1. The effect of aging, Parkinson's disease, and exogenous dopamine on the neural response associated with auditory regularity processing
- Author
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Björn Herrmann, Abdullah Al Jaja, Penny A. MacDonald, and Jessica A. Grahn
- Subjects
Male ,0301 basic medicine ,Aging ,Parkinson's disease ,Brain activity and meditation ,Dopamine ,Disease ,Electroencephalography ,Affect (psychology) ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Auditory regularity ,medicine ,Psychology ,Humans ,0501 psychology and cognitive sciences ,Aged ,Scene analysis ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,05 social sciences ,Dopaminergic ,Neurosciences ,Brain ,Parkinson Disease ,Middle Aged ,medicine.disease ,Ventral tegmental area ,Regularity processing ,Sound ,030104 developmental biology ,medicine.anatomical_structure ,Auditory Perception ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Neuroscience ,030217 neurology & neurosurgery ,Developmental Biology ,medicine.drug - Abstract
© 2020 Elsevier Inc. Processing regular patterns in auditory scenes is important for navigating complex environments. Electroencephalography studies find enhancement of sustained brain activity, correlating with the emergence of a regular pattern in sounds. How aging, aging-related diseases such as Parkinson's disease (PD), and treatment of PD with dopaminergic therapy affect this fundamental function remain unknown. We addressed this knowledge gap. Healthy younger and older adults and patients with PD listened to sounds that contained or were devoid of regular patterns. Healthy older adults and patients with PD were tested twice—off and on dopaminergic medication, in counterbalanced order. Regularity-evoked, sustained electroencephalography activity was reduced in older, compared with younger adults. Patients with PD and older controls evidenced comparable attenuation of the sustained response. Dopaminergic therapy further weakened the sustained response in both older controls and patients with PD. These findings suggest that fundamental regularity processing is impacted by aging but not specifically by PD. The finding that dopaminergic therapy attenuates rather than improves the sustained response coheres with the dopamine overdose response and is in line with previous findings that regularity processing implicates brain regions receiving dopamine from the ventral tegmental area that is relatively spared in PD and normal aging.
- Published
- 2020
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