghosh, Subhamay Ghosh, Sarra Giannopoulou, Malick Gibani, Chris Gibb, Ben Gibbison, Kerry Gibbons, Alex Gibson, Bethan Gibson, Jamie Gibson, Kimberley Gibson, Kirsty Gibson, Sian Gibson, Mary Gigi, Cat Gilbert, Jeanette Gilbert, Kayleigh Gilbert, Benjamin Giles, James Gilham, Mandy Gill, Lynne Gill, Paul Gillen, Annelies Gillesen, Katherine Gillespie, Elizabeth Gillham, Andrew Gillian, Deborah Gilliland, Robert Gillott, Danielle Gilmour, Kate Gilmour, Lesley Gilmour, Louis Ginn, Franciscus Ginting, Theodora Giokanini-Royal, Anna Gipson, Barbie Giri, Joanna Girling, Rhian Gisby, Angelena Gkioni, Aikaterini Gkoritsa, Effrossyni Gkrania-Klotsas, Amy Gladwell, James Glanville, Jessica Glasgow, Susannah Glasgow, Jon Glass, Lynn Glass, Sharon Glaysher, Lisa Gledhill, Eleanor Glenday, Ana Glennon, Jodie Glossop, John Glover, Kyle Glover, Michelle Glover, Jan Glover Bengtsson, Deborah Glowski, Sharon Glynn, Chevanthy Gnanalingam, Julie Goddard, Wendy Goddard, Emily Godden, Jo Godden, Sarah Godlee, Emma Godson, Gillian Godwin, Sukanya Gogoi, Aiky Goh, Manjinder Gohel, Rebeca Goiriz, Sriya Gokaraju, Raphael Goldacre, Arthur Goldsmith, Portia Goldsmith, Darren Gomersall, Lucia Gomez, Raquel Gomez-Marcos, Ali Gondal, Celia Gonzalez, Jack Goodall, Vicky Goodall, Bob Goodenough, Anna Goodfellow, Laura Goodfellow, James Goodlife, Camelia Goodwin, Elizabeth Goodwin, Jayne Goodwin, Paula Goodyear, Rajiv Gooentilleke, Michelle Goonasekara, Sheila Gooseman, Shameer Gopal, Chris Gordon, Sally Gordon, Robin Gore, Hugh Gorick, Caitlin Gorman, Claire Gorman, Stuart Gormely, Maria Gorniok, Diana Gorog, Michelle Gorst, Thomas Gorsuch, Jayshreebahen Gosai, Rebecca Gosling, Sally Gosling, Georgina Gosney, Vanessa Goss, Dzintars Gotham, Naomi Gott, Elizabeth Goudie, Nicole Gould, Susan Gould, Charlotte Goumalatsou, Lysander Gourbault, Abha Govind, Rajesh Govindan, Sharon Gowans, Girish Gowda, Rohit Gowda, Hannah Gower, Pankaj Goyal, Sunil Goyal, Sushant Goyal, Cheryl Graham, Clive Graham, Jonathan Graham, Justin Graham, Libby Graham, Rachel Graham, Sharon Graham, Matthew Graham-Brown, Julia Grahamslaw, Gianluca Grana, Tracyanne Grandison, Louis Grandjean, Alison Grant, Ann Grant, David Grant, Kirstie Grant, Matthew Grant, Pauleen Grant, Rhys Gravell, Jenny Graves, Alasdair Gray, Catherine Gray, Georgina Gray, Glaxy Gray, Jackie Gray, Karen Gray, Nicola Gray, Roxanne Gray, Sebastian Gray, Alan Grayson, Fiona Greaves, Paul Greaves, Alastair Green, Amy Green, Amy S Green, Charlotte Green, Christopher A Green, David Green, Frederick Green, Joel Green, Marie Green, Nicola Green, Stacey Green, Diarra Greene, Philippa Greenfield, Alan Greenhalgh, Daniel Greenwood, Sandra Greer, James Gregory, Jane Gregory, Katie Gregory, Tamsin Gregory, Jill Greig, Julia Greig, Rebecca Grenfell, Teena Grenier, Jack Grenville, Jo Gresty, Susan Grevatt, Glaxy Grey, Samuel Gribben, Andrew Gribbin, Amy Gribble, Natasha Grieg, Douglas Grieve, Ben Griffin, Denise Griffin, Mel Griffin, Sian Griffith, Andrew Griffiths, Daniel Griffiths, David Griffiths, Donna Griffiths, Isabel Griffiths, Mark Griffiths, Nicola Griffiths, Oliver Griffiths, Sandra Griffiths, Sarah Griffiths, Scott Griffiths, Yvonne Griffiths, Sofia Grigoriadou, Steph Grigsby, Paul Grist, Evelina Grobovaite, Dorothy Grogono, Clarissa Grondin, Rachel Groome, Pauline Grose, Liliana Grosu, Jenny Grounds, Margaret Grout, Helen Grover, Jayne Groves, Neil Grubb, Julie Grundy, Francesca Guarino, Sharada Gudur, Jacinta Guerin, Sharazeq Guettari, Shivang Gulati, Vikas Gulia, Harsha Gunasekara, Pumali Gunasekera, Malin Gunawardena, Kirun Gunganah, Jessica Gunn, Emma Gunter, Anup Kumar Gupta, Alok Gupta, Atul Gupta, Rajeev Gupta, Richa Gupta, Rishi Gupta, Tarun Gupta, Vineet Gupta, Ankur Gupta-Wright, Victoria Guratsky, Alvyda Gureviciute, Sambasivarao Gurram, Anju Gurung, Bhawana Gurung, Lilly Gurung, Shraddha Gurung, Sabi Gurung Rai, Hazel Guth, Nick Guthrine, Pradip Gyanwali, Sushma Gyawali, Nam Xuan Ha, Nguyen Thanh Ha, Ruth Habibi, Berkin Hack, James Hackett, Pamela Hackney, Christian Hacon, Aiman Haddad, Denise Hadfield, Nicholas Hadfield, Sally Hadfield, Michalis Hadjiandreou, Nikolaos Hadjisavvas, Anna Haestier, Nauman Hafiz, Rana Hafiz-Ur-Rehman, Javed Hafsa, Samantha Hagan, Jack W Hague, Rosemary Hague, Nafeesah Haider, Kate Haigh, Victoria Haile, Jessica Hailstone, Christina Haines, Scott Hainey, Morton Hair, Brigid Hairsine, Juraj Hajnik, Danielle Hake, Lukman Hakeem, Anne Haldeos, Writaja Halder, Emily 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Hannington, Merhej Hannun, Aidan Hanrath, Helena Hanratty, Daniel Hansen, Anita Hanson, Ashley Hanson, Helen Hanson, Jane Hanson, Kathryn Hanson, Steve Hanson, Ala Haqiqi, Monjurul Haque, Henry Harcourt, Lesley Harden, Zoe Harding, Simon Hardman, Marc Hardwick, Gareth Hardy, Joanna Hardy, Yasmine Hardy, Kumar Haresh, Rachel Harford, Beverley Hargadon, James Hargraves, Carolyn Hargreaves, Alice Harin, Mohammed Haris, Edward Harlock, Paula Harman, Tracy Harman, Mark Harmer, Muhammad A Haroon, Charlie Harper, Heather Harper, James Harper, Peter Harper, Rosemary Harper, Sarah Harrhy, Kate Harrington, Sian Harrington, Yasmin Harrington-Davies, Jade Harris, Jess Harris, John Harris, Laura Harris, Marie-Clare Harris, Nichola Harris, Sophie Harris, David Harrison, Laura Harrison, Melanie Harrison, Olakunbi A Harrison, Rachael Harrison, Rowan Harrison, Susie Harrison, Thomas Harrison, Wendy Harrison, Elizabeth Harrod, Ciaran Hart, Dominic Hart, Jessica Hartley, Lisa Hartley, Rosemary Hartley, Ruth Hartley, Tom Hartley, William Hartrey, Phillipa Hartridge, Stuart Hartshorn, Alice Harvey, Angela Harvey, Anna Harvey, Max Harvey, Catherine Harwood, Helen Harwood, Zoe Harzeli, Brigitte Haselden, Kazi Hashem, Mohammed Hashimm, Tadaaki Hashimoto, Imranullah Hashmi, Jack Haslam, Zena Haslam, Grace Hasnip, Adil Hassan, Ali Hassan, Amro Hassan, Awab Hassan, Zeinab Hassan, Sapna Hassasing, Jane Hassell, Philip Hassell, Alex Hastings, Bethany Hastings, Janice Hastings, Sarah Hathaway-Lees, Jonathan Hatton, Jennifer Hau, May Havinden-Williams, Stefan Havlik, Daniel B Hawcutt, Kadean Hawes, Liz Hawes, Nicola Hawes, Lydia Hawker, Annie Hawkins, Joe Hawkins, Nancy Hawkins, W John Hawkins, Dan Hawley, Ed Hawley-Jones, Edward Haworth, Alasdair W Hay, Cathy Hay, Amna Hayat, Jamal Hayat, Mohamed-Riyal Hayathu, Anne Hayes, Jonas Hayes, Kate Hayes, Melony Hayes, Fiona Hayes, Patrick Hayle, Chloe Haylett, Antara Hayman, Melanie Hayman, Matthew Haynes, Richard Haynes, Rachel Hayre, Carole Hays, Sarah Haysom, James Hayward, Patrick Haywood, Hazel Haywood Hasford, Tracy Hazelton, Phoebe Hazenberg, Zhengmai He, Elizabeth Headon, Carrie Heal, Brendan Healy, Jessica L Healy, Amy Hearn, David Heasman, Angela Heath, Debbie Heath, Rowan Heath, Diane Heaton, Adam Heavens, Kerry Hebbron, Catherine Heckman, Gemma Hector, Sadie Heddon, Andy Hedges, Katrine Hedges, Cheryl Heeley, Elaine Heeney, Richard Heinink, Rajdeep Heire, Ingvild Helgesen, Joanne Hemingway, Ulla Hemmila, Beth Hemmings, Scott Hemphill, Deborah Hemsley, Abigail Henderson, Eilidh Henderson, Jennifer Henderson, Steven Henderson, Joanne Henry, Karol Henry, Lavinia Henry, Margo Henry, Natalie Henry, David Henshall, Gillian Herdman, Rosaleen Herdman-Grant, Morag Herkes, Lucas E Hermans, Fe Marie Hernandez, Emma Heron, Lisa Heron, William Herrington, Emilia Heselden, Peta Heslop, Tracey Heslop, Simon Hester, Emily Hetherington, Joseph Hetherington, Chamila Hettiarachchi, Pramodh Hettiarachchi, Hayley Hewer, John Hewertson, Anna Hewetson, Sue Hewins, Nicola Hewitson, Claire Hewitt, Davina Hewitt, Richard Hewitt, Samuel Hey, Robert S Heyderman, Mathis Heydtmann, Joseph Heys, Jonathan Heywood, Meg Hibbert, John Hickey, Naomi Hickey, Peter Hickey, Nicky Hickman, Alex Hicks, Jenny Hicks, Scott R Hicks, Phan Thi Thu Hien, Daniel Higbee, Lucy Higgins, Andrew Higham, Martin Highcock, Judith Highgate, Mondy Hikmat, Amanda Hill, Helen Hill, Joanne Hill, Lisa Hill, Lucy Hill, Phoebe Hill, Uta Hill, Annette Hilldrith, Catherine Hillman-Cooper, Jon Hilton, Zoe Hilton, Sarah Hinch, Andrew Hindle, Esther Hindley, Alice Hindmarsh, Paul Hine, Kim Hinshaw, Clare Hird, Claire Hirst, Lindsay Hirst, Jemma Hives, Htet M Hlaing, Benson Ho, David K K Ho, Rosemary Ho, Michaela Hoare, David Hobden, Gill Hobden, Maria Hobrok, Simon Hobson, Christopher Hodge, Simon Hodge, Lesley Hodgen, George Hodgetts, Holly Hodgkins, Sally Hodgkinson, David Hodgson, Helen Hodgson, Luke Hodgson, Sheila Hodgson, Gemma Hodkinson, Kenneth Hodson, Mike Hodson, Alison Hogan, Matthew Hogben, Lucy Hogg, Lee Hoggett, Abigail Holborow, Catherine Holbrook, Rebecca Holbrook, Catherine Holden, Jill Holden, Melinda Holden, Sophie Holden, Thomas Holder, Niels Holdhof, Hannah Holdsworth, Lisa Holland, Maureen Holland, Nicky Holland, Poppy Holland, Susan Holland, Marie L Hollands, Elizabeth Holliday, Kyra Holliday, Mark Holliday, Nina Holling, Laszlo Hollos, Nora Hollos, Leah Holloway, Simon Holloway, Max Hollowday, Marcus Hollyer, Amy Holman, Ann Holmes, Megan Holmes, Raphael Holmes, Rebecca Holmes, Kelly Holroyd, Beth Holroyd-Hind, Lyndsey Holt, Siobhan Holt, Susie Holt, Alexandra Holyome, Marie Home, Renate Homewood, Kate Hong, Louise Hoole, Clare Hooper, Samantha Hope, Susan Hope, Bridget Hopkins, Peter W Horby, Stephanie Horler, Anil Hormis, Daniel Hornan, Nicola Hornby, Thomas Horne, Zoey Horne, Rebecca Horner, Caroline Horrobin, Latoya Horsford, Megan Horsford, Mark Horsford, Valana Horsham, Alexander Horsley, Ashley Horsley, Elizabeth Horsley, Sarah Horton, Jane Hosea, Toby Hoskins, Muhammad S Hossain, Rashed Hossain, Maxine Hough, Sarah Hough, Catherine Houghton, Kathryn Houghton, Rebecca Houlihan, Kay Housely, Hamish Houston, Roseanna Hovvels, Lee How, Laura Howaniec, Joanne Howard, Kate Howard, Laura Howard, Linda Howard, Lucy Howard, Megan Howard, Sarah Howard, Stuart Howard, Richard Howard-Griffin, Louise Howard-Sandy, Serena Howe, Alice Howell, Mark Howells, Lyn Howie, Kerry Howlett, Sophie Howlett, Ruth Howman, Josh Hrycaiczuk, Hein Htet, Naing Z Htoon, Su Htwe, Ying Hu, Chiang O H Huah, Sylvia Huang, Kelly Hubbard, Abby Huckle, Shahzya Huda, Alison Hudak, Lisa Hudig, Heather Hudson, Suzanne Hudson, Oli Hudson, Alison Hufton, Connor Huggins, Alistair Hughes, Caitlin Hughes, Emma Hughes, Gareth Hughes, Heather Hughes, Luke Hughes, Martin Hughes, Rachel Hughes, Rebecca Hughes, Samantha Hughes, Stephen Hughes, Vikki Hughes, Wesley Hughes, Lukas Huhn, Ching Hui, Ruth Hulbert, Diana Hull, Grace Hull, Robert Hull, Amanda Hulme, Peter Hulme, Wendy Hulse, George Hulston, Ryan Hum, Megan Hume, Charlotte Humphrey, Alasdair Humphries, Amy Humphries, Joanne Humphries, Charlotte Hunt, Fiona Hunt, Jane Hunt, Jonquil Hunt, Kristen Hunt, Luke Hunt, Molly Hunt, Sophie Hunt, Alexandra Hunter, Catherine Hunter, Ewan Hunter, Karl Hunter, Neil Hunter, Ross Hunter, Sophie Hunter, George Huntington, Fuad Huq, Elizabeth Hurditch, Judith Hurdman, Cian Hurley, Katrina Hurley, Mohammed A Husain, Syeda Y Husaini, Coralie Huson, Afreen Hussain, Chreif Hussain, Ibraar Hussain, Ifza Hussain, Mohammad Hussain, Mohammed Hussain, Muhammad Hussain, Reda Hussain, Rizwana Hussain, Samia Hussain, Sanniah Hussain, Yasmin Hussain, Mohammed Hussam El-Din, Samahir F E M Hussein, Ziad Hussein, Rebecca Hussey, Adiel Haqiq Hussien, Anja Hutchinson, Camille Hutchinson, Dorothy Hutchinson, Elizabeth Hutchinson, John Hutchinson, Claire Hutsby, Paula Hutton, Nguyen Quang Huy, Thuong Huyen, Tran Bang Huyen, Nguyen Thi Huyen Thuong, Hieu Huynh, Daniella Hydes, Jamie Hyde-Wyatt, Niamh Hynes, Megan Hyslop, Angeliki Iakovou, Katherine Ibison, Mazen Ibraheim, Abdalla Ibrahim, Ahmed Ibrahim, Asil Ibrahim, Javed Ibrahim, Mamoun Ibrahim, Mohamed Ibrahim, Wadah Ibrahim, Becky Icke, Adetokunbo Idowu Idowu, Muhammad Idrees, Nauman Idrees, Hina Iftikhar, Mawara Iftikhar, Chukwuemeka Igwe, Ogechukwu Igwe, Mohammad Ijaz, Amaju Ikomi, Clare Iles, Stamatina Iliodromiti, Mary Ilsley, Lorna Ilves, Fatima Mariam Ilyas, La'ali Imam-Gutierrez, Mohamed Iman, Christopher Imray, Haider Imtiaz, Jack Ingham, Jo Ingham, Julie Ingham, Rory Ingham, Tejas Ingle, Jennifer Inglis, Samantha Inglis-Hawkes, Anne Ingram, Luke Ingram, Tanya Ingram, Nicholas Innes, Peter Inns, Vithusha Inpadhas, Ken Inweregbu, Andreea A Ionescu, Ana Ionita, Ilian Petkov Iordanov, Anil Ipe, Javaid Iqbal, Madiha Iqbal, Mishal Iqbal, Mohammed Iqbal, Faisal Iqbal Sait, Iziegbe Irabor, Jane Ireland, Jamie Irisari, Robert Irons, Mohannad Irshad, Muhammad S Irshad, Janice Irvine, Val Irvine, Robert Irving, Mina Ishak, Erica Isherwood, George Isitt, Aminul Islam, MD Tariqul Islam, Samsul Islam, Abdurrahman Islim, Ali Ismail, Omar Ismail, Caroline Ison, M'hamedi Israa, Sharon Isralls, Herny Istiqomah, Monica Ivan, Chineze Ivenso, Nicholas Ivin, Ashleigh Ivy, Sophie Iwanikiw, Karen Ixer, Menaka Iyer, Mia Iyer, Kashif Jabbar, Calum Jack, Joanne Jackman, Sophie Jackman, Amanda Jackson, Ben Jackson, Beth Jackson, Ella Jackson, Helen Jackson, Lauren Jackson, Melanie Jackson, Nicola Jackson, Shane Jackson, Yvonne Jackson, John Jacob, Patricia Jacob, Reni Jacob, Nicola Jacques, Anisa Jafar, Daniel Jafferji, Ali Jaffery, Chandrashekar Jagadish, Vijay Jagannathan, Abubacarr Jagne, Mandeep Jagpal, Neemisha Jain, Seema Jain, Susan Jain, Swati Jain, Sanjay Jaiswal, Danyal Jajbhay, Thomas Jaki, Bintou Jallow, Yusuf Jaly, Rose Jama, Ashraf Jamal, Sabine Jamal, Zeba Jamal, Yasmin Jameel, Albie James, Christie James, Claire James, Kate James, Lee James, Linda James, Lorraine James, Mark James, Monica James, Nicholas James, Olivia James, Patricia James, Rebecca James, Ruth James, Sharon James, Somerset James, Tracy James, Jack Jameson, Louise Jamieson, Aaron Jamison, Phoebe Jane, Karen Janes, Azara Janmohamed, Deepa Japp, Peter Jaques, Victor Jardim, Catherine Jardine, Claire Jarman, Emma Jarnell, Ellie Jarvie, Claire Jarvis, Rosina Jarvis, Patrycja Jastrzebska, Hafsa Javed, Aristotle Javier, Mays Jawad, Lona Jawaheer, Anu Jayachandran, D Jayachandran, Anita Jayadev, Angelina Jayakumar, Deepak Jayaram, Ravi Jayaram, Geeshath Jayasekera, Thilina Jayatilleke, Abi Jayebalan, Jane Jeater, Saman Jeddi, Vandana Jeebun, Mohammad S Jeelani, Katie Jeffery, Helen Jeffrey, Rachel Jeffrey, Nathan Jeffreys, Benjamin Jeffs, Carol Jeffs, Jegan P Jeganathan Ponraj, Debbie Jegede, Taylor Jemima, Ifan Jenkin, Alison Jenkins, Christopher Jenkins, David Jenkins, Elinor Jenkins, Ian Jenkins, Paula Jenkins, Sarah Jenkins, Sian Jenkins, Stephen Jenkins, Felicia 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Julie Jones, Kate E Jones, Kimberly Jones, Laura Jones, Laura M Jones, Louise Jones, Mathew Jones, Nancy Jones, Nicola Jones, Olivia Jones, Paul Jones, Philip H Jones, Rhianna Jones, Ruth E Jones, Samantha Jones, Sophie Jones, Stefanie Jones, Steve Jones, Susan Jones, Taya Jones, Thomas Jones, Tim Jones, Tracey Jones, Ramya Jonnalagadda, Rebecca Jordache, Michele Jordan, Sarah Jordan, Abi Jose, Litty Jose, Louise Jose, Sanal Jose, Anna Joseph, Gigee Joseph, P Aiden Joseph, Rosane Joseph, Sibet Joseph, Dhaara Joshi, Mehul Joshi, Pratichi Joshi, Tushar Joshi, Benz Josiah, Lijo Joy, Tiffany Joyce, Hong Ju, Adriel Ju Wen Kwek, Andrew Judd, Edward Jude, Parminder Judge, Jessica Juhl, Sirisha Jujjavarapu, Mark Juniper, Edmund Juszczak, Deepthi Jyothish, Kasamu Kabiru Dawa, Mark Kacar, Nikhil Kadam, Nicole Kader, Ajai Kailey, Matthew Kain, Gail Kakoullis, Azad Kala Bhushan, Richard J K Kalayi, Roobala Kaliannan Periyasami, Efthymia Kallistrou, Thomas Kalmus Eliasz, Seika Kalsoom, Elisa Kam, John Kamara, Ajay Kamath, Prakash Kamath, Ravindra Kamath, Siddharth A Kamerkar, Nick Kametas, Musaiwale Kamfose, Charlotte Kamundi, Dharmesh Kanabar, Leia Kane, Osei Kankam, Thogulava Kannan, Abhinav Kant, Vikas Kapil, Ritoo Kapoor, Sonal Kapoor, S Kaprapina, Sourjya Kar, Janaka Kara, Elshad Karbasi, Shivaali Karelia, Rona Kark, Abhilasha Karkey, Aruna Karki, Soheilali Karmali, Viji Karunanithi, Nicholas Karunaratne, Natashja Kasianczuk, Anbhu Kasiappan Balasubramanian, Vidya Kasipandian, Rizwan Kassam, Janarth Kathirgamachelvam, Mpumelelo Kati, Victoria Katsande, Kulbinder Kaul, Daljit Kaur, Dervinder Kaur, Jasmin Kaur, Jaspreet Kaur, Simran Kaur, Zunaira Kausar, Lisa Kavanagh, susan Kavanagh, Mohammad A Al Kawser, Andrea Kay, Julie Kay, Robert Kay, Sarah Kay, Jossy N Kayappurathu, Srijana Kayastha, Callum Kaye, Ahemd Kazeem, Pooja KC, Min Ke, Timothy Keady, Rachel Kearns, Nichola Kearsley, Joanne Keating, John Keating, Liza Keating, Elizabeth Keddie-Gray, Breffni Keegan, Rachel Keen, Natalie Keenan, Jonathan Kefas, Stephen Kegg, Laura Keith, Uzoamaka Keke, Joanne Kellett, Jo Kelliher, Alison Kelly, David Kelly, Diane Kelly, Dominic Kelly, Emma Kelly, Hannah Kelly, Laura Kelly, Louisa Kelly, Martin Kelly, Michael Kelly, Rosalind Kelly, Sinead Kelly, Stephanie Kelly, Stephen Kelly, Mary Kelly-Baxter, Olivia Kelsall, Marketa Keltos, Timothy Kemp, Emma Kendall, Alexandra Kendall-Smith, Sarah Kennard, Ann Kennedy, James Kennedy, Melanie Kennedy, Sophie Kennedy-Hay, Julia Kenny, Melanie Kent, Lynne Keogan, Alexander Keough, Dawn Kernaghan, A Kerr, Andrew Kerr, Caroline Kerrison, Anthony Kerry, Helen Kerslake, Ian Kerslake, Helen Kerss, Jocelyn Keshet-Price, Evelyne Kestelyn, Georgina Keyte, Abdul Khadar, Dipika Khadka, Ali Khalid, Hadika Khalid, Muhammad U Khalid, Syed Khalid, Mariha Khalid, Tarek Khalifa, Amir Khalil, Asma Khalil, Sijjad Khalil, Abubakar Khan, Ali Khan, Al-Imran Khan, Arham Khan, Asad Khan, Aurangzeb Khan, Burhan Khan, Fatimah Khan, Kausik Khan, Malik A Khan, Marria Khan, Mehrunnisha Khan, Mohammad Khan, Myra Khan, Nayeem Khan, Nuzhath Khan, Omar Khan, Rabia Khan, Rahila Khan, Shabana Khan, Shahul Khan, Shoaib Khan, Tasaduksultan Khan, Waleed Khan, Waseem Khan, Zuhair Khan, Mohammad S Khan Tharin, Usman F Khatana, Januka Khatri, Jibran Khatri, Jyoti Khatri, Hafiza Khatun, Taslima Khatun, Mena Kheia, Jacyntha Khera, Htet Htet Ei Khin, Najaf Khoja, Kiran Khokhar, Minh Quang Khong, Joshua Khoo, Chloe Khurana, Joyce Kibaru, Faith Kibutu, Andrew Kidd, Michelle Kidd, Joe Kidney, Shane Kidney, Will Kieffer, James Kilbane, Caroline Kilby, Eileen Killen, Beverley Kilner, Susan Kilroy, Bomee Kim, Jee W Kim, Minhee Kim, Aly Kimber, Sarah Kimber, Andy King, Barbara King, Hayley King, Jennifer King, Jenny King, Kirsten King, Matthew King, Rachel King, Sarah King, Victoria King, Emily King-Oakley, Laura Kingsmore, Deborah J Kinnear, Fiona Kinney, Sidra Kiran, Alison Kirby, Adam Kirk, Jeremy Kirk, Jill Kirk, Jodie Kirk, Amy Kirkby, Emily Kirkham, Gemma Kirkman, Lucy Kirkpatrick, Ursula Kirwan, Toby Kitching, Laura Kitto, Lauren Kittridge, Sarah Klaczek, Frieder Kleemann, Susan Kmachia, Christopher P Knapp, Lucy Knibbs, Alicia Knight, Fraser Knight, Marian Knight, Sarah Knight, Steven Knight, Tom Knight, Ellen Knights, Jane Knights, Martin Knolle, Paul Knopp, Charlotte Knowles, Karen Knowles, Laurence Knowles, Emily Knox, Lucy Knox, Oliver Koch, Marta Kocsor, Ronan Kodituwakku, Gouri Koduri, Yuan J Koe, Janak Koirala, Aisha Koirata, Eirene Kolakaluri, Magdalena Kolodziej, Eirini Kolokouri, Samantha Kon, Niladri Konar, Mari Kononen, Athanasios Konstantinidis, Rachel Kontogonis, Hui Fen Koo, Imogen Koopmans, Emmanuela Kopyj, Laura Korcierz, James Korolewicz, George Koshy, Chris Kosmidis, Csilla Kosztolanyi, Jalpa Kotecha, Easwari Kothandaraman, Katerina Koukou, Athanasia Kountourgioti, Koushan Kouranloo, Rukhsana Kousar'c, Margarita Kousteni, Anastasia Koutalopoula, Maja Kovac, Alex Kozak Eskenazia, Kestutis Krasauskas, Raghu Krishnamurthy, Vinodh Krishnamurthy, Manju Krishnan, Hari Krishnan, Nagaratna Krishnapalli, Suzanne Krizak, Stephen Krueper, Sean Krupej, James Krzowski, Ria Kubaisi, Agnieszka Kubisz-Pudelko, Shavita Kuckreja, Soren Kudsk-Iversen, Aurimas Kudzinskas, Chirag Kukadiya, Nainesha Kulkarni, Susantika Kumala Dewi, Marian Kuma-Mintah, Aditi Kumar, Ayesha Kumar, Mayur Kumar, Ramesh Kumar, Ravi Kumar, Rita Kumar, Rupa Kumar, Satish Kumar, Vikas Kumar, Vimal Kumar, Arun Kundu, Heinke Kunst, Shaibya Singh Kunwar, Klaudia Kupiec, Amit Kurani, Mohammed Kurdy, Kevin Kuriakose, Rincy Kurian, Vimal Kurmars, Cameron Kuronen-Stewart, Ranganai S Kusangaya, Vlad Kushakovsky, Anna Kutera, Apexa Kuverji, Amma Kyei-Mensah, Henriette Kyepa, Thyra Kyere-Diabour, Moe Kyi, Nyan M Kyi, Laura Kyle, Karali-Tsilimpari Kyriaki, Julius Labao, Louise Lacey, Nikki Lack, Maria Lacson, Zahra Ladan, Emma Ladlow, Heather Lafferty, Alice Lagnado, Shondipon Laha, Sushil Lahane, Clement Lai, James Lai, Paula Laidler, Robert Laing, Inez Laing-Faiers, Emily Laity, Katharine Lake, Nicki Lakeman, David Lalloo, Fiona Lalloo, Alison Lam, Classy Lam, Fiona Lamb, Lucy Lamb, Thomas Lamb, Oscar Lambert, Pauline Lambert, Claudia Lameirinhas, Mohammed K G Lami, Holly Lamont, Michal Lamparski, Djillali Lamrani, Christine Lanaghan, Ivone Lancona-Malcolm, Geraldine Landers, Martin J Landray, Matthew Lane, Nicholas Lane, Alidih Lang, Stephen Lang, Daniel Langer, Margaret Langley, Charles Langoya, Emma Langridge, Emily Langthorne, Helen Langton, Beatriz Lara, Taiya Large, Lawrencia Naadu Lartey, Samuel Lassa, Anna Last, Scott Latham, Victoria Latham, Afzal Latheef, Larissa Latif, Nang Latt, Carmen Lau, Dawn Lau, Eva Lau, Gonzalez G Laura, Myra Laurenson, Eloise Lavington, Hou Law, Jessica Law, June Law, Kar Y Law, Penny Law, Richard Law, Laura Lawless, Chris Lawrence, Emma Lawrence, Geoffrey Lawrence, Holly M Lawrence, Neil Lawrence, Ryan Lawrie, Louise Lawson, Natalie Lawson, Rod Lawson, Michael Lay, Stephen Laybourne, Christine Laycock, Reina Layug, Maria Lazo, Thi Thao Le, Vietland Le, Amelia Lea, William Lea, Louisa E Leach, Ian Leadbitter, Thomas Leahy, Richard Lean, Lorna Leandro, Darren Leaning, Ruth Leary, Sandra Leason, Marie A Ledingham, Caroline Lee, Emma Lee, Hannah Lee, Irish Lee, Joshua Lee, Judith Lee, Sam Lee, Shannon Lee, Shi Han Lee, Simon Lee, Sindy Lee, Stephanie Lee, Tracey Lee, Xiang Lee, Robyn Lee, Diana Lees, Jennifer Lees, Helen Legge, Julian Leggett, Katie Leigh-Ellis, David Leitch, Nicky Leitch, Eleni Lekoudis, Petula Lemessy, Nicholas Lemoine, Rebecca Lenagh, Katy Leng, Katrina Lennon, Liz Lennon, Beth Leonard, Kelly Leonard, Wen Leong, Nicky Leopold, Oskar Lepiarczyk, Isla Leslie, Eva Noviani Lestari, Eleni Lester, Emma Levell, Chris Levett, Anastasia Levynska, Alice Lewin, Alison Lewis, Christopher Lewis, David Lewis, Dee Lewis, Heather Lewis, Joanne Lewis, Joseph Lewis, Kathryn Lewis, Keir Lewis, Leon Lewis, Mandy Lewis, Marissa Lewis, Nicolas Lewis, Robert Lewis, Catherine Lewis-Clarke, Adam Lewszuk, Penny Lewthwaite, Samantha Ley, Angela Liao, Victoria Licence, David Lieberman, Susan Liebeschuetz, Teresa Light, Nicky Lightfoot, Patrick Lillie, Ashling Lillis, Ben Lim, Carys Lim, Ee T Lim, Ivy Lim, Terence Lim, Wei Shen Lim, Wilson Lim, James Limb, Dipraj Limbu, Usha Limbu, Christian Linares, Dermot Linden, Gabriella Lindergard, Kate Lindley, Charlotte Lindsay, Emily Lindsay, Max Lindsay, Helen Lindsay- Clarke, Mirella Ling, Claire Lingam, Linette Linkson, Thinzar Linn, Mike Linney, Conrad Lippold, George Lipscomb, Karen Lipscomb, Laura Lipskis, Ana Lisboa, Evangeline Lister, Jeff Little, Sam Little, Lucy Littlejohn, Sky Liu, Xuedi Liu, Daniel K Llanera, Rhiannon Llewellyn, Martin Llewelyn, Adam Lloyd, Aimee Lloyd, Arwel Lloyd, Oliver Lloyd, Richard Lloyd, Su Lo, David Loader, Caroline Loan, Livia Lobosco, Lydianne Lock, Sara Lock, Stephen Lock, Angela Locke, Jacqueline Locke, Thomas Locke, Teresa Lockett, Jeorghino Lodge, Krishan Lodhia, Martina Lofthouse, Heather Loftus, Meg Logan, Chloe A Logue, Sook Yin Loh, Siddharth Lokanathan, Kaatje Lomme, Emily London, Gabriella Long, Natalie Long, Katherine Longbottom, Bev Longhurst, Mark Longshaw, Sarah Longstaffe, Jennifer Lonnen, Caroline Lonsdale, Laura Looby, Ronda Loosley, Liliana Lopes, Paola Lopez, Paula Lopez, Robert W Lord, Stephen Lord, Claire Lorimer, Francesco Loro, Rachel Lorusso, Catherine Loughlin, Wayne Lovegrove, Robert Loveless, Maxine Lovell, Angeliki Loverdou, Andrew Low, Jen Mae Low, Shona Low, Alastair Lowe, Catherine Lowe, Emily Lowe, Faye Lowe, Leanne Lowe, Michael Lowe, Richard Lowsby, Vicki Lowthorpe, Gamu Lubimbi, Alexandra Lubina Solomon, Georgia Lucas, Jacob Lucas, Alice Lucey, Olivia Lucey, Suzanne Luck, Lok Hin Lui, Akish Luintel, H Luke, Jane Luke, Naomi Lungu, Apurva Lunia, Muriel Lunn, Ji Luo, Mark Luscombe, Jocelyn Luveta, Cindy N Luximon, Khine Lwin, Myat Lwin, Alison Lye, Barrie Lyell, Elisavet Lyka, Audrey Lynas, Ceri Lynch, Daniel Lynch, Daniella Lynch, Stephen Lynch, Rea-Grace Maamari, Hannah Mabb, Louies Mabelin, George Mabeza, Jessica Macaro, Kateryna Macconaill, Chloe Macdonald, Andrew Macduff, Claire Macfadyen, James G Macfarlane, Jill Macfarlane, Laura Macfarlane, Irene Macharia, Lisa MacInnes, Iain MacIntyre, Jill MacIntyre, Kirsten Mack, Callum Mackay, Euan Mackay, Laura Mackay, Alexander Mackenzie, Matt Mackenzie, Robert MacKenzie Ross, Ami Mackey, Fiona Mackie, Jennifer Mackie, Robert Mackie, Carolyn Mackinlay, Claire Mackintosh, Katherine Mackintosh, Mary J MacLeod, Shona Macleod, Michael Macmahon, Andrew MacNair, Catherine Macphee, Iain Macpherson, Catriona Macrae, Allan MacRaild, Yasser Madani, Alannah Madden, Mary Madden, Christopher Madden-McKee, Sally Maddison, Norman Madeja, Pradeep Madhivathanan, Madhavi Madhusudhana, Alpha Madu, Lorraine Madziva, Marion Mafham, Nick Magee, Frederick Magezi, Negar Maghsoodi, Christopher Magier, Lessica M Magnaye, Marios Magriplis, Michelle Magtalas, Natasha Mahabir, Subramanian Mahadevan-Bava, Amitaa Maharajh, Anjanie Maharajh, Kijan Maharjan, Madan Maharjan, Ajit Mahaveer, Bal Mahay, Kanta Mahay, Amy Mahdi, Hibo Mahdi, Noor Mahdi, Thushika Mahendiran, Siva Mahendran, Sarah Maher, Anistta Maheswaran, Shameera Maheswaran, Tina Maheswaran, Parisa Mahjoob-Afag, Ahmed Mahmood, Farhana Mahmood, Hussain Mahmood, Waheed Mahmood, Zahra Mahmood, Hager Mahmoud, Mohammed Mahmud, Ewan Mahony, Tabitha Mahungu, Oumou Maiga, Luke Mair, Toluwani Majekdunmi, Kesson Majid, Amy Major, Rupert Major, Jaydip Majumdar, Mohammad K H Majumder, Tsz L A Mak, Annabel Makan, Esther Makanju, Stephen Makin, Wura-Ola Makinde, Yahya Makkeyah, Marius Malanca, Hannah Malcolm, Flora Malein, Neeraj Malhan, Agnieszka Malicka, Ayesha Malik, Gulshan Malik, Mohammed Maljk, Paul Mallett, Petrina Mallinder, Georgia Mallison, Louise Mallon, Edward Malone, Gracie Maloney, Madhu Mamman, Irene Man, Kathy Man, Rossana Mancinelli, Marco Mancuso-Marcello, Shrawan K Mandal, Sudeshna Mandal, Tracy Manders, Lauren Manderson, Justin Mandeville, Tara Mane, Roope Manhas, Carmen Maniero, Ravi Manikonda, Ilham Manjra, Rowan Mankiewitz, Bobby Mann, Jonathan Manning, Sarah Manning, Pascoe Mannion, Katherine Mansi, Katarina Manso, Dina Mansour, Mohamed Mansour, Ramy Mansour, Isheunesu T Mapfunde, Predeesh Mappa, Arrusaw Maqsood, Hemant Maraj, Clare Marchand, Neil Marcus, Anna Marcyniuk, Maria Marecka, Deborah Maren, Gomathi Margabanthu, Jordi Margalef, Lavinia Margarit, Georgios Margaritopoulos, Mike Margarson, Fernandez Maria del Rocio, Teresa Maria Pfyl, Victor Mariano, Ashleigh Maric, Grace Markham, Ben Marks, Maria Marks, P Marks, Emily Marler, Elisabeth Marouzet, Arran Marriott, Cheryl Marriott, Nemonie Marriott, Christopher Marsden, Karen Marsden, Paul Marsden, Sarah Marsden, Tracy Marsden, Cathryn Marsh, Glen Marsh, Robyn Marsh, Adam Marshall, Andrew Marshall, Gail Marshall, Henry Marshall, Jaimie Marshall, Jenna Marshall, Nicola Marshall, Riley Marshall, Steven Marshall, Jennifer Marshall, Emmeline Martin, Gaynor Martin, Hayley Martin, Hope Martin, Jane Martin, Karen Martin, Kate Martin, Laila Martin, Martha Martin, Michael Martin, Noelia Martin, Tim Martin, Winston Martin, Sarah Martin, Tim Martindale, Marcus Martineau, Lauren Martinez, Jose C Martinez Garrido, Juan Martin-Lazaro, Vijay K Maruthamuthu, Bukhari Marwan, Gemma Maryan, Roman Mary-Genetu, Sam Maryosh, Vidan Masani, Allison Mascagni, Diego Maseda, Zandile Maseko, Sheila Mashate, Yasaman Mashhoudi, Al Mashta, Izhaq Masih, Sanna Masih, Nicholas Maskell, Perry Maskell, Prabina Maskey, Matthew Masoli, Julia Mason, Rebecca Mason, Richard Mason, Ruth Mason, Claire Mason, Mohammad Masood, Mohammad T Masood, Syed S M E Masood, Thalia Massa, Ian Massey, Joseph Masters, Aaqib Masud, Lear Matapure, Cristina Matei, Ropafadzo Matewe, Esther Matey, Manraj Matharu, Stephy Mathen, Alex Mather, Nicole Mather, Jonathan Mathers, Joanna Matheson, Amal Mathew, Anna Mathew, Bijoy Mathew, Moncy Mathew, Verghese Mathew, Jesha Mathews, Kate Mathias, Alexander Mathioudakis, Darwin Matila, Wadzanai Matimba-Mupaya, Nashaba Matin, Elina Matisa, Ellen Matkins, Max Matonhodze, Elijah Matovu, Jaysankar Mattappillil, Alison J Matthews, Clive Matthews, Heather Matthews, Helen Matthews, Lehentha Mattocks, Charlotte Maughan, Tara Titian Maulidya, Emma Mawson, Fiona Maxton, Adam Maxwell, Veronica Maxwell, Emily May, James May, Joanne May, Philippa May, Irving Mayanagao, Matthew Maycock, Jordan Mayer, Graham Mayers, Victoria A Maynard, Thomas Mayo, Lioniza Mayola, Shelley Mayor, Ibreaheim Mazen, Thamani Mazhani, Andrea Mazzella, Nyambura Mburu, Angeline Mbuyisha, Celine Mc Cague, Eleanor McAleese, Paul McAlinden, Lesley McAllister, Audrey McAlpine, Graeme McAlpine, Jonathan McAndrew, Hamish McAuley, Sarah McAuliffe, Claire McBrearty, Erin McBride, Michael McBuigan, James McBurney, Laura McCabe, Gemma L McCafferty, Laura McCafferty, Amanda McCairn, Jake McCammon, Nicole McCammon, Conor McCann, Erin McCann, Alexandra McCarrick, Brendan McCarron, Eoghan McCarthy, Michelle McCarthy, Natalie McCarthy, Sinead McCaughey, Tara McClay, Beverley McClelland, Declan McClintock, Michael McCloskey, Kirsten McCollum, Alasdair McCorkindale, Patricia McCormack, Jacqueline McCormick, Jake McCormick, Wendy McCormick, Paul McCourt, Jame McCrae, Sharon McCready, Gordan McCreath, Helen McCreedy, Claire McCue, Iain J McCullagh, Liz McCullagh, Megan McCullagh, Conor McCullough, Katherine McCullough, Nicola McCullough, Sarah McCullough, Fiona McCurrach, John McDermott, Paula McDermott, Rory McDermott, Katharine McDevitt, Helen McDill, Basil McDonald, Carly McDonald, Claire McDonald, Debbie McDonald, Rob McDonald, Sam McDonald, Damhnaic McDonald, Natasha McDonnell, Catherine McDougall, Lilly McDougall, Rowan McDougall, Irene McEleavy, Fred McElwaine, Julie McEntee, Evanna McEvoy, Claire McEwan, Ruth McEwen, Margaret McFadden, Denise McFarland, Margaret McFarland, Rachel McFarland, Joe McFlynn, Erin McGarry, Lorcan McGarvey, Alex McGeachan, Frederick McGee, Laura McGenily, Clodagh McGettigan, Michael McGettrick, Christopher McGhee, Fiona McGill, Sarah McGinnity, Neil McGlinchey, Phil McGlone, Deborah McGlynn, Claire McGoldrick, Clare McGoldrick, Elizabeth McGough, Christopher McGovern, Roisin McGovern, Angela McGowan, Anne McGown, Brendan McGrath, Amanda McGregor, Annemarie McGregor, Michael P McGuigan, Heather McGuinness, Sean McGuire, Tara McHugh, Caroline McInnes, Neil McInnes, Jerome McIntosh, Karen McIntyre, Mhairi McIntyre, Lorna McKay, Conor P McKeag, Jacqueline McKeane, Madeleine McKee, Joseph McKeever, Judith McKenna, Shirley McKenna, Mary McKenzie, Donogh McKeogh, Caroline McKerr, Anthony M McKie, Hayley Mckie, Laura Mckie, Gerard McKnight, Heather McLachlan, Andrew McLaren, Barbara McLaren, Nicola McLarty, Danielle Mclaughlan, Maria McLaughlin, James McLay, Mary McLeish, Tina McLennan, Stewart McLure, Anne Marie McMahon, Genevieve McMahon, Mike McMahon, Stephen McMahon, Terence McManus, Moyra McMaster, P McMaster, Paddy McMaster, Faye Mcmeeken, Samuel McMeekin, Nicola McMillan, Katherine McMillen, Jason McMinn, Liam McMorrow, Heather McMullen, Christopher McMurran, Helen McNally, Fiona McNeela, Lynne McNeil, Claire McNeill, Jessica McNeill, Shea McNeill, Una McNelis, Melanie McNulty, Roisin McNulty, Christopher McParland, Mark McPhail, Alison McQueen, Anna McSkeane, Denise McSorland, Therese McSorley, Gini McTaggart, Jacqueline McTaggart, Joanna Mead, Paul Mead, Emma Meadows, Olivia Meakin, Ben Mearns, Claire Mearns, Kim Mears, William Mears, Manjula Meda, Ayren Mediana, Ross Medine, Thomas Medveczky, Sharon Meehan, Emily Meeks, Abbi Megan, Nevan Meghani, Salim Meghjee, Sharon Megson, Amina Mehar, Mehr N Mehmood, Rohan Mehra, Rohan Mehta, Graeme Meintjes, James Meirill, James Meiring, Rayane Mejri, Ellen Mekonnen, Sabina Melander, Adriana-Stefania Melinte, Jennifer Mellersh, Lucy Melling, Christie Mellish, Francesca Mellor, Joe S Mellor, Samantha Mellor, Zoe Mellor, Katrina Mellows, Vladimir Melnic, Alice Melville, Dominique Melville, Julie Melville, Helen Membrey, Mark Mencias, Adam Mendelski, Marc Mendelson, Cheryl Mendonca, Carron Meney, Colin Menezes, Winifred Mensah, Alexander Mentzer, Dan Menzies, Sarah Menzies, Sue Mepham, Oliver Mercer, Pauline Mercer, Arwa Merchant, Fatema Merchant, Mihaela Mercioniu, Megan Meredith, Marta Merida Morillas, Blair Merrick, Jack Merritt, Sharon Merritt, Simon Merritt, Paul-Peter Merron, Ekta Merwaha, Simon Message, Jenny Messenger, Gabriel Metcalf-Cuenca, Alexandra Metcalfe, Benjamin Metcalfe, Kneale Metcalfe, Stella Metherell, Alexsandra Metryka, Louise Mew, Simon Meyrick, Nhlanhla Mguni, Atiqa Miah, Jagrul Miah, Nahima Miah, Areeb Mian, Gabriela Mic, Lawrence Micah-Amuah, Dariush Micallef, Alice Michael, Angiy Michael, Shery Michael, Natalia Michalak, Loredana Michalca-Mason, Ola Michalec, Janet Middle, Hayley Middleton, Jennifer T Middleton, Maeve Middleton, Sophie Middleton, Shelley Mieres, Loredana Mihalca-Mason, Theresia Mikolasch, Sarah Milgate, Colin Millar, Jonathan Millar, James Millard, David Miller, Johnathan Miller, Lucy Miller, Rachel Miller, Naomi Miller-Biot, Alex Miller-Fik, Louise Millett, Barry Milligan, Hazel Milligan, Iain Milligan, Caitlin Milliken, Katherine Millington, Rhys Millington, Samuel Millington, Helen Mills, Janet Mills, Rebecca E Mills, Helen Millward, Rebecca Miln, Alice Milne, Charlotte Milne, Louise Milne, Joanne Milner, Leanne Milner, Zayar Min, Samuel Mindel, Prince Amankwah Baffour Minkah, Chrissie Minnis, Paul Minnis, Konstantina Minou, Natalie Minskip, Jane Minton, Frederico Miranda, Mukaj Mirela, Taimur Mirza, Anjum Misbahuddin, Aseem Mishra, Biswa Mishra, Eleanor Mishra, Ritu Mishra, Sannidhya Misra, Deena Mistry, Heena Mistry, Dushyant Mital, Sarah Mitchard, Ben Mitchell, Caroline Mitchell, Luke J Mitchell, Piers Mitchell, Philip Mitchelmore, Andrew Mitra, Atideb Mitra, Sandip Mitra, Nomsa Mlambo, Emma Moakes, Kirsten Moar, Emma Moatt, Daniela Mock Font, Gita Modgil, Abdelrahman Mohamed, Arez Mohamed, Osab Mohamed, Akram Mohammad, Waheed Mohammad, Aliabdulla Mohammed, Omer Mohammed, Yaser N S Mohammed, Bilal A Mohamud, Amr Moharram, Hoi-Ping Mok, Jonathan Mok, Leslie Mokogwu, Marcelino Molina, Christine Moller-Christensen, Mateus Mollet, Malid Molloholli, Aoife Molloy, Linda Molloy, Andrew Molyneux, Rebekah Molyneux, Tasnim Momoniat, Holly Monaghan, Krista Monaghan, Shiva Mongolu, Tesha Monika, Katelyn Monsell, Mahmoud Montasser, Alan Montgomery, Hugh Montgomery, Prebashan Moodley, Margaret Moody, Nick Moody, Angela Moon, James Moon, Ji-Hye Moon, Maria Moon, May Moonan, Parvez Moondi, Suzanne Moorby, Jim Moorcroft, Alex Moore, Christopher Moore, David A J Moore, Faye Moore, Judith Moore, Laura Moore, Natalie Moore, Sally Moore, Siobhan Moore, Sonia Moore, Vanessa Moore, Rachel Moores, Ed Morab, Jose Morales, Nuria Moramorell, Louise Moran, Grishma Moray, Jeronimo Moreno-Cuesta, Alexander Morgan, Amy Morgan, Caitlin Morgan, Christine Morgan, Colin Morgan, Holly Morgan, Katie Morgan, Lauren Morgan, Leila Morgan, Lewis Morgan, Matthew Morgan, Patrick Morgan, Katie Morgan-Jones, Emily Morgan-Smith, Joseph Morilla, Anna Morley, Thomas Morley, Wendy Morley, Anna Morris, Damian Morris, Fiona Morris, Helen Morris, Juliet Morris, Katie Morris, Laura Morris, Lucy Morris, Mary-Anne Morris, Niall Morris, Paul Morris, Sheila Morris, Susan Morris, Douglas Morrison, Moira Morrison, Scott Morrison, Mary Morrissey, Abbie C Morrow, Anna Morrow, Franca Morselli, Gordon Mortem, Valerie Mortland, Chelsea Morton, Gordon Morton, Priti Morzaria, Daniel Mosby, Linda Moseley, Karyn Moshal, Ben Moshy, Alison Moss, Charlotte Moss, James Moss, Sarah Moss, Stuart Moss, Omar Mostafa, Georgia Moth, Nicki Motherwell, Sharon Mottershaw, Harmesh Moudgil, Johanna Mouland, Caroline Moulds, Hilary Moulton, Ginny Mounce, Elizabeth Mousley, Chris Mowatt, Karen Moxham, Borja Moya, Quberkani Moyo, Eunice Mshengu, Sheila Mtuwa, Ali Muazzam, Iqtedar A Muazzam, Nykki Muchenje, Dalia Mudawi, Girish Muddegowda, Rabia Mufti, Imran Mugal, Ahsan Mughal, Javaid Muglu, Fawad Muhammad, Javed Muhammad, Carol Muir, Aparna Mukherjee, Dipak Mukherjee, Jameel Mukhtar, Syed A A Mukhtar, Denise Mukimbiri, John Mulcahy, Michelle Mulcahy, Peter Mulgrew, Ben Mulhearn, Arafat Mulla, Dee Mullan, Dileepkumar Mullasseril Kutten, Niall Mullen, Rosemary Mullett, Ciara Mulligan, Sandra Mulligan, Lana Mumelj, Andrew Mumford, Mohammed Munavvar, Henry Munby, Hannah Munday, Anne-Marie Munro, Sheila Munt, McDonald Mupudzi, Arshid Murad, Oluwatosin H Muraina, Koteshwara Muralidhara, Mhairi Murdoch, Jennifer Murira, Alison Murphy, Ben Murphy, Carl Murphy, Cathal Murphy, Erin Murphy, Gail Murphy, Hannah Murphy, Peter Murphy, Rebecca Murphy, Sheenagh Murphy, Simon Murphy, Clare Murray, David Murray, Dawn Murray, Eleanor Murray, Katie Murray, Kenneth Murray, Lindy Murray, Lisa Murray, Lorna Murray, Tracey Murray, Eoin Murtagh, Mithun Murthy, Catherine Murton, Rosie Murton, Neeka Muru, Rosemary Musanhu, Maimuna Mushabe, Omaisa Mushtaq, Sohmal Musini, Ahmed M M Mustafa, Elhaytham Mustafa, Mustafa Mustafa, Ibrahim Mustapha, Naveed Mustfa, Zhain Mustufvi, Callum Mutch, Rachel Mutch, Eric Mutema, Balakumar Muthukrishnan, Sheree Mutton, Natasha Muzengi, Memory Mwadeyi, Bettina Mwale, Esther Mwaura, Raji Myagerimath, Alice Myers, Sam Myers, James S Myerson, Khin Swe Myint, Yadee Myint, Georgina Mynott, Libor Myslivecek, Patricia Nabayego, Evelyn Nadar, Iftikhar Nadeem, Moosa Nadheem, Behzad Nadjm, Asma Naeem, Hassan Naeem, Salman Naeem, Samraiz Nafees, Mohamed Nafei, Widya Naftalia, Thapas Nagarajan, Leah Naglik, Imrun Nagra, Deepak Nagra, Mina Naguib, Kirushthiga Naguleswaran, K Shonit Nagumantry, Kevin Naicker, Sarveshni Naidoo, Gireesha Naik, Rishi Naik, Samir Naik, Devu S Nair, Rajiv Nair, Tanushree Nair, Jay Naisbitt, Kerry Naismith, Deborah Nakiboneka-Ssenabulya, Sri Nallapareddy, Soum Nallapeta, Arumugan Nallasivan, Ha Xuan Nam, Uttam Nanda, Aarti Nandani, Tara Nandwani, Ali Raza Naqvi, Asadullah Naqvi, Sara Naqvi, Sophia Nasa, Dominic Nash, Nader Nasheed, Abdul Nasimudeen, Umer Nasir, Nasronudin Nasronudin, Tahir Nasser, Anuja Natarajan, Geetha Natarajan, Nalin Natarajan, Nikhila Natarajan, Rajkumar Natarajan, Preethy Nath, Noel Nathaniel, Mala Nathvani, Priyan Nathwani, George Nava, Neena Navaneetham, Jeya Navaratnam, Helen Navarra, Sadaf Naveed, John Navin, Khuteja Nawaz, Sarfaraz Nawaz, Shasta Nawaz, Bonilla Nayar, Suzanne Naylor, Moez Nayyar, Farrah Naz, Mobeena Naz, Babak Nazari, Abida Nazir, S Nazir, Sehar Nazir, Dumisani Ncomanzi, Onyinye Ndefo, Narcisse B Ndoumbe, Abigail Neal, Alan Neal, Elaine Neary, Mostafa Negmeldin, Jonathan Neil, Paula Neill, Hector E Neils, Avideah Nejad, Jeremy Nel, Louise Nel, Andrew Nelson, Benjamin Nelson, Lauren Nelson, Marie Nelson, Memory Nelson, Richard Nelson, Scott Nelson, Sven Nelson, Erni Nelwan, Rajesh Nemane, Samiksha Nepal, Daniel Nethercott, Kimberley Netherton, Kimberley Nettleton, Kabita Neupane, Alison Newby, Angela Newby, David Newby, Tracy Newcombe, Helen Newell, Charlotte Newman, Diana Newman, Hannah Newman, Julie Newman, Oscar Newman, Tabitha Newman, Thomas Newman, Rachel Newport, Maria Newton, Anthony Y K C Ng, Hui En Jewel Ng, Ka Wing Ng, Maxine Ng, Sarah Ng, Wee Jin Ng, Yee W M Ng, Thomas Ngan, Thanh Ha Ngo, Gabriel CE Ngui, Alice Ngumo, Hong Khanh Nguyen, Minh Thu Nguyen, Nguyen Thi Thao Nguyen, Quang Nguyen, Thi Huyen Trang Nguyen, Thi Thao Nguyen, Thi Thao Nguyen Nguyen, Thi Thuong Nguyen, Thi Thuy Phuong Nguyen, Keith Ngwenya, Caoimhe Nic Fhogartaigh, Nathalie Nicholas, Philip Nicholas, Rachel Nicholas, Rebecca Nicholas, Donna Nicholls, Lisa Nicholls, Sarah Nicholls, Alice Nicholson, Anne Nicholson, Annette Nicholson, Ian Nickson, Eileen Nicol, Elizabeth Nicol, Rebecca Nicol, Pantelis Nicola, Antony Nicoll, Tania Nightingale, Faria Nikita, Pantzaris Nikolaos, Georgii Nikonovich, Annette Nilsson, Kofi Nimako, Louise Nimako, Camus Nimmo, Preethy Ninan, Mahesh Nirmalan, Richa Niroula, Attiya Nisar, Muhammad Nisar, Tosia Nisar, Toby Nisbett, Aksinya Nisha James, Sabaahat Nishat, Tomoko Nishiyama, Sara Nix, Jennifer Nixon, Maxine Nixon, Khwaja Nizam Ud Din, Maria Nizami, Serafeim Nizamis, Raymond Njafuh, India Noakes, Lyrics Noba, Jennifer Noble, Jonathon Noble, Harriet Noble, Hsu M Noe, Jerry Nolan, Jackson Nolasco, Zahid Noor, Zaid Noori, Jayne Norcliffe, Louis Norman, Rachel Norman, Emma Norris, Karen Norris, Lillian Norris, Sally Ann Nortcliffe, Fiona North, Julie North, Thomas North, John Northfield, Samantha Northover, Jurgens Nortje, Donna Norton, Rowen Norton, Holly Notman, Khalid Nourein, Timea Novak, Nuria Novas Duarte, Catherine Novis, Justyna A Nowak, Khin Phwe Nu, Mohamed Nugdallah, Anne M Nugent, Justine Nugent, Cahyo Wibisono Nugroho, Numbere Numbere, Kribashnie Nundlall, Arvind Nune, Kieran Nunn, Michelle Nunn, Jane Nunnick, Yvonne Nupa, Fadumo Nur, Zubeir Nurgat, Amy Nuttall, Lorenza Nwafor, Paul C Nwajiugo, Godfrey Nyamugunduru, Livina Nyanor, Maggie Nyirenda, Kerry Nyland, Donal O Rinn, Daire O Shea, Megan O Toole, Marianne O'Hara, Chloe O'Hara, Laura O'Keefe, Kevin O'Reilly, William O'Rourke, Caroline Oakley, Naomi Oakley, Susan Oakley, Begho Obale, Clements Oboh, Clare O'Brien, Julie O'Brien, Kirsty O'Brien, Linda O'Brien, Neale O'Brien, Rachel O'Brien, Tracey O'Brien, Emma O'Bryan, Ross Obukofe, Christopher O'Callaghan, Lorcan O'Connell, Tadg OConnor, Chris O'Connor, Grainne O'Connor, Miranda Odam, Sam Oddie, Sharon Oddy, Yejide Odedina, Krishma Odedra, Sven W Odelberg, Natasha Odell, Omolola Oderinde, Jessica Odone, Lynn O'Donohoe, Catherine O'Donovan, Isabel Odysseos-Beaumont, Stephen O'Farrell, Pamela Offord, Morgan O'Flaherty, Emmanuel Ofori, Tanwa Ogbara, Catherine Ogilvie, Ciaran O'Gorman, Ibrahim Ogunjembola, Oluwatomilola Ogunkeye, Udeme Ohia, Shalini Ojha, Sushma Ojha, Ohiowele Ojo, Fiona O'kane, Mark O'Kane, Tolu Okeke, Eleanor OKell, Alicia Okines, Iheoma Okpala, Ernest Okpo, F Okpoko, Maryanne Okubanjo, Chiamaka Oladipo, Liel A Olaivar, Raphael Olaiya, Jacob Olatujoye, Tim Old, Gregory Oleszkiewicz, Annie Oliver, Catherine Oliver, Jesse Oliver, Lucinda Oliver, Martyn Oliver, Zoe Oliver, Nurudeen O Olokoto, Folusho Olonipile, Olumide Olufuwa, Olatomiwa Olukoya, Akinlolu Oluwole-Ojo, Laura O'Malley, Priscilla Kesewaa Omane-Donkor, Maryam Omar, Mohamad Omar, Zohra Omar, Nimca Omer, Eti Omoregie, Connaire O'Neill, Lauran O'Neill, Chon Sum Ong, Onyinye Onuoha, Chidera Onyeagor, Chan Nyein Oo, Zin Nwe Oo, Huah Chiang Ooi, Sze Hwei Ooi, Amin Oomatia, Alfred Opata, Maria Opena, Richard Oram, Christy Ord, Jonathan Ord, Clare Oreilly, Lola Orekoya, Devaki O'Riordan, Sean O'Riordan, Izabela Orlikowska, Amy Orme, Hannah Orme, Laura O'Rourke, Charlotte Orr, Sarah Orr, Christopher Orton, Anna Osadcow, Rawlings Osagie, Rostam Osanlou, Lynn Osborne, Nigel Osborne, Rebecca Osborne, Wendy Osborne, William Osborne, Charles Osbourne, Jennifer Osei-Bobie, Joseph Osman, Wa'el Osman, Bashir Osman, G Osoata, Marlies Ostermann, Eoin O'Sullivan, Susan O'Sullivan, Mercy Adomah Oteng, Noor Otey, Otheroro K. Otite, Marie O'Toole, Jingxiu Ouyang, Rachel Owen, Stephanie Owen, Emma Owens, Yetunde Owoseni, Michael Owston, Ruth Oxlade, Feray Ozdes, Jamie Pack, Alice Packham, Sophie Packham, Piotr Paczko, Grace Padden, Anand Padmakumar, Catrin Page, Iain Page, Joseph Page, Shannon Page, Valerie Page, Jodi Paget, Katherine Pagett, Lee Paisley, Susannah Pajak, Susie Pajak, Glykeria Pakou, Angela Pakozdi, Soubhik Pal, Sushi Pal, April Palacios, Vishnu B Palagiri Sai, Vadivu Palaniappan, Priya Palanivelu, Adrian Palfreeman, Heather Palfrey, Vinod Palissery, Deepshikha Palit, Sherly Pallipparambil Antony, Jason Palman, Alistair Palmer, Helen Palmer, Janet Palmer, Lynne Palmer, Ross Palmer, Andrea Pambouka, Ian Pamphlett, Daniel Pan, Anmol Pandey, Nithya Pandian, Krishnaa Pandya, Tej Pandya, Hem Raj Paneru, Alice Panes, Jessica Pang, Yee Wei Pang, Raju Pangeni, Laura Pannell, Kanwar Pannu, Suman Pant, Sathianathan Panthakalam, Charles T Pantin, Norman Pao, Helen Papaconstantinou, Nectarios Sophocles Papavarnavas, Padmasayee Papineni, Kitty Paques, Abdul W Paracha, Kerry Paradowski, Vinay Parambil, Supathum Paranamana, Siddhant Raja Parashar, Ian Parberry, Amy Parekh, Dhruv Parekh, Louise Parfitt, Helen Parfrey, Omi Parikh, Gemma Parish, John Park, Vivak Parkash, Angela Parker, Ben Parker, Emma Parker, Helen Parker, Jacob Parker, Julie Parker, Laura Parker, Lucy Parker, Natasha Parker, Nicola Parker, Sara Parker, Sean Parker, Kirstin Parkin, Anna Parkinson, Molly Parkinson, Valerie Parkinson, Chetan Parmar, Viraj Parmar, Victoria Parris, Chloe Parrish, Bethan Parry, Helen C Parry, Siobhan Parslow-Williams, Maria Parsonage, Georgie Parsons, Joseph Parsons, Penny Parsons, Richard Partridge, Zeeshan Parvez, Kevin Parvin, Lauren Passby, Samuel Passey, Heather Passmore, Juan Pastrana, Jonathan Patachako, Mital Patal, Sarah Patch, Aamie Patel, Alkesh Patel, Amisha Patel, Bijal Patel, Dakshesh Patel, Darshna Patel, Hemani Patel, Jaymik Patel, Kamal Patel, Kayur Patel, Kiran Patel, Krish Patel, Manish Patel, Margi Patel, Martyn Patel, Mehul Patel, Naleem Patel, Nehalbhai Patel, Prital Patel, Saagar Patel, Sanjay Patel, Soonie Patel, Trishna Patel, Zaakirah Patel, Vishal Patel, Kirsteen Paterson, Sangeeta Pathak, Sunil Pathak, Nazima Pathan, Alexandra Patience, Donna Patience, Russell Patmore, Sonia Patole, Lia Paton, Abigail Patrick, Georgie Patrick, Jean Patrick, Simon Patten, Ben Pattenden, Charlotte Patterson, Jean Patterson, Linda Patterson, Molly Patterson, Robert Patterson, Martin Pattrick, Damodar Paudel, Kamala Paudel, Manu Paudel, Suman Paudel, Moriarty Paul, Suman Paul, Leigh Pauls, Stephane Paulus, Amelia Pavely, Matthew J Pavitt, Susan Pavord, Brendan Payne, Elizabeth Payne, Mark Payne, Ruth Payne, Linda Peacock, Louise Peacock, Sarah Peacock, Henry Peake, Jasmine Pearce, Rachel Pearse, Rupert Pearse, Andrew Pearson, Daniel Pearson, Harriet Pearson, Karen Pearson, Samuel A Pearson, Sandra Pearson, Alice Peasley, Hilary Peddie, Steven Peebles, Russell Peek, Adam Peer, Shahid Peerbhoy, Claire Pegg, Eleanor Peggie, Hannah Peggie, Suzannah Peglar, Benjamin H Peirce, Mary Peirse, Claire Pelham, Abigail Pemberton, Melchizedek Penacerrada, Anthony Pender, Carmel Pendlebury, Jessica Pendlebury, Rachel Penfold, Catherine Penman, Julie Penman, Rachel Penman, Justin Penner, Kristi Penney, Anna Pennington, James Penny, Justin Pepperell, Rachel Percival, Adriana Pereira, Rita Pereira, Carlota Pereira Dias Alves, Indika Perera, Marek Perera, Elena Perez, Jane Perez, Tanaraj Perinpanathan, Lakshmi Periyasamy, Emma Perkins, Ida Pernicova, Elizabeth Perritt, Alice Perry, Alison Perry, Emily Perry, Meghan Perry, Thomas M Perumpral, Guilherme Pessoa-Amorim, Ruth Petch, Lionel Peter, Cecilia Peters, Lucy Peters, Mark Peters, Steve Peters, Tim Peters, Remy Petersen, Alexandra Peterson, Leon Peto, Iulia Petras, Boyanka Petrova, Mirela Petrova, Ellen Petrovics, Tom Pettigrew, Marius Pezard-Snell, Paul Pfeffer, Gunjan Phalod, Ngoc Thach Pham, Van Phuc Pham, Thi Thu Hien Phan, Mysore Phanish, Paul Phelan, Christopher Philbey, Jennifer Philbin, Aled Phillips, Alex Phillips, Bethan Phillips, Dylan Phillips, Nicola Phillips, Patrick Phillips, Rachael Phillips, Thomas Phillips, Marie Phipps, Michael Phipps, Nguyen Thanh Phong, Virach Phongsathorn, Mandeep Phull, Ho Thi Kim Phung, Anita Phuyal, Aye Kyaw Phyo, Myat T T PI, Sara Pick, James Pickard, Charlotte Pickering, Frances Pickering, Gillian Pickering, Thomas Pickett, Joanna Pickles, Shirley Pickstock, Benjamin Pickwell-Smith, Natalia Pieniazek, Charlie Piercy, Angelo Pieris, Samia Pilgrim, Paul Anthony Pillai, Laura Pilling, Zoe Pilsworth, Heather Pinches, Stacey Pinches, Kirsty Pine, Muni T Pinjala, Stefania Pintus, Graeme Piper, Tasneem Pirani, Marie Pitchford, Marcus Pittman, Sally Pitts, Nicolene Plaatjies, Naomi Platt, Robert Pleass, Megan Plowright, Laura Plummer, Charles Plumptre, Jonathan Pobjoy, Tatiana Pogreban, Charles Poku, Stephen Poku, Petra Polgarova, Rachel Pollard, Louisa Pollock, Oluwamayowa Poluyi, Gary J Polwarth, Fiona Pomery, Ida M F Ponce, Ponmurugan Ponnusamy, Suresh Ponnusamy, Aravind Ponnuswamy, Inês Ponte Bettencourt dos Reis, Suman Pooboni, Alice Poole, Lynda Poole, Michele Poole, Sharon Poon, Tajinder Poonian, Jack Porteous, Mark Porteous, David Porter, Jo Porter, Linda Porter, Ross Porter, Anna Posada, Kelly Postlethwaite, Manoj Potdar, Carla Pothecary, Narayana Pothina, Priyadarshan Potla, Dorota Potoczna, Jason Pott, Alison Potter, Andrew Potter, Jean Potter, Sarah Potter, Tracey Potter, Elspeth Potton, Joanne B Potts, Julie Potts, Kathryn Potts, Beli Poudyal, Una Poultney, Katherine Poulton, Vanessa Poustie, James Powell, Jordan Powell, Natassia Powell, Sandra Powell, Deborah Power, Nick Power, Sharon Power, Joseph Poxon, Emma Poyner, Robin Poyner, Aishwarya Prabhu, Sandhi Prabowo, Vidushi Pradhan, Gyanwali Pradip, Helena Prady, Rosita Prananingtias, Aalekh Prasad, Krishna Prasad, Usha Prasad, Fredy Prasanth Raj, Sangeetha Prasath, Nicky G Pratiwi, Anezka Pratley, Steven Pratt, Chrisan Bimo Prayuda, David Preiss, Claire Prendergast, Lynn Prentice, Peter Prentice, Verity Prescott, Laura Presland, Catharine Prest, Stephen Preston, Martha Pretorius, Natalie Prevatt, Sandra Prew, Ashley Price, Carly Price, Claire Price, David Price, Elizabeth Price, Katie Price, Laura J Price, Nathan Price, Vivien Price, Rachael Price-Eland, Anne Priest, Jimena Prieto, Lorraine Primrose, Clare Prince, John Prince, Judith Prince, Laura Prince, Shirley Pringle, Melissa Prior-Ong, Veronika Pristopan, Kelly Pritchard, Lucy Pritchard, Simon Pritchard, Verma Priyash, Andrew Procter, Clare Proctor, Mike Protopapas, Rebecca Proudfoot, Benjamin Prudon, David Pryor, Solomon Pudi, Angela Puffett, Joanne Pugh, Lawrence Pugh, Mark T Pugh, Nichola Pugh, Richard Pugh, Veronika Puisa, Eni Puji Lestari, Safa Puliyakkadi, Jennifer Pullen, Kirandip Punia, Saleel Punnilath Abdulsamad, Laura Purandare, Daniel Purchase, Corrina Purdue, Rachel Purdy, Bally Purewal, Rebecca Purnell, Molly Pursell, Gregory Purssord, Rory Purves, Sarah Purvis, Khairunnisa Puspatriani, Daniel Putensen, Bhamini Puvaneswaran, Alex Puxty, Kathryn Puxty, Zoe Puyrigaud, Eleanor Pyart, Emily Pye, Michael Pynn, Tariq Qadeer, Mohammad Qayum, Corrine Quah, Sheena Quaid, Nathaniel Quail, Charlotte Quamina, Nguyen Ngo Quang, Georgia Quartermaine, Tara Quasim, Alice Quayle, Eleanor Quek, Siobhan Quenby, Xinyi Qui, Vanessa Quick, Julie Quigley, Juan-Carlos Quijano-Campos, Jhanielle Quindoyos, Andrew Quinn, James Quinn, Tom Quinn, Quratulain Quratulain, Danya Qureshi, Ehsaan Qureshi, Hasanain Qureshi, Iram Qureshi, Khadija Qureshi, Nawaz Qureshi, Qurratulain Qurratulain, Saad Qutab, Muhammad S Rabbani, Simon Rabinowicz, Madalina Raceala, Alan Rachid, Brian Eka Rachman, Raissa Rachman, Laura Rad, Jane Radford, Liz Radford, Jayachandran Radhakrishnan, Hannah Rafferty, Muhammad Y Rafiq, Shabana Rafiq, Cecillia Rafique, Jethin Rafique, Muhammad Rafique, Ravi Ragatha, Aiswarya Raghunathan, Abigail Raguro, Shankho D Raha, Sana Rahama, Mutia Rahardjani, Karen Rahilly, Faisal Rahim, Abdul H Rahimi, Haseena R Rahimi, Muhammad Rahman, Salim Ur Rahman, Sohail Rahmany, Prajan Rai, Sabi Rai, Supriya Rai, Lenka Raisova, Ajay Raithatha, Arjun Raj, Anithya Rajagopal, Pradeep Rajagopalan, Nithy Rajaiah, Kanendran Rajalingam, Arvind Rajasekaran, Aylur Rajasri, Bibek Rajbhandari, Sagar Rajbhandari, Thurkka Rajeswaran, Jyothi Rajeswary, Jeyanthy Rajkanna, Indhuja Rajkumar, Gayathri Rajmohan, Ruth Rallan, Katherine Ralston, Maximilian Ralston, Matsa Ram, Balaji Ramabhadran, Fathima Ramali, Mohamed Ramali, Athimalaipet Ramanan, Shashikira Ramanna, Maheshi Ramasamy, Irfah Rambe, Aradhana Ramchandani, Dhanishta Ramdin, Jozel Ramirez, Mylah Ramirez, Geshwin Ramnarain, Amrita Ramnarine, Lidia Ramos, Tommy Rampling, Shanthi Ramraj, Janine Ramsay, Alex Ramshaw, Aleem Rana, Ghulam F Rana, Naeem Rana, Rehman Rana, Abby Rand, James Rand, Harpal Randheva, Poonam Ranga, Manmeet Rangar, Harini Rangarajan, Sameer Ranjan, Hannah Rank, Poormina Ranka, Rajesh Rankhelawon, Alastair Rankin, Anita Rao, Sandhya Rao, Sanjay Rao, Deepak Rao, Althaf A Rasheed, Khalid Rashid, Madeleine Rason, Valentina Raspa, Somil Rastogi, Fazila Rasul, Simbisai Ratcliff, Sam Ratcliffe, Sophy Ratcliffe, Priti Rath, Sanjeev Rath, Mohmad I Rather, Krishnaraj Rathod, Selina Rathore, Aravinden Ratnakumar, Jonathan Ratoff, Deepa Rattehalli, Davide Ravaccia, Malvi Raval, Phil Ravencroft, Jason Raw, Rachael Raw, Manisha Rawal, Sulaiman A Rawashdeh, Hywel Rawlins, Gautam Ray, Adam Raymond-White, Dana Raynard, Helen Rayner, Nicola Rayner, Amy Raynsford, Salman Razvi, Zarine Razvi, Kerry Read, Sarah Read, Michael Reay, Anne Reddington, Ajay Reddy, Anvesh Reddy, Harsha Reddy, Heidi Redfearn, Aine Redfern-Walsh, Ianto Redknap, Nell Redman, Alex Redome, Joan Redome, Anna Reed, John Reed, Andrew Rees, Caitlin Rees, Helen Rees, James Rees, Martyn Rees, Sarah Rees, Stephanie Rees, Tabitha Rees, Elinor Rees-Jones, Fiona Regan, Karen Regan, Martin Regan, Susan Regan, Kanchan Rege, Amuda Regmi, Ahmed Rehan, A Rehman, Hafiz Rehman, Shoib Rehman, Zainab Rehman, Ada Reid, Andrew Reid, Jennifer Reid, Jeremy Reid, Sharon Reid, Mkyla Reilly, Sharon Reilly, Christina Reith, Arisa Reka, Alda Remegoso, Dinakaran Rengan, Louise Renouf, Stephen Renshaw, Remya Renu Vattekkat, Henrik Reschreiter, Mark Revels, Adam Revill, Glynis Rewitzky, Severine Rey, Charles Reynard, Dominic Reynish, Heather Reynolds, Peter Reynolds, Piero Reynolds, Jonathan Rhodes, Naghma Riaz, Patricia Ribeiro, Emily Rice, Matthew Rice, Natalie Rice, Mel Rich, Alex Richards, Alison Richards, Liz Richards, Suzanne Richards, Celia Richardson, Emma Richardson, Fiona Richardson, Jamie Richardson, Julie Richardson, Madeleine Richardson, Neil Richardson, Nicky Richardson, Joanne Riches, Katie Riches, Leah Richmond, Ruth Richmond, William Ricketts, Hannah Rickman, Anna Riddell, Stephanie Ridgway, Mohamed Ridha, Carrie Ridley, Paul Ridley, Gudrun Rieck, Linsey Rigby, Myckala Rigby, Daniel Rigler, Samita Rijal, Nur Rika, Hannah Riley, Matthew Riley, Phil Riley, Atika Rimainar, Zwesty V P Rimba, Dominic Rimmer, Winarni Rina, Robert Rintoul, Andrew Riordan, David Ripley, Naomi Rippon, Chloe Rishton, Michael Riste, David Ritchie, Jane Ritchie, Andy Ritchings, Pilar Rivera Ortega, Vanessa Rivers, Batool Rizvi, Syed A S Rizvi, Syed H M Rizvi, James Robb, Edel Robbins, Charles Roberts, Gareth Roberts, Ian Roberts, Jane Roberts, Jean Roberts, Karen Roberts, Mark Roberts, Nicky Roberts, Philip Roberts, Rebecca Roberts, Victoria Roberts, Calum Robertson, James Robertson, Jamie Robertson, Kirsten Robertson, Nichola Robertson, Stuart Robertson, Mhairi Robertson, Nicole Robin, Caroline Robinson, Emma Robinson, Gisela Robinson, Hannah Robinson, Jane Robinson, Jemima Robinson, Kate Robinson, Liz Robinson, Matthew Robinson, Nicky Robinson, Richard Robinson, Ryan Robinson, Sandra Robinson, Alexandra Robinson, Steve Robson, Anna Rocca, Lisa Roche, Samantha Roche, Natalie Rodden, Alistair Roddick, Elin Roddy, Jack Roddy, Marion Roderick, Alison Rodger, Faye Rodger, Megan Rodger, Michael Rodger, Alicia Rodgers, Deirdre Rodgers, Natasha Rodgers, Penny Rodgers, Rocio Rodriguez-Belmonte, Nicholas Roe, Charles Roehr, Gill Rogers, Jason Rogers, Joanne Rogers, John Rogers, Leigh Rogers, Lindsay Rogers, Michaela Rogers, Paula Rogers, Susan Rogers, Thomas Rogers, Jana Rojkova, Kshetra Kumari Roka, Sakib Rokadiya, Lee Rollins, Jennifer Rollo, Catherine Rolls, Alexander Rond-Alliston, Claire Rook, Kevin Rooney, Lynsey Rooney, Lace P Rosaroso, Emily J Rosby, Abigail Rose, Alastair Rose, Annie Rose, Steve Rose, Zoe Rose, Josephine Rosier, Anna Roskilly, Gavin A Ross, Isobel Ross, Jack Ross, Jennifer Rossdale, Andrew Ross-Parker, Anthony Rostron, Alfian Nur Rosyid, Alex Rothman, Joanne Rothwell, Lindsay Roughley, Catherine A Rourke, Kathryn Rowan, Neil Rowan, Stephen Rowan, Anna Rowe, Nicola Rowe, Louise Rowe-Leete, Benjamin Rowlands, Elen Rowlands, Megan Rowley, Subarna Roy, Matthew Roycroft, Anna Roynon-Reed, Ann R Royson, Sam Rozewicz, Anna Rudenko, Senthan Rudrakumar, Banu Rudran, Shannon Ruff, Prita Rughani, Rory Rule, Sharon Rundell, Eve Rushforth, Jeremy Rushmer, Darren Rusk, Peter Russell, Richard Russell, Cristina Russo, Marieke Rutgers, Krzysztof Rutkowski, Aidan Ryan, Brendan Ryan, Kathryn Ryan, Lucy Ryan, Matthew Ryan, Pat Ryan, Phil Ryan, Declan Ryan-Wakeling, Elena Rybka, Maggie Ryder, Sophie Ryder, M Saad, Gwendolyn Saalmink, Javeson Sabale, Suganya Sabaretnam, Noman Sadiq, Emma Sadler, Ashiq Saffy, Beth Sage, Harkiran Sagoo, Sobia Sagrir, Rajnish Saha, Sian Saha, Nikhil Sahdev, Sarvjit Sahedra, Jagdeep Sahota, Nooria Said, Shalini Saini, Bryony Saint, Anam Sajid, Sreekanth Sakthi, Hikari Sakuri, Murthy Saladi, Abdul Salam, Armorel Salberg, Erika Salciute, Gina Saleeb, Mumtaz Saleh, Hizni Salih, Laylan Salih, Duha Salim, Sarah Salisbury, SiteEneye Saliu, Rustam Salman, Jenny Salmon, Rebecca Salmon, Dario Salutous, Mfon Sam, Sally Sam, Tinashe Samakomva, Razan Saman, Sakeena Samar, Selva Saminathan, Renaldo Samlal, Emily Sammons, David Sammut, Mark Sammut, Saud Sammut, Thomas Sammut, Sunitha Sampath, Claire Sampson, Julia Sampson, Aashna Samson, Anda Samson, Johnson Samuel, Merna Samuel, Reena Samuel, Thomas D L Samuel, Younan Samuel, Kevin Samuels, Theo Samuels, Joanna Samways, Manjula Samyraju, Ilves Sana, Veronica Sanchez, Amada Sanchez Gonzalez, Alina Sanda-Gomez, Peter Sandercock, Jack Sanders, Amy Sanderson, Tom Sanderson, Kuljinder Sandhu, Loveleen Sandhu, Sam Sandow, Victoria Sandrey, Sarah Sands, Langizya Sanga, Harwinder Sangha, Jasmine Sanghera, Mirriam Sangombe, Mathew Sanju, Lakshmi Sankaran, Filipa Santos, Catarina Santos Ferreira De Almeida, Rojy Santosh, Jayanta Sanyal, Aureo F Sanz-Cepero, Yunima Sapkota, Dan Saragih, Dinesh Saralaya, Anggita Saraswati, Arun Saraswatula, Pira Saravanamuthu, Joshua Sarella, Avishay Sarfatti, Rebecca Sargent, Beatrix Sari, Diah Sari, Khatija Sarkar, Rahuldeb Sarkar, Sruthi Sarma, Paulo Sarmiento, Zainab Sarwar, Thea Sass, Krishna Satchithananthasivam, Sonia Sathe, Sobitha Sathianandan, Abilash Sathyanarayanan, Lavanya S J P Sathyanarayanan, Thozhukat Sathyapalan, Prakash Satodia, Vera Saulite, Andrew Saunders, Rachel Saunders, Samantha Saunders, Anne Saunderson, Heather Savill, Karishma Savlani, Gauri Saxena, Matthew Saxton, Amrinder Sayan, Ian Sayers, Diane Scaletta, Deborah Scanlon, Jeremy Scanlon, Lyndsay Scarratt, Sean Scattergood, Alvin Schadenberg, Jenna Schafers, Wendy Schneblen, Ella Schofield, Rebecca Schofield, Samuel Schofield, David Scholes, Karen Scholes, Alex Schoolmeesters, Natasha Schumacher, Nicola Schunke, Martin Schuster Bruce, Karin Schwarz, Antonia Scobie, Thomas Scoones, Tim Scorrer, Alex Scott, Alistair Scott, Anne Scott, Catherine Scott, Christine Scott, Emily Scott, Kathyn Scott, Leanne Scott, Martha Scott, Stephen Scott, Timothy Scott, Zoe Scott, Sarah Scourfield, Wendy Scrase, Nicholas A Scriven, Angela Scullion, Therese Scullion, Emily Seager, Cathy Seagrave, Rebecca Seaman, Eleanor Sear, Isabella Seaton, Annette Seatter, Anna Seckington, Joanna Sedano, Gabrielle Seddon, Gemma Sedgwick, Yee Yong See, Muhammad A Seelarbokus, Christopher Sefton, Matias Segovia, Fatima Seidu, Gillian Sekadde, Faye Selby, Georgina Selby, Claire Sellar, Rachael Sellars, Katharine Sellers, Joseph Selley, Victoria Sellick, Gobika Selvadurai, Brintha Selvarajah, Haresh Selvaskandan, Subothini S Selvendran, Jeyakumar Selwyn, Alison Semmens, Gary Semple, Michael Sen, Nandini Sen, Seema Sen, Aditya Sengupta, Niladri Sengupta, Susana Senra, HoJan Senya, Teona Serafimova, Elisa Sernicola, Dheeraj Sethi, Shivam Sethi, Niranjan Setty, Abigail Seward, Teswaree Sewdin, Terri-Ann Sewell, Jack Seymour, Katherine Seymour, Hussam Shabbir, Fiona Shackley, Tariq Shafi, Faiza Shafique, Aashni Shah, Ahmar Shah, Anand Shah, Bhavni Shah, Hussun-Ara Shah, Momin Shah, Neil Shah, Pallav Shah, Priyank Shah, Qasim Shah, Rupal Shah, Sarfaraz H Shah, Snehal Shah, Suraj Shah, Syed Shah, Wajid Shah, Saarma Shahad, Sousan Shahi, Sipan Shahnazari, Najam Shahzad, Muhammad Shahzeb, Aisha Shaibu, Zara Shaida, Amina Y Shaikh, Maliha Shaikh, Rajit Shail, Mariya Shaji, Muhammad Shakeel, Roshni Shakya, Korah Shalan, Nadia Shamim, Ummulbaneen Shamji, Anindya Shams, Kazi Shams, Rasha Shamsah, Thomas Shanahan, Hamed Sharaf, Asir Sharif, Ajay Sharma, Ash Sharma, Bhawna Sharma, Mona Sharma, Ojasvi Sharma, Poonam Sharma, Rajeev Sharma, Sagar Sharma, Sanjeev Sharma, Sarkhara Sharma, Seema D Sharma, Shriv Sharma, Sonal Sharma, Alexander Sharp, Charles Sharp, Gemma Sharp, Kerry Sharp, Louise M Sharp, Paula Sharratt, Phoebe Sharratt, Katherine Sharrocks, Serene Shashaa, Alexandra Shaw, Christopher Shaw, Daisy Shaw, David Shaw, Deborah Shaw, Joanne Shaw, Jonathon Shaw, Lisa Shaw, Michele Shaw, Tomos G Shaw, Anna Shawcross, James Shawcross, Jill Shawe, Lou Shayler, Sophy Shedwell, Jonathan Sheffield, Zak Shehata, Arshiya Sheik, Asif Sheikh, Noorann Sheikh, Benjamin Shelley, Sarah Shelton, Anil Shenoy, Julie Shenton, Sarah Shephardson, Amy Shepherd, Kate Shepherd, Lorna Shepherd, Scott Shepherd, Gareth Sheppard, Rhian Sheppeard, Helen Sheridan, Ray Sheridan, Samuel Sherridan, Leanne Sherris, Susanna Sherwin, Shaad Shibly, Fathimath F Shiham, Cassandra Shilladay, Ben Shillitoe, Delane Shingadia, Chiaki Shioi, Anand Shirgaonkar, Kim Shirley, Helen Shirt, Adebusola Shonubi, Jane Shoote, Ruth Shorrocks, Rob Shortman, Rohan Shotton, Sarah Shotton, Charmaine Shovelton, Ervin Shpuza, Anil Shrestha, Apurba Shrestha, Nora Shrestha, Reema Shrestha, Suchita Shrestha, Karen Shuker, Jonathan Shurlock, Jack Shurmer, Erfanur R Shuvo, Gilbert Siame, Loria Siamia, Moses Siaw-Frimpong, Seshnag Siddavaram, Nasir Siddique, Shahla Siddique, Sohail Siddique, Elaine Siddle, Emma Sidebotham, Jo Sidebottom, Roy Sievers, Katie Siggens, Nyma Sikondari, Ilman Silanas, Sofia V Silva, Claudia Silva Moniz, Malcolm Sim, Theresa Simangan, Vimbai Simbi, Robert Sime, George Simmons, Oliver Simmons, Richard Simms, Laura Simon, Merritt Simon, Natalie Simon, Samantha Simpkins, Angela Simpson, Anna Simpson, Danny Simpson, Georgina Simpson, Joanne Simpson, Kerry Simpson, Maria Simpson, Phillip Simpson, Thomas Simpson, Kathryn Simpson, Simon Sinclair, Cindy Sing, Ankita Singh, Claire Singh, Davinder Singh, Jayaprakash Singh, Jyoti Singh, Lokeshwar Singh, Manjeet Singh, Nadira Singh, Pankaj Singh, Prabhsimran Singh, Salil Singh, Saurabh Singh, Shivani Singh, Sumi Singh, Parag Singhal, Bryan Singizi, Vicky Singler, Manas Sinha, Punam Sinha, Sharad Sinha, Utkarsh Sinha, Guy Sisson, Sarah Sithiravel, Karthikadevi Sivakumar, Shanmugasundaram Sivakumar, Darsh Sivakumran, Sivanthi Sivanadarajah, Pasupathy-Rajah Sivasothy, Asok Skaria, Nicole Skehan, Robert Skelly, Orlagh Skelton, Imogen Skene, Denise Skinner, Tabitha Skinner, Victoria Skinner, Agnieszka Skorko, Iwona Skorupinska, Mariola Skorupinska, Amy Slack, Katie Slack, Heather Slade, Mark Slade, Lynda Slater, Nicola Slawson, Rachel Slingsby, Andrew Sloan, Brendan Sloan, Derek Sloan, Geraldine Sloane, Malgorzata Slowinska, Benjamin Small, Ellen Small, Samuel Small, Adam Smallridge, Dawn Smalls, Karen Denise Smallshaw, Andy Smallwood, Brittany Smart, Lynne Smart, Justyna Smeaton, Carien Smit, Aileen Smith, Alex Smith, Amanda Smith, Amy Smith, Andrew Smith, Catherine Smith, Chris Smith, Christopher Smith, Coral Smith, Debra Smith, Dominic Smith, Eleanor Smith, Harriet Smith, Hazel Smith, Helen Smith, Jacky Smith, Jessica Smith, Kate Smith, Kerry Smith, Lara Smith, Linda Smith, Lisa Smith, Loren Smith, Maria Smith, Mark Smith, Martha A Smith, Mel Smith, Nicholas Smith, Oliver Smith, Philippa Smith, Rachel Smith, Rebecca Smith, Rheanna Smith, Richard Smith, Sally Smith, Samantha Smith, Stacey Smith, Stephanie Smith, Susan Smith, Tracy Smith, Victoria Smith, Imogen Smith, John Smith, Sue Smolen, Sara Smuts, Naoise Smyth, Annette Snell, David Snell, Luke Snell, Alfred So, Beng So, Michelle Soan, Toluleyi Sobande, Sonia Sobowiec Kouman, Alberto Sobrino Diaz, Basit Sohail, Bina Sohail, Herminder Sohal, Roy Soiza, Olajumoke Solademi, Babak Soleimani, Amanda Solesbury, Mohamed Soliman, Bernadette Solis, Reanne Solly, Louise Solomon, Subash Somalanka, Chandrashekaraiah Somashekar, Sven Sommerfield, Govind Soni, Raj Sonia, Temi Sonoiki, Shiu-Ching Soo, Pavandeep Soor, Germander Soothill, Jennifer Soren, Apina Sothinathan, Pragalathan Sothirajah, Jessica Sousa, Najwa Soussi, Donna Southam, David Southern, Iain Southern, Louise Southern, Sara M Southin, Jessica Southwell, Thomas Southworth, Sandra Sowden, Jason Sowter, Claudia Spalding, Enti Spata, Catherine Speare, Katie Spears, Mark Spears, Lynne Speirs, Susan Speirs, Michelle Spence, Niamh Spence, Branwell Spencer, Gisele Spencer, Rebecca Spencer, Sue Spencer, Tom Spencer, Helen Spickett, Jennifer Spillane, William Spiller, Kerry Spinks, Michelle Spinks, Nick Spittle, Sarah Spray, Janet Spriggs, Oliver Spring, Gemma Squires, Jack Squires, Rebecca Squires, Ram Sreenivasan, Shiva Sreenivasan, K Sri Paranthamen, Rajesh Srikantaiah, Koottalai Srinivasan, Ramesh Srinivasan, Asha Srirajamadhuveeti, Vino Srirathan, Rhodri Stacey, Sybil Stacpoole, Louise Stadon, William J Stagg, Jocasta Staines, Nikki Staines, Katie Stammers, Roxana Stanciu, Grazyna Stanczuk, Thomas Standley, Brittany Staniforth, Andrew Stanton, Lisa Stanton, Robyn Staples, Simon Stapley, Natalie Staplin, Adam Stark, Elizabeth Starkey, David S Starnes, Michelle Starr, Rachel Stead, Clare Stebbing, Conor Steele, Henry Steer, John Steer, Vergnano Stefania, Paula Stefanowska, Femke Steffensen, Caroline Stemp, Emma Stenson, Alison Stephens, David Stephensen, Elaine Stephenson, Monique Sterrenburg, Jennifer Stevens, Melanie Stevens, Will Stevens, Amy Stevenson, Andrew Stevenson, Lesley Stevenson, Sarah Stevenson, Matthew Steward, Christopher Stewart, Claire Stewart, Colin Stewart, Dobree A Stewart, Katelyn Stewart, Keely Stewart, Kristina Stewart, McKenna Stewart, Melissa Stewart, Rachel Stewart, Richard Stewart, Jo Stickley, Gemma Stiller, Sarah Stirrup, Sarah Stock, Alexander Stockdale, Danielle Stocker, Lynne Stockham, Paul Stockton, Emma Stoddard, Kevin Stoffberg, Chelsea Stokes, Chris Stokes, Ben Stone, Roisin Stone, Sarah Stone, Emma-Jane Stoner, Imogen Storey, Kim Storton, Frederick Stourton, Angela Strachan, Catherine Strait, Emma Stratton, Jane Stratton, Sam Straw, Dieter Streit, Emma Stride, Sally Stringer, Sophia Strong-Sheldrake, Siske Struik, Carmel Stuart, Anna Stubbs, Harrison Stubbs, Ann Sturdy, Sharon Sturney, Matt Stuttard, Cristina Suarez, Karuna Subba, Christian P Subbe, Keerth Subramaniam, Manjula Subramanian, Vaidyanathan Subramanian, Venkatram Subramanian, Chinari Subudhi, Rebecca Suckling, Srivatsan Sudershan, Peter Sugden, Putri A Suherman, Rudresh Sukla, Anila Sukumaran, Ezoubi Suleiman, Ali Suliman, Fatimah Suliman, Sugrah Sultan, Uun Sumardi, Samyukta Sundar, Radha Sundaram, Reka Sundhar, Edmond Sung, Nadia Sunni, Jay Suntharalingam, Amitava Sur, Dharmic Suresh, Nayanika Suresh, Shilpa Suresh, Michael Surtees, C Susan, Danielle Suter, Rohan Suthar, Helen Sutherland, Rachel Sutherland, Rebecca Sutherland, Sara-Beth Sutherland, Dovile Sutinyte, Deborah Sutton, Sam Sutton, Siobhan Sutton, Mihaela Sutu, Marie-Louise Svensson, Sima Svirpliene, Andrew Swain, Rose Swain, Thomas Swaine, Christopher Swales, Carla Swanson-Low, Tirion Swart, Stephen Sweetman, Ealish Swift, Paul Swift, Pauline Swift, Rachael Swift, Rachel Swingler, Sophie Swinhoe, Katarzyna Swist-Szulik, Luke Swithenbank, Omair Syed, Catriona Sykes, Daisy Sykes, Eliot Sykes, Luke Sylvester, Declan Symington, Dominic Symon, Andrew Syndercombe, Zoe Syrimi, Jen Syson, Gemma Szabo, Denise Szabó, Tamas Szakmany, Nina Szarazova, Megan Szekely, Adele Szekeres, Matthew Szeto, Kinga Szymiczek, Maria Tadros, Amr Tageldin, Lucy Tague, Hasan Tahir, Muhammad Tahir, Michael Tai, Jennifer Tait, Abigail Takyi, Peter Talbot, Alison Talbot -Smith, James Talbot-Ponsonby, Richard Tallent, Bradley Tallon, Adrian Tan, Bee Theng Tan, Hock Tan, Huey Tan, Jenny Tan, Jun Seng Tan, Keith Tan, WeiTeen Tan, Anand Tana, Alex Tanner, Christina Tanney, Tabitha Tanqueray, Emma Tanton, Anita Tantri, Tm Tanzil-Al-Imran, Hayley Tarft, Priyal Taribagil, Obaid Tarin, Syed Tariq, David Tarpey, Esther Tarr, Lisa Tarrant, Antonia Tasiou, Alex Tate, Margaret L Tate, Matthew Tate, Paul Tate, Kate Tatham, Silvia S Tavares, Vera Tavoukjian, Shao An Isaac Tay, Alexander Taylor, Beverley Taylor, Charlie Taylor, Charlotte A Taylor, David Taylor, Elisabeth Taylor, Holly Taylor, Janet Taylor, Jennifer Taylor, Joanne Taylor, Julie Taylor, Karen Taylor, Leanne Taylor, Margaret Taylor, Matthew Taylor, Melanie Taylor, Natalie Taylor, Rachael Taylor, Rachel Taylor, Samantha Taylor, Suzanne Taylor, Tracey Taylor, Vicky Taylor, Victoria Taylor, Michelle Taylor-Siddons, Thomas Taynton, Amelia Te, Francesca Teasdale, Jessica Teasdale, Katherine Teasdale, Julie Tebbutt, Caroline Tee, Izla Teeluck, Borja Tejero Moya, Rajni Tejwani, Adam Telfer, Vibha Teli, Jennifer Tempany, Julie Temple, Natalie Temple, Helen Tench, Yi He Teoh, Radoslaw Tereszkowski-Kaminski, Lynne Terrett, Louise Terry, Tesha Islami Monika Tesha, Dariusz Tetla, Shirish Tewari, Daniel Tewkesbury, Joana Texeira, ChiaLing Tey, Miriam Thake, Clare Thakker, Manish Thakker, Jayna Thakrar, Bishal Jung Thakuri, Bhavneet Thamu, Nguyen Thi Thao, Amita Thapa, Hilary Thatcher, Andrew Thayanandan, Krishna Thazhatheyil, Eaint Thein, Lambrini Theocharidou, Phyu Thet, Kapeendran Thevarajah, Mayooran Thevendra, Nang Thiri Phoo, Yvette Thirlwall, Muthu Thirumaran, Alice Thomas, Andrew Thomas, Caradog Thomas, Emma Thomas, Enson Thomas, Esther Thomas, Helen Thomas, James Thomas, Jordan L Thomas, Karen Thomas, Koshy Thomas, Lucy Thomas, Rachel Thomas, Rebecca Thomas, Rhys Thomas, Ruth Thomas, Sarah Thomas, Sherine Thomas, Tessy Thomas, Vicky Thomas, Kirsty Thomasson, Rhian Thomas-Turner, Catherine Thompson, Christopher Thompson, Clara Thompson, Emma Thompson, Fiona Thompson, Hilary Thompson, Jessica Thompson, Katharine Thompson, Laura Thompson, Liz Thompson, Luke Thompson, Michael Thompson, Orla Thompson, Rebecca Thompson, Roger Thompson, Yolanda Thompson, Nicola Thomson, Patrick Thorburn, Natasha Thorn, Charlotte Thorne, Nicola Thorne, Alice Thornton, Danielle Thornton, Jim Thornton, Richard Thornton, Sara Thornton, Susan Thornton, Thomas Thornton, Tracey Thornton, Christopher Thorpe, Nigel Thorpe, Sarah Thorpe, Paradeep Thozthumparambil, Laura Thrasyvoulou, Hannah Thraves, Genevieve Thueux, Pinky Thu-Ta, Vicky Thwaiotes, C Louise Thwaites, Guy Thwaites, Simon Tiberi, Serena Tieger, Carey Tierney, Caroline Tierney, Mark Tighe, Sorrell Tilbey, Christopher Till, Amanda Tiller, Heather Tiller, John Timerick, Elizabeth Timlick, Alan Timmins, Alison Timmis, Hayley Timms, Anne-Marie Timoroksa, Samakomva Tinashe, Stephanie Tingley, Nicola Tinker, Heather Tinkler, Marianne Tinkler, Jacqui Tipper, Ajay Tirumalai Adisesh, Helen Tivenan, Katarzyna Tluchowska, Helen T-Michael, Anne Todd, Jackie Todd, Shirley Todd, Stacy Todd, Olga Toffoletti, Mohamed Tohfa, Sue Tohill, Melanie Tolson, Ana L Tomas, Natalia Tomasova, Sharon Tomlin, Simon Tomlins, Jo Tomlinson, Kerry Tomlinson, James Tonkin, Ivan Tonna, Catherine Toohey, Kirsty Topham, Mathew Topping, Audrey Torokwa, Collette Torrance, Omar Touma, Laura Tous Sampol, Ruhaif Tousis, Melissa Tout, Peter Tovey, Gareth Towersey, Jill Townley, Richard Tozer, Dang Khoa Tran, Hien Tran, Huyen Bang Tran, Michelle Tran, Nguyen Bao Tran, Van Giang Tran, Van Kien Tran, Helen Tranter, Jenny Travers, Christopher Travill, Sarah Traynor, Leanne Trethowan, Estefania Treus Gude, Mary Trevelyan, Nicola A Trewick, Ascanio Tridente, Sanchia Triggs, Fiona Trim, Alex Trimmings, Tom Trinick, Kate Trivedi, Sven Troedson, Emily Tropman, Amy Trotter, Spyridon Trous, Helen Trower, Madeleine Trowsdale Stannard, Nigel Trudgill, Robert Truell, Nick Truman, Maria Truslove, Shaun Trussell, Tariq Trussell, Kyriaki Tsakiridou, Christine Tsang, Peter Tsang, Tan Tsawayo, Kyriaki K Tsilimpari, Georgios Tsinaslanidis, Merika Tsitsi, Simon Tso, Natasha Tucker, Sally Tucker, Stephanie Tucker, Daisy E Tudor, Aisha Tufail, Jess Tuff, Jemma Tuffney, Redmond Tully, Tulus Tulus Satriasih, Grace Tunesi, Killiam Turbitt, Rezon Turel, Tolga Turgut, Claudia Turley, Alison Turnbull, Aine Turner, Ash Turner, Charlotte Turner, Gail Turner, Georgina Turner, Kate Turner, Kelly Turner, Kim Turner, Lucy Turner, Lynne C Turner, Mark Turner, Patricia Turner, Sally Turner, Samantha Turner, Sarah Turner, Victoria Turner, Ian Turner-bone, Sharon Turney, Jon Turvey, Conor Tweed, David Tweed, Rebecca Twemlow, Emma Twohey, Bhavya Tyagi, Vedang Tyagi, Abigail Tyer, Amanda Tyler, Jayne Tyler, Jennifer Tyler, Alison Tyzack, Petros Tzavaras, Ioannis Tzinieris, A Wahid Uddin, Mohammad S Uddin, Ruhama Uddin, Ruzena Uddin, Jacinta Ugoji, Edith N Ukaegbu, Mazhar Ul Haq, Waqar Ul Hassan, Zia Ul-Haq, Salamat Ullah, Sana Ullah, Sanda Ullah, Ju Um, Athavan Umaipalan, Anil Umate, Judith Umeadi, Akudo Umeh, Wilfred Umeojiako, Ben Ummat, Emma Underhill, Charlotte Underwood, Jonathan Underwood, Adam Unsworth, Veerpal Uppal, Veerpal S Uppal, Gerry Upson, Masood Ur Rasool, Alison Uriel, Sebastian Urruela, Hiromi Uru, Jess Usher, Miranda Usher, Rebecca Usher, Alexandra Usher-Rea, Andrew Ustianowski, Effua Usuf, Febriansyah Nur Utomo, Hiromi Uzu, Linda C Vaccari, Uddhav Vaghela, Abhay Vaidya, Denny Vail, Bernardas Valecka, Jennifer Valentine, Balan Valeria, Pramodh Vallabhaneni, Nick Vallotton, Luke Vamplew, Ekaterini Vamvakiti, Joannis Vamvakopoulos, Sarah Van Blydenstein, Lucia van Bruggen, Maud van de Venne, Alex van der Meer, Nora van der Stelt, Lynne van Koutrik, Alexander Van Loggerenberg, Joseph Vance-Daniel, Rama Vancheeswaran, Samuel I Vandeyoon, Padma Vankayalapati, Piyush Vanmali, Chloe Vansomeren, William Van't Hoff, Sejal Vara, Stehen J Vardy, Anu Varghese, Maria Varghese, William Varney, Giulia Varnier, Anna-Nektaria Varouxaki, Resti Varquez, Valeria Vasadi, Olivia Vass, Katherine Vassell, Vimal Vasu, Vasanthi Vasudevan, Manu Vatish, Sue Vaughan, Heloyes Vayalaman, Darini Vayapooree, Christopher Vaz, Niki Veale, Sachuda Veerasamy, Swati Velankar, Luxmi Velauthar, Neyme Veli, Nicola Vella, Aravind Velugupati, Anitha Velusamy, Ian Venables, Mavi Venditti, Ramya Venkataramakrishnan, Richard Venn, Robert Venn, Michelle Venter, Lyn Ventilacion, Joanne Vere, Mark Veres, Stefania Vergnano, Will Verling, Amit Verma, Rachel Vernall, Britney Vernon, Mark Vertue, Liberty Verueco, Jerik Verula, Anna Veterini, Natalie Vethanayagam, Shambavi Vettikumaran, Lucy Veys, Carinna Vickers, Saji Victor, SImpson Victoria, Celine P Vidaillac, Jennifer Vidler, Bavithra Vijayakumar, Vinod W Vijayaraghavan Nalini, Brigita Vilcinskaite, Alicija Vileito, Neringa Vilimiene, Lynn Vinall, Sylvia Vinay, Latha Vinayakarao, Olivia Vincent, Rachel Vincent, Rosie Vincent, Pritpal Virdee, Emma Virgilio, Abdullah M Virk, Elisa Visentin, Martina Vitaglione, Karunakaran Vithian, Sorice Vittoria, Sankkita Vivekananthan, Elena Vlad, Ben Vlies, Linda von Oven, Claire Vooght, Kim Thi Vu Thai, Kritchai Vutipongsatorn, Alain Vuylsteke, Eleftheria Vyras, Richard Wach, Beverley Wadams, Susan Wadd, Natalia Waddington, Phillip Wade, Jonathan Wadsley, Kirsten Wadsworth, Syed E I Wafa, Daniel Wagstaff, Lynda Wagstaff, Dalia Wahab, Zaroug Wahbi, Abiodun Waheed Adigun, Sawan Waidyanatha, Alicia Waite, Rachel Wake, Alice Wakefield, William Wakeford, Fiona Wakinshaw, Emma Waldeck, Andrew Walden, Lorna Walding, Alexandria Waldron, Joanne Waldron, Emma Wales, Batool Wali, Danielle Walker, Gemma Walker, Harriet Walker, Ian Walker, Kevin Walker, Kim Walker, Lauren Walker, Linda Walker, Lynne Walker, Olivia Walker, Rachel Walker, Rebecca Walker, Sara Walker, Susan Walker, Gillian Wallace, Rebecca Wallbutton, Jessica Wallen, Karl Wallendszus, Arabella Waller, Rosemary Waller, Gabiel Wallis, Gabriel Wallis, Louise Wallis, Matthew Wallis, Emma Walmsley, Donna Walsh, Elizabeth Walsh, Livia Walsh, Deborah Walstow, Daniel Walter, Alex Walters, Holt Walters, James Walters, Jocelyn Walters, Eileen Walton, Lucy Walton, Maisie Walton, Michael Walton, Olivia Walton, Sharon Walton, Susan Walton, Mandy Wan, Junita Wanda, Mary Wands, Rachel Wane, Frank Wang, Nick Wang, Ran Wang, Shentong Wang, Deborah Warbrick, Samantha Warburton, Christopher Ward, Deborah Ward, Emma Ward, Hannah Ward, Janice Ward, Joanna Ward, Luke Ward, Nicola Ward, Rachael Ward, Thomas Ward, Tom Ward, Scott A Warden, Gibril Wardere, Steve Wardle, Hassan Wardy, Gareth Waring, Scott Waring, Jenny Warmington, Ben Warner, Christian Warner, Lewis Warnock, Sarah Warran, Jade Warren, Lisa Warren, Rebecca Warren, Yolanda Warren, Davina Warrender, Hannah Warren-Miell, Adilia Warris, Gill Warwick, Helen Wassall, Sean Wasserman, Elizabeth Wasson, Hazel J Watchorn, Holly Waterfall, Abby Waters, Donald Waters, Mark Waterstone, Abigail Watkin, Catherine Watkins, Catrin Watkins, Eleanor Watkins, Karen Watkins, Lynn Watkins, Abigail Watson, Adam J R Watson, Ekaterina Watson, Eleanor Watson, Felicity Watson, J G R Watson, Louisa Watson, Paul Watson, Rebecca Watson, Robert Watson, Kathleen Watson, Malcolm Watters, Donna Watterson, Khairiah Wattimena, Daniel Watts, John Watts, Merlin Watts, Victoria Waugh, Emma Wayman, Matthew Wayman, Akhlaq Wazir, Mark Weatherhead, Nick Weatherly, Chloe Webb, Claire Webb, Hayley Webb, Kathryn Webb, Kylie Webb, Stephen Webb, Cheryl Websdale, Deborah Webster, Ian Webster, Jemma Webster, Tim Webster, Jordan Wedlin, Ling Wee, Rebecca Weerakoon, Thanuja Weerasinghe, Janaka Weeratunga, Maria Weetman, Shuying Wei, Immo Weichert, Emma Welch, Hugh Welch, James Welch, Leanne Welch, Steven Welch, Benjamin Welham, Samantha Weller, Lucy Wellings, Brian Wells, Susan Wellstead, Berni Welsh, Richard Welsh, Ingeborg Welters, Rachael Welton, Victoria Wenn, Lauren Wentworth, Joan Wesonga, Kate Wesseldine, Joe West, Magdelena West, Raha West, Ruth West, Sophie West, Luke Western, Ruth Westhead, Heather Weston, Alice Westwood, Kelly Westwood, Sharon Westwood, Bill Wetherill, Sharon Wheaver, Helen Wheeler, Ben Whelan, Matthew Whelband, Amanda Whileman, Alison Whitcher, Andrew White, Ayesha White, Benjamin White, Catherine White, Christopher White, Duncan White, James White, Jonathan White, Katie White, Marie White, Nick White, Nikki White, Sarah White, Sonia White, Tracey White, Catherine Whitehead, Kelly Whitehorn, Anne Whitehouse, Claire Whitehouse, Tony Whitehouse, Julia Whiteley, Louiza Whiteley, Sophie Whiteley, Rachael Whitham, Gabriel Whitlingum, David Whitmore, Elizabeth Whittaker, Lindsay Whittam, Ashley Whittington, Helen Whittle, Robert Whittle, Eunice Wiafe, Lou Wiblin, Olivia Wickens, John Widdrington, Jason Wieboldt, Hannah Wieringa, Cornelia Wiesender, Laura Wiffen, Andrew Wight, Ashleigh Wignall, Christopher Wignall, Annamaria Wilce, Danielle Wilcock, Emma Wilcock, Louise Wilcox, Ben Wild, Laura Wild, Stephen Wild, Michael Wilde, Laura Wilding, Peter Wilding, Tracey Wildsmith, Joe Wileman, Joy Wiles, Kate Wiles, Elva Wilhelmsen, Thomas Wiliams, Janet Wilkie, David Wilkin, Hannah Wilkins, Joy Wilkins, Suzanne Wilkins, Iain Wilkinson, Lesley Wilkinson, Nicola Wilkinson, Sophia Wilkinson, Susan Wilkinson, Tim Wilkinson, Sylvia Willetts, Aimee Williams, Alexandra Williams, Alison Williams, Angharad Williams, Anna Williams, Ava Williams, Carl Williams, Caroline V Williams, Claire Williams, Dewi Williams, Eleri Williams, Gail Williams, Gemma Williams, Gina Williams, Hannah Williams, Heledd Williams, James Williams, Jennie Williams, Jill Williams, John Williams, Joseph Williams, Karen Williams, Kathryn Williams, Mandy Williams, Marie Williams, Mark Williams, Matthew Williams, Patricia Williams, Penny Williams, Rachel Williams, Robin Williams, Rupert Williams, Samson Williams, Sarah Williams, Sophie Williams, Steffan Williams, Tamanna Williams, Tania Williams, Annie Williamson, Cath Williamson, Catherine Williamson, Dawn Williamson, James D Williamson, Jodie Williamson, Rachel Williamson, Helen Williamson, Elaine Willis, Elizabeth Willis, Emily Willis, Heather Willis, Herika Willis, Joanna Willis, Louise Wills, Lucy Willsher, Catherine Willshire, Francesca Willson, Jayne Willson, Alison Wilson, Andrea Wilson, Anna Wilson, Antoinette Wilson, Billy Wilson, David Wilson, Imogen Wilson, James Wilson, Karen Wilson, Kate Wilson, Kristy-Ann Wilson, Lucinda Wilson, Mark Wilson, Stephen Wilson, Toni Wilson, John Wilson, Khin Lei Yee Win, Marlar Win, Than Win, Tin Tin Win, Wut Yee Win Win, Lucinda Winckworth, Laura Winder, Piers Winder, Stuart Winearl, Helen Winmill, Simon Winn, Carmen Winpenny, Helen Winslow, Helen Winter, Jonathan Winter, Barbara Winter-Goodwin, Joseph Winterton, Hannah Winwood, Jack Wischhusen, Stephen Wisdom, Matthew Wise, Martin Wiselka, Rebecca Wiseman, Sophie Wiseman, Steven Wishart, Tabitha WIshlade, Eric Witele, Nicholas Withers, Janet Wittes, Donna Wixted, Therese Wodehouse, Will Wolf, Nicola Wolff, Kirsten Wolffsohn, Rebecca Wolf-Roberts, Elena Wolodimeroff, Adam Wolstencroft, Alan Wong, Charlotte Wong, Chi-Hung Wong, Chi-Man Wong, Edwin Wong, Jessica S Y Wong, Kit Y Wong, Mei Yin Wong, Nick Wong, Sam Wong, Ting Wong, Aaron B Wongkyezeng, Amanda Wood, Caroline Wood, Dianne Wood, Fiona Wood, Gordon Wood, Hannah Wood, Jennifer Wood, Joe Wood, Lisa Wood, Louise Wood, Madeleine Wood, Stephen Wood, Tracy Wood, Katharine Woodall, Rebecca Woodfield, Christopher Woodford, Elizabeth Woodford, Jill Woodford, Louise Woodhead, Timothy Woodhead, Philip Woodland, Marc Woodman, Myles Woodman, Stephen Woodmansey, Charlotte Woods, Jane Woods, Katherine Woods, Sarah Woods, Zoe Woodward, Megan Woolcock, Gemma Wooldridge, Rebecca Woolf, Chris Woollard, Christopher Woollard, Louisa Woollen, Emma Woolley, Jade Woolley, Daniel Woosey, Dan Wootton, Joanne Wootton, Daniel Worley, Stephy Worton, Jonathan Wraight, Maria Wray, Kim Wren, Lynn Wren, Caroline Wrey Brown, Catherine Wright, Demi Wright, Francesca Wright, Holly Wright, Imogen Wright, Lianne Wright, Rachel Wright, Sarah Wright, Stephanie Wright, Tim Wright, Caroline Wroe, Hannah Wroe, Henry Wu, Peishan Wu, Pensee Wu, Jonathan Wubetu, Fitria Wulandari, Retno Wulandari, Subie Wurie, Craig Wyatt, Frederick Wyn-Griffiths, Inez Wynter, Bindhu Xavier, Arnold Xhikola, Bingru E Xia, Zhongyang Xia, Effua Yacoba, Santosh Yadav, Masseh Yakubi, May Yan, Yuuki Yanagisawa, Freda Yang, Yingjia Yang, Michael Yanney, Woei Lin Yap, Nabil Yaqoob, Salima Yasmin, Bryan Yates, David Yates, Edward Yates, Helen Yates, Thomas Yates, Mark Yates, Jessica Ye, Charlotte Yearwood Martin, Khin Yein, Fiona Yelnoorkar, Lam Minh Yen, Alastair Yeoh, Chun Yu Yeung, Peter Yew, Durgesh Yewatkar, Laura Ylquimiche Melly, Inez Ynter, H Yong, Jemma Yorke, Jasmine Youens, Abdel Younes Ibrahim, Eoin Young, Gail Young, Louise Young, Asfand Yousafzar, Sajeda Youssouf, Ahmed Yousuf, Hartantri Yovita, Chrissie Yu, Jack S J Yuan, Nindya Yufaniaputri, Bernard Yung, Daniel Yusef, Said Yusef, Intekhab Yusuf, Anna-Sophia Zafar, Silvia Zagalo, Su Zaher, Aqsa Zahoor, Mahrukh Zainab, Thornton Zak, Kareem Zaki, Nabhan Zakir, Kasia Zalewska, Ane Zamalloa, Mohsin Zaman, Shakir Zaman, Julie Zamikula, Louise Zammit, Marie Zammit-Mangion, Marcelina Zawadzka, Mohammed Zayed, Esther Zebracki, Daniel Zehnder, Lisa Zeidan, Darius Zeinali, Jing Zhang, Xiaobei Zhao, Dongling Zheng, Doreen Zhu, Madiha Zia, Omar Zibdeh, Rabia Zill-E-Huma, Ei Thankt Zin, Eva Zincone, Garikai Zindoga, Eleanor Zinkin, Vivian Zinyemba, Christos Zipitis, Letizia Zitter, Arkadiusz Zmierczak, Garazi Zubikarai, Azam Zubir, Naz Zuhra, Rasha Zulaikha, Sabrina Zulfikar, Carol Zullo, Ana Zuriaga-Alvaro, University of St Andrews. Infection and Global Health Division, University of St Andrews. School of Medicine, and Group, RECOVERY Collaborative

Subjects
Adult, Male, Hypoxia/etiology, SARS-CoV-2, COVID-19, 3rd-DAS, General Medicine, Adrenal Cortex Hormones/therapeutic use, AC, Dexamethasone/therapeutic use, Hospitals, Oxygen, Treatment Outcome, SDG 3 - Good Health and Well-being, MCP, Humans, Female
Abstract

Background Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group. Methods This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation Findings Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen (eight [1%]) or simple oxygen only (1264 [99%]) were randomly allocated to receive usual care plus higher dose corticosteroids (659 patients) versus usual care alone (613 patients, of whom 87% received low-dose corticosteroids during the follow-up period). Of those randomly assigned, 745 (59%) were in Asia, 512 (40%) in the UK, and 15 (1%) in Africa. 248 (19%) had diabetes and 769 (60%) were male. Overall, 123 (19%) of 659 patients allocated to higher dose corticosteroids versus 75 (12%) of 613 patients allocated to usual care died within 28 days (rate ratio 1·59 [95% CI 1·20–2·10]; p=0·0012). There was also an excess of pneumonia reported to be due to non-COVID infection (64 cases [10%] vs 37 cases [6%]; absolute difference 3·7% [95% CI 0·7–6·6]) and an increase in hyperglycaemia requiring increased insulin dose (142 [22%] vs 87 [14%]; absolute difference 7·4% [95% CI 3·2–11·5]). Interpretation In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation. Funding UK Research and Innovation (Medical Research Council), National Institute of Health and Care Research, and Wellcome Trust.

Published
2023
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30. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals

Author

Williams, Katherine E, Miroshnychenko, Olga, Johansen, Eric B, Niles, Richard K, Sundaram, Rajeshwari, Kannan, Kurunthachalam, Albertolle, Matthew, Zhou, Yan, Prasad, Namrata, Drake, Penelope M, Giudice, Linda C, Hall, Steven C, Witkowska, H Ewa, Louis, Germaine M Buck, and Fisher, Susan J

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Endometriosis, Estrogen, Infertility, Contraception/Reproduction, Clinical Research, Women's Health, Pain Research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Reproductive health and childbirth, Good Health and Well Being, Adipose Tissue, Adult, Ascitic Fluid, Contraceptives, Oral, Hormonal, Female, Humans, Leukocyte Elastase, Matrix Metalloproteinase 9, Omentum, Proteome, Peritoneal fluid, Urine, Omental fat, Mass spectrometry, Environmental chemicals, Biochemistry and Cell Biology, Plant Biology, Analytical Chemistry, Biochemistry & Molecular Biology, Biochemistry and cell biology, Plant biology, Medical biochemistry and metabolomics
Abstract

Endometriosis, ectopic growth of the uterine lining (endometrium), which affects 6-11% of reproductive age women, is associated with pelvic pain and infertility. We investigated the peritoneal fluid (PF), urine and omental fat (OF) proteomes of women with endometriosis vs. individuals with no surgically visualized endometriosis. All participants were enrolled in the NICHD-funded ENDO Study. A two-step proteomic study was performed. The first, a broad survey, employed a semi-quantitative gel LC-mass spectrometry (MS) workflow: SDS PAGE fractionation, trypsin digestion and LC-MS/MS. The results showed sample integrity but failed to detect any differences between women with and without endometriosis. The second step was a quantitative analysis of OF samples. We employed another sample set (n=30) from women ± disease and isobaric mass-tag (iTRAQ) chemistry to label peptides and 2D LC-MS/MS for protein identification and quantification. Three proteins-matrix metalloproteinase-9, neutrophil elastase, and FAM49B-were significantly lower in abundance in samples from women with endometriosis. Interestingly, neutrophil elastase and FAM49B levels were associated with higher levels of a subset of endocrine disrupting chemicals (EDCs) that were previously measured in the same samples. The results of these experiments showed the feasibility of associating endometriosis with changes in the OF protein repertoire and EDC levels.Biological significanceEndometriosis, pathological growth of the uterine lining, is associated with significant morbidities, including pain and infertility. However, the causes of this common condition are poorly understood. This study determined whether endometriosis was associated with changes in the protein composition of peritoneal fluid, urine and/or omental fat. A protein of unknown function (FAM49B) and two proteinases (metalloproteinase-9, neutrophil elastase) were down regulated in OF samples from women with versus without endometriosis. These findings suggested proteinase imbalances at sites that were distant from the endometriotic lesions. Additionally, FAM49B and neutrophil elastase levels were associated with higher levels of a subset of environmental chemicals that were quantified in the same samples, suggesting other possible associations. Thus, this work generated hypotheses that will be tested in further studies.

Published
2015

31. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Author

Majithia, Amit R, Flannick, Jason, Shahinian, Peter, Guo, Michael, Bray, Mark-Anthony, Fontanillas, Pierre, Gabriel, Stacey B, Rosen, Evan D, Altshuler, David, Manning, Alisa K, Hartl, Christopher, Agarwala, Vineeta, Green, Todd, Banks, Eric, DePristo, Mark, Poplin, Ryan, Shakir, Khalid, Fennell, Timothy, Njølstad, Pål R, Burtt, Noël, Gabriel, Stacey, Fuchsberger, Christian, Kang, Hun Min, Sim, Xueling, Ma, Clement, Locke, Adam, Blackwell, Thomas, Jackson, Anne, Teslovich, Tanya M, Stringham, Heather, Chines, Peter, Kwan, Phoenix, Huyghe, Jeroen, Tan, Adrian, Jun, Goo, Stitzel, Michael, Bergman, Richard N, Bonnycastle, Lori, Tuomilehto, Jaakko, Collins, Francis S, Scott, Laura, Mohlke, Karen, Abecasis, Gonçalo, Boehnke, Michael, Strom, Tim, Gieger, Christian, Nurasyid, Martina Müller, Grallert, Harald, Kriebel, Jennifer, Ried, Janina, de Angelis, Martin Hrabé, Huth, Cornelia, Meisinger, Christa, Peters, Annette, Rathmann, Wolfgang, Strauch, Konstantin, Meitinger, Thomas, Kravic, Jasmina, Algren, Peter, Ladenvall, Claes, Toumi, Tiinamaija, Isomaa, Bo, Groop, Leif, Gaulton, Kyle, Moutsianas, Loukas, Rivas, Manny, Pearson, Richard, Mahajan, Anubha, Prokopenko, Inga, Kumar, Ashish, Perry, John, Howie, Bryan, van de Bunt, Martijn, Small, Kerrin, Lindgren, Cecilia, Lunter, Gerton, Robertson, Neil, Rayner, William, Morris, Andrew, Buck, David, Hattersley, Andrew, Spector, Tim, McVean, Gil, Frayling, Tim, Donnelly, Peter, McCarthy, Mark, Gupta, Namrata, Taylor, Herman, Fox, Ervin, Cheh, Christopher Newton, Wilson, James G, O'Donnell, Christopher J, Kathiresan, Sekar, Hirschhorn, Joel, Seidman, JG, and Seidman, Christine

Subjects
Genetics, Biotechnology, Human Genome, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Adipocytes, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cell Differentiation, Diabetes Mellitus, Type 2, Ethnicity, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, PPAR gamma, Polymorphism, Single Nucleotide, Risk Factors, Sequence Analysis, DNA, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium
Abstract

Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione medications. In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D). Whether and how rare variants in PPARG and defects in adipocyte differentiation influence risk of T2D in the general population remains undetermined. By sequencing PPARG in 19,752 T2D cases and controls drawn from multiple studies and ethnic groups, we identified 49 previously unidentified, nonsynonymous PPARG variants (MAF < 0.5%). Considered in aggregate (with or without computational prediction of functional consequence), these rare variants showed no association with T2D (OR = 1.35; P = 0.17). The function of the 49 variants was experimentally tested in a novel high-throughput human adipocyte differentiation assay, and nine were found to have reduced activity in the assay. Carrying any of these nine LOF variants was associated with a substantial increase in risk of T2D (OR = 7.22; P = 0.005). The combination of large-scale DNA sequencing and functional testing in the laboratory reveals that approximately 1 in 1,000 individuals carries a variant in PPARG that reduces function in a human adipocyte differentiation assay and is associated with a substantial risk of T2D.

Published
2014

32. Comorbidity profiles and inpatient outcomes during hospitalization for heart failure: an analysis of the U.S. Nationwide inpatient sample.

Author

Lee, Christopher, Chien, Christopher, Bidwell, Julie, Gelow, Jill, Denfeld, Quin, Masterson Creber, Ruth, Buck, Harleah, and Mudd, James

Subjects
Aged, Comorbidity, Female, Heart Failure, Hospital Costs, Humans, Length of Stay, Male, Patient Admission, Prevalence, Prognosis, Risk Factors, Time Factors, United States
Abstract

BACKGROUND: Treatment of heart failure (HF) is particularly complex in the presence of comorbidities. We sought to identify and associate comorbidity profiles with inpatient outcomes during HF hospitalizations. METHODS: Latent mixture modeling was used to identify common profiles of comorbidities during adult hospitalizations for HF from the 2009 Nationwide Inpatient Sample (n = 192,327). RESULTS: Most discharges were characterized by common comorbidities. A lifestyle profile was characterized by a high prevalence of uncomplicated diabetes, hypertension, chronic pulmonary disorders and obesity. A renal profile had the highest prevalence of renal disease, complicated diabetes, and fluid and electrolyte imbalances. A neurovascular profile represented the highest prevalence of cerebrovascular disease, paralysis, myocardial infarction and peripheral vascular disease. Relative to the common profile, the lifestyle profile was associated with a 15% longer length of stay (LOS) and 12% greater cost, the renal profile was associated with a 30% higher risk of death, 27% longer LOS and 24% greater cost, and the neurovascular profile was associated with a 45% higher risk of death, 34% longer LOS and 37% greater cost (all p

Published
2014

33. JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.

Author

Sundqvist, Emilie, Buck, Dorothea, Warnke, Clemens, Albrecht, Eva, Gieger, Christian, Khademi, Mohsen, Lima Bomfim, Izaura, Fogdell-Hahn, Anna, Link, Jenny, Alfredsson, Lars, Søndergaard, Helle Bach, Hillert, Jan, International Multiple Sclerosis Genetics Consortium, Oturai, Annette B, Hemmer, Bernhard, Kockum, Ingrid, and Olsson, Tomas

Subjects
International Multiple Sclerosis Genetics Consortium, CD4-Positive T-Lymphocytes, Humans, JC Virus, Polyomavirus Infections, Haplotypes, Alleles, Female, Male, HLA-DQ beta-Chains, HLA-DRB1 Chains, Scandinavian and Nordic Countries, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

JC polyomavirus (JCV) carriers with a compromised immune system, such as in HIV, or subjects on immune-modulating therapies, such as anti VLA-4 therapy may develop progressive multifocal leukoencephalopathy (PML) which is a lytic infection of oligodendrocytes in the brain. Serum antibodies to JCV mark infection occur only in 50-60% of infected individuals, and high JCV-antibody titers seem to increase the risk of developing PML. We here investigated the role of human leukocyte antigen (HLA), instrumental in immune defense in JCV antibody response. Anti-JCV antibody status, as a surrogate for JCV infection, were compared to HLA class I and II alleles in 1621 Scandinavian persons with MS and 1064 population-based Swedish controls and associations were replicated in 718 German persons with MS. HLA-alleles were determined by SNP imputation, sequence specific (SSP) kits and a reverse PCR sequence-specific oligonucleotide (PCR-SSO) method. An initial GWAS screen displayed a strong HLA class II region signal. The HLA-DRB1*15 haplotype was strongly negatively associated to JCV sero-status in Scandinavian MS cases (OR = 0.42, p = 7×10(-15)) and controls (OR = 0.53, p = 2×10(-5)). In contrast, the DQB1*06:03 haplotype was positively associated with JCV sero-status, in Scandinavian MS cases (OR = 1.63, p = 0.006), and controls (OR = 2.69, p = 1×10(-5)). The German dataset confirmed these findings (OR = 0.54, p = 1×10(-4) and OR = 1.58, p = 0.03 respectively for these haplotypes). HLA class II restricted immune responses, and hence CD4+ T cell immunity is pivotal for JCV infection control. Alleles within the HLA-DR1*15 haplotype are associated with a protective effect on JCV infection. Alleles within the DQB1*06:03 haplotype show an opposite association. These associations between JC virus antibody response and human leucocyte antigens supports the notion that CD4+ T cells are crucial in the immune defence to JCV and lays the ground for risk stratification for PML and development of therapy and prevention.

Published
2014

34. Comparison of visual and semiquantitative analysis of 18F-FDOPA-PET/CT for recurrence detection in glioblastoma patients

Author

Herrmann, Ken, Czernin, Johannes, Cloughesy, Timothy, Lai, Albert, Pomykala, Kelsey L, Benz, Matthias R, Buck, Andreas K, Phelps, Michael E, and Chen, Wei

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Biomedical Imaging, Rare Diseases, Neurosciences, Cancer, Brain Cancer, Brain Disorders, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Adult, Aged, Aged, 80 and over, Dihydroxyphenylalanine, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Glioblastoma, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Positron-Emission Tomography, Prognosis, Radiopharmaceuticals, Survival Rate, Tomography, X-Ray Computed, Young Adult, glioblastoma, F-18-FDOPA, recurrence detection, 18F-FDOPA, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundAmino acid transport imaging with 18F-FDOPA PET is increasingly used for detection of glioblastoma recurrence. However, a standardized image interpretation for 18F-FDOPA brain PET studies has not yet been established. This study compares visual and semiquantitative analysis parameters for detection of tumor recurrence and correlates them with progression-free survival (PFS).MethodsOne-hundred ten patients (72 male:38 female) with suspected tumor recurrence who underwent 18F-FDOPA PET imaging were studied. PET scans were analyzed visually (5-point scale) and semiquantitatively (lesion-to-striatum- and lesion- to-normal-brain-tissue ratios using both SUV(mean) and SUV(max)). Accuracies for recurrence detection were calculated using histopathology and clinical follow-up for validation. Receiving operator characteristic and Kaplan-Meier survival analysis were performed to derive imaging-based prediction of PFS and overall survival (OS).ResultsAccuracies for detection of glioblastoma recurrence were similar for visual (82%) and semiquantitative (range, 77%-82%) analysis. Both visual and semiquantitative indices were significant predictors of PFS, with mean lesion-to normal brain tissue ratios providing the best discriminator (mean survival, 39.4 vs 9.3 months; P < .001). None of the investigated parameters was predictive for OS.ConclusionsBoth visual and semiquantitative indices detected glioblastoma recurrence with high accuracy and were predictive for PFS. Lesion-to-normal-tissue ratios were the best discriminators of PFS; however, none of the investigated parameters predicted OS. These retrospectively established analysis parameters need to be confirmed prospectively.

Published
2014

35. Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study.

Author

Buck Louis, Germaine, Peterson, C, Chen, Zhen, Sundaram, Rajeshwari, Stanford, Joseph, Varner, Michael, Kennedy, Anne, Sun, Liping, Wang, Lei, Guo, Ying, Kannan, Kurunthachalam, Giudice, Linda, Fujimoto, Victor, and Croughan, Mary

Subjects
Adult, Benzhydryl Compounds, Biomarkers, Cohort Studies, Endometriosis, Environmental Pollutants, Female, Humans, Laparoscopy, Phenols, Phthalic Acids, Treatment Outcome
Abstract

OBJECTIVE: To explore the relation between bisphenol A and 14 phthalate metabolites and endometriosis. DESIGN: Matched cohort design. SETTING: Fourteen clinical centers. PATIENT(S): The operative cohort comprised 495 women undergoing laparoscopy/laparotomy, whereas the population cohort comprised 131 women matched on age and residence. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Surgically visualized or pelvic magnetic resonance imaging diagnosed endometriosis in the two cohorts, respectively. RESULT(S): Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression adjusting for age, body mass index, and creatinine. In the population cohort, six phthalate metabolites-mono-n-butyl phthalate, mono-[(2-carboxymethyl) hexyl] phthalate, mono (2-ethyl-5-carboxyphentyl) phthalate, mono (2-ethylhexyl) phthalate, mono (2-ethyl-5-hydroxyhexyl) phthalate, and mono (2-ethyl-5-oxohexyl) phthalate-were significantly associated with an approximately twofold increase in the odds of an endometriosis diagnosis. Two phthalates were associated with endometriosis in the operative cohort when restricting to visualized and histologic endometriosis (monooctyl phthalate; OR 1.38; 95% CI 1.10-1.72) or when restricting comparison women to those with a postoperative diagnosis of a normal pelvis [mono (2-ethylhexyl) phthalate; OR 1.35; 95% CI 1.03-1.78]. CONCLUSION(S): Select phthalates were associated with higher odds of an endometriosis diagnosis for women with magnetic resonance imaging-diagnosed endometriosis. The lack of consistency of findings across cohorts underscores the impact of methodology on findings.

Published
2013

36. Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study

Author

Louis, Germaine M Buck, Peterson, C Matthew, Chen, Zhen, Croughan, Mary, Sundaram, Rajeshwari, Stanford, Joseph, Varner, Michael W, Kennedy, Anne, Giudice, Linda, Fujimoto, Victor Y, Sun, Liping, Wang, Lei, Guo, Ying, and Kannan, Kurunthachalam

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Prevention, Clinical Research, Contraception/Reproduction, Endometriosis, Pain Research, Reproductive health and childbirth, Adult, Benzhydryl Compounds, Biomarkers, Cohort Studies, Environmental Pollutants, Female, Humans, Laparoscopy, Phenols, Phthalic Acids, Treatment Outcome, Bisphenol A, endometriosis, endocrine disrupting chemicals, epidemiology, phthalates, Clinical Sciences, Paediatrics and Reproductive Medicine, Public Health and Health Services, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

ObjectiveTo explore the relation between bisphenol A and 14 phthalate metabolites and endometriosis.DesignMatched cohort design.SettingFourteen clinical centers.Patient(s)The operative cohort comprised 495 women undergoing laparoscopy/laparotomy, whereas the population cohort comprised 131 women matched on age and residence.Intervention(s)None.Main outcome measure(s)Surgically visualized or pelvic magnetic resonance imaging diagnosed endometriosis in the two cohorts, respectively.Result(s)Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression adjusting for age, body mass index, and creatinine. In the population cohort, six phthalate metabolites-mono-n-butyl phthalate, mono-[(2-carboxymethyl) hexyl] phthalate, mono (2-ethyl-5-carboxyphentyl) phthalate, mono (2-ethylhexyl) phthalate, mono (2-ethyl-5-hydroxyhexyl) phthalate, and mono (2-ethyl-5-oxohexyl) phthalate-were significantly associated with an approximately twofold increase in the odds of an endometriosis diagnosis. Two phthalates were associated with endometriosis in the operative cohort when restricting to visualized and histologic endometriosis (monooctyl phthalate; OR 1.38; 95% CI 1.10-1.72) or when restricting comparison women to those with a postoperative diagnosis of a normal pelvis [mono (2-ethylhexyl) phthalate; OR 1.35; 95% CI 1.03-1.78].Conclusion(s)Select phthalates were associated with higher odds of an endometriosis diagnosis for women with magnetic resonance imaging-diagnosed endometriosis. The lack of consistency of findings across cohorts underscores the impact of methodology on findings.

Published
2013

37. Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO Study.

Author

Peterson, C Matthew, Johnstone, Erica B, Hammoud, Ahmad O, Stanford, Joseph B, Varner, Michael W, Kennedy, Anne, Chen, Zhen, Sun, Liping, Fujimoto, Victor Y, Hediger, Mary L, Buck Louis, Germaine M, and ENDO Study Working Group

Subjects
ENDO Study Working Group, Pelvis, Humans, Infertility, Endometriosis, Dysmenorrhea, Pelvic Pain, Magnetic Resonance Imaging, Laparoscopy, Laparotomy, Incidence, Logistic Models, Odds Ratio, Risk Factors, Case-Control Studies, Cohort Studies, Prospective Studies, Gravidity, Parity, Pregnancy, Adolescent, Adult, Female, Young Adult, Pain Research, Contraception/Reproduction, Clinical Research, Prevention, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Reproductive health and childbirth, Good Health and Well Being, Body mass index, dysmenorrhea, endometriosis, epidemiology, infertility, laparoscopy, magnetic resonance imaging, risk factors, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine
Abstract

ObjectiveWe sought to identify risk factors for endometriosis and their consistency across study populations in the Endometriosis: Natural History, Diagnosis, and Outcomes (ENDO) Study.Study designIn this prospective matched, exposure cohort design, 495 women aged 18-44 years undergoing pelvic surgery (exposed to surgery, operative cohort) were compared to an age- and residence-matched population cohort of 131 women (unexposed to surgery, population cohort). Endometriosis was diagnosed visually at laparoscopy/laparotomy or by pelvic magnetic resonance imaging in the operative and population cohorts, respectively. Logistic regression estimated the adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for each cohort.ResultsThe incidence of visualized endometriosis was 40% in the operative cohort (11.8% stage 3-4 by revised criteria from the American Society for Reproductive Medicine), and 11% stage 3-4 in the population cohort by magnetic resonance imaging. An infertility history increased the odds of an endometriosis diagnosis in both the operative (AOR, 2.43; 95% CI, 1.57-3.76) and population (AOR, 7.91; 95% CI, 1.69-37.2) cohorts. In the operative cohort only, dysmenorrhea (AOR, 2.46; 95% CI, 1.28-4.72) and pelvic pain (AOR, 3.67; 95% CI, 2.44-5.50) increased the odds of diagnosis, while gravidity (AOR, 0.49; 95% CI, 0.32-0.75), parity (AOR, 0.42; 95% CI, 0.28-0.64), and body mass index (AOR, 0.95; 95% CI, 0.93-0.98) decreased the odds of diagnosis. In all sensitivity analyses for different diagnostic subgroups, infertility history remained a strong risk factor.ConclusionAn infertility history was a consistent risk factor for endometriosis in both the operative and population cohorts of the ENDO Study. Additionally, identified risk factors for endometriosis vary based upon cohort selection and diagnostic accuracy. Finally, endometriosis in the population may be more common than recognized.

Published
2013

38. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage

Author

Bradley Shaffer, H, Minx, Patrick, Warren, Daniel E, Shedlock, Andrew M, Thomson, Robert C, Valenzuela, Nicole, Abramyan, John, Amemiya, Chris T, Badenhorst, Daleen, Biggar, Kyle K, Borchert, Glen M, Botka, Christopher W, Bowden, Rachel M, Braun, Edward L, Bronikowski, Anne M, Bruneau, Benoit G, Buck, Leslie T, Capel, Blanche, Castoe, Todd A, Czerwinski, Mike, Delehaunty, Kim D, Edwards, Scott V, Fronick, Catrina C, Fujita, Matthew K, Fulton, Lucinda, Graves, Tina A, Green, Richard E, Haerty, Wilfried, Hariharan, Ramkumar, Hernandez, Omar, Hillier, LaDeana W, Holloway, Alisha K, Janes, Daniel, Janzen, Fredric J, Kandoth, Cyriac, Kong, Lesheng, de Koning, AP Jason, Li, Yang, Literman, Robert, McGaugh, Suzanne E, Mork, Lindsey, O'Laughlin, Michelle, Paitz, Ryan T, Pollock, David D, Ponting, Chris P, Radhakrishnan, Srihari, Raney, Brian J, Richman, Joy M, St John, John, Schwartz, Tonia, Sethuraman, Arun, Spinks, Phillip Q, Storey, Kenneth B, Thane, Nay, Vinar, Tomas, Zimmerman, Laura M, Warren, Wesley C, Mardis, Elaine R, and Wilson, Richard K

Subjects
Biological Sciences, Ecology, Evolutionary Biology, Genetics, Biotechnology, Human Genome, Adaptation, Physiological, Animals, Base Composition, Evolution, Molecular, Female, Freezing, Genome, Humans, Hypoxia, Immune System, Isochores, Likelihood Functions, Longevity, Male, MicroRNAs, Models, Genetic, Molecular Sequence Annotation, Multigene Family, Phylogeny, Pseudogenes, Reference Standards, Repetitive Sequences, Nucleic Acid, Selection, Genetic, Sex Determination Processes, Temperature, Turtles, Amniote phylogeny, anoxia tolerance, chelonian, freeze tolerance, genomics, longevity, phylogenomics, physiology, turtle, evolutionary rates, Environmental Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundWe describe the genome of the western painted turtle, Chrysemys picta bellii, one of the most widespread, abundant, and well-studied turtles. We place the genome into a comparative evolutionary context, and focus on genomic features associated with tooth loss, immune function, longevity, sex differentiation and determination, and the species' physiological capacities to withstand extreme anoxia and tissue freezing.ResultsOur phylogenetic analyses confirm that turtles are the sister group to living archosaurs, and demonstrate an extraordinarily slow rate of sequence evolution in the painted turtle. The ability of the painted turtle to withstand complete anoxia and partial freezing appears to be associated with common vertebrate gene networks, and we identify candidate genes for future functional analyses. Tooth loss shares a common pattern of pseudogenization and degradation of tooth-specific genes with birds, although the rate of accumulation of mutations is much slower in the painted turtle. Genes associated with sex differentiation generally reflect phylogeny rather than convergence in sex determination functionality. Among gene families that demonstrate exceptional expansions or show signatures of strong natural selection, immune function and musculoskeletal patterning genes are consistently over-represented.ConclusionsOur comparative genomic analyses indicate that common vertebrate regulatory networks, some of which have analogs in human diseases, are often involved in the western painted turtle's extraordinary physiological capacities. As these regulatory pathways are analyzed at the functional level, the painted turtle may offer important insights into the management of a number of human health disorders.

Published
2013

39. Direct comparison of fixed flexion, radiography and MRI in knee osteoarthritis: responsiveness data from the Osteoarthritis Initiative

Author

Wirth, W, Duryea, J, Le Graverand, M-P Hellio, John, MR, Nevitt, M, Buck, RJ, Eckstein, F, and Group, for the OA Initiative Investigators

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Arthritis, Aging, Biomedical Imaging, Musculoskeletal, Aged, Cartilage, Articular, Female, Femur, Follow-Up Studies, Humans, Knee Joint, Magnetic Resonance Imaging, Male, Middle Aged, Osteoarthritis, Knee, Radiography, Reproducibility of Results, Risk Factors, OA Initiative Investigators Group, Biomedical Engineering, Human Movement and Sports Sciences, Arthritis & Rheumatology, Clinical sciences, Sports science and exercise
Abstract

ObjectiveMinimum radiographic joint space width (mJSW) represents the Food and Drug Administration (FDA) standard for demonstrating structural therapeutic benefits for knee osteoarthritis (KOA), but only shows moderate responsiveness (sensitivity to change). We directly compare the responsiveness of magnetic resonance imaging (MRI)-based cartilage thickness and JSW measures from fixed-flexion radiography (FFR) and explore the correlation of region-matched changes between both methods.MethodsNine hundred and sixty-seven knees of Osteoarthritis Initiative participants with radiographic KOA were studied: 445 over 1 year with coronal FLASH MRI and FFR, and 375/522 over 1/2 years with sagittal DESS MRI and FFR. Standardized response means (SRM) of cartilage thickness and mJSW were compared using the sign-test.ResultsWith FLASH MRI, SRM was -0.28 for medial femorotibial compartment (MFTC) cartilage loss vs -0.15 for mJSW, and -0.32 vs -0.22 for the most sensitive MRI subregion (central MFTC) vs the most sensitive fixed-location JSW(x = 0.25). With DESS MRI, 1-year SRM was -0.34 for MFTC vs -0.22 for mJSW and -0.44 vs -0.28 for central MFTC vs JSW(x = 0.225). Over 2 years, the SRM was significantly greater for MFTC than for mJSW (-0.43 vs -0.31, P = 0.017) and for central MFTC than for JSW(x = 0.225) (-0.51 vs -0.44, P < 0.001). Correlations between changes in spatially matched MRI subregions and fixed-location JSW were not consistently higher (r = 0.10-0.51) than those between non-matched locations (r = 0.15-0.50).ConclusionsMRI displays greater responsiveness in KOA than JSW FFR-based JSW, with the greatest SRM observed in the central medial femorotibial compartment. Fixed-location radiographic measures appear not capable of determining the spatial distribution of femorotibial cartilage loss.

Published
2013

40. Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health

Author

Bin Zhu, Zhi Tao, Laahirie Edupuganti, Myrna G. Serrano, and Gregory A. Buck

Subjects
Infectious Diseases, Reproductive Health, Pregnancy, Microbiota, Vagina, Infant, Newborn, Humans, Premature Birth, Female, Biodiversity, Molecular Biology, Microbiology
Abstract

The microbiome of the female reproductive tract defies the convention that high biodiversity is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous vaginal microbiome composed of species of Lactobacillus is generally associated with health, whereas vaginal microbiomes consisting of other taxa are generally associated with dysbiosis and a higher risk of disease.

Published
2023

41. Cartilage thickening in early radiographic knee osteoarthritis: A within‐person, between‐knee comparison

Author

Cotofana, Sebastian, Buck, Robert, Wirth, Wolfgang, Roemer, Frank, Duryea, Jeff, Nevitt, Michael, Eckstein, Felix, and Group, Osteoarthritis Initiative Investigators

Subjects
Allied Health and Rehabilitation Science, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Arthritis, Clinical Research, Chronic Pain, Osteoarthritis, Pain Research, Aging, Musculoskeletal, Aged, Cartilage, Articular, Cross-Sectional Studies, Early Diagnosis, Female, Femur, Humans, Knee Joint, Magnetic Resonance Imaging, Male, Middle Aged, Multivariate Analysis, Osteoarthritis, Knee, Osteophyte, Radiography, Tibia, Weight-Bearing, Osteoarthritis Initiative Investigators Group, Public Health and Health Services, Psychology, Clinical sciences, Allied health and rehabilitation science
Abstract

ObjectiveTo determine whether the presence of definite osteophytes (in the absence of joint space narrowing [JSN]) on radiographs is associated with (subregional) increases in cartilage thickness in a within-person, between-knee cross-sectional comparison of participants in the Osteoarthritis Initiative. Based on previous results, the external weight-bearing medial femoral condyle (ecMF) and external weight-bearing lateral femoral condyle (ecLF) subregions were selected as primary end points.MethodsBoth knees of 61 Osteoarthritis Initiative participants (n = 4,796) displayed definite tibial or femoral marginal osteophytes and no JSN in 1 knee, and no signs of radiographic osteoarthritis (OA) in the contralateral knee; this was confirmed by an expert central reader. In these participants, cartilage thickness was measured in 16 femorotibial subregions of each knee, based on sagittal double-echo steady-state with water excitation magnetic resonance images. Location-specific joint space width from fixed-flexion radiographs was determined using dedicated software. Location-specific associations of osteophytes with cartilage thickness were evaluated using paired t-tests and mixed-effects models.ResultsOf the 61 participants, 48% had only medial osteophytes, 36% only lateral osteophytes, and 16% bicompartmental osteophytes. The knees with osteophytes had significantly thicker cartilage than contralateral knees without osteophytes in the ecMF (mean ± SD +71 ± 223 μmoles, equivalent to an increase of +5.5%; P = 0.015) and ecLF (mean ± SD +64 ± 195 μmoles, +4.1%; P = 0.013). No significant differences between knees were noted in other subregions or in joint space width. Cartilage thickness in the ecMF and ecLF was significantly associated with tibial osteophytes in the same (medial or lateral) compartment (P = 0.003).ConclusionThe knees with early radiographic OA display thicker cartilage than (contralateral) knees without radiographic findings of OA, specifically in the external femoral subregions of compartments with marginal osteophytes.

Published
2012

42. Perfluorochemicals and Endometriosis

Author

Louis, Germaine M Buck, Peterson, C Matthew, Chen, Zhen, Hediger, Mary L, Croughan, Mary S, Sundaram, Rajeshwari, Stanford, Joseph B, Fujimoto, Victor Y, Varner, Michael W, Giudice, Linda C, Kennedy, Anne, Sun, Liping, Wu, Qian, and Kannan, Kurunthachalam

Subjects
Clinical Research, Endometriosis, Adolescent, Adult, Caprylates, Environmental Exposure, Environmental Pollutants, Female, Fluorocarbons, Humans, San Francisco, Utah, Young Adult, Statistics, Public Health and Health Services, Epidemiology
Abstract

BackgroundEnvironmental chemicals may be associated with endometriosis. No published research has focused on the possible role of perfluorochemicals (PFCs) despite their widespread presence in human tissues.MethodsWe formulated two samples. The first was an operative sample comprising 495 women aged 18-44 years scheduled for laparoscopy/laparotomy at one of 14 participating clinical sites in the Salt Lake City or San Francisco area, 2007-2009. The second was a population-based sample comprising 131 women matched to the operative sample on age and residence within a 50-mile radius of participating clinics. Interviews and anthropometric assessments were conducted at enrollment, along with blood collection for the analysis of nine PFCs, which were quantified using liquid chromatography-tandem mass spectrometry. Endometriosis was defined based on surgical visualization (in the operative sample) or magnetic resonance imaging (in the population sample). Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) for each PFC (log-transformed), adjusting for age and body mass index, and then parity.ResultsSerum perfluorooctanoic acid (PFOA; OR = 1.89 [95% CI = 1.17-3.06]) and perfluorononanoic acid (2.20 [1.02-4.75]) were associated with endometriosis in the operative sample; findings were moderately attenuated with parity adjustment (1.62 [0.99-2.66] and 1.99 [0.91-4.33], respectively). Perfluorooctane sulfonic acid (1.86 [1.05-3.30]) and PFOA (2.58 [1.18-5.64]) increased the odds for moderate/severe endometriosis, although the odds were similarly attenuated with parity adjustment (OR = 1.50 and 1.86, respectively).ConclusionsSelect PFCs were associated with an endometriosis diagnosis. These associations await corroboration.

Published
2012

43. Perfluorochemicals and endometriosis: the ENDO study.

Author

Louis, Germaine M Buck, Peterson, C Matthew, Chen, Zhen, Hediger, Mary L, Croughan, Mary S, Sundaram, Rajeshwari, Stanford, Joseph B, Fujimoto, Victor Y, Varner, Michael W, Giudice, Linda C, Kennedy, Anne, Sun, Liping, Wu, Qian, and Kannan, Kurunthachalam

Subjects
Humans, Endometriosis, Caprylates, Fluorocarbons, Environmental Pollutants, Environmental Exposure, Adolescent, Adult, San Francisco, Utah, Female, Young Adult, Epidemiology, Statistics, Public Health and Health Services
Abstract

BackgroundEnvironmental chemicals may be associated with endometriosis. No published research has focused on the possible role of perfluorochemicals (PFCs) despite their widespread presence in human tissues.MethodsWe formulated two samples. The first was an operative sample comprising 495 women aged 18-44 years scheduled for laparoscopy/laparotomy at one of 14 participating clinical sites in the Salt Lake City or San Francisco area, 2007-2009. The second was a population-based sample comprising 131 women matched to the operative sample on age and residence within a 50-mile radius of participating clinics. Interviews and anthropometric assessments were conducted at enrollment, along with blood collection for the analysis of nine PFCs, which were quantified using liquid chromatography-tandem mass spectrometry. Endometriosis was defined based on surgical visualization (in the operative sample) or magnetic resonance imaging (in the population sample). Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) for each PFC (log-transformed), adjusting for age and body mass index, and then parity.ResultsSerum perfluorooctanoic acid (PFOA; OR = 1.89 [95% CI = 1.17-3.06]) and perfluorononanoic acid (2.20 [1.02-4.75]) were associated with endometriosis in the operative sample; findings were moderately attenuated with parity adjustment (1.62 [0.99-2.66] and 1.99 [0.91-4.33], respectively). Perfluorooctane sulfonic acid (1.86 [1.05-3.30]) and PFOA (2.58 [1.18-5.64]) increased the odds for moderate/severe endometriosis, although the odds were similarly attenuated with parity adjustment (OR = 1.50 and 1.86, respectively).ConclusionsSelect PFCs were associated with an endometriosis diagnosis. These associations await corroboration.

Published
2012

44. 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Author

Warren, Helen, Dudbridge, Frank, Fletcher, Olivia, Orr, Nick, Johnson, Nichola, Hopper, John L, Apicella, Carmel, Southey, Melissa C, Mahmoodi, Maryam, Schmidt, Marjanka K, Broeks, Annegien, Cornelissen, Sten, Braaf, Linda M, Muir, Kenneth R, Lophatananon, Artitaya, Chaiwerawattana, Arkom, Wiangnon, Surapon, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Schulz-Wendtland, Ruediger, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Guénel, Pascal, Truong, Thérèse, Laurent-Puig, Pierre, Mulot, Claire, Bojesen, Stig E, Nielsen, Sune F, Flyger, Henrik, Nordestgaard, Børge G, Milne, Roger L, Benítez, Javier, Arias-Pérez, José-Ignacio, Zamora, M Pilar, Anton-Culver, Hoda, Ziogas, Argyrios, Bernstein, Leslie, Dur, Christina Clarke, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Langheinz, Anne, Meindl, Alfons, Golatta, Michael, Bartram, Claus R, Schmutzler, Rita K, Brauch, Hiltrud, Justenhoven, Christina, Brüning, Thomas, Network, for The GENICA, Chang-Claude, Jenny, Wang-Gohrke, Shan, Eilber, Ursula, Dörk, Thilo, Schürmann, Peter, Bremer, Michael, Hillemanns, Peter, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Bogdanova, Natalia, Antonenkova, Natalia, Rogov, Yuriy, Bermisheva, Marina, Prokofyeva, Darya, Zinnatullina, Guzel, Khusnutdinova, Elza, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Hartikainen, Jaana M, Kataja, Vesa, Chenevix-Trench, Georgia, Beesley, Jonathan, Chen, Xiaoqing, Investigators, for kConFab, Group, Australian Ovarian Cancer Study, Lambrechts, Diether, Smeets, Ann, Paridaens, Robert, Weltens, Caroline, Flesch-Janys, Dieter, Buck, Katharina, Behrens, Sabine, Peterlongo, Paolo, Bernard, Loris, Manoukian, Siranoush, Radice, Paolo, Couch, Fergus J, Vachon, Celine, Wang, Xianshu, and Olson, Janet

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Genetics, Human Genome, Aging, Breast Cancer, Clinical Research, Cancer, 2.1 Biological and endogenous factors, Aetiology, Aged, Breast Neoplasms, Case-Control Studies, Chromosome Mapping, Chromosomes, Human, Pair 9, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Estrogen, Receptors, Progesterone, GENICA Network, kConFab Investigators, Australian Ovarian Cancer Study Group, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundOur recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).MethodsTo further investigate the rs865686-breast cancer association, we conducted a replication study within the Breast Cancer Association Consortium, which comprises 37 case-control studies (48,394 cases, 50,836 controls).ResultsThis replication study provides additional strong evidence of an inverse association between rs865686 and breast cancer risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, P = 2.01 × 10(-29)] among women of European ancestry. There were ethnic differences in the estimated minor (G)-allele frequency among controls [0.09, 0.30, and 0.38 among, respectively, Asians, Eastern Europeans, and other Europeans; P for heterogeneity (P(het)) = 1.3 × 10(-143)], but no evidence of ethnic differences in per allele OR (P(het) = 0.43). rs865686 was associated with estrogen receptor-positive (ER(+)) disease (per G-allele OR, 0.89; 95% CI, 0.86-0.91; P = 3.13 × 10(-22)) but less strongly, if at all, with ER-negative (ER(-)) disease (OR, 0.98; 95% CI, 0.94-1.02; P = 0.26; P(het) = 1.16 × 10(-6)), with no evidence of independent heterogeneity by progesterone receptor or HER2 status. The strength of the breast cancer association decreased with increasing age at diagnosis, with case-only analysis showing a trend in the number of copies of the G allele with increasing age at diagnosis (P for linear trend = 0.0095), but only among women with ER(+) tumors.ConclusionsThis study is the first to show that rs865686 is a susceptibility marker for ER(+) breast cancer.ImpactThe findings further support the view that genetic susceptibility varies according to tumor subtype.

Published
2012

45. Natural history of fibroids in pregnancy: National Institute of Child Health and Human Development Fetal Growth Studies - Singletons cohort

Author

Susanna D, Mitro, Shyamal, Peddada, Zhen, Chen, Germaine M, Buck Louis, Jessica L, Gleason, Cuilin, Zhang, and Katherine L, Grantz

Subjects
Adult, Leiomyoma, National Institute of Child Health and Human Development (U.S.), Obstetrics and Gynecology, United States, Abortion, Spontaneous, Cohort Studies, Fetal Development, Reproductive Medicine, Pregnancy, Uterine Neoplasms, Humans, Female, Prospective Studies, Child
Abstract

To describe the natural history of fibroids in pregnancy in a racially diverse cohort and explore whether fibroid changes were associated with participant characteristics.Prospective cohort study.Twelve clinical sites.Pregnant women (n = 2774; 27% non-Hispanic White, 28% non-Hispanic Black, 29% Hispanic, 17% Asian/Pacific Islander) who had up to 6 obstetric ultrasounds in gestational weeks 10-41.Sonographers recorded fibroid number and volume of the 3 largest fibroids at each visit. Generalized linear mixed models estimated the trajectories of fibroid number and total volume (overall and stratified by total volume at first visualization: equivalent to a fibroid of1 cm [small], 1 to3 cm [medium], or ≥3 cm [large] in diameter). We tested the interactions between the trajectories and race/ethnicity, age (26, 26-30, 31-34, and ≥35 years), body mass index (25, 25-29.9, and ≥30 kg/mAverage change in total fibroid volume during pregnancy.Overall, 9.6% (266/2,774) of women had a visualized fibroid at any time during pregnancy, including 9% (67/745) of non-Hispanic White women, 14% (106/770) of non-Hispanic Black women, 6% (47/794) of Hispanic women, and 10% (46/465) of Asian or Pacific Islander women. The mean total fibroid volume decreased by 1.0% (95% confidence interval [CI], -1.9%, -0.2%) per week, with a variation in starting total volume. On average, the total volume increased by 2.0% (95% CI, -0.3%, 4.5%) per week among women with small volume; decreased by 0.5% (95% CI, -2.0%, 1.0%) per week among women with medium volume; and decreased by 2.2% (95% CI, -3.4%, -1.0%) per week among women with large volume at first visualization. The volume change also varied by race or ethnicity, parity, age, and miscarriage history. For example, non-Hispanic Black women's total fibroid volume decreased more than those of non-Hispanic White, Hispanic and Asian/Pacific Islander women (-2.6%, 0.1%, 0.5%, and 0.9% average change per week, respectively). The visualized fibroid number declined on an average by 1.2% per week (95% CI, -1.9%, -0.5%) without significant variation by demographic characteristics.The total fibroid volume declined on average throughout pregnancy. However, summarizing across all fibroids disguises substantial heterogeneity by starting total fibroid volume and maternal characteristics. The findings may be a useful reference for clinicians to anticipate how fibroids may change in obstetric patients.NCT00912132.

Published
2022
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46. Development of a blood calcium test for hypocalcemia diagnosis in dairy cows

Author

Yongpeng, Fu, Marcos G, Colazo, and Jeroen, De Buck

Subjects
Calmodulin, Hypocalcemia, General Veterinary, Animals, Cattle Diseases, Lactation, Calcium, Cattle, Female, Trehalase
Abstract

Hypocalcemia, defined as total blood calcium concentrations below 2.1 mM, has detrimental impacts on welfare, production and reproduction in dairy cattle. Yet, no cow-side test exists for testing total bovine blood calcium. Here, we modified the split trehalase complementation assay to detect total calcium in serum by incorporating calmodulin and the M13 peptide as fusion partners to the trehalase fragments. In the presence of calcium, calmodulin undergoes a conformation change and gains strong affinity for M13 peptide. A high reactive assay for calcium was developed with detection threshold of 10 uM and dynamic range between 1 uM and 1 mM. The addition of a specific concentration of calcium chelator, EDTA, in mild acidic conditions, shifted the dynamic range to physiological calcium concentrations and transformed the sensor from ionized calcium sensor to total calcium sensor. The sensor was validated on a collection of 213 bovine serum samples by comparison with quantitative colorimetric calcium test. A correlation coefficient of 0.81 was achieved and the accuracy of detecting subclinical hypocalcemia was 0.86 and specificity of 100%. The area under the Receiver Operating Characteristic curve was 0.93. The concordance correlation coefficient (0.80), Bland-Altman plot and weighted Kappa coefficient (0.71) demonstrated a substantial agreement between both methods. In conclusion, a novel total calcium test was developed that can be used as a convenient high throughput laboratory test and with potential to be incorporated into a version compatible with on-farm testing.

Published
2022
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47. A school-based health and mindfulness curriculum improves children's objectively measured sleep: a prospective observational cohort study

Author

Lauren A. Anker, Omer Linkovski, Makoto Kawai, Casey Buck, Brenda Flores, Ruth O'Hara, Christina F. Chick, Isabelle Cotto, Ryan Matlow, Deanna N. Shinsky, Priyanka N Hiteshi, Rosy Karna, Kai Parker-Fong, Victor G. Carrion, Christine E. Gould, Anisha G. Singh, Oscar Leyva, Logan Schneider, Josh Jordan, Christian R Nolan, Travis Bradley, and Sophia Pirog

Subjects
Pulmonary and Respiratory Medicine, Mindfulness, medicine.diagnostic_test, business.industry, Polysomnography, Erikson's stages of psychosocial development, Cognition, Sleep in non-human animals, Neurology, Medicine, Humans, Female, Neurology (clinical), Curriculum, Prospective Studies, business, Child, Sleep, Socioeconomic status, Clinical psychology, Cohort study
Abstract

Poor sleep impedes children's cognitive, emotional, and psychosocial development. Pediatric sleep dysregulation is common, and children who live in communities of low socioeconomic status experience additional risk factors for short sleep duration and poor sleep quality. School-based training in mindfulness and yoga-informed practices can improve children's behavior and well-being, but effects on objectively measured sleep are unknown.Effects of a school-based health and mindfulness curriculum, which taught practices such as paced breathing, on sleep and stress were examined in 115 children (49 girls, ages 8 to 11 at baseline). Fifty-eight children in a community of low socioeconomic status received the curriculum twice weekly for 2 years. Fifty-seven children in a socioeconomic status-matched community engaged in their usual physical education class instead. In-home ambulatory polysomnography and perceived social stress were measured in all children at 3 time points: at baseline (ie, prior to curriculum exposure) and at 2 yearly follow-ups.Children receiving the curriculum gained an average of 74 minutes of total sleep time, and 24 minutes of rapid eye movement sleep, per night over the 2-year study period. Children not receiving the curriculum experienced a decrease in total sleep time averaging 64 minutes per night, with no changes in rapid eye movement sleep. Sleep improved within the first 3 months of curriculum exposure, in a dose-dependent fashion. Higher curriculum engagement (eg, using the breathing exercises outside of class) was associated with larger gains in total and rapid eye movement sleep duration. Aggregate within-group changes in social stress were not significant. However, among children receiving the curriculum, those who experienced larger gains in total and rapid eye movement sleep duration also experienced larger increases in perceived social stress.A school-based health and mindfulness curriculum improved children's objectively measured sleep over 2 years. Social stress did not mediate these effects; instead, mindfulness training may have increased awareness of environmental stressors, while developing tools to reduce stress vulnerability.Chick CF, Singh A, Anker LA, et al. A school-based health and mindfulness curriculum improves children's objectively measured sleep: a prospective observational cohort study.

Published
2023

48. The role of partner support for health behaviours in people living with and beyond cancer: A qualitative study

Author

Natalie Gil, Abigail Fisher, Rebecca J. Beeken, Simon Pini, Natalie Miller, Caroline Buck, Phillippa Lally, and Rana Conway

Subjects
Male, Psychiatry and Mental health, Oncology, Neoplasms, Health Behavior, Humans, Social Support, Female, Experimental and Cognitive Psychology, Life Style, Qualitative Research
Abstract

Objective This study aimed to qualitatively explore how partner support for health behaviours is perceived, received, and utilised in people living with and beyond cancer (LWBC). Methods Semi-structured audio interviews were conducted with 24 participants, 15 men and nine women, living with and beyond breast, prostate, and colorectal cancer. Inductive and deductive Thematic Analysis was used to analyse the data. Results Three key themes with six subthemes were identified relating to partner support for health behaviours: (1) Interdependence (Reciprocity, Overt Control, Influence & Motivation) (2) Concordance (Shared Attitudes & Health Beliefs, Shared Health Behaviour) and (3) Communal Coping (Communal Orientation towards Health and Decision Making, Co-operative Action in Health Behaviour). Conclusions Partner support plays a unique and significant role in the health behaviours of people LWBC. Partners play a collaborative role in managing health and facilitating health behaviours, while the high level of concordance in couples may represent a potential barrier to change via the reinforcement of maladaptive health beliefs and behaviours. Implications for Cancer Survivors Overall, findings demonstrate that partners should be considered and included where possible when designing future behaviour change interventions for people LWBC.

Published
2022
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49. Getting a Grip on Strength Measurement in Children (6-13 Y)

Author

Rob Buck, Michael Ian Lambert, and AMS - Sports

Subjects
Male, Hand Strength, Pediatrics, Perinatology and Child Health, Humans, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Female, Child
Abstract

Purpose: To identify the smallest change in handgrip strength (HGS) in children that can be considered of practical significance. Method: A total of 290 male and female children, aged 6–13 years, performed a HGS testing protocol 3 times within a 7-day period. The typical error of measurement (TE), coefficient of variation, and smallest worthwhile change (SWC) were calculated for each sex and age group (grade). Results: The TE for the combined group of grade 1 to 7 children was 1.3 kg. Changes in HGS associated with a small change were 1.3 kg, making it difficult for the HGS test to detect these changes. The TE was less than the medium (3.3 kg) and large (5.3 kg) changes in HGS for all the grades and sexes, making changes of these magnitudes more interpretable as they exceed the “noise” (TE) of the measurement. Conclusion: Changes in HGS greater than the TE and SWC can be considered real changes of practical significance. This provides researchers with an extra level of analysis when trying to determine the practical relevance of the observed changes.

Published
2022
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50. Effects of Spring Warming on Seasonal Neuroendocrinology and Activation of the Reproductive Axis in Hibernating Arctic Ground Squirrels

Author

Helen E Chmura, Cassandra Duncan, Ben Saer, Jeanette T Moore, Brian M Barnes, C Loren Buck, Andrew S I Loudon, and Cory T Williams

Subjects
Male, Symposium, Reproduction, Animals, Sciuridae, Thyrotropin, Female, Animal Science and Zoology, Seasons, Neuroendocrinology, Plant Science
Abstract

Many animals adjust the timing of seasonal events, such as reproduction, molt, migration, and hibernation, in response to interannual variation and directional climate-driven changes in temperature. However, the mechanisms by which temperature influences seasonal timing are relatively under-explored. Seasonal timing involves retrograde signaling in which thyrotropin (TSH) in the pars tuberalis (PT) alters expression of thyroid hormone (TH) deiodinases (Dio2/Dio3) in tanycyte cells lining the third ventricle of the hypothalamus. This, in turn, affects the availability of triiodothyronine (T3) within the mediobasal hypothalamus—increased hypothalamic T3 restores a summer phenotype and activates the reproductive axis in long-day breeders. Recently, we showed that retrograde TH signaling is activated during late hibernation in arctic ground squirrels (Urocitellus parryii) held in constant darkness and constant ambient temperature. Sensitivity of seasonal pathways to nonphotic cues, such as temperature, is likely particularly important to hibernating species that are sequestered in hibernacula during spring. To address this issue, we exposed captive arctic ground squirrels of both sexes to an ecologically relevant increase in ambient temperature (from −6 to −1°C) late in hibernation and examined the effects of warming on the seasonal retrograde TSH/Dio/T3 signaling pathway, as well as downstream elements of the reproductive axis. We found that warmed males tended to have higher PT TSHβ expression and significantly heavier testis mass whereas the TSH/Dio/T3 signaling pathway was unaffected by warming in females, although warmed females exhibited a slight decrease in ovarian mass. Our findings suggest that temperature could have different effects on gonadal growth in male and female arctic ground squirrels, which could lead to mismatched timing in response to rapid climate change.

Published
2022
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