Author: "Bassols, A." / Topic: female - Searchworks@Jio Institute Digital Library Search Results

131 results on '"Bassols, A."'

1. TSH and FT4 Reference Intervals in Pregnancy

Author: Joris A J Osinga, Arash Derakhshan, Glenn E Palomaki, Ghalia Ashoor, Tuija Männistö, Spyridoula Maraka, Liangmiao Chen, Sofie Bliddal, Xuemian Lu, Peter N Taylor, Tanja G M Vrijkotte, Fang-Biao Tao, Suzanne J Brown, Farkhanda Ghafoor, Kris Poppe, Flora Veltri, Lida Chatzi, Bijay Vaidya, Maarten A C Broeren, Beverley M Shields, Sachiko Itoh, Lorena Mosso, Polina V Popova, Anna D Anopova, Reiko Kishi, Ashraf Aminorroaya, Maryam Kianpour, Abel López-Bermejo, Emily Oken, Amna Pirzada, Marina Vafeiadi, Wichor M Bramer, Eila Suvanto, Jun Yoshinaga, Kun Huang, Judit Bassols, Laura Boucai, Ulla Feldt-Rasmussen, Elena N Grineva, Elizabeth N Pearce, Erik K Alexander, Victor J M Pop, Scott M Nelson, John P Walsh, Robin P Peeters, Layal Chaker, Kypros H Nicolaides, Mary E D’Alton, Tim I M Korevaar, Internal Medicine, Epidemiology, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, ARD - Amsterdam Reproduction and Development, and APH - Aging & Later Life
Subjects: Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Thyroid Gland, Thyrotropin, free thyroxine (FT4), Thyroid Function Tests, reference values, Iodide Peroxidase, Biochemistry, thyroid, Thyroxine, Endocrinology, SDG 3 - Good Health and Well-being, thyrotropin (TSH), Humans, Female, pregnancy
Abstract: Context Interpretation of thyroid function tests during pregnancy is limited by the generalizability of reference intervals between cohorts due to inconsistent methodology. Objective (1) To provide an overview of published reference intervals for thyrotropin (TSH) and free thyroxine (FT4) in pregnancy, (2) to assess the consequences of common methodological between-study differences by combining raw data from different cohorts. Methods (1) Ovid MEDLINE, EMBASE, and Web of Science were searched until December 12, 2021. Studies were assessed in duplicate. (2) The individual participant data (IPD) meta-analysis was performed in participating cohorts in the Consortium on Thyroid and Pregnancy. Results (1) Large between-study methodological differences were identified, 11 of 102 included studies were in accordance with current guidelines; (2) 22 cohorts involving 63 198 participants were included in the meta-analysis. Not excluding thyroid peroxidase antibody–positive participants led to a rise in the upper limits of TSH in all cohorts, especially in the first (mean +17.4%; range +1.6 to +30.3%) and second trimester (mean +9.8%; range +0.6 to +32.3%). The use of the 95th percentile led to considerable changes in upper limits, varying from –10.8% to –21.8% for TSH and –1.2% to –13.2% for FT4. All other additional exclusion criteria changed reference interval cut-offs by a maximum of 3.5%. Applying these findings to the 102 studies included in the systematic review, 48 studies could be used in a clinical setting. Conclusion We provide an overview of clinically relevant reference intervals for TSH and FT4 in pregnancy. The results of the meta-analysis indicate that future studies can adopt a simplified study setup without additional exclusion criteria.
Published: 2022
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2. Mental health help-seeking among Brazilian medical students: Who suffers unassisted?

Author: Tamires Martins Bastos, Daniela Benzano Bumaguin, Vitória Rech Astolfi, Aurora Zamora Xavier, Mauricio Scopel Hoffmann, Felipe Ornell, Daniel Tornaim Spritzer, Ana Margareth Siqueira Bassols, Lisia von Diemen, Pricilla Braga Laskoski, and Simone Hauck
Subjects: Psychiatry and Mental health, Cross-Sectional Studies, Mental Health, Students, Medical, Depression, Surveys and Questionnaires, Humans, Female, Anxiety, Patient Acceptance of Health Care, Brazil
Abstract: Introduction: Several barriers for mental health help-seeking were identified among medical students, including minimizing mental illness. Studies examining aspects particular to those who perceive psychological impairment but do not access treatment are necessary for planning interventions. Aims: To identify help-seeking barriers based on the students’ perception about their need for treatment and psychiatric symptoms. Methods: Cross-sectional study assessing 436 Brazilian medical students (833 attending the medical school = 52.3% response rate). Data collection covered sociodemographic data, mental health, academic environment, and Beck Inventories of Depression (BDI) and Anxiety (BAI). Non-parametric tests and hierarchical logistic regression were used to compare students undergoing treatment, those willing to access treatment, and the ones reporting no need for treatment. Results: Among the 382 students who completed the survey (87.6% completion rate), 38.5% ( n = 147) were in treatment, and 33% ( n = 126) were in need. Moderate to severe risk of alcohol abuse was observed in 45.9% ( n = 50) of students reporting no need for treatment. Regression models suggested that perceiving need for treatment – whether already undergoing it or not – was associated with the severity of depressive symptoms (OR 1.14 [95% CI 1.07–1.21]), female assigned sex (OR 2.18 [95% CI 1.23–3.88]), LGBTQ+ (OR 2.47 [95% CI 1.09–5.60]) and reporting good relationship with the family (OR 0.26 [95% CI 0.08–0.83]). Models comparing students in treatment and those in need, pointed that the factors associated with lacking mental health care were age (OR 0.90 [95% CI 0.82–0.99]), perception of a heavy workload (OR 2.43 [95% CI 1.35–4.38]) and good relationship with colleagues (OR 3.51 [95% CI 1.81–6.81]). Discussion: Social variables and the severity of depressive symptoms are positively associated with perceived need for treatment. Age and academic environment factors were related to help-seeking behavior among students with appropriate self-awareness. We discuss these findings’ implications for planning interventions.
Published: 2022
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3. Evaluation of potential biomarkers to determine adequate colostrum provision in male dairy-beef calves upon arrival at the rearing facility beyond 14 days of age

Author: L. Pisoni, S. Marti, J. Pujols, Y. Saco, N. Gomez, A. Bassols, M. Devant, Producció Animal, and Producció de Remugants
Subjects: Male, Colostrum, Alkaline Phosphatase, Animal Feed, Animals, Newborn, Pregnancy, Immunoglobulin G, Genetics, Animals, Female, Cattle, Animal Science and Zoology, Biomarkers, Food Science
Abstract: Colostrum consumption is crucial for passive immunization and development of the newborn calf. However, the incidence on failed transfer of passive immunity in male calves destined to dairy-beef production remains high to date. In addition, the lack of an automated procedure to validate the immunization status upon arrival at rearing facilities in calves beyond 14 d of age impedes the identification of failed transfer of passive immunity, and therefore, of those calves at high risk of suffering diseases. For this study, 82 newborn male Holstein calves (43.3 ± 0.86 kg of body weight; mean ± standard error) from a commercial dairy farm were used to investigate potential serum biomarkers of colostrum provision. The potential biomarkers selected were IgG, IgG1, cholesterol, alkaline phosphatase, gamma-glutamyl transferase (GGT), and total protein (TP). Treatments were as follows: high-colostrum (HC; n = 49), in which calves received 4 L of colostrum within the first 2 h after birth and 2 L of colostrum in the next 3 feedings within the first 24 h after birth, for a total of 10 L of colostrum; and low-colostrum (LC; n = 33), in which calves received only 2 L of colostrum within the first 2 h after birth. After colostrum consumption, calves were allocated to individual hutches and fed 2 L of milk replacer twice daily at a concentration of 125 g/L as fed. Starter feed and water were offered ad libitum. At approximately 14 d of age (14.2 ± 0.81 d of age; mean ± standard error) calves were transported 2.5 h to a research unit at IRTA (Torre Marimon, Spain) simulating the arrival to a rearing facility. Blood samples were collected before feeding at birth, 48 h after birth, and at arrival to the rearing facility. Results on the serum concentrations of the potential biomarkers at arrival to the rearing facility showed that IgG, IgG1, GGT, and TP were greater for the HC calves compared with the LC calves. Serum concentrations of cholesterol and alkaline phosphatase did not show differences between treatment groups. Additionally, body weight losses from birth until arrival to the rearing facility were greater for the LC treatment compared with the HC. Because of their low cost, quickness, and ease of measurement, GGT and TP were good indicators of colostrum intake in calves arriving at rearing facilities beyond 14 d of age. info:eu-repo/semantics/publishedVersion
Published: 2022

4. Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth

Author: Berta Mas-Pares, Mariona Jové, Meritxell Martín-Gari, Silvia Xargay-Torrent, Abel López-Bermejo, Francis de Zegher, Marta Díaz, Alexandra Bonmatí-Santané, Lourdes Ibáñez, Judit Bassols, Gemma Carreras-Badosa, and Ariadna Gomez-Vilarrubla
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Term Birth, Offspring, Placenta, Birth weight, Gestational Age, Biology, Weight Gain, Desaturase and elongase, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, medicine, Birth Weight, Humans, Fatty acids, reproductive and urinary physiology, SGA, chemistry.chemical_classification, Fetus, 030219 obstetrics & reproductive medicine, Fatty Acids, Infant, Newborn, Obstetrics and Gynecology, Fatty acid, Gestational age, medicine.disease, female genital diseases and pregnancy complications, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Reproductive Medicine, chemistry, Case-Control Studies, Infant, Small for Gestational Age, Gestation, Small for gestational age, Female, Developmental Biology
Abstract: Introduction: Fatty acids are essential nutrients for the fetus and are supplied by the mother through the placenta. Desaturase and elongase enzymes play an important role in modulating the fatty acid composition of body tissues. We aimed to compare the fatty acid profile and the estimated desaturase and elongase activities in the placenta of appropriate (AGA) versus small-for-gestational-age (SGA), and to determine their relationship with the offspring size at birth. Methods: The placental fatty acid profile was analyzed by gas chromatography in 84 infants (45 AGA and 30 SGA) from a prenatal cohort study. The estimated desaturase and elongase activities were calculated from productprecursor fatty acid ratios. Results were associated with maternal (age, body mass index and weight gain during gestation) and neonatal (gestational age, sex, birth weight and birth length) parameters. Results: Differences in placental fatty acid composition between AGA and SGA infants rather than correlations thereof with neonatal parameters were observed. Placentas from SGA infants contained lower levels of omega-3 (ALA, EPA, DPA, and DHA) and high omega-6/omega-3 ratios (AA/DHA and LA/ALA), as well as low elongase (Elovl5) and high desaturase (D9Dn7 and D5Dn6) activity as compared to AGA infants (all p < 0.0001). Discussion: Placentas of AGA and SGA infants differed in fatty acids profile as well as in estimated desaturase and elongase activities. A striking feature of SGA placentas was the low availability of omega-3. Hence, omega-3 fatty acid status deserves further attention, as a potential target of prenatal interventions. This study was supported by grants from the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (ISCIII), Madrid, Spain (PI17/ 00557 and PI19/00451 to JB), projects co-funded by FEDER (Fondo Europeo de Desarrollo Regional).
Published: 2021
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5. Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis

Author: Sofie Bliddal, Arash Derakhshan, Yi Xiao, Liang-Miao Chen, Tuija Männistö, Ghalia Ashoor, Fangbiao Tao, Suzanne J. Brown, Marina Vafeiadi, Sachiko Itoh, Elena Nikolaevna Grineva, Peter Taylor, Farkhanda Ghafoor, Bijay Vaidya, Andrew Hattersley, Lorena Mosso, Emily Oken, Reiko Kishi, Erik K. Alexander, Spyridoula Maraka, Kun Huang, Layal Chaker, Judit Bassols, Amna Pirzada, Abel López-Bermejo, Laura Boucai, Robin P. Peeters, Elizabeth N. Pearce, Scott McGill Nelson, Leda Chatzi, Tanja G. Vrijkotte, Polina V. Popova, John P. Walsh, Kypros H. Nicolaides, Eila Suvanto, Xuemian Lu, Victor J.M. Pop, Julie Lyng Forman, Tim I.M. Korevaar, Ulla Feldt-Rasmussen, Internal Medicine, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, ARD - Amsterdam Reproduction and Development, and APH - Aging & Later Life
Subjects: thyroid peroxidase antibodies, Endocrinology, Diabetes and Metabolism, Thyrotropin, Iodide Peroxidase, Thyroglobulin, Thyroid Diseases, thyroid, Thyroxine, Endocrinology, Cross-Sectional Studies, SDG 3 - Good Health and Well-being, Pregnancy, thyroid autoimmunity, Humans, Triiodothyronine, Female, thyroglobulin antibodies, meta-Analysis, Autoantibodies
Abstract: Objectives: Thyroid autoimmunity is common in pregnant women and associated with thyroid dysfunction and adverse obstetric outcomes. Most studies focus on thyroid peroxidase antibodies (TPOAbs) assessed by a negative-positive dichotomy and rarely take into account thyroglobulin antibodies (TgAbs). This study aimed at determining the association of TPOAbs and TgAbs, respectively, and interdependently, with maternal thyroid function. Methods: This was a meta-Analysis of individual participant cross-sectional data from 20 cohorts in the Consortium on Thyroid and Pregnancy. Women with multiple pregnancy, pregnancy by assisted reproductive technology, history of thyroid disease, or use of thyroid interfering medication were excluded. Associations of (log2) TPOAbs and TgAbs (with/without mutual adjustment) with cohort-specific z-scores of (log2) thyrotropin (TSH), free triiodothyronine (fT3), total triiodothyronine (TT3), free thyroxine (fT4), total thyroxine (TT4), or triiodothyronine:thyroxine (T3:T4) ratio were evaluated in a linear mixed model. Results: In total, 51,138 women participated (51,094 had TPOAb-data and 27,874 had TgAb-data). Isolated TPOAb positivity was present in 4.1% [95% confidence interval, CI: 3.0 to 5.2], isolated TgAb positivity in 4.8% [CI: 2.9 to 6.6], and positivity for both antibodies in 4.7% [CI: 3.1 to 6.3]. Compared with antibody-negative women, TSH was higher in women with isolated TPOAb positivity (z-score increment 0.40, CI: 0.16 to 0.64) and TgAb positivity (0.21, CI: 0.10 to 0.32), but highest in those positive for both antibodies (0.54, CI: 0.36 to 0.71). There was a dose-response effect of higher TPOAb and TgAb concentrations with higher TSH (TSH z-score increment for TPOAbs 0.12, CI: 0.09 to 0.15, TgAbs 0.08, CI: 0.02 to 0.15). When adjusting analyses for the other antibody, only the association of TPOAbs remained statistically significant. A higher TPOAb concentration was associated with lower fT4 (p < 0.001) and higher T3:T4 ratio (0.09, CI: 0.03 to 0.14), however, the association with fT4 was not significant when adjusting for TgAbs (p = 0.16). Conclusions: This individual participant data meta-Analysis demonstrated an increase in TSH with isolated TPOAb positivity and TgAb positivity, respectively, which was amplified for individuals positive for both antibodies. There was a dose-dependent association of TPOAbs, but not TgAbs, with TSH when adjusting for the other antibody. This supports current practice of using TPOAbs in initial laboratory testing of pregnant women suspected of autoimmune thyroid disease. However, studies on the differences between TPOAb-And TgAb-positive women are needed to fully understand the spectrum of phenotypes.
Published: 2022

6. Alternative antimicrobials for prophylaxis of the Group B Streptococcus maternal-fetal disease

Author: Felipe Bassols, Jessica Dallé, Mirela Foresti Jimenez, Suelyn Ramos, Emilly Dall'Oglio, and Vicente Sperb Antonello
Subjects: Adult, medicine.medical_specialty, Adolescent, medicine.drug_class, Antibiotics, Cefazolin, Microbiology, Streptococcus agalactiae, Young Adult, Anti-Infective Agents, Pregnancy, Risk Factors, Streptococcal Infections, Virology, Ampicillin, Internal medicine, medicine, Humans, Pregnancy Complications, Infectious, Antibiotic prophylaxis, Risk factor, Retrospective Studies, business.industry, General Medicine, Antibiotic Prophylaxis, Infectious Disease Transmission, Vertical, Penicillin, Regimen, Neonatal infection, Infectious Diseases, Female, Parasitology, business, Brazil, medicine.drug
Abstract: Introduction: GBS colonization is an important risk factor for maternal and neonatal infection morbidity and mortality. Intrapartum antibiotics may prevent vertical transmission of GBS from colonized mothers to their babies. The objective of this study was to evaluate the effectiveness of cefazolin prophylactic regimen for GBS disease, comparing it to the established penicillin-based protocols, given the opportunity provided by the temporary unavailability of first-choice antibiotics in Brazil. Methodology: A retrospective analysis was conducted at the Hospital Femina Obstetrics Service between January and December 2015. Ninety-eight pregnant women received standard penicillin (70 patients) or ampicillin (28 patients) antibiotic prophylaxis, and 251 pregnant women received an alternative prophylaxis with cefazolin during the study period. Risk factor, Maternal and neonatal outcomes were evaluated and compared between groups. Results: No significant difference was found in maternal (RR = 0.71; IC 95%:0.30-1.68; p = 0.709) and neonatal (RR = 0.84; IC 95%:0.61-1.15; p = 0.271) outcomes between those patients using the alternative antibiotic prophylaxis in comparison to the standard antibiotics, with the dependent variable of maternal and neonatal outcomes grouped and controlled for potential confounding variables. Conclusions: The antibiotics used as alternatives to penicillin and ampicillin for the prevention of maternal-fetal GBS disease are poorly studied, and this study indicate that cefazolin can be an optimal choice, offering safety in the use of this antibiotic in situations where penicillins are contraindicated or unavailable.
Published: 2020
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7. Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis

Author: Freddy J K Toloza, Arash Derakhshan, Tuija Männistö, Sofie Bliddal, Polina V Popova, David M Carty, Liangmiao Chen, Peter Taylor, Lorena Mosso, Emily Oken, Eila Suvanto, Sachiko Itoh, Reiko Kishi, Judit Bassols, Juha Auvinen, Abel López-Bermejo, Suzanne J Brown, Laura Boucai, Aya Hisada, Jun Yoshinaga, Ekaterina Shilova, Elena N Grineva, Tanja G M Vrijkotte, Jordi Sunyer, Ana Jiménez-Zabala, Isolina Riaño-Galan, Maria-Jose Lopez-Espinosa, Larry J Prokop, Naykky Singh Ospina, Juan P Brito, Rene Rodriguez-Gutierrez, Erik K Alexander, Layal Chaker, Elizabeth N Pearce, Robin P Peeters, Ulla Feldt-Rasmussen, Mònica Guxens, Leda Chatzi, Christian Delles, Jeanine E Roeters van Lennep, Victor J M Pop, Xuemian Lu, John P Walsh, Scott M Nelson, Tim I M Korevaar, Spyridoula Maraka, Internal Medicine, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, ARD - Amsterdam Reproduction and Development, and APH - Aging & Later Life
Subjects: Male, endocrine system, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Thyrotropin, Hypertension, Pregnancy-Induced, Hyperthyroidism, Thyroid Diseases, Pregnancy Complications, Thyroxine, Endocrinology, Hypothyroidism, Pre-Eclampsia, SDG 3 - Good Health and Well-being, Pregnancy, Internal Medicine, Humans, Female, Prospective Studies, Systematic Reviews as Topic
Abstract: BACKGROUND: Adequate maternal thyroid function is important for an uncomplicated pregnancy. Although multiple observational studies have evaluated the association between thyroid dysfunction and hypertensive disorders of pregnancy, the methods and definitions of abnormalities in thyroid function tests were heterogeneous, and the results were conflicting. We aimed to examine the association between abnormalities in thyroid function tests and risk of gestational hypertension and pre-eclampsia. METHODS: In this systematic review and meta-analysis of individual-participant data, we searched MEDLINE (Ovid), Embase, Scopus, and the Cochrane Database of Systematic Reviews from date of inception to Dec 27, 2019, for prospective cohort studies with data on maternal concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT(4)), thyroid peroxidase (TPO) antibodies, individually or in combination, as well as on gestational hypertension, pre-eclampsia, or both. We issued open invitations to study authors to participate in the Consortium on Thyroid and Pregnancy and to share the individual-participant data. We excluded participants who had pre-existing thyroid disease or multifetal pregnancy, or were taking medications that affect thyroid function. The primary outcomes were documented gestational hypertension and pre-eclampsia. Individual-participant data were analysed using logistic mixed-effects regression models adjusting for maternal age, BMI, smoking, parity, ethnicity, and gestational age at blood sampling. The study protocol was registered with PROSPERO, CRD42019128585. FINDINGS: We identified 1539 published studies, of which 33 cohorts met the inclusion criteria and 19 cohorts were included after the authors agreed to participate. Our study population comprised 46 528 pregnant women, of whom 39 826 (85·6%) women had sufficient data (TSH and FT(4) concentrations and TPO antibody status) to be classified according to their thyroid function status. Of these women, 1275 (3·2%) had subclinical hypothyroidism, 933 (2·3%) had isolated hypothyroxinaemia, 619 (1·6%) had subclinical hyperthyroidism, and 337 (0·8%) had overt hyperthyroidism. Compared with euthyroidism, subclinical hypothyroidism was associated with a higher risk of pre-eclampsia (2·1% vs 3·6%; OR 1·53 [95% CI 1·09-2·15]). Subclinical hyperthyroidism, isolated hypothyroxinaemia, or TPO antibody positivity were not associated with gestational hypertension or pre-eclampsia. In continuous analyses, both a higher and a lower TSH concentration were associated with a higher risk of pre-eclampsia (p=0·0001). FT(4) concentrations were not associated with the outcomes measured. INTERPRETATION: Compared with euthyroidism, subclinical hypothyroidism during pregnancy was associated with a higher risk of pre-eclampsia. There was a U-shaped association of TSH with pre-eclampsia. These results quantify the risks of gestational hypertension or pre-eclampsia in women with thyroid function test abnormalities, adding to the total body of evidence on the risk of adverse maternal and fetal outcomes of thyroid dysfunction during pregnancy. These findings have potential implications for defining the optimal treatment target in women treated with levothyroxine during pregnancy, which needs to be assessed in future interventional studies. FUNDING: Arkansas Biosciences Institute and Netherlands Organization for Scientific Research.
Published: 2022
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8. Work From Home or Bring Home the Work? Burnout and Procrastination in Brazilian Workers During the COVID-19 Pandemic

Author: Daniel Luccas Arenas, Anna Viduani, Ana Margareth Siqueira Bassols, and Simone Hauck
Subjects: Male, Cross-Sectional Studies, Teleworking, Public Health, Environmental and Occupational Health, COVID-19, Humans, Female, Burnout, Psychological, Procrastination, Child, Burnout, Professional, Pandemics, Brazil
Abstract: To investigate burnout and procrastination in a sample of Brazilian workers during the COVID-19 pandemic according to their current work mode.This cross-sectional study used data from an online survey conducted in 2020: 435 workers were included. The Copenhagen Burnout Inventory and the Irrational Procrastination Scale were used to access burnout and procrastination respectively.There was no difference between workers working from home (WFH) and at face-to-face work regarding burnout symptoms. However, the WFH group had higher levels of procrastination. Clinically significant levels of burnout were associated with being female, increased childcare load and living with children under 12years old.WFH may have more advantages than disadvantages in ideal conditions. However, work-life imbalances seem to be a key aspect regarding distress among workers WFH, especially in women with small children.
Published: 2022

9. A High-Fat Diet Modifies Brain Neurotransmitter Profile and Hippocampal Proteome and Morphology in an IUGR Pig Model

Author: Natalia Yeste, Jorge Pérez-Valle, Ana Heras-Molina, José Luis Pesántez-Pacheco, Esteban Porrini, Antonio González-Bulnes, Anna Bassols, Producción Científica UCH 2022, and UCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos
Subjects: Proteomics, Proteome, Neurotransmitters, Swine, Producción animal, Hipocampo (Cerebro), neurotransmitters, metabolism, high-fat diet, hippocampus, intrauterine growth restriction, brain, pig, Aceites y grasas en nutrición, Diet, High-Fat, Hippocampus, Neurotransmisores, Pregnancy, Animals, Humans, Cerdos - Alimentación, Neurotransmitter Agents, Nutrition and Dietetics, Fetal Growth Retardation, Lipids in nutrition, Brain, Swine - Neurology, Cerdos - Neurología, Female, Swine - Feeding and feeds, Hippocampus (Brain), Food Science
Abstract: This research was funded by the Spanish Ministry of Economy and Competitivity (AGL2015-68463-C2-2-P to A.B. and projects AGL2013-48121-C3-R and AGL2016-79321-C2-1-R to A.G.-B.), cofunded by FEDER. N.Y. is recipient of a graduate student fellowship from the Spanish FPU National Program Grant (Ministry of Science, Innovation and Universities; number FPU17/01881). A.H.-M. is recipient of a graduate student fellowship from the Spanish FPI National Program Grant (Ministry of Science, Innovation and Universities; number BES-2017-080541). Intrauterine Growth Restriction (IUGR) hinders the correct growth of the fetus during pregnancy due to the lack of oxygen or nutrients. The developing fetus gives priority to brain development ("brain sparing"), but the risk exists of neurological and cognitive deficits at short or long term. On the other hand, diets rich in fat exert pernicious effects on brain function. Using a pig model of spontaneous IUGR, we have studied the effect on the adult of a long-term high-fat diet (HFD) on the neurotransmitter profile in several brain areas, and the morphology and the proteome of the hippocampus. Our hypothesis was that animals affected by IUGR (born with low birth weight) would present a different susceptibility to an HFD when they become adults, compared with normal birth-weight animals. Our results indicate that HFD affected the serotoninergic pathway, but it did not provoke relevant changes in the morphology of the hippocampus. Finally, the proteomic analysis revealed that, in some instances, NBW and LBW individuals respond to HFD in different ways. In particular, NBW animals presented changes in oxidative phosphorylation and the extracellular matrix, whereas LBW animals presented differences in RNA splicing, anterograde and retrograde transport and the mTOR pathway.
Published: 2022

10. Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children

Author: Gemma Carreras-Badosa, Judit Bassols, Silvia Xargay-Torrent, Berta Mas-Pares, Lourdes Ibáñez, Francis de Zegher, Ariadna Gomez-Vilarrubla, Abel López-Bermejo, Anna Prats-Puig, and Elsa Puerto-Carranza
Subjects: Male, Growth Differentiation Factor 15, Adolescent, medicine.drug_class, Science, Adaptive immunity, Ronyó, Serum iga, Adolescents, Kidney, Teenagers, Article, Anti-inflammatory, ADIPOSE-TISSUE INFLAMMATION, Immune system, Humans, Medicine, Obesity, Child, Adiposity, Science & Technology, Multidisciplinary, biology, business.industry, Confounding, Endocrine system and metabolic diseases, Adipose tissues, medicine.disease, Healthy Volunteers, Immunoglobulina A, Immunoglobulin A, Multidisciplinary Sciences, Teixit adipós, Immunoglobulin G, embryonic structures, Cohort, Immunology, biology.protein, Science & Technology - Other Topics, Obesitat, Female, GDF15, Antibody, business
Abstract: Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins in a children's cohort assessed longitudinally during childhood. Results showed that circulating GDF-15 positively associated with IgA (p
Published: 2021
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11. microRNAs in newborns with low birth weight: relation to birth size and body composition

Author: Abel López-Bermejo, Cristina Plou, Rita Malpique, Judit Bassols, Lourdes Ibáñez, Gemma Carreras-Badosa, Francis de Zegher, and Cristina Garcia-Beltran
Subjects: Adult, Adolescent, Physiology, Gestational Age, Umbilical cord, Fetal Development, microRNA, Medicine, Birth Weight, Humans, Child, reproductive and urinary physiology, business.industry, Infant, Newborn, Infant, Anthropometry, Infant, Low Birth Weight, female genital diseases and pregnancy complications, Low birth weight, MicroRNAs, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Cohort, Lean body mass, Body Composition, Gestation, Female, medicine.symptom, business, human activities, Biomarkers, Umbilical Cord Serum
Abstract: Background Children with low birth weight (LBW) have a higher risk of developing endocrine-metabolic disorders later in life. Deregulation of specific microRNAs (miRNAs) could underscore the programming of adult pathologies. We analyzed the miRNA expression pattern in both umbilical cord serum samples from LBW and appropriate-for-gestational-age (AGA) newborns and maternal serum samples in the 3rd trimester of gestation, and delineated the relationships with fetal growth, body composition, and markers of metabolic risk. Methods Serum samples of 12 selected mother-newborn pairs, including 6 LBW and 6 AGA newborns, were used for assessing miRNA profile by RNA-sequencing. The miRNAs with differential expression were validated in a larger cohort [49 maternal samples and 49 umbilical cord samples (24 LBW, 25 AGA)] by RT-qPCR. Anthropometric, endocrine-metabolic markers and body composition (by DXA) in infants were determined longitudinally over 12 months. Results LBW newborns presented reduced circulating concentrations of miR-191-3p (P = 0.015). miR-191-3p levels reliably differentiated LBW from AGA individuals (ROC AUC = 0.76) and were positively associated with anthropometric and body composition measures at birth and weight Z-score at 12 months (P Conclusions miR-191-3p was reliably different in LBW individuals, and could be a new player in the epigenetic mechanisms linking LBW and future endocrine-metabolic adverse outcomes. Impact Children with low birth weight (LBW) have a higher risk of developing endocrine-metabolic disorders. Deregulation of specific microRNAs (miRNAs) could underscore the programming of those pathologies. miR-191-3p is downregulated in serum of LBW newborns, and its concentrations associate positively with neonatal anthropometric measures, with lean mass and bone accretion at age 15 days and with weight Z-score at age 12 months. miR-191-3p was reliably different in individuals with LBW, and could be a new player in the epigenetic mechanisms connecting LBW and future endocrine-metabolic adverse outcomes.
Published: 2021

12. Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children

Author: Berta Mas-Pares, Francis de Zegher, Elsa Puerto-Carranza, Jose-Maria Martinez-Calcerrada, Judit Bassols, Silvia Xargay-Torrent, Ariadna Gomez-Vilarrubla, Abel López-Bermejo, Irene Marcelo, and Lourdes Ibáñez
Subjects: Male, Trastorns del metabolisme, Kidneys -- Diseases, 030232 urology & nephrology, Blood lipids, Overweight, Body Mass Index, 0302 clinical medicine, Risk Factors, Medicine, 030212 general & internal medicine, Longitudinal Studies, Child, Children, Multidisciplinary, Endocrine system and metabolic diseases, Disorders of metabolism, Obesitat, Female, medicine.symptom, Resistència a la insulina, Infants, Sistema cardiovascular -- Malalties en els infants, Glomerular Filtration Rate, medicine.medical_specialty, Waist, Ronyons -- Malalties, Science, Renal function, Paediatric research, Article, 03 medical and health sciences, Insulin resistance, Metabolic Diseases, Internal medicine, Humans, Obesity, business.industry, Cardiometabolic Risk Factors, nutritional and metabolic diseases, medicine.disease, Blood pressure, Insulin Resistance, business, Body mass index, Cardiovascular diseases in children
Abstract: Associations between glomerular filtration rate (GFR) and cardiometabolic risk factors have been reported in adult and pediatric patients with renal disease. We aimed to assess the relationship between the estimated GFR (eGFR) and cardiometabolic risk factors in apparently healthy children. A longitudinal study in 401 asymptomatic Caucasian children (mean age 8 years) followed up after 4 years (mean age 12 years). GFR was estimated using the pediatric form of the FAS-equation. Children were classified at baseline according to their obesity status (normal weight and overweight) and according to eGFR levels (lower, average, and higher). The association of eGFR with anthropometric data [body mass index (BMI) and waist], blood pressure [systolic (SBP) and diastolic (DBP)], metabolic parameters [glucose, insulin resistance (HOMA-IR) and serum lipids], and renal ultrasonography measurements were assessed at baseline and follow-up. Baseline eGFR associated with several cardiometabolic risk factors at follow-up including higher waist, SBP, HOMA-IR, and kidney size (all p
Published: 2021

13. Metabolic programming in the offspring after gestational overfeeding in the mother: toward neonatal rescuing with metformin in a swine model

Author: Sílvia Xargay-Torrent, Berta Mas-Parés, Gemma Carreras-Badosa, Esther Lizárraga-Mollinedo, Joan Tibau, Josep Reixach, Estíbaliz Platero-Gutierrez, Anna Prats-Puig, Francis De Zegher, Lourdes Ibáñez, Judit Bassols, and Abel López-Bermejo
Subjects: Nutrition and Dietetics, Overnutrition, Adipose Tissue, Swine, Endocrinology, Diabetes and Metabolism, Fructosamine, Medicine (miscellaneous), Animals, Humans, Mothers, Female, Weight Gain, Metformin
Abstract: Maternal overfeeding during gestation may lead to adverse metabolic programming in the offspring mediated by epigenetic alterations. Potential reversal, in early life, of these alterations may help in the prevention of future cardio-metabolic conditions. In this context, our aims were: (1) to study the effects of maternal overfeeding on the metabolic and epigenetic programming of offspring's adipose tissue; and (2) to test the potential of postnatal metformin treatment to reverse these changes.We used a swine animal model where commercial production sows were either overfed or kept under standard diet during gestation, and piglets at birth were randomly assigned to metformin (n = 16 per group) or vehicle treatment during lactation (n = 16 per group).Piglets born to overfed sows showed a worse metabolic profile (higher weight, weight gain from birth and abdominal circumference; all p 0.05) together with altered serological markers (increased HOMA-IR, fructosamine, total cholesterol, C-Reactive Protein and lower HMW adiponectin; all p 0.05). The visceral adipose tissue also showed altered morphology (increased adipocyte area, perimeter and diameter; all p 0.05), as well as changes in gene expression (higher CCL2 and INSR, lower DLK1; all p 0.05), and in DNA methylation (96 hypermethylated and 99 hypomethylated CpG sites; FDR 0.05). Metformin treatment significantly ameliorated the abnormal metabolic profile, decreasing piglets' weight, weight gain from birth, abdominal circumference and fructosamine (all p 0.05) and reduced adipocyte area, perimeter, and diameter in visceral adipose tissue (all p 0.05). In addition, metformin treatment potentiated several associations between gene expression in visceral adipose tissue and the altered metabolic markers.Maternal overfeeding during gestation leads to metabolic abnormalities in the offspring, including adipose tissue alterations. Early metformin treatment mitigates these effects and could help rescue the offspring's metabolic health.
Published: 2021

14. Three Continents, Two Fathers, One Donor: A Non-Puerperal Relactation Case Study

Author: Gayle Subramaniam, Indira Lopez-Bassols, and Lara Olchanetzky Duke
Subjects: Male, medicine.medical_specialty, Breast pumping, Milk, Human, business.industry, Obstetrics, Breastfeeding, Obstetrics and Gynecology, Infant, Domperidone, Fathers, Breast Feeding, Medicine, Humans, Lactation, Female, business, Child, Induced lactation
Abstract: Introduction A woman was able to relactate 7 years after breastfeeding her children. She donated her expressed milk to her friends, a same-sex male couple, who had a child through surrogacy in the United States. She lived in London and shipped her milk to Hong Kong, where they lived. The infant thrived on the donated expressed milk received during the first 3 months of his life. Main issue This case is unusual because the woman was not breastfeeding at the time, which would have made expressing easier, and she was not adopting. She consulted a National Childbirth Trust Breastfeeding Counsellor and an International Board Certified Lactation Consultant® who helped her explore non-puerperal relactation protocols. Management Her plan started 6 months before the birth and included the use of domperidone, frequent expressing by hand and with a hospital-grade pump. A breastfeeding specialist physician made suggestions on the dosage of domperidone. She donated a total of 35.06 L. She had the full support of her partner and family. Conclusion Non-puerperal induced lactation and relactation offer ways to make human milk accessible to all infants, particularly those from LGBTQ+ families in which no parent is lactating, as was the case with the same-sex male couple participating in this study. It is essential to disseminate the knowledge and skills needed to support non-puerperal induced lactation and relactation among all healthcare professionals involved.
Published: 2021

15. Catch-up growth in juvenile rats, fat expansion, and dysregulation of visceral adipose tissue

Author: Lourdes Ibáñez, Berta Mas-Pares, Judit Bassols, Anna Prats-Puig, Esther Lizarraga-Mollinedo, Francis de Zegher, Abel López-Bermejo, Silvia Xargay-Torrent, Gemma Carreras-Badosa, and Xavier Remesar
Subjects: Male, medicine.medical_specialty, Brown fat cell differentiation, Adipose tissue, White adipose tissue, Growth, Intra-Abdominal Fat, Biology, Real-Time Polymerase Chain Reaction, Pediatrics, 03 medical and health sciences, 0302 clinical medicine, Immune system, Insulin resistance, Downregulation and upregulation, 030225 pediatrics, Internal medicine, Rates, Brown adipose tissue, medicine, Animals, Rats, Wistar, PI3K/AKT/mTOR pathway, Science & Technology, Fetal Growth Retardation, Reproducibility of Results, Adipose tissues, medicine.disease, Rats, Disease Models, Animal, Teixit adipós, medicine.anatomical_structure, Endocrinology, Gene Expression Regulation, Pediatrics, Perinatology and Child Health, Body Composition, Female, Life Sciences & Biomedicine, Creixement, 030217 neurology & neurosurgery
Abstract: BACKGROUND: Accelerated catch-up growth following intrauterine restriction increases the risk of developing visceral adiposity and metabolic abnormalities. However, the underlying molecular mechanisms of such metabolic programming are still poorly understood. METHODS: A Wistar rat model of catch-up growth following intrauterine restriction was used. A gene expression array was performed in the retroperitoneal adipose tissue sampled at postnatal day (PD) 42. RESULTS: Five hundred and forty-six differentially expressed genes (DEGs) were identified (adjusted p value
Published: 2021

16. Assisted Nursing: A Case Study of an Infant With a Complete Unilateral Cleft Lip and Palate

Author: Indira Lopez-Bassols
Subjects: Male, Pediatrics, medicine.medical_specialty, Milk, Human, business.industry, medicine.medical_treatment, Cleft Lip, Breastfeeding, Obstetrics and Gynecology, Infant, 030206 dentistry, Cleft Palate, 03 medical and health sciences, 0302 clinical medicine, Palatoplasty, Breast Feeding, 030225 pediatrics, medicine, Humans, Breastfeeding difficulties, Female, Cheiloplasty, business, Child
Abstract: Background This case presents a mother’s feeding experience of an infant born with a complete unilateral cleft lip and palate from birth until both were repaired. She fed him directly at the breast with assistance, controlling the delivery of the mother’s own milk. The infant received only his mother’s own milk, no bottles, and the excess expressed milk was donated to a milk bank. Main issue The Cleft Team supported the mother’s wish to breastfeed but expressed realism that cleft lip and palate infants could not create suction. Success had never been observed in the unit. Instead, the team suggested expressing to deliver as much of the mother’s own milk. The mother had previously breastfed her three children and was keen on finding innovative ways to breastfeed. Management Several techniques were trialed with the help of an International Board Certified Lactation Consultant. The most sustainable and successful was the use of a nipple shield applied to the maternal nipple areola complex to cover the lip palate. Underneath, a nasogastric tube connected to a syringe delivered the mother’s own milk. Exclusive expressing protected maternal supply, the infant’s nutrition and growth were monitored carefully and this technique reinforced mother–infant bonding. Conclusion Feeding with the modifications was challenging at times. However, maternal satisfaction was high because the mother had achieved her goal of breastfeeding without assistance post cheiloplasty and palatoplasty. This case adds to the limited body of research about feeding infants with cleft lips and palates directly at the breast.
Published: 2020

17. Effects of a high-fat-diet supplemented with probiotics and ω3-fatty acids on appetite regulatory neuropeptides and neurotransmitters in a pig model

Author: Anna Bassols, Daniel Valent, M Rodríguez-Palmero, E Fàbrega, M Font-I-Furnols, J Tibau, J A Moreno-Muñoz, Laura Arroyo, Producció Animal, Indústries Alimentàries, Benestar Animal, Qualitat i Tecnologia Alimentària, and Genètica i Millora Animal
Subjects: 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, 663/664, Swine, media_common.quotation_subject, Hypothalamus, Neuropeptide, Biology, Diet, High-Fat, Weight Gain, Hippocampus, Microbiology, 03 medical and health sciences, Orexin-A, 0302 clinical medicine, Neurochemical, Dopamine, Internal medicine, Fatty Acids, Omega-3, medicine, Animals, Obesity, media_common, Neurotransmitter Agents, Appetite Regulation, Probiotics, Neuropeptides, Dopaminergic, digestive, oral, and skin physiology, Appetite, Neuropeptide Y receptor, Disease Models, Animal, 030104 developmental biology, Endocrinology, Dietary Supplements, 3,4-Dihydroxyphenylacetic Acid, Female, 030217 neurology & neurosurgery, medicine.drug
Abstract: The pig is a valuable animal model to study obesity in humans due to the physiological similarity between humans and pigs in terms of digestive and associated metabolic processes. The dietary use of vegetal protein, probiotics and omega-3 fatty acids is recommended to control weight gain and to fight obesity-associated metabolic disorders. Likewise, there are recent reports on their beneficial effects on brain functions. The hypothalamus is the central part of the brain that regulates food intake by means of the production of food intake-regulatory hypothalamic neuropeptides, as neuropeptide Y (NPY), orexin A and pro-opiomelanocortin (POMC), and neurotransmitters, such as dopamine and serotonin. Other mesolimbic areas, such as the hippocampus, are also involved in the control of food intake. In this study, the effect of a high fat diet (HFD) alone or supplemented with these additives on brain neuropeptides and neurotransmitters was assessed in forty-three young pigs fed for 10 weeks with a control diet (T1), a high fat diet (HFD, T2), and HFD with vegetal protein supplemented with Bifidobacterium breve CECT8242 alone (T3) or in combination with omega-3 fatty acids (T4). A HFD provoked changes in regulatory neuropeptides and 3,4-dihydroxyphenylacetic acid (DOPAC) in the hypothalamus and alterations mostly in the dopaminergic system in the ventral hippocampus. Supplementation of the HFD with B. breve CECT8242, especially in combination with omega-3 fatty acids, was able to partially reverse the effects of HFD. Correlations between productive and neurochemical parameters supported these findings. These results confirm that pigs are an appropriate animal model alternative to rodents for the study of the effects of HFD on weight gain and obesity. Furthermore, they indicate the potential benefits of probiotics and omega-3 fatty acids on brain function. info:eu-repo/semantics/acceptedVersion
Published: 2020

18. Association of maternal thyroid function with birth weight: a systematic review and individual-participant data meta-analysis

Author: John P. Walsh, Robert J. French, Wichor M. Bramer, Eila Suvanto, Marina Vafeiadi, Juha Auvinen, Abel López-Bermejo, Robin P. Peeters, Arash Derakhshan, Marisa Rebagliato, Peter N. Taylor, Bijay Vaidya, Judit Bassols, Amna Pirzada, Xuemian Lu, Eric A.P. Steegers, Bridget A. Knight, Tanja G. M. Vrijkotte, Farkhanda Ghafoor, Mònica Guxens, Tuija Männistö, Jordi Sunyer, Suzanne J. Brown, Laura Boucai, Leda Chatzi, Margreet Meems, Jun Yoshinaga, Scott M. Nelson, David M. Carty, Ana Jiménez-Zabala, Polina V. Popova, Emily Oken, Layal Chaker, Isolina Riaño, Lorena Mosso, Colin M. Dayan, Liangmiao Chen, Elena N. Grineva, Victor J M Pop, Erik K. Alexander, Aya Hisada, Ulla Feldt-Rasmussen, Christian Delles, Tim I M Korevaar, Elizabeth N. Pearce, Sofie Bliddal, Public and occupational health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, ARD - Amsterdam Reproduction and Development, APH - Methodology, Internal Medicine, Obstetrics & Gynecology, Epidemiology, and Child and Adolescent Psychiatry / Psychology
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Thyroid Gland, Levothyroxine, Thyrotropin, Gestational Age, 030209 endocrinology & metabolism, Thyroid Function Tests, Thyroid function tests, Article, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Hypothyroidism, Pregnancy, Thyroid peroxidase, Internal Medicine, medicine, Birth Weight, Humans, 030212 general & internal medicine, medicine.diagnostic_test, biology, Obstetrics, business.industry, Thyroid disease, Infant, Newborn, Gestational age, Infant, Low Birth Weight, medicine.disease, Pregnancy Complications, Thyroxine, biology.protein, Small for gestational age, Female, Thyroid function, business, medicine.drug
Abstract: BACKGROUND: Adequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birth weight but there are still important knowledge gaps regarding the impact of subclinical thyroid function test abnormalities on birth weight, in general or during the late second and third trimester of pregnancy, remains unknown. The aim of this study was to examine associations of maternal thyroid function with birth weight. METHODS: For this individual-participant data meta-analysis we searched Medline (Ovid), Embase.com, Web-of-Science, Cochrane CENTRAL and Google Scholar from inception to March 18(th) 2018, and published open invitations to join the Consortium on Thyroid and Pregnancy, to identify prospective cohort studies with data on maternal thyroid function during pregnancy and birth weight. We excluded participants with multiple pregnancies, in vitro fertilization, pre-existing thyroid disease or thyroid medication usage, miscarriages and stillbirth. Main outcomes were small for gestational age (SGA), large for gestational age (LGA) (defined by the lowest or highest 10(th) population-specific percentile of birth weight standardized to gestational age and sex, respectively) and birth weight. We analysed individual participant data using mixed-effects regression models adjusting for maternal age, body mass index, ethnicity, smoking, parity, gestational age at blood sampling, fetal sex and gestational age at birth (the latter two only in case of birth weight continuously). The study protocol was pre-registered at the International Prospective Register of Systematic Reviews (PROSPERO), number CRD42016043496. RESULTS: From 2,526 published reports, 36 cohorts met the inclusion criteria and were invited to participate of which 15 agreed and after addition of 5 unpublished datasets, a total of 20 cohorts were included. After exclusions, the study population comprised 48,145 mother-child pairs of whom 1,275 (3·1%) had subclinical hypothyroidism (increased TSH with normal FT4) and 929 (2·2%) had isolated hypothyroxinaemia (decreased FT4 with normal TSH). Maternal subclinical hypothyroidism was associated with a higher risk of SGA compared to euthyroidism (11·8% vs. 10·0% respectively, adjusted risk difference 2·4% [95% CI, 0·4 to 4·8]; odds ratio (OR) 1·24 [95% CI 1·04 to 1.48], P=0·015) and lower mean birth weight (adjusted risk difference −38g [95% CI −61 to −15], P=0·001) with a higher effect estimate for measurement in the 3(rd) trimester compared with the 1(st) or 2(nd) trimester. Isolated hypothyroxinaemia was associated with a lower risk of SGA compared to euthyroidism (7·3% vs. 10·0%, adjusted risk difference −2·9 [95% CI, −4·5 to −0·9]; OR, 0·70 [95% CI 0·55 to 0·91], P=0·007) and higher mean birth weight (difference, 45g [95% CI 18 to 73], P=0·001). Each 1-SD higher maternal TSH concentration was associated with lower birth weight (−6g [−10 to −2], per SD, P=0·003), with higher effect estimates in TPOAb-positive than TPO-negative women (P for interaction=0·10). Each 1-SD higher FT4 concentration was associated with lower birth weight (−21g [95% CI −25 to −17] per SD, P
Published: 2020

19. Metabolically Healthy Obesity and High Carotid Intima-Media Thickness in Children and Adolescents: International Childhood Vascular Structure Evaluation Consortium

Author: Qian Zhang, Abel López-Bermejo, Yaping Hou, Berta Mas-Pares, Carmelo Antonio Caserta, Tatianne Moura Estrela Gusmão, George S. Stergiou, Costan G. Magnussen, Mônica de Oliveira Simões, Silvia Xargay-Torrent, Anna Prats-Puig, Liu Yang, Hua Chen, Elisabetta L. Romeo, Wang Shui, Judit Bassols, Xiaohuan Lou, Teng Guo, Bo Xi, Yanqing Zhang, Lili Yang, Evangelos Grammatikos, Mingming Wang, Carla Campos Muniz Medeiros, Yuanyuan Zhang, Pascal Bovet, Gemma Carreras-Badosa, Anastasios Kollias, Danielle Franklin de Carvalho, Thacira Dantas Almeida Ramos, Angela Amante, and Min Zhao
Subjects: Male, China, Pediatric Obesity, medicine.medical_specialty, Adolescent, Cross-sectional study, Health Status, Endocrinology, Diabetes and Metabolism, Population, Blood Pressure, 030209 endocrinology & metabolism, Overweight, Carotid Intima-Media Thickness, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Metabolically healthy obesity, Prevalence, Internal Medicine, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Child, education, Advanced and Specialized Nursing, Obesity, Metabolically Benign, education.field_of_study, Greece, business.industry, Odds ratio, medicine.disease, Obesity, Cross-Sectional Studies, Logistic Models, Italy, Intima-media thickness, Spain, cardiovascular system, Population study, Female, medicine.symptom, business, Brazil, Follow-Up Studies
Abstract: OBJECTIVE It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy of CVD risk, in children and adolescents. RESEARCH DESIGN AND METHODS Data were available for 3,497 children and adolescents aged 6–17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force. Metabolic status (defined as “healthy” [no risk factors] or “unhealthy” [one or more risk factors]) was based on four CVD risk factors: elevated blood pressure, elevated triglyceride levels, reduced HDL cholesterol, and elevated fasting glucose. High cIMT was defined as cIMT ≥90th percentile for sex, age, and study population. Logistic regression model was used to examine the association of weight and metabolic status with high cIMT, with adjustment for sex, age, race/ethnicity, and study center. RESULTS In comparison with metabolically healthy normal weight, odds ratios (ORs) for high cIMT were 2.29 (95% CI 1.58–3.32) for metabolically healthy overweight and 3.91 (2.46–6.21) for MHO. ORs for high cIMT were 1.44 (1.03–2.02) for unhealthy normal weight, 3.49 (2.51–4.85) for unhealthy overweight, and 6.96 (5.05–9.61) for unhealthy obesity. CONCLUSIONS Among children and adolescents, cIMT was higher for both MHO and metabolically healthy overweight compared with metabolically healthy normal weight. Our findings reinforce the need for weight control in children and adolescents irrespective of their metabolic status.
Published: 2018
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20. Socioeconomic inequalities in health and the use of healthcare services in Catalonia: analysis of the individual data of 7.5 million residents

Author: Nicolau Martín Bassols, Anna García-Altés, Montse Mias, Cristina Colls, and Dolores Ruiz-Muñoz
Subjects: Male, Evidence-Based Public Health Policy and Practice, Economic crisis, Epidemiology, Health Status, 0302 clinical medicine, administrative data, Socioeconomic related health inequalities, Health care, Medicine, 030212 general & internal medicine, Evidencebased health policies, media_common, Copayment, education.field_of_study, Health Services, Middle Aged, population data, Social protection, Female, Public Health, 0305 other medical science, Adult, medicine.medical_specialty, Adolescent, media_common.quotation_subject, Population, 030209 endocrinology & metabolism, Pharmacy, Young Adult, 03 medical and health sciences, Environmental health, Development economics, Humans, Social inequality, Medical prescription, education, Socioeconomic status, Consumption (economics), Equity (economics), 030505 public health, business.industry, Public health, Public Health, Environmental and Occupational Health, healthcare use, socio-economic level, health inequalities, Patient Acceptance of Health Care, Mental health, Cross-Sectional Studies, Social Class, Socioeconomic Factors, Spain, Unemployment, Catalan Health System, business, Delivery of Health Care, Welfare
Abstract: Social protection systems are related to each community’s culture. In most of the developed countries with welfare systems, healthcare provides universal access to their population. Despite its achievements, the main concern today of public health systems is financial sustainability. The challenge results from the fact that most of the health systems are very set in their ways and do not seem much prepared to answer the upcoming challenges in healthcare. Specifically, health systems might be ill-pepared to implement the interventions likely to be required to fight against the inequity that will result from those future developments. This forces to rethink our systems and to direct universalism to a greater extent towards the most needy, fragile population that have been left behind by the economic crisis and may suffer loss of access to some innovations in healthcare. This is particularly the case of the Spanish system. This does not seem prepared to prioritise services and set proper population targets to show resilience to the consequences of future technological and economic changes. In Catalonia, a wealthy region in Spain,1 despite rather good health outcomes for a reasonable healthcare expenditure, in terms of equality, the gap in socioeconomic inequalities has already increased during the last decades, first by immigration, driven by the economic boom, followed by unemployment caused by the economic crisis. They have generated new vulnerable groups (unemployed, children and elderly). In addition, some proposals from the former Spanish conservative government to change the terms of access to universal health services to pursue fiscal deficit control2 may make things worse. The economic consequences of the past crisis overlap with problems related to technological innovation and pressures on utilisation of the health system, emerging further issues on equity. We know that in order to face them, the old universalism of the …
Published: 2018
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21. Impact of Diabetes Mellitus and Insulin on Nonalcoholic Fatty Liver Disease in the Morbidly Obese

Author: Alexandre Losekann, Marciane Fantinelli, Claudia B.M. Strey, Guilherme F. Bassols, Sabrina S. Gobbato, Gabriela P. Coral, Luiz Alberto De Carli, and Sergio Ricardo Pioner
Subjects: Adult, Male, medicine.medical_specialty, Cirrhosis, Steatosis, medicine.medical_treatment, Specialties of internal medicine, 030204 cardiovascular system & hematology, Severity of Illness Index, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Risk Factors, Diabetes mellitus, Internal medicine, Nonalcoholic fatty liver disease, Prevalence, medicine, Humans, Hypoglycemic Agents, Insulin, Retrospective Studies, Bariatric surgery, Hepatology, business.industry, Fatty liver, NASH, Type 2 Diabetes Mellitus, General Medicine, Middle Aged, Prognosis, medicine.disease, Obesity, Morbid, Diabetes Mellitus, Type 2, RC581-951, Disease Progression, Female, 030211 gastroenterology & hepatology, Steatohepatitis, business, Obese patients, Brazil, Dyslipidemia
Abstract: Introduction and aim The prevalence of obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease are increasing. Type 2 diabetes mellitus may aggravate non-alcoholic fatty liver disease, increasing the risk of developing cirrhosis and hepatocellular carcinoma. This study aims to determine the effect of type 2 diabetes mellitus and insulin therapy on non-alcoholic fatty liver disease in the patients with morbid obesity. Material and methods Clinical, anthropometric and laboratory data were analyzed together with intraoperative liver biopsies from morbidly obese patients undergoing bariatric surgery. Results 219 patients with morbid obesity were evaluated. Systemic arterial hypertension (55.9% vs. 33.8%, p = 0.004) and dyslipidemia (67.1% vs. 39.0%, p l 0.001) were more prevalent in patients with diabetes when compared to patients without diabetes. In multivariate analysis, type 2 diabetes mellitus was an independent risk factor for severe steatosis (RR = 2.04, p = 0.023) and severe fibrosis (RR = 4.57, p = 0.013). Insulin therapy was significantly associated with non-alcoholic steatohepatitis (RR = 1.89, p = 0.001) and fibrosis (RR = 1.75, p = 0.050) when all patients were analysed, but when only patients with diabetes were analysed, insulin therapy was not associated with non-alcoholic steatohepatitis or fibrosis. Conclusion Type 2 diabetes mellitus plays an important role in the progression of non-alcoholic fatty liver disease as an independent risk factor for severe fibrosis.
Published: 2018

22. Peer support intervention as a tool to address college students’ mental health amidst the COVID-19 pandemic

Author: Anna Viduani, Daniel Luccas Arenas, Simone Hauck, and Ana Margareth Siqueira Bassols
Subjects: Male, medicine.medical_specialty, Adolescent, Universities, Physical Distancing, MEDLINE, Anxiety, Peer support, Psychological Distress, Peer Group, Young Adult, Social support, Intervention (counseling), Pandemic, medicine, Humans, Young adult, Students, Psychiatry, SARS-CoV-2, COVID-19, Social Support, Peer group, Mental health, Psychiatry and Mental health, Mental Health, Adolescent Behavior, Communicable Disease Control, Female, Psychology, Brazil, Internet-Based Intervention
Published: 2020
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23. Safety of hospital discharge before return of bowel function after elective colorectal surgery

Author: J Chapman, S, Blanco-Colino, R, Pérez-Ajates, S, O Anabitarte Bautista, Hodson, J, C Glasbey, J, Pata, F, Pellino, G, Sgrò, A, Soares, A, T van Elst, S Van Straten, Nepogodiev, D, Borakati, A, F Bath, M, H Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Žebrák, R, Paramasivam, R, Martensen, A, M Larsen, H, Rädeker, L, E Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Schaeff, V, Otto, A, Jakubauskas, M, R van Elst, T, Chu, M, Pvb, Fagan, I Wells, C, A Alagoa João, Juloski, J, Y El Kasmy El Kasmi, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, B Ozkan, B, A Yagız Sen, K Aktas, M, E Baki, B, Yüksek, B, Kamarajah, S, A Khaw, R, Mills, E, Goodson, R, Thakral, N, D Ablett, A, Adra, M, Kwek, I, M Khan, S, Quinn, P, R Manley, L, Badran, A, Ramjeeawon, A, Campbell, A, L Tan, H, S Rye, D, Rajaraman, N, G Norman, J, Vutipongsatorn, K, Solomou, G, Akhbari, M, Ali, A, Murray, V, M Baker, D, D Brandao, B, Stainer, B, Thavayogan, R, Jones, D, O Onafowokan, O, Gharooni, A, Dabab, N, Carlton-Carew, S, Kungwengwe, G, Gabriel, M, Sewart, E, C Shortland, T, Lawday, S, Pockney, P, Dawson, A, D Brumfitt, C, Stewart, P, B, Ng, K Luong, J, Ivanov, V, Borisova, A, Neykov, V, Kunčarová, K, Kološová, B, Antonova, T, Farkašová, M, L Harbjerg, J, Brandsborg, S, Brinck, S, D Kjaer, M, Mark-Christensen, A, P Unbehaun, K, Dalsgaard, P, D Lycke, K, Lenaoures, P, Brigand, C, Dumange, E, Gout, M, Moehwald, C, Prem, M, Alhalabi, O, Sliwinski, S, Krupp, J, Gablenz, E, Schmitzer, L, Kopp, A, Steinle, J, Gsenger, J, J Pohl, L, Riccardi, M, M Christodoulou, I, Konstantinidis, M, Machairas, N, Zoikas, A, Balalis, D, K Manatakis, D, L Aguilera, M, Marano, L, Fleres, F, Lovisetto, F, Sasia, D, Segalini, E, Pata, G, Lucchi, A, Sagnotta, A, Campagnaro, T, Petrelli, F, Gallo, G, Papandrea, M, Testa, V, Sinibaldi, G, F Di Candido, Colombo, F, Perrone, G, Aresu, S, Biancafarina, A, Canonico, G, Pagnanelli, M, Curletti, G, Bini, R, A de Manzoni Garberini, Impellizzeri, H, Cillara, N, Tutino, R, Picciariello, A, Coletta, D, Savino, G, Ferrara, F, Tamini, N, Talamo, G, Parini, D, Giamundo, P, A Lo Conte, Pagano, G, Ripetti, V, Pesce, A, Menduni, N, Giudicissi, R, Goldin, E, Rega, D, Belli, A, Andriola, V, Gordini, L, Foppa, C, Piccolo, G, Birindelli, A, Ferrari, C, Ballarini, Z, Tirelli, F, Milone, M, M De Rosa, S Pipitone Federico, N, Molteni, B, L Tilocca, P, Sancini, G, N Piozzi, G, Lauretta, A, Poillucci, G, Mulas, S, Simcikas, D, Portelli, L, Jwm van Wijnbergen, L Dinger, T, Sfh Ten Doesschate, Ashm van Dalen, D van den Bos, D, Hansmann, M, J Medina Feliz, Z Kuiper, S, Abdulrahman, Z, R Pruijssers, S, Farik, S, M Elliott, B, P Geneta, V, Wilton, S, Kandelaki, H, L Peng, S, Campbell, S, K Lim, Y, S Yassaie, S, Murray, M, Haran, C, Tan, J, Castro, J, Laranjeira, A, Catarino, S, Neves-Marques, C, G Correia, J, N Vieira, B, C Quintela, A, L Serra, M, Maciel, J, Cunha, M, J Aparício, D, Neves, J, Azevedo, J, Romano, M, Eiró, F, Romano, J, Monteiro, C, Claro, M, R Almeida, M, Peyroteo, M, D Machado, N, Capote, H, Ferreira, M, Sousa, X, Devesa, H, Cavadas, D, Guerreiro, I, Costa, M, Rosete, M, Salman, M, English, C, Mohammed, N, Litvin, A, V Ćuk, V, Mészárosová, K, Jaich, R, H De Lima, Brooks, S, Marx, M, M Nshalati Salvation, J García Cardo, Mora-Guzmán, I, J Sancho Muriel, U de Andres Olabarria, Muriel, P, C Jimenez Viñas, Alconchel, F, O Esteban Sinovas, C Fairén Oro, M López Otero, S Figueroa Jiménez, O Claramonte Bellmunt, J Martínez Caballero, Rubio-Pérez, I, M Aguilar-Martínez, M, J Segura-Sampedro, J, C Olmedo Moreno, D Negre Parra, M Estévez Diz, A, Martín-Balbuena, R, C Bustamante Recuenco, E Licardie Bolaños, R, Fernández, P, A Díaz Padillo, Forero-Torres, A, I Alberdi San Román, H Salvador Rosés, M Merayo Álvarez, P Villarejo Campos, C Lopes Moreira, C, P Uriol Peralta, M Serrano Navidad, Ripollés-Melchor, J, Garcea, A, H Gómez Facundo, P Troncoso Pereira, V Pérez Guarinos, C, Blaser, B, Piazza, G, Gagliardi, B, Serin, H, S Yurdaor, S, Arslan, E, Kopac, O, Uyanik, A, B Ozmen, B, Tiftik, E, Aksoy, B, Yalcinkaya, A, Ozoglu, F, D Kocer, M, Bilicen, G, N Cinar, E, Uslu, Ö, Kaya, Y, Demirci, K, Wong, J, Mmh, Farhan-Alanie, Suresh, G, Asif, A, J Finch, B, Bhahirathan, Y, Herron, J, Z Yi Tew, Obukofe, R, Russell, C, Suchett-Kay, I, Netke, T, Williams, L, Kisiel, A, Y Liu, F, Claireaux, H, James, P, Mondal, A, Kalderon, R, H Nadama, H, Al-Saraff, Z, Jph, Tam, Powell-Chandler, A, Wood, F, Rebecca, Gorgievska, Ragavoodoo, A, Thakrar, C, Rojoa, D, Palmer, C, Davidson, K, Giacci, L, Hale, J, W Gan, F, Makin-Taylor, R, Y Hey, C, Toh, C, M Findlay, J, Griffiths, N, Ganesananthan, S, Jasionowska, S, Poustie, M, Wong, C, Turner, T, Pyc, W, Sloper, W, Warner, C, Coey, J, Mason, D, Sait, S, Kowal, M, Owen, M, Saiyed, A, Ashworth, I, Akbari, K, Curran, M, Martin, P, Parker, D, Kwok, K, Lye, C, Ghaly, M, Sammour, T, Lewis, D, Mundasad, R, Wilkes, A, Ctercteko, G, Maslyankov, S, Dimov, R, Iliev, S, Dimitrov, D, Marek, F, Örhalmi, J, Skalický, P, Skalický, T, Chrz, K, Christensen, P, Worsøe, J, S Kristensen, E, J Emmertsen, K, S Loeve, U, L Mihaljevic, A, Herrle, F, M Konstantinidis, K, Korkolis, D, Karanikas, I, Vincenti, L, Anania, G, Borghi, F, Agresta, F, Maretto, I, Parisi, A, Bucci, L, G De Palma, Guglielmi, A, Cucinotta, E, F La Torre, Cianchi, F, Guerrieri, M, Trompetto, M, Persiani, R, Micheletto, G, Delrio, P, Cantafio, S, Ronconi, M, Pag, Bisagni, M De Prizio, Franceschi, A, Galleano, R, Cavallini, M, Brescia, A, D'Ambra, L, Benevento, A, Niolu, P, Calgaro, M, Colangelo, E, Grottola, T, F Altomare, D, Puleo, S, Salamone, G, Pietrabissa, A, Poggioli, G, Erdas, E, Ottonello, R, Tonini, V, Selvaggi, F, Sammarco, G, Ceccarelli, G, C De Nisco, Surgo, D, Taglietti, L, Ozolins, A, Sivinš, A, Poskus, T, Psaila, J, A Bemelman, W, J Graat, L, Langenhoff, B, Bpl, Wijnhoven, Ahw van de 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Kenny R., Kan P., Lee D.E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Llavall A.C., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y.L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Burford C., Huq T., Irwin E., Matthews L., Ngu W.S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C.S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S.P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., Kler A., Reynolds L., Mohamed S.H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J.Y., Lim D.W.E., Buick T., Boland M., Piya S., Devlin R., Fairfield C.J., George R.J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J.L., Hammond R.F.L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., 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M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D.B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I.R., Senorans M.P.G., Amor L.G., Ramirez A.C., Abrisqueta J., Gomez M.E., Arroyo A., Cerdan C., Romeu N.G., Enriquez-Navascues J.M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F.A., Eray I.C., Biyiklioglu O., Cetin M.F., Isik A.E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A.A., Al-hadithi A., Lau I.S.F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Livie J., Chaudhry F.A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Salman M., Skejo, Licari L., Men, Chapman, S. 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Z., Abdulrahman, Z., Pruijssers, S. R., Geneta, V. P., Chu, M., Wilton, S., Kandelaki, H., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Murray, M., Haran, C., Tan, J., Castro, J., Laranjeira, A., Catarino, S., Neves-Marques, C., Correia, J. G., Vieira, B. N., Quintela, A. C., Serra, M. L., Maciel, J., Cunha, M., Aparicio, D. J., Neves, J., Azevedo, J., Romano, M., Eiro, F., Romano, J., Monteiro, C., Claro, M., Capote, H., Ferreira, M., Sousa, X., Peyroteo, M., Machado, N. D., Guerreiro, I., Costa, M., Rosete, M., Salman, M., English, C., Mohammed, N., Litvin, A., Cuk, V. V., Meszarosova, K., Jaich, R., De Lima, H., Brooks, S., Marx, M., Salvation, M. N., Cardo, J. G., Mora-Guzman, I., Muriel, J. S., de Andres Olabarria, U., Muriel, P., Vinas, C. J., Alconchel, F., Sinovas, O. E., Oro, C. F., Otero, M. L., Jimenez, S. F., Bellmunt, O. C., Caballero, J. M., Rubio-Perez, I., Aguilar-Martinez, M. M., Segura-Sampedro, J. J., Moreno, C. O., Parra, D. N., Diz, A. M. 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M., Griffiths, N., Ganesananthan, S., Jasionowska, S., Poustie, M., Wong, C., Turner, T., Pyc, W., Sloper, W., Warner, C., Coey, J., Mason, D., Sait, S., Kowal, M., Owen, M., Saiyed, A., Ashworth, I., Akbari, K., Curran, M., Martin, P., Parker, D., Kwok, K., Lye, C., Ghaly, M., Sammour, T., Lewis, D., Mundasad, R., Wilkes, A., Ctercteko, G., Maslyankov, S., Dimov, R., Iliev, S., Dimitrov, D., Marek, F., Orhalmi, J., Skalicky, P., Skalicky, T., Chrz, K., Christensen, P., Worsoe, J., Kristensen, E. S., Emmertsen, K. J., Loeve, U. S., Mihaljevic, A. L., Herrle, F., Konstantinidis, K. M., Korkolis, D., Karanikas, I., Vincenti, L., Anania, G., Borghi, F., Agresta, F., Maretto, I., Parisi, A., Bucci, L., De Palma, G., Guglielmi, A., Cucinotta, E., La Torre, F., Cianchi, F., Guerrieri, M., Trompetto, M., Persiani, R., Micheletto, G., Delrio, P., Cantafio, S., Ronconi, M., Bisagni, P. A. 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G., Hubner, M., Petermann, D., Sauvain, M. O., Ozben, V., Gecim, I. E., Disci, E., Rencuzogullari, A., Kurt, A., Bisgin, T., Pehlivan, M., Isik, A., Onur, E., Leventoglu, S., Keskin, M., Guner, A., Sahin, S. T., Ozbalci, G. S., Pergel, A., Albayrak, D., Bruce, D., Fearnhead, N., Arthur, J., Harron, M., Beattie, G., Titu, L., Saunders, M., Phillips, J., Dindyal, S., Cresswell, B., Gercek, Y., Lee, J., Linn, T., Faulkner, G., Lockwood, S., Rees, J., Charalabopoulos, A., Campbell, B., Kontovounisios, C., Amarnath, T., Johnson, M., Epanomeritakis, E., Vigs, S., Nastro, P., Gilliam, A., Smolarek, S., Wilson, T., Orbell, J., Mcintyre, R., Agarwal, T., Hainsworth, P., Patel, P., Vijay, J., Liu, B., Rao, P. D., Roxburgh, C., Vipond, M., Youssef, H., Thorn, C., Schizas, A., Denley, S., Bowley, D., Das, K., Cuming, T., Saha, A., Chung, L., Pitt, J., Davis, P., Jones, O., Taylor, M., Bhargava, A., Haji, A., Watson, N., Bloom, I., Singh, B., Norwood, M., Gurjar, S., Stylianides, N., Mirza, S., Evans, M., Williams, G., Patil, P., Hernon, J., Finch, G., Green, S., Chapple, K., Fafemi, O., Warusavitarne, J., Samee, A., Carden, C., Ong, L., Verma, K., Joseph, A., Rawat, N., Pinkney, T., Oke, O., Glen, P., Maxwell-Armstrong, C., Oliphant, R., Garner, J., Moug, S. J., Middleton, S., Lund, J. N., Smart, N. J., Osborn, G., Moore, T., Raymond, T., Knowles, C. H., Hany, T. S., Clarke, R., Khera, G., Brady, R., Sellahewa, C., Mason, C., Torrance, A., Lasithiotakis, K., Knight, J., Pullybank, A., Ainsworth, P., Reid, F., Ramwell, A., Maslekar, S., George, R., Skull, A., Holtham, S., Muhammad, K., Lal, R., Varcada, M., Smith, F. M., Howlader, M., Defriend, D., Kirk, S., Richards, T., Evans, C., Borg, C. 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W., Gabbas, G., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Morino, M., Mistrangelo, M., Clerico, G., De Santi, G., Bitonti, M. F., Frattalone, M., Fico, V., Santullo, F., Belia, F., Spinelli, A., Marco, M., Bevilacqua, M., Tringali, D., Bevilacqua, E., Panizzo, V., La Manna, V., Migliore, G., Aversano, A., Bucci, A. F., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Barberis, A., Serra, D., Grassia, M., Romelli, M., Ruggiero, S., Percassi, A., Piccinini, A. 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X., Peckham, H., Yeoh, T., Yong, S. Q., Chen, J. Y., Siva, S., Sam, Z. H., Gilani, M., Goh, Y. N., Muthukumar, M. G., Phillips, S., Tjoakarfa, J., Giri, A., Suresan, S., Thomas, P., Johnson, T. A., Williams, R. I., Rashid, A., Kushairi, A., Rais, A., James, A., Bugelli, M., Chechelnitskaya, Y., Sandhu, N., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Bradley, E., Mctiernan, M., Macdonald, S., Sharkey, S., Mclaughlin, N., Amey, C., Kraria, L., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Jegatheeswaran, L., Madhavan, A., Warne, M., Malcolm, F. L., Lessware, T., Wilkerson, H. T., Chatterjee-Woolman, S., Yoong, A., Ahmed, W. U. R., Longshaw, A., Flannery, O., Green, R., Leaning, M., Cragg, J., Sharriff, H., Doherty, C., Kwan, K. W. L., Sanders-Crook, L., Bhatia, S., Eames, S., Lewis, F., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Boyce, L., English, W. J., Lam, S., Chipeta, C., Jain, C., Garofalidou, T., Novotny, S. A., Locke, S., Bowman, C., Begaj, A., Murphy, C., Radcliffe, K., Chong, J. T., Jeffrey, E., Chaudhury, N., Rajendran, K., Akbar, Z., Walters, B., Kulendrarajah, B., Tran, N., Shrestha, S., Parmar, S., Gallagher, C., Hennessy, L., Pentti, E., Badhrinarayanan, S., Fung, A., Mansoor, M., Kenny, R., Kan, P., Lee, D. E., Khosla, S., Samake, M., Shaban, F., Aftab, R., Gough, M., Woodburn, B., Vayalapra, S., Mcmurrugh, K., Jimulia, D., Deol, S., Pike, S., Embury-Young, Y., Patel, M., Kilgallon, E., Keating, R., Walsh, A., Khan, H., Logue, G., Orekoya, M., Alasmar, M., Charalambides, M., Llavall, A. C., Williamson, E., Bharwada, Y., Zearmal, S., Evans, H., Panikkar, M., de la Cruz, G., Caplan, J., Ruparelia, A., Tanvir, T., Soare, C., Pang, Y. L., Trotter, J., Zaidi, A., Thakrar, V., Pulickal, P., Ahmed, H., Parnell, J., Lennock, S., Ford, V., Brignall, R., O'Neill, D., Hanna, R., Kane, R., Nicola, M., Rajput, K., Xiao, Y., Michael, S., Wright, E., Juniper, S., Thompson, E., Hoskyns, L., Kanitkar, A., Ross, C., Unsworth, A., Rshaidat, H., Demarre, K., Chiang, A., Bareh, A., van Dellen, J., Faqihinejad, C., Gadhvi, A., Grant, R., Lewsey, J., Morris, A., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Palkhi, A., Bhopal, S., Burford, C., Huq, T., Irwin, E., Matthews, L., Ngu, W. S., Hosfield, T., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Chowdhury, H., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Christie, S., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Brayley, J., Palmer, A., Charalambos, M., Jones, C. S., Toner, S., Cowden, R., Lee, L., Nicol, P., Holman, O., Imtiaz, M., Albert, V., Leung, S. P., Erotocritou, M., Stroud, R., Wilkin, R., Thomson, W., Mackee, L., Kler, A., Reynolds, L., Mohamed, S. H., Majeed, Y., Fakim, B., Jones, A., Liversedge, G., Carrington, Z., Windebank, J., Izzarina, A., Akbani, U., Craven, J., Aldarragi, A., Harding, S., Millward, A., Bedford, M., Gopalan, V., Midgen, A., Khadka, P., Cheng, O., Taneja, S., Manobharath, N., Kok, J. Y., Lim, D. W. E., Buick, T., Boland, M., Piya, S., Devlin, R., Fairfield, C. J., George, R. J., Rahi, M., Zaman, S., Hajiev, S., Ross, T., Crisp, E., Thompson, C., Charalambous, A., Hollywood, J. L., Hammond, R. F. L., Matthews, J., Mendonca, V., Spinty, J., Khan, K., Cheng, J., Glynn, N., Muhammad, U., Khan, M., Anderson, L., Mccormack, K., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Nelson, L., Ratnasingham, D., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Horner, C., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Ng, J., Jung, M., Lee, Y. D., Harris, M., White, S., Boev, B., Tonchev, P., Prochazka, V., Risko, J., Skalicky, A., Ravn, S., Ojakaar, A., Dorr-Harim, C., Koutserimpas, C., Giraudo, G., Armellini, A., Ruzzenente, A., Mazzeo, C., De Padua, C., Luc, A. R., Maroli, A., Vitali, M., Gusai, G. P., Quattromani, R., Virgilio, E., Berti, S., Di Mola, F. F., Papagni, V., Tuminello, F., Vittori, L., Longheu, A., Loche, G. A., Braccio, B., De Luca, E., Resta, G., Ancans, G., Tamosiunas, A., Petrulionis, M., Abdulrahman, N., van de Pas, K. G. H., Thomas, G., Brandsma, A. M., Davids, J., Rottier, S. J., de Roy van Zuidewijn, D., Hawkins, R., Ong, H. I., Li, Y., Desmond, B., Winstanley, J., Martins, M., Americano, M., Frade, S., Senhorinho, R., Peixoto, R., Alves-Vale, C., Lamas, M., O'Connor, D. B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Senorans, M. P. G., Amor, L. G., Ramirez, A. C., Abrisqueta, J., Gomez, M. E., Arroyo, A., Cerdan, C., Romeu, N. G., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., and Donnelly, C.
Subjects: operative, Male, postoperative discharge, Postoperative Complications, 0302 clinical medicine, Colostomy, CRITERIA, Prospective Studies, Bowel function, Colectomy, IMAGINE, stoma, intestines, Proctectomy, Ileostomy, digestive, oral, and skin physiology, patient discharge, colorectal surgery, hospital discharge, bowel function, RECOVERY, Middle Aged, adult, colostomy, elective surgical procedures, female, follow-up studies, humans, ileostomy, ileus, male, middle aged, multivariate analysis, patient readmission, patient safety, postoperative complications, prospective studies, recovery of function, colectomy, proctectomy, Patient Discharge, Colorectal surgery, ileus - - discharge - bowel function - elective - colorectal surgery, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Patient Safety, Cohort study, safety, Adult, medicine.medical_specialty, Ileus, Patient Readmission, defecation, 03 medical and health sciences, medicine, Hospital discharge, Humans, colorectal surgery, colorectal resection, Colorectal resection, defecation, postoperative complications, colorectal surgery, intestines, patient discharge, patient readmission, safety, surgical procedures, operative, colorectal resection, ileus, business.industry, Recovery of Function, Odds ratio, medicine.disease, digestive system diseases, surgical procedures, Surgery, Multivariate Analysis, Defecation, business, Follow-Up Studies
Abstract: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110).Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.El íleo es frecuente tras la cirugía colorrectal y se asocia con un aumento del riesgo de las complicaciones postoperatorias. Identificar las características de una recuperación normal del tránsito y la idoneidad para el alta hospitalaria es una tarea difícil. Este estudio examinó la seguridad del alta hospitalaria antes del restablecimiento de la función intestinal. MÉTODOS: Se llevó a cabo un estudio de cohortes prospectivo y multicéntrico a través de una red de colaboración internacional. Se incluyeron pacientes adultos sometidos a resección electiva colorrectal entre enero y abril 2018. El objetivo principal fue el reingreso hospitalario durante los 30 primeros días tras la intervención. Se utilizó un análisis de regresión multivariable para evaluar el impacto del momento del alta en función del restablecimiento de la función intestinal. El objetivo secundario fue las complicaciones postoperatorias en los primeros 30 días después de la cirugía, valoradas mediante el sistema de clasificación de Clavien-Dindo.Se incluyeron en el análisis 3.288 pacientes, de los cuales 301 (9,2%) fueron dados de alta antes del restablecimiento de la función intestinal. La mediana de la estancia hospitalaria de los pacientes dados de alta antes y después del restablecimiento de la función intestinal fue 5 (rango intercuartílico: 4-7) y 7 (6-8) días, respectivamente (P 0,001). No hubo diferencias significativas en las tasas de reingreso entre estos grupos (6,6% versus 8,0%; P = 0,499), y este resultado se mantuvo en el análisis multivariable tras el ajuste por diferencias basales (razón de opotunidades, odds ratio, OR 0,90; i.c. del 95% 0,55-1,46, P = 0,659). Las tasas de complicaciones postoperarorias fueron similares en aquellos dados de alta antes o después del restablecimiento de la función intestinal (complicaciones menores: 34,7% versus 39,5%; complicaciones mayores 3,3% versus 3,4%; P = 0,110). CONCLUSIÓN: Dar de alta antes del restablecimiento de la función intestinal tras cirugía colorrectal electiva parece ser seguro en pacientes debidamente seleccionados.
Published: 2020
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24. Use of Static Cutoffs of Hypertension to Determine High cIMT in Children and Adolescents: An International Collaboration Study

Author: Min Zhao, Angela Amante, Lili Yang, Anna Prats-Puig, Thacira Dantas Almeida Ramos, Costan G. Magnussen, Bo Xi, Wang Shui, Liu Yang, Mingming Wang, Evangelos Grammatikos, George S. Stergiou, Mônica de Oliveira Simões, Berta Mas-Pares, Lucia Pacifico, Gemma Carreras-Badosa, Carla Campos Muniz Medeiros, Mieczysław Litwin, Danielle Franklin de Carvalho, Elisabetta L. Romeo, Silvia Xargay-Torrent, John E. Deanfield, Thomas Reinehr, Anastasios Kollias, Peter H. Whincup, Christopher G. Owen, Carmelo A. Caserta, Judit Bassols, Abel López-Bermejo, and Tatianne Moura Estrela Gusmão
Subjects: Male, Pediatrics, medicine.medical_specialty, Percentile, Pediatric Obesity, Adolescent, Population, Blood Pressure, 030204 cardiovascular system & hematology, Global Health, Carotid Intima-Media Thickness, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, medicine, Humans, 030212 general & internal medicine, education, Child, education.field_of_study, Receiver operating characteristic, business.industry, Guideline, Odds ratio, Confidence interval, Blood pressure, Cross-Sectional Studies, Hypertension, Female, Morbidity, Cardiology and Cardiovascular Medicine, business, Body mass index
Abstract: Background Pediatric hypertension is typically defined as blood pressure ≥ sex-, age-, and height-specific 95th percentile (high) cutoffs. Given the number of strata, there are hundreds of cutoffs for defining elevated and high blood pressure that make it cumbersome to use in clinical practice. This study aimed to evaluate the utility of the static cutoffs for pediatric hypertension (120/80 mm Hg for children and 130/80 mm Hg for adolescents) in determining high carotid intimamedia thickness (cIMT) in children and adolescents. Methods Data were from 6 population-based cross-sectional studies in Brazil, China, Greece, Italy, Spain, and the United Kingdom. A total of 4280 children and adolescents, aged 6 to 17 years, were included. High cIMT was defined as cIMT ≥ sex-, age- and cohort-specific 90th percentile cutoffs. Results Compared with normal blood pressure, hypertension defined using the percentile-based cutoffs from 2017 American Academy of Pediatrics guideline, and the static cutoffs were associated with similar higher odds for high cIMT (percentile-based cutoffs: odds ratio [OR], 1.46, 95% confidence interval [CI], 1.15-1.86; static cutoffs: OR, 1.65, 95% CI, 1.25-2.17), after adjustment for sex, age, race/ethnicity, body mass index, high-density lipoprotein-cholesterol, triglyceride, and fasting blood glucose. The similar utility of 2 definitions in determining high cIMT was further confirmed by area under the receiver operating characteristic curve and net reclassification improvement methods (P for difference > 0.05). Conclusion Static cutoffs (120/80 mm Hg for children, 130/80 mm Hg for adolescents) performed similarly compared with percentile-based cutoffs in determining high cIMT, supporting the use of static cutoffs in identifying pediatric hypertension in clinical practice.
Published: 2019

25. Circulating IGF-1 Independently Predicts Blood Pressure in Children With Higher Calcium-Phosphorus Product Levels

Author: Esther Lizarraga-Mollinedo, Silvia Xargay-Torrent, Mercè Montesinos-Costa, Berta Mas-Pares, Lourdes Ibáñez, Estefanía Dorado-Ceballos, Judit Bassols, Abel López-Bermejo, Francis de Zegher, and Anna Benavides-Boixader
Subjects: Male, medicine.medical_specialty, Waist, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Blood Pressure, Biochemistry, Cohort Studies, Endocrinology, Insulin resistance, Risk Factors, Internal medicine, Vitamin D and neurology, medicine, Calcium-phosphorus product, Humans, Longitudinal Studies, Age of Onset, Insulin-Like Growth Factor I, Child, business.industry, Chemistry, Insulin, Biochemistry (medical), Confounding, Phosphorus, medicine.disease, Prognosis, Pulse pressure, Blood pressure, Cardiovascular Diseases, Spain, Child, Preschool, Hypertension, Homeostatic model assessment, Calcium, Female, business, Biomarkers
Abstract: Objective To study the association between insulin-like growth factor 1 (IGF-1) and blood pressure in children, in particular, the potential interaction with the serum calcium-phosphorus product (Ca*P). Methods A longitudinal study included 521 children (age 8.8 ± 0.1) from northeastern Spain, of whom 158 were followed-up after 5 years. IGF-1, insulin-like growth factor-binding protein 3 (IGFBP-3), and serum calcium and phosphorus were measured at baseline. Anthropometric (body-mass index [BMI] and waist) and cardiometabolic variables (systolic [SBP] and diastolic blood pressure), pulse pressure, insulin, homeostatic model assessment of insulin resistance [HOMA-IR], high-density lipoprotein [HDL]-cholesterol, and triglycerides) were assessed at baseline and at the end of follow-up. Statistical analysis included Pearson correlations followed by multivariable linear regression analyses. Results Baseline IGF-1 and IGF-1/IGFBP-3 molar ratio positively correlated with baseline and follow-up BMI, waist, SBP, pulse pressure, insulin, HOMA-IR and triglycerides (r 0.138-0.603; all P < 0.05). The associations with SBP were stronger with increasing Ca*P (r 0.261-0.625 for IGF-1; and r 0.174-0.583 for IGF-1/IGFBP-3). After adjusting for confounding variables, baseline IGF-1 and IGF-1/IGFBP-3 remained independently associated with both baseline and follow-up SBP in children in the highest Ca*P tertile (β = 0.245-0.381; P < 0.01; model R2 = 0.246-0.566). Conclusions Our results suggest that IGF-1 in childhood is an independent predictor of SBP in apparently healthy children, especially in those with high Ca*P levels.
Published: 2019

26. Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

Author: Cristina Óvilo, Anna Bassols, Daniel Valent, Consolacion Garcia-Contreras, Laura Arroyo, Antonio Gonzalez-Bulnes, Marta Vazquez-Gomez, and Beatriz Isabel
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, Swine, Offspring, Intrauterine growth restriction, Hippocampus, Amygdala, 03 medical and health sciences, chemistry.chemical_compound, Catecholamines, Limbic system, 0302 clinical medicine, Developmental Neuroscience, Pregnancy, Dopamine, Internal medicine, medicine, Animals, Chromatography, High Pressure Liquid, reproductive and urinary physiology, Neurotransmitter Agents, Sex Characteristics, Fetal Growth Retardation, Body Weight, Homovanillic acid, Age Factors, Brain, Neurotransmitters, medicine.disease, female genital diseases and pregnancy complications, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Animals, Newborn, chemistry, Indoleamines, Female, Psychology, 030217 neurology & neurosurgery, Developmental Biology, medicine.drug, Sex characteristics
Abstract: The current study aimed to determine, using a swine model of intrauterine growth restriction (IUGR), whether short- and long-term neurological deficiencies and interactive dysfunctions of Low Birth-Weight (LBW) offspring might be related to altered pattern of neurotransmitters. Hence, we compared the quantities of different neurotransmitters (catecholamines and indoleamines), which were determined by HPLC, at brain structures related to the limbic system (hippocampus and amygdala) in 14 LBW and 10 Normal Body-Weight (NBW) newborn piglets. The results showed, firstly, significant effects of sex on the NBW newborns, with females having higher dopamine (DA) concentrations than males. The IUGR processes affected DA metabolism, with LBW piglets having lower concentrations of noradrenaline at the hippocampus and higher concentrations of the DA metabolites, homovanillic acid (HVA), at both the hippocampus and the amygdala than NBW neonates. The effects of IUGR were modulated by sex; there were no significant differences between LBW and NBW females, but LBW males had higher HVA concentration at the amygdala and higher concentration of 5-hydroxyindoleacetic acid, the serotonin metabolite, at the hippocampus than NBW males. In conclusion, the present study shows that IUGR is mainly related to changes, modulated by sex, in the concentrations of catecholamine neurotransmitters, which are related to adaptation to physical activity and to essential cognitive functions such as learning, memory, reward-motivated behavior and stress. © 2016 ISDN
Published: 2016
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27. Gestational diabetes is associated with changes in placental microbiota and microbiome

Author: Abel López-Bermejo, José Manuel Fernández-Real, Gemma Carreras-Badosa, Rémy Burcelin, Vincent Blasco-Baque, Judit Bassols, and Matteo Serino
Subjects: Adult, DNA, Bacterial, 0301 basic medicine, endocrine system diseases, Placenta, Gene Expression, Physiology, Biology, Blood cell, 03 medical and health sciences, 0302 clinical medicine, Immune system, Pregnancy, RNA, Ribosomal, 16S, medicine, Humans, Calcium Signaling, Microbiome, 030219 obstetrics & reproductive medicine, Acinetobacter, Microbiota, Human microbiome, nutritional and metabolic diseases, medicine.disease, Phenotype, female genital diseases and pregnancy complications, Gestational diabetes, Diabetes, Gestational, RNA, Bacterial, Interleukin 10, 030104 developmental biology, medicine.anatomical_structure, Case-Control Studies, Pediatrics, Perinatology and Child Health, Cytokines, Female, Gammaproteobacteria
Abstract: The human microbiota is a modulator of the immune system. Variations in the placental microbiota could be related with pregnancy disorders. We profiled the placental microbiota and microbiome in women with gestational diabetes (GDM) and studied its relation to maternal metabolism and placental expression of anti-inflammatory cytokines. Placental microbiota and microbiome and expression of anti-inflammatory cytokines (IL10, TIMP3, ITGAX, and MRC1MR) were analyzed in placentas from women with GDM and from control women. Fasting insulin, glucose, O’Sullivan glucose, lipids, and blood cell counts were assessed at second and third trimester of pregnancy. Bacteria belonging to the Pseudomonadales order and Acinetobacter genus showed lower relative abundance in women with GDM compared to control (P < 0.05). In GDM, lower abundance of placental Acinetobacter associated with a more adverse metabolic (higher O’Sullivan glucose) and inflammatory phenotype (lower blood eosinophil count and lower placental expression of IL10 and TIMP3) (P < 0.05 to P = 0.001). Calcium signaling pathway was increased in GDM placental microbiome. A distinct microbiota profile and microbiome is present in GDM. Acinetobacter has been recently shown to induce IL-10 in mice. GDM could constitute a state of placental microbiota-driven altered immunologic tolerance, making placental microbiota a new target for therapy in GDM.
Published: 2016
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28. Methylation of the C19MC microRNA locus in the placenta: association with maternal and chilhood body size

Author: Abel López-Bermejo, Gemma Carreras-Badosa, Robert Feil, David B. Dunger, Anna Prats-Puig, Lourdes Ibáñez, Judit Bassols, Michael Girardot, Silvia Xargay-Torrent, Francis de Zegher, Berta Mas-Pares, Clive J. Petry, Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Department of Paediatrics, University of Cambridge [UK] (CAM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Petry, Clive J [0000-0002-6642-9825], D E Zegher, Francis [0000-0002-2491-5884], Dunger, David B [0000-0002-2566-9304], and Apollo - University of Cambridge Repository
Subjects: Adult, Male, Waist, Offspring, Endocrinology, Diabetes and Metabolism, Placenta, Parenteral transmission, Medicine (miscellaneous), Mothers, 030209 endocrinology & metabolism, Biology, Polymorphism, Single Nucleotide, Andrology, 03 medical and health sciences, Fathers, Young Adult, 0302 clinical medicine, Pregnancy, medicine, SNP, Body Size, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 030212 general & internal medicine, Child, [SDV.BDD]Life Sciences [q-bio]/Development Biology, ComputingMilieux_MISCELLANEOUS, [SDV.GEN]Life Sciences [q-bio]/Genetics, Nutrition and Dietetics, Infant, Newborn, Methylation, DNA Methylation, medicine.disease, 3. Good health, MicroRNAs, medicine.anatomical_structure, DNA methylation, Female, Chromosomes, Human, Pair 19, Follow-Up Studies
Abstract: OBJECTIVES: To study DNA methylation at the C19MC locus in the placenta and its association with (1) parental body size, (2) transmission of haplotypes for the C19MC rs55765443 SNP, and (3) offspring's body size and/or body composition at birth and in childhood. SUBJECTS AND METHODS: Seventy-two pregnant women-infant pairs and 63 fathers were included in the study. Weight and height of mothers, fathers and newborns were registered during pregnancy or at birth (n = 72). Placental DNA methylation at the C19MC imprinting control region (ICR) was quantified by bisulfite pyrosequencing. Genotyping of the SNP was performed using restriction fragment length polymorphisms. The children's body size and composition were reassessed at age 6 years (n = 32). RESULTS: Lower levels of placental C19MC methylation were associated with increased body size of mother, specifically with higher pregestational and predelivery weights and height of the mother (β from -0.294 to -0.371; R2 from 0.04 to 0.10 and all p
Published: 2019
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29. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth A Systematic Review and Meta-analysis

Author: Wichor M. Bramer, Leda Chatzi, Polina V. Popova, Lorena Mosso, Margreet Meems, Layal Chaker, Arash Derakhshan, Jordi Sunyer, Eric A. P. Steegers, Colin M. Dayan, Peter N. Taylor, Tuija Männistö, Suzanne J. Brown, Elena N. Grineva, Isolina Riaño, Ulla Feldt-Rasmussen, Judit Bassols, Emily Oken, Victor J M Pop, Jun Yoshinaga, Mònica Guxens, Juha Auvinen, Alexandra S. Tkachuck, Scott M. Nelson, Bijay Vaidya, Tanja G. M. Vrijkotte, Shafqat Mukhtar, Xuemian Lu, Christian Delles, Mario Murcia, David M. Carty, Farkhanda Ghafoor, Liangmiao Chen, Tim I M Korevaar, Elizabeth N. Pearce, Sofie Bliddal, Abel López-Bermejo, Ana Jiménez-Zabala, Laura Boucai, John P. Walsh, Beverley M. Shields, Marcel E Meima, Robin P. Peeters, Aya Hisada, Erik K. Alexander, Eila Suvanto, Marina Vafeiadi, Internal Medicine, Erasmus MC other, Child and Adolescent Psychiatry / Psychology, Obstetrics & Gynecology, Public and occupational health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, Amsterdam Reproduction & Development (AR&D), APH - Methodology, Medical and Clinical Psychology, Epidemiology, and Applied Economics
Subjects: Thyrotropin/blood, Iodide Peroxidase/immunology, Premature Birth/etiology, Thyrotropin, Hypothyroidism/complications, Thyroid Function Tests, 01 natural sciences, Thyroxine/blood, 0302 clinical medicine, Maternal hypothyroidism, Thyroid Diseases/blood, Pregnancy, Euthyroid, 030212 general & internal medicine, 030219 obstetrics & reproductive medicine, biology, medicine.diagnostic_test, Obstetrics, Thyroid disease, Absolute risk reduction, Obstetrics and Gynecology, Gestational age, General Medicine, Premature birth, Premature Birth, Female, Thyroid function, medicine.drug, Adult, endocrine system, medicine.medical_specialty, Levothyroxine, Gestational Age, Iodide Peroxidase, Thyroid function tests, Autoimmune Diseases, 03 medical and health sciences, Hypothyroidism, Thyroid peroxidase, medicine, Very Preterm Birth, Humans, 0101 mathematics, Autoantibodies, business.industry, 010102 general mathematics, Infant, Newborn, Infant, Odds ratio, Newborn, medicine.disease, Thyroid Diseases, Pregnancy Complications/blood, Pregnancy Complications, Thyroxine, Autoimmune Diseases/blood, biology.protein, Autoantibodies/blood, business
Abstract: Preterm birth complicates 5% to 15% of births worldwide, and although it is the most important direct cause of morbidity and mortality in children younger than 5 years, no known risk factors can be identified in the majority of cases. However, overt hypothyroidism and hyperthyroidism during pregnancy are well-known risk factors for preterm birth, and as such, the purpose of this study was to assess whether thyroid function test abnormalities and thyroid peroxidase (TPO) antibody positivity were associated with preterm birth. The study conducted a systematic review on the association of thyroid function or autoimmunity with preterm birth published from database inception to March 18, 2018, without language restrictions, using the Ovid MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar databases. Possible studies for inclusion were independently assessed for suitability by 2 of the authors, and study quality and risk of bias were assessed using the Newcastle-Ottawa Scale. Then, authors were contacted to ascertain interest in participating in the individual patient meta-analysis. The primary outcome was preterm birth defined as a gestational age at birth of less than 37 weeks, as assessed using either ultrasound measurements or time after the last menstrual period. Secondary outcomes were very preterm birth (
Published: 2019

30. Renal size and cardiovascular risk in prepubertal children

Author: Francis de Zegher, Judit Bassols, Lourdes Ibáñez, Esther Lizarraga-Mollinedo, Berta Mas-Pares, Abel López-Bermejo, Elena Riera-Pérez, Cristina Padrós-Fornieles, Anna Prats-Puig, Jose-Maria Martinez-Calcerrada, Silvia Xargay-Torrent, and Gemma Carreras-Badosa
Subjects: Male, CHRONIC KIDNEY-DISEASE, 0301 basic medicine, Multivariate analysis, Kidneys -- Diseases, lcsh:Medicine, Blood Pressure, BLOOD-PRESSURE, Renal length, Overweight, Kidney, Carotid Intima-Media Thickness, INTIMA-MEDIA THICKNESS, GLOMERULAR-FILTRATION-RATE, Insuficiència renal crònica en els infants, 0302 clinical medicine, Risk Factors, Medicine, Child, lcsh:Science, Multidisciplinary, Kidney diseases, Anthropometry, ASSOCIATION, Multidisciplinary Sciences, Cardiovascular system, medicine.anatomical_structure, Cardiovascular Diseases, Cardiology, Science & Technology - Other Topics, Female, medicine.symptom, Chronic renal failure in children, Sistema cardiovascular -- Malalties en els infants, medicine.medical_specialty, Ronyons -- Malalties, Article, Adipose capsule of kidney, 03 medical and health sciences, AGE, Internal medicine, Humans, cardiovascular diseases, Sistema cardiovascular, Science & Technology, HYPERTENSION, business.industry, lcsh:R, medicine.disease, BIRTH-WEIGHT, NEPHRON NUMBER, 030104 developmental biology, Blood pressure, Multivariate Analysis, VOLUME, Linear Models, Malalties del ronyó, lcsh:Q, business, 030217 neurology & neurosurgery, Kidney disease, Cardiovascular diseases in children
Abstract: Renal size is an important parameter for the evaluation and diagnosis of kidney disease and has been associated with several cardiovascular risk factors in patients with kidney failure. These results are however discordant and studies in healthy children are lacking. We aimed to study the association between renal size (length and volume) and cardiovascular risk parameters in healthy children. Clinical, analytical and ultrasound parameters [renal length, renal volume, perirenal fat and carotid intima-media thickness (cIMT)] were determined in 515 healthy prepubertal children (176 lean, 208 overweight and 131 obese). Renal length and volume associated significantly and positively with several anthropometric and cardiovascular risk parameters including cIMT and systolic blood pressure (SBP) (all p
Published: 2019

31. Umbilical Cord miRNAs in Small-for-Gestational-Age Children and Association With Catch-Up Growth: A Pilot Study

Author: Berta Mas-Pares, Esther Lizarraga-Mollinedo, José Maria Martínez-Calcerrada, Silvia Xargay-Torrent, Francis de Zegher, Judit Bassols, Alexandra Bonmati, Anna Prats-Puig, Gemma Carreras-Badosa, Abel López-Bermejo, and Lourdes Ibáñez
Subjects: Adult, Male, medicine.medical_specialty, Multivariate analysis, Waist, Offspring, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Physiology, Context (language use), Pilot Projects, Biochemistry, Umbilical cord, Umbilical Cord, Endocrinology, Internal medicine, medicine, Humans, Risk factor, business.industry, Biochemistry (medical), Infant, Newborn, Infant, medicine.disease, MicroRNAs, medicine.anatomical_structure, Infant, Small for Gestational Age, Small for gestational age, Female, medicine.symptom, business, Weight gain, Biomarkers
Abstract: Context Catch-up growth in infants who are small for gestational age (SGA) is a risk factor for the development of cardiometabolic diseases in adulthood. The basis and mechanisms underpinning catch-up growth in newborns who are SGA are unknown. Objective To identify umbilical cord miRNAs associated with catch-up growth in infants who are SGA and study their relationship with offspring’s cardiometabolic parameters. Design miRNA PCR panels were used to study the miRNA profile in umbilical cord tissue of five infants who were SGA with catch-up (SGA-CU), five without catch-up (SGA-nonCU), and five control infants [appropriate for gestational age (AGA)]. The miRNAs with the smallest nominal P values were validated in 64 infants (22 AGA, 18 SGA-nonCU, and 24 SGA-CU) and correlated with anthropometric parameters at 1 (n = 64) and 6 years of age (n = 30). Results miR-501-3p, miR-576-5p, miR-770-5p, and miR-876-3p had nominally significant associations with increased weight, height, weight catch-up, and height catch-up at 1 year, and miR-374b-3p, miR-548c-5p, and miR-576-5p had nominally significant associations with increased weight, height, waist, hip, and renal fat at 6 years. Multivariate analysis suggested miR-576-5p as a predictor of weight catch-up and height catch-up at 1 year, as well as weight, waist, and renal fat at 6 years. In silico studies suggested that miR-576-5p participates in the regulation of inflammatory, growth, and proliferation signaling pathways. Conclusions Umbilical cord miRNAs could be novel biomarkers for the early identification of catch-up growth in infants who are SGA. miR-576-5p may contribute to the regulation of postnatal growth and influence the risk for cardiometabolic diseases associated with a mismatch between prenatal and postnatal weight gain.
Published: 2018

32. Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth

Author: Gemma, Carreras-Badosa, Xavier, Remesar, Anna, Prats-Puig, Sílvia, Xargay-Torrent, Esther, Lizarraga-Mollinedo, Francis, de Zegher, Lourdes, Ibáñez, Judit, Bassols, and Abel, López-Bermejo
Subjects: Male, Risk, Fetal Growth Retardation, Membrane Proteins, Cell Differentiation, Intra-Abdominal Fat, Rats, Fetal Development, Pregnancy, Adipocytes, Animals, Insulin, Intercellular Signaling Peptides and Proteins, Female, Obesity, Insulin Resistance, Rats, Wistar, Muscle, Skeletal
Abstract: Although prenatal and postnatal programming of metabolic diseases in adulthood is well established, the mechanisms underpinning metabolic programming are not. Dlk1, a key regulator of fetal development, inhibits adipocyte differentiation and restricts fetal growth.Assess DLk1 expression in a Wistar rat model of catch-up growth following intrauterine restriction. Dams fed ad libitum delivered control pups (C) and dams on a 50% calorie-restricted diet delivered pups with low birth weight (R). Restricted offspring fed a standard rat chow showed catch-up growth (R/C) but those kept on a calorie-restricted diet did not (R/R).Decreased Dlk1 expression was observed in adipose tissue and skeletal muscle of R/C pups along with excessive visceral fat accumulation, decreased circulating adiponectin, increased triglycerides and HOMA-IR (from p 0.05 to p 0.0001). Moreover, in R/C pups the reduced Dlk1 expression in adipose tissue and skeletal muscle correlated with visceral fat (r = -0.820, p 00001) and HOMA-IR (r = -0.745, p = 0.002).Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction. Modulation of Dlk1 expression could be among the targets for the early prevention of fetal programming of adult metabolic disorders.
Published: 2018

33. Circulating sex hormone binding globulin: An integrating biomarker for an adverse cardio-metabolic profile in obese pregnant women

Author: Judit Bassols, Pilar Soriano, Elena Alvarez-Castano, Lourdes Ibáñez, Francis de Zegher, Abel López-Bermejo, Sara Borrat-Padrosa, Anna Prats-Puig, Silvia Xargay-Torrent, Gemma Carreras-Badosa, Mª Jose Ferri, and Universitat de Barcelona
Subjects: Blood Glucose, Physiology, Maternal Health, lcsh:Medicine, Blood Pressure, Weight Gain, Biochemistry, Body Mass Index, Cohort Studies, 0302 clinical medicine, Sex hormone-binding globulin, Endocrinology, Pregnancy, Sex Hormone-Binding Globulin, YOUNG-ADULTS, Medicine and Health Sciences, Birth Weight, Insulin, Sex hormones, Testosterone, Lipid Hormones, Hormones sexuals, lcsh:Science, reproductive and urinary physiology, 030219 obstetrics & reproductive medicine, Multidisciplinary, biology, FREE TESTOSTERONE, C-Peptide, Biochemical markers, Obstetrics and Gynecology, GESTATIONAL DIABETES-MELLITUS, POLYCYSTIC-OVARY-SYNDROME, Multidisciplinary Sciences, C-Reactive Protein, POSTMENOPAUSAL WOMEN, Physiological Parameters, CARDIOVASCULAR-DISEASE, SERUM ANDROGENS, Marcadors bioquímics, Androgens, Gestation, Science & Technology - Other Topics, Obesitat, Female, Adiponectin, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Research Article, Adult, medicine.medical_specialty, Birth weight, Cardiology, 030209 endocrinology & metabolism, White People, Cardiologia, 03 medical and health sciences, MATERNAL OBESITY, Embarassades, Internal medicine, medicine, Sex Hormones, Humans, Obesity, Triglycerides, Diabetic Endocrinology, Glycated Hemoglobin, Science & Technology, business.industry, Pregnant women, lcsh:R, Body Weight, Infant, Newborn, Biology and Life Sciences, medicine.disease, BIRTH-WEIGHT, Hormones, Pregnancy Complications, biology.protein, RISK-FACTORS, Women's Health, lcsh:Q, business, Body mass index, Weight gain, Biomarkers
Abstract: Sex hormone-binding globulin (SHBG) negatively associates with pre-gestational body mass index (BMI) and gestational weight gain. The link with other cardio-metabolic risk factors in pregnant women is poorly understood. Our aim was to study the association of SHBG levels with common cardio-metabolic risk parameters in pregnant woman. Serum SHBG was quantified in 291 Caucasian pregnant women (142 with normal weight, 42 with pregestational obesity, 50 with gestational obesity and 57 with pregestational plus gestational obesity) with uncomplicated pregnancies and parturition. Cardio-metabolic [C-reactive protein (CRP), blood pressure (BP), glycosylated hemoglobin (HbAc1), glucose, C-peptide, insulin, triglycerides and high molecular weight (HMW) adiponectin], and endocrine [testosterone and estradiol] parameters were also assessed. SHBG was negatively correlated with BMI, but also with CRP, BP, HbAc1, pre and post-load glucose, C-peptide, HOMA-IR, triglycerides; and positively with HMW adiponectin (all p
Published: 2018

34. Iron Status and Metabolically Unhealthy Obesity in Prepubertal Children

Author: Gemma Carreras-Badosa, Judit Bassols, José Manuel Fernández-Real, Milton Fabian Suárez-Ortegón, Isabella Echeverri, Abel López-Bermejo, and Anna Prats-Puig
Subjects: Male, Pediatric Obesity, Adolescent, Endocrinology, Diabetes and Metabolism, Iron, Medicine (miscellaneous), Physiology, 030209 endocrinology & metabolism, Pilot Projects, Overweight, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Metabolically healthy obesity, medicine, Humans, 030212 general & internal medicine, Sexual Maturation, Child, Exercise, chemistry.chemical_classification, Metabolic Syndrome, Nutrition and Dietetics, biology, business.industry, C-reactive protein, Puberty, medicine.disease, Obesity, Ferritin, C-Reactive Protein, Cross-Sectional Studies, Phenotype, chemistry, Transferrin, Child, Preschool, biology.protein, Female, medicine.symptom, Metabolic syndrome, business, Body mass index
Abstract: This study aimed to evaluate the association of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) with iron status markers in prepubertal children.Three hundred twelve prepubertal children with overweight and obesity from a pediatric general Spanish population were evaluated. MHO and MUO were defined as obesity with the absence or presence of metabolic syndrome components. Phenotypes of metabolically healthy overweight including obesity (MHOV) and metabolically unhealthy overweight including obesity (MUOV) were also studied and defined using the same criteria. Serum ferritin, transferrin, and blood hemoglobin levels were evaluated.Prevalence rates of MHOV and MHO were 35% (n = 111/312) and 27.1% (n = 42/155), respectively. Ferritin and hemoglobin levels were higher in children with MUOV versus MHOV (P 0.05). MUO was positively associated with ferritin (beta [95% CI] = 0.43 [0.05 to 0.81]) and hemoglobin levels (0.43 [0.05 to 0.81]). These associations remained significant independently of age, sex, C-reactive protein, physical activity, and BMI/waist z scores in bivariate linear regression models. In multivariable models, transaminase levels attenuated the association of MUO with ferritin and hemoglobin levels (P 0.05).MUOV and MUO are associated with higher ferritin and hemoglobin levels in prepubertal children affected by overweight and obesity. Increased circulating ferritin in MUO might be influenced by liver injury.
Published: 2018

35. Housing and road transport modify the brain neurotransmitter systems of pigs: Do pigs raised in different conditions cope differently with unknown environments?

Author: Laura Arroyo, Anna Bassols, Ricard Carreras, Daniel Valent, Raquel Peña, Josefa Sabrià, Antonio Velarde, Producció Animal, and Benestar Animal
Subjects: Animals -- Transport, Swine, Sus scrofa, Escorxadors, Hippocampus, Social Sciences, Transportation, Biochemistry, Cortisol, 0302 clinical medicine, Catecholamines, Neurotrophic factors, Medicine and Health Sciences, Psychology, Lipid Hormones, Animal Husbandry, Amines, Prefrontal cortex, Mammals, Neurotransmitter Agents, Multidisciplinary, Behavior, Animal, Organic Compounds, Dopaminergic, Brain, Eukaryota, Neurochemistry, 04 agricultural and veterinary sciences, Neurotransmitters, Animal husbandry, Transportation Infrastructure, Adaptation, Physiological, Housing, Animal, Chemistry, Vertebrates, Physical Sciences, Medicine, Engineering and Technology, Livestock, Female, Anatomy, Neurochemicals, Abattoirs, Research Article, medicine.medical_specialty, Biogenic Amines, Serotonin, Science, Animals -- Efectes de l'estrès sobre, Prefrontal Cortex, Psychological Stress, Biology, Serotonergic, Animal Welfare, Civil Engineering, 03 medical and health sciences, Stress, Physiological, Internal medicine, Animal welfare, Mental Health and Psychiatry, medicine, Animals, Steroid Hormones, business.industry, Brain-Derived Neurotrophic Factor, Organic Chemistry, 0402 animal and dairy science, Organisms, Chemical Compounds, Biology and Life Sciences, 040201 dairy & animal science, Hormones, Roads, Endocrinology, Amniotes, business, Dopaminergics, 030217 neurology & neurosurgery, Neuroscience
Abstract: How housing and transport conditions may affect welfare in porcine production is a leading topic in livestock research. This study investigated whether pigs present a different neurological response to management conditions and to ascertain whether pigs living partially outdoors cope differently with road transport-associated stress. Twenty-four female pigs were divided in two groups: one living indoors (ID, n = 12) and the other housed combining indoor conditions with 4 hours per day of outdoor pasture (OD, n = 12). After one month, one set of animals from each housing condition were driven in a truck to the slaughterhouse in low-stress conditions (5 min drive, no mixing groups, soft management, LS group, n = 12) or high-stress conditions (2 hours drive, mixing groups, harsh management, HS group, n = 12). At the slaughterhouse, blood was collected, and the prefrontal cortex (PFC) and the hippocampus (HC) dissected. OD pigs had lower serum haptoglobin and increased dopaminergic pathway (DA-system) in the PFC, suggesting that living outdoors increases their wellbeing. HS conditions increased serum creatine kinase (CK) and affected several brain pathways: activation of the noradrenergic (NA-system) and DA -system in the PFC and the activation of the DA-system and an increase in c-Fos as well as a decrease in brain-derived neurotrophic factor (BDNF) in the HC. The serotonergic system (5-HT-system) was mildly altered in both areas. There was an interaction between housing and transport in serum NA and the DA-system in the HC, indicating that living conditions affected the response to stress. Multivariate analysis was able to discriminate the four animal groups. In conclusion, this work indicates that housing conditions and road transport markedly modifies the neurophysiology of pigs, and suggests that animals raised partially outdoors respond differently to transport-associated stress than animals raised indoors, indicating that they cope differently with unknown environments. info:eu-repo/semantics/publishedVersion
Published: 2018

36. Circulating Fatty Acid Synthase in pregnant women: Relationship to blood pressure, maternal metabolism and newborn parameters

Author: Francis de Zegher, Gemma Carreras-Badosa, Ericka Mendoza, Teresa Puig, Anna Prats-Puig, Monserrat Bruel, Abel López-Bermejo, Lourdes Ibáñez, Montserrat Vázquez-Ruíz, Judit Bassols, and Universitat de Barcelona
Subjects: 0301 basic medicine, Adult, medicine.medical_specialty, Síndrome metabòlica, medicine.medical_treatment, Placenta, Embaràs, Àcids grassos, Blood Pressure, Biology, Article, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Embarassades, 0302 clinical medicine, Insulin resistance, Pregnancy, Internal medicine, medicine, Humans, Insulin, Fatty acids, Fetus, Multidisciplinary, Pregnant women, Infant, Newborn, medicine.disease, Lipid Metabolism, Complicacions en l'embaràs, Metabolic syndrome, Fatty acid synthase, 030104 developmental biology, Blood pressure, Endocrinology, medicine.anatomical_structure, Glucose, 030220 oncology & carcinogenesis, Complications of pregnancy, Hypertension, biology.protein, Gestation, Female, Hipertensió, Fatty Acid Synthases, Insulin Resistance
Abstract: The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. FASN is highly expressed in the human placenta. We aimed to investigate the relationship circulating FASN has with blood pressure, maternal metabolism and newborn parameters in healthy pregnant women. Circulating FASN was assessed in 115 asymptomatic pregnant women in the second trimester of gestation along with C-peptide, fasting glucose and insulin, post-load glucose lipids, HMW-adiponectin and blood pressure (the latter was assessed in each trimester of gestation). At birth, newborns and placentas were weighed. FASN expression was also able to be assessed in 80 placentas. Higher circulating FASN was associated with lower systolic blood pressure (SBP), with a more favourable metabolic phenotype (lower fasting glucose and insulin, post load glucose, HbAc1, HOMA-IR and C-peptide), and with lower placental and birth weight (all p FASN expression related positively to circulating FASN (p
Published: 2018

37. Serum Ferritin Relates to Carotid Intima-Media Thickness in Offspring of Fathers With Higher Serum Ferritin Levels

Author: José Manuel Fernández-Real, Anna Prats-Puig, Wifredo Ricart, María U. Moreno, Judit Bassols, Abel López-Bermejo, and Gemma Carreras-Badosa
Subjects: Carotid Artery Diseases, Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Adolescent, Cross-sectional study, Offspring, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, Fathers, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Child, biology, C-reactive protein, Age Factors, Up-Regulation, Ferritin, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, Intima-media thickness, Predictive value of tests, Ferritins, Cohort, biology.protein, Female, Cardiology and Cardiovascular Medicine, Body mass index, Biomarkers
Abstract: Objective— Body iron status has been linked to atherosclerosis in adults. The purposes of our study were to determine (1) the association between circulating ferritin levels and carotid intima-media thickness (cIMT) in a cohort of apparently healthy children and (2) the association between cIMT and parental ferritin levels. Approach and Results— Circulating ferritin levels (microparticle enzyme immunoassay), metabolic parameters, and cIMT (ultrasonography) were analyzed cross-sectionally in a cohort of 692 healthy white children with a mean age of 8±2 years (52% girls and 48% boys). In consecutive 123 children from the cross-sectional sample, the same serum assessments were also performed at baseline in their parents, and the cIMT was repeated after 3 years of follow-up in the children at a mean age of 11±2 years (53% girls and 47% boys). Weak but significant positive associations were evident between children’s circulating ferritin levels and cIMT ( r =0.123; P =0.001) and with the change in cIMT 3 years later a tendency was also observed ( r =0.185; P =0.048). In multiple regression analyses, circulating ferritin levels contributed independently to cIMT variance (β=0.090; P =0.026; R 2 =10%) and cIMT change variance (β=0.216; P =0.019; R 2 = 3.4%) after controlling for body mass index, high-sensitivity C-reactive protein, age, sex, and low-density lipoprotein-cholesterol levels. This association was, however, remarkably significant (β=0.509; P =0.001; R 2 = 20.4%) in children whose fathers had ferritin levels above the median value (122.5 ng/mL).The latter association remained significant after correction for multiple testing. Maternal’s ferritin levels showed no interaction in this association. Conclusions— These results suggest a paternal-specific effect on cIMT partially reflected by father’s ferritin levels.
Published: 2016
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38. Effectiveness of Local Anesthetics in Laparoscopic Cholecystectomy

Author: Eloisa Radaelli, Analuíza Savaris, Marcelo M. Souto, Guilherme F. Bassols, and Andiara E. Giordani
Subjects: Male, medicine.medical_specialty, Visual analogue scale, medicine.medical_treatment, law.invention, Double-Blind Method, Randomized controlled trial, Cholelithiasis, law, medicine, Humans, Anesthetics, Local, Pain Measurement, Retrospective Studies, Bupivacaine, Pain, Postoperative, business.industry, Gallbladder, Retrospective cohort study, Middle Aged, Surgery, Clinical trial, Dissection, Treatment Outcome, medicine.anatomical_structure, Cholecystectomy, Laparoscopic, Anesthesia, Female, Cholecystectomy, business, Anesthesia, Local, medicine.drug
Abstract: Background Laparoscopic cholecystectomy is the gold standard for gallstone disease. Postoperative pain still is considerable and may prevent early discharge. Methods A randomized controlled blind clinical trial was designed for all patients undergoing laparoscopic cholecystectomy. The groups were control (group A), preincisional trocar wound infiltration with bupivacaine (group B), and preincisional trocar wound infiltration and intraperitoneal instillation of bupivacaine over the gallbladder and liver surface before starting the dissection (group C). The operative technique and postoperative analgesia were standardized. The pain in 6 hours was assessed with the visual analog scale as the primary outcome. Results The visual analog pain scores in the intraperitoneal bupivacaine were similar to the trocar wound infiltration alone and both were lower than the control group (P=0.05616). Conclusions Intraperitoneal application of local anesthetics and trocar wound infiltration did not lower the pain scores in comparison with trocar wound infiltration in our study.
Published: 2015
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39. Liver volume and hepatic adiposity in childhood: relations to body growth and visceral fat

Author: Abel López-Bermejo, Lourdes Ibáñez, J Pavia, Marta Díaz, Rita Malpique, F. de Zegher, Judit Bassols, Francesc Villarroya, and A Congo
Subjects: Male, Pediatric Obesity, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Birth weight, Medicine (miscellaneous), 030209 endocrinology & metabolism, Intra-Abdominal Fat, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Sex hormone-binding globulin, Risk Factors, Internal medicine, medicine, Humans, Longitudinal Studies, Prospective Studies, Growth Charts, Child, Prospective cohort study, Nutrition and Dietetics, biology, business.industry, Infant, Newborn, Overweight, Anthropometry, medicine.disease, Fatty Liver, Endocrinology, Liver, Infant, Small for Gestational Age, Multivariate Analysis, biology.protein, Small for gestational age, Female, 030211 gastroenterology & hepatology, Metabolic syndrome, business, Body mass index
Abstract: BACKGROUND AND OBJECTIVE: The sequence of prenatal growth restraint and postnatal catch-up growth may lead to hepato-visceral adiposity, insulin resistance and low-grade inflammation before the onset of puberty. In prepubertal children born appropriate for gestational age (AGA) or small for gestational age (SGA), we assessed potential relationships between the aforementioned sequence and liver volume. SUBJECTS/METHODS: The study population consisted of 86 children (41 AGA and 45 SGA with catch-up growth; age (mean±s.e.m.), 8.5±0.1 years), recruited into two prospective longitudinal studies. Anthropometry, endocrine-metabolic variables and inflammatory and hepatic markers were assessed, along with liver volume, hepatic adiposity and abdominal fat partitioning (by magnetic resonance imaging). RESULTS: AGA and SGA children differed in hepato-visceral adiposity, but had similar liver volumes. Boys had larger livers than girls, and higher sex hormone binding globulin and inflammation markers. Liver volume correlated with height Z-score, body mass index Z-score, HOMA-IR (homeostasis model assessment-insulin resistance) and with subcutaneous and visceral fat, but not with birth weight Z-score or with hepatic adiposity. Height, visceral fat, gender and HOMA-IR were major determinants of liver volume, together explaining 61% of its variance. CONCLUSIONS: The trajectory from prenatal restraint, via postnatal catch-up, to hepato-visceral adiposity and insulin resistance does not appear to be detectably influenced by prepubertal alterations of liver volume. Further follow-up will disclose the potential role of liver volume in the pubertal segment of this trajectory, and whether the augmented fat content and visceral adiposity in SGA subjects is followed by the development of metabolic syndrome and hepatic dysfunction in adulthood.
Published: 2018

40. Neutrophil-to-lymphocyte ratio: an inflammation marker related to cardiovascular risk in children

Author: Judit Bassols, Montserrat Gispert-Sauch, Lourdes Ibáñez, Francis de Zegher, Gemma Carreras-Badosa, Abel López-Bermejo, Inés Osiniri, Montserrat Planella-Colomer, Ferran Diaz-Roldan, Anna Prats-Puig, and Lluís Mayol
Subjects: Male, Neutrophils, Lymphocyte, Blood Pressure, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, Gastroenterology, Body Mass Index, 0302 clinical medicine, Risk Factors, Lymphocytes, Child, education.field_of_study, Age Factors, Hematology, Prognosis, medicine.anatomical_structure, Cardiovascular Diseases, Child, Preschool, 030220 oncology & carcinogenesis, Female, Waist Circumference, medicine.symptom, medicine.medical_specialty, Waist, Population, Inflammation, Risk Assessment, White People, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Lymphocyte Count, Neutrophil to lymphocyte ratio, education, business.industry, Puberty, Cross-Sectional Studies, Endocrinology, Blood pressure, Intima-media thickness, Spain, Chronic Disease, Multivariate Analysis, Linear Models, business, Body mass index
Abstract: SummaryLow-grade chronic inflammation plays a pathogenic role in cardiovascular disease. An increase in the ratio of circulating neutrophils to lymphocytes (N/L ratio) may serve as a marker of cardiovascular risk in adults. It was the study objective to study whether N/L ratio associates with vascular parameters in children. Subjects were 501 prepubertal and early pubertal Caucasian children (mean age 8.0 years; mean body mass index (BMI) Z-score 0.2 ± 0.9; 266 boys and 235 girls) recruited within an ongoing population-based study. The subjects were stratified into three groups according to age. Neutrophil, lymphocyte, BMI, waist circumference, systolic blood pressure (SBP) and carotid intima-media thickness (cIMT), assessed in all children. The N/L ratio, derived from the absolute neutrophil and lymphocyte counts. In children aged < 7 years (n=190, all prepubertal), no associations were observed between N/L ratio and either anthropometric or cardiovascular parameters. In children aged 7–9 years (n=171, 1.7 % early pubertal), higher N/L ratio associated with higher BMI Z-score and waist circumference (p=0.008 to p< 0.0001). In children aged > 9 years (n=140, 29.2 % early pubertal), N/L ratio associated again with BMI Z-score and waist circumference and also positively with SBP and cIMT (all p=0.008 to p< 0.0001). These associations remained significant in linear regression models following adjustment for possible confounding variables such as age, gender, fasting triglycerides, C-reactive protein and puberty (and for SBP and cIMT, adjustment also for BMI). In conclusion, our results provide the first evidence that a higher N/L ratio is associated with a less favourable cardiovascular profile in children and delineate the development of these associations from late childhood onwards.
Published: 2015
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41. Serum 25-hydroxyvitamin D and cardiovascular disease risk factors in women with excessive weight gain during pregnancy and in their offspring at age 5-6 years

Author: Pilar Soriano-Rodríguez, Lourdes Ibáñez, Abel López-Bermejo, Ferran Diaz-Roldan, Cristina Armero-Bujaldón, Francis de Zegher, Laia Solé-Amat, Gemma Carreras-Badosa, Judit Bassols, and Anna Prats-Puig
Subjects: Male, medicine.medical_specialty, Offspring, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030209 endocrinology & metabolism, Overweight, Intra-Abdominal Fat, Carotid Intima-Media Thickness, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, Internal medicine, Vitamin D and neurology, Medicine, Humans, 030212 general & internal medicine, Vitamin D, Child, Nutrition and Dietetics, biology, business.industry, C-reactive protein, medicine.disease, Gestational Weight Gain, Endocrinology, Cardiovascular Diseases, Child, Preschool, biology.protein, Gestation, Female, medicine.symptom, business, Body mass index, Weight gain, Follow-Up Studies
Abstract: Low 25-hydroxyvitamin D levels [25(OH)D] may increase the risk for cardiovascular disease (CVD). In pregnant women excessive weight gain and 25(OH)D deficiency are common complications and both could have deleterious consequences on their children. We aimed to study the relationship between serum 25(OH)D and CVD risk factors in pregnant women and in their offspring at school age. Fasting serum 25(OH)D and its bioavailable fraction were quantified in 310 healthy pregnant women [with adequate (n = 113), insufficient (n = 113) and excessive (n = 84) weight gain]. A follow-up at 5–6 years was performed in sixty-six children born of these mothers. Lipids, insulin, glucose, and high-sensitivity C-reactive protein (hsCRP) were measured in all subjects. Children’s carotid intima-media thickness (cIMT) together with visceral and intra-abdominal fat were measured by ultrasonography. Lower maternal 25(OH)D concentrations were associated with lower maternal age, and higher body mass index, triglycerides and hsCRP (all p
Published: 2017

42. Perirenal fat is related to carotid intima-media thickness in children

Author: Elena Riera-Pérez, Judit Bassols, Inés Osiniri, Abel López-Bermejo, F. de Zegher, J-M Martínez-Calcerrada, Silvia Xargay-Torrent, Gemma Carreras-Badosa, M Feliu-Alsina, Anna Prats-Puig, Lourdes Ibáñez, and Esther Lizarraga-Mollinedo
Subjects: Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Abdominal Fat, Medicine (miscellaneous), Blood lipids, 030209 endocrinology & metabolism, Blood Pressure, 030204 cardiovascular system & hematology, Overweight, Asymptomatic, Gastroenterology, Carotid Intima-Media Thickness, Adipose capsule of kidney, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Risk Factors, Internal medicine, medicine, Humans, Obesity, Child, Nutrition and Dietetics, Adiponectin, business.industry, medicine.disease, Intima-media thickness, Female, medicine.symptom, business, Body mass index
Abstract: BACKGROUND/OBJECTIVES: It is well known that increased abdominal fat is associated with cardiovascular (CV) risk. Perirenal fat has been recently associated with CV risk in adults. However, studies with children are lacking. We investigated the relationship of perirenal fat and other abdominal fat depots (including preperitoneal, intra-abdominal and subcutaneous fat) with carotid intima-media thickness (cIMT-a surrogate marker of CV risk) in prepubertal children, so as to identify novel markers that can be easily assessed and used in the early prevention of cardiovascular disease. SUBJECTS/METHODS: Subjects were 702 asymptomatic prepubertal Caucasian children (418 lean, 142 overweight and 142 obese) who were recruited in a primary care setting. Ultrasound measurements (perirenal, preperitoneal, intra-abdominal and subcutaneous fat and cIMT), clinical (body mass index (BMI) and systolic blood pressure) and metabolic parameters (insulin resistance (HOMA-IR), high molecular weight (HMW) adiponectin and serum lipids) were assessed. RESULTS: Perirenal fat was associated with diverse metabolic and CV risk factors in all the studied subjects. However, in overweight and obese children, perirenal fat was mostly associated with cIMT (P
Published: 2017

43. Effects on pig immunophysiology, PBMC proteome and brain neurotransmitters caused by group mixing stress and human-animal relationship

Author: Antonio Velarde, Kuai Yu, Ricard Carreras, Daniel Valent, Eva Mainau, Raquel Peña, Anna Bassols, and Laura Arroyo
Subjects: 0301 basic medicine, Proteomics, Hydrocortisone, Proteome, Swine, Glycobiology, lcsh:Medicine, medicine.disease_cause, Biochemistry, Mass Spectrometry, chemistry.chemical_compound, Gene expression, Lipid Hormones, lcsh:Science, Cytoskeleton, chemistry.chemical_classification, Mammals, Neurotransmitter Agents, Multidisciplinary, Glutathione peroxidase, Acute-phase protein, Brain, Neurochemistry, Neurotransmitters, Home-animal, Relacions, Vertebrates, Female, Cellular Structures and Organelles, Research Article, Biogenic Amines, Serotonin, Motor Proteins, Protein degradation, Biology, Peripheral blood mononuclear cell, Andrology, 03 medical and health sciences, Molecular Motors, Stress, Physiological, DNA-binding proteins, medicine, Animals, Humans, Glycoproteins, Steroid Hormones, Glutathione Peroxidase, lcsh:R, Organisms, Biology and Life Sciences, Fibrinogen, Proteins, Glutathione, Cell Biology, Hormones, Oxidative Stress, 030104 developmental biology, chemistry, Amniotes, Leukocytes, Mononuclear, lcsh:Q, Oxidative stress, Neuroscience, Acute-Phase Proteins
Abstract: Peripheral blood mononuclear cells (PBMC) are an interesting sample for searching for biomarkers with proteomic techniques because they are easy to obtain and do not contain highly abundant, potentially masking proteins. Two groups of pigs (n = 56) were subjected to mixing under farm conditions and afterwards subjected to different management treatments: negative handling (NH) and positive handling (PH). Serum and PBMC samples were collected at the beginning of the experiment one week after mixing (t0) and after two months of different handling (t2). Brain areas were collected after slaughter and neurotransmitters quantified by HPLC. Hair cortisol and serum acute phase proteins decreased and serum glutathione peroxidase increased at t2, indicating a lower degree of stress at t2 after adaptation to the farm. Differential gel electrophoresis (DIGE) was applied to study the effects of time and treatment on the PBMC proteome. A total of 54 differentially expressed proteins were identified, which were involved in immune system modulation, cell adhesion and motility, gene expression, splicing and translation, protein degradation and folding, oxidative stress and metabolism. Thirty-seven protein spots were up-regulated at t2 versus t0 whereas 27 were down-regulated. Many of the identified proteins share the characteristic of being potentially up or down-regulated by cortisol, indicating that changes in protein abundance between t0 and t2 are, at least in part, consequence of lower stress upon adaptation to the farm conditions after group mixing. Only slight changes in brain neurotransmitters and PBMC oxidative stress markers were observed. In conclusion, the variation in hair cortisol and serum APPs as well as the careful analysis of the identified proteins indicate that changes in protein composition in PBMC throughout time is mainly due to a decrease in the stress status of the individuals, following accommodation to the farm and the new group.
Published: 2017

44. Undercarboxylated osteocalcin relates to cardiovascular risk markers in offspring of families with metabolic syndrome

Author: José Cristóbal Buñuel-Álvarez, Francis de Zegher, Pilar Soriano-Rodríguez, Gemma Carreras-Badosa, Abel López-Bermejo, Inés Osiniri, Carmen Vila-Pablos, Lourdes Ibáñez, Judit Bassols, and Anna Prats-Puig
Subjects: Male, medicine.medical_specialty, Offspring, Osteocalcin, Disease, Carotid Intima-Media Thickness, Asymptomatic, Risk Factors, Internal medicine, medicine, Humans, Undercarboxylated osteocalcin, Child, Metabolic Syndrome, biology, business.industry, medicine.disease, Endocrinology, Intima-media thickness, Cardiovascular Diseases, Child, Preschool, biology.protein, Female, Metabolic syndrome, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: The undercarboxylated form of osteocalcin (ucOC) is an emerging marker of cardiovascular disease. It is unknown if ucOC in related to common cardiovascular risk markers in children. In offspring of families with and without metabolic syndrome (MetS+ and MetS- families), we assessed whether ucOC was related to a continuous metabolic syndrome score (MetS score) and to carotid intima-media thickness (cIMT).ucOC and total OC, MetS score and cIMT were assessed in 203 asymptomatic prepubertal children (age 7.6 ± 0.1 yr; 49% girls), of whom 99 were from MetS+ families.In children from MetS+ families, percent ucOC was higher than in children from MetS- families (p0.01). In offspring from MetS+ families, higher ucOC and especially higher percent ucOC was independently associated with both the MetS score and cIMT (both p ≤ 0.01).The undercarboxylated form of OC is related to common cardiovascular risk markers in children at risk for cardiovascular disease.
Published: 2014
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45. SWATH-MS quantitative proteomic investigation of intrauterine growth restriction in a porcine model reveals sex differences in hippocampus development

Author: Consolacion Garcia-Contreras, Marta Vazquez-Gomez, Daniel Valent, Antonio Gonzalez-Bulnes, Wei Wu, Lorenzo E. Hernández-Castellano, Natalia Yeste, Laura Arroyo, Anna Bassols, and Emøke Bendixen
Subjects: Male, Proteomics, 0301 basic medicine, Swine, Offspring, Central nervous system, Biophysics, Intrauterine growth restriction, Physiology, Nerve Tissue Proteins, Hippocampal formation, Biology, Hippocampus, Biochemistry, 03 medical and health sciences, Fetus, medicine, Animals, Humans, Hippocampus (mythology), reproductive and urinary physiology, Pig, Sex Characteristics, Pregnancy, Fetal Growth Retardation, 030102 biochemistry & molecular biology, Lipid metabolism, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, embryonic structures, SWATH-MS, Sex, Female
Abstract: Intrauterine growth restriction (IUGR) is characterized by reduced growth and weight of the foetus, mainly due to the lack of nutrients and oxygen. Animals affected by IUGR show changes in specific brain areas and several neuronal processes. Female offspring affected by IUGR show increased survival and development compared to males. The objective of this study was to analyse changes in the hippocampus proteome in male and female piglets affected by IUGR. Seven pregnant Iberian sows were fed from Day 35 of pregnancy onwards at 50% of their requirements. At Day 100 of pregnancy, foetuses were obtained and classified by sex and weight, as mild IUGR (Normal Body Weight) versus severe IUGR (Low Body Weight). Hippocampi were dissected and the proteomes analysed by SWATH-MS DIA. In this study, 1497 proteins were identified of which 260 were quantitatively analysed. All differential proteins were more abundant in females versus males and were involved in protein synthesis, neuronal development, metabolism, antiapoptotic signalling and vesicular transport. Our findings support that female foetuses tolerate nutrient limitation better than males, especially under mild IUGR. Under severe IUGR, females still seems to maintain normal lipid metabolism and antiapoptotic signalling, which may be related to the increased female survival. SIGNIFICANCE: In the last years, proteomics have been used to evidence differences related to sex in non-reproductive organs. Intrauterine Growth Restriction (IUGR) can affect female and male offspring differently. Female offspring has stronger protective strategies compared to males, enhancing growth and postnatal survival. Most studies regarding this issue have focused on metabolic organs (i.e. liver). However, the predominance of neurodevelopmental disorders in males suggests that the central nervous system in female offspring adapt better to nutritional stress conditions than that of males. Based on the differential protein expression in hippocampal samples, our work demonstrates that female foetuses indeed adapt better to IUGR than males, especially under mild IUGR conditions. In severe IUGR conditions, differences between males and females were not so evident, but even in this case, the remaining differences suggest increased survival in females than in males.
Published: 2019
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46. Circulating GLP-1 in infants born small-for-gestational-age: breast-feeding versus formula-feeding

Author: Marta Díaz, Lourdes Ibáñez, Giorgia Sebastiani, Abel López-Bermejo, F. de Zegher, and Judit Bassols
Subjects: Male, medicine.medical_specialty, Diabetes risk, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Hypothalamus, Medicine (miscellaneous), Glucagon-Like Peptide 1, Diabetes mellitus, Internal medicine, Humans, Medicine, Longitudinal Studies, Infant Nutritional Physiological Phenomena, reproductive and urinary physiology, media_common, Neuronal Plasticity, Nutrition and Dietetics, business.industry, Infant, Newborn, Infant, Appetite, medicine.disease, Infant Formula, female genital diseases and pregnancy complications, Breast Feeding, Endocrinology, Infant formula, Infant, Small for Gestational Age, Small for gestational age, Female, Adiponectin, medicine.symptom, business, Body mass index, Breast feeding, Weight gain
Abstract: Prenatal growth restraint associates with the risk for later diabetes, particularly if such restraint is followed by postnatal formula-feeding (FOF) rather than breast-feeding (BRF). Circulating incretins can influence the neonatal programming of hypothalamic setpoints for appetite and energy expenditure, and are thus candidate mediators of the long-term effects exerted by early nutrition. We have tested this concept by measuring (at birth and at age 4 months) the circulating concentrations of glucagon-like peptide-1 (GLP-1) in BRF infants born appropriate-for-gestational-age (AGA; n=63) and in small-for-gestational-age (SGA) infants receiving either BRF (n=28) or FOF (n=26). At birth, concentrations of GLP-1 were similar in AGA and SGA infants. At 4 months, pre-feeding GLP-1 concentrations were higher than at birth; SGA-BRF infants had GLP-1 concentrations similar to those in AGA-BRF infants but SGA-FOF infants had higher concentrations. In conclusion, nutrition appears to influence the circulating GLP-1 concentrations in SGA infants and may thereby modulate long-term diabetes risk.
Published: 2015
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47. Dysregulation of Placental miRNA in Maternal Obesity Is Associated With Pre- and Postnatal Growth

Author: Marta Guindo-Martínez, José Manuel Fernández-Real, Josep-Maria Mercader, Abel López-Bermejo, David Torrents, Jose-Maria Martinez-Calcerrada, Alexandra Bonmati, Judit Bassols, Anna Prats-Puig, Francis de Zegher, Gemma Carreras-Badosa, F Ortega, and Lourdes Ibáñez
Subjects: 0301 basic medicine, Adult, medicine.medical_specialty, Offspring, Endocrinology, Diabetes and Metabolism, Placenta, Clinical Biochemistry, Intrauterine growth restriction, Prenatal diagnosis, Context (language use), Gestational Age, Biology, Weight Gain, Biochemistry, Sensitivity and Specificity, Preeclampsia, Body Mass Index, Fetal Development, 03 medical and health sciences, Endocrinology, Child Development, Pregnancy, Reference Values, Internal medicine, Prenatal Diagnosis, microRNA, medicine, Humans, Obesity, Postnatal growth, business.industry, Biochemistry (medical), Infant, Newborn, medicine.disease, Pregnancy Complications, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Case-Control Studies, Gestation, Female, business, Biomarkers
Abstract: Human placenta exhibits a specific microRNA (miRNA) expression pattern. Some of these miRNAs are dysregulated in pregnancy disorders such as preeclampsia and intrauterine growth restriction and are potential biomarkers for these pathologies.To study the placental miRNA profile in pregnant women with pregestational overweight/obesity (preOB) or gestational obesity (gestOB) and explore the associations between placental miRNAs dysregulated in maternal obesity and prenatal and postnatal growth.TaqMan Low Density Arrays and real-time polymerase chain reaction were used to profile the placental miRNAs in 70 pregnant women (20 preOB, 25 gestOB, and 25 control). Placentas and newborns were weighed at delivery, and infants were weighed at 1, 4, and 12 months of age.Eight miRNAs were decreased in placentas from preOB or gestOB (miR-100, miR-1269, miR-1285, miR-181, miR-185, miR-214, miR-296, and miR-487) (all P0.05). Among them, miR-100, miR-1285, miR-296, and miR-487 were associated with maternal metabolic parameters (all P0.05) and were predictors of lower birth weight (all P0.05; R230%) and increased postnatal weight gain (all P0.05; R220%). In silico analysis showed that these miRNAs were related to cell proliferation and insulin signaling pathways. miR-296 was also present in plasma samples and associated with placental expression and prenatal and postnatal growth parameters (all P0.05).We identified a specific placental miRNA profile in maternal obesity. Placental miRNAs dysregulated in maternal obesity may be involved in mediation of growth-promoting effects of maternal obesity on offspring and could be used as early markers of prenatal and postnatal growth.
Published: 2017

48. The placental imprinted DLK1-DIO3 domain: a new link to prenatal and postnatal growth in humans

Author: Cristina Sabench, Lourdes Ibáñez, Abel López-Bermejo, Francis de Zegher, Judit Bassols, Agnes Magret, Gemma Carreras-Badosa, Patricia Cavelier, Robert Feil, Anna Prats-Puig, Institut de Génétique Moléculaire de Montpellier (IGMM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
Subjects: 0301 basic medicine, Adult, Male, imprinting, Placenta, Biology, Pregnancy Proteins, Iodide Peroxidase, Epigenesis, Genetic, Fetal Development, infant growth, 03 medical and health sciences, Genomic Imprinting, fetal growth, Intergenic region, Pregnancy, Gene expression, Birth Weight, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Gene, Newborn/*growth & development Iodide Peroxidase/*genetics Male Placenta/*metabolism Pregnancy Pregnancy Proteins/*genetics RNA, 2. Zero hunger, MEG3, DLK1-DIO3 domain, Body Weight, Infant, Newborn, Obstetrics and Gynecology, Genetic Female Fetal Development/*genetics Genomic Imprinting Humans Infant, Methylation, Sequence Analysis, DNA, DNA Methylation, Adult Birth Weight/genetics Body Height/genetics Body Weight/genetics *DNA Methylation Epigenesis, Molecular biology, methylation, Body Height, 030104 developmental biology, Differentially methylated regions, CpG site, DNA methylation, Female, RNA, Long Noncoding, Long Noncoding Sequence Analysis, DNA *DLK1-DIO3 domain *fetal growth *imprinting *infant growth *methylation
Abstract: Background The developmentally important DLK1-DIO3 imprinted domain on human chromosome 14 is regulated by 2 differentially methylated regions, the intergenic differentially methylated region and the MEG3 differentially methylated region. Objective The aim was to determine the natural variation in DNA methylation at these differentially methylated regions in human placentas, and to determine its link to gene expression levels at the domain. The second goal was to explore whether the domain’s methylation and gene expression correlate with prenatal and early postnatal growth of the conceptus. Study Design Using pyrosequencing, we determined methylation levels at CpG dinucleotides across the 2 regulatory differentially methylated regions in placentas from 91 healthy mothers. At birth, placentas and infants were weighed (gestational age 39 ± 1 weeks; birthweight SD score 0.1 ± 0.8) and placental biopsies were collected. RNA expression was quantitated by real-time polymerase chain reaction. Infants’ weights and lengths were followed up monthly during the first year. Results Methylation levels at the 2 regulatory differentially methylated regions were linked and varied considerably between placentas. MEG3 promoter differentially methylated region methylation correlated negatively with weight increase (β = –0.406, P = .001, R 2 = 0.206) and length increase (β = –0.363, P = .002, R 2 = 0.230) during the first postnatal year. The methylation level of the intergenic differentially methylated region correlated with DIO3 expression (β = 0.313, P = .032, R 2 = 0.152). Furthermore, the expression of both DIO3 and RTL1 (both imprinted genes within the DLK1-DIO3 domain) was negatively associated with birthweight (β = –0.331, P = .002, R 2 = 0.165; and β = –0.307, P = .005, R 2 = 0.159, respectively). RTL1 expression, in addition, was negatively linked to birth length (β = –0.306, P = .007, R 2 = 0.162). Conclusion Our combined findings strongly suggest that placental DNA methylation at the DLK1-DIO3 domain’s intergenic differentially methylated region and MEG3 promoter differentially methylated region relates to measures of early human growth, and may thus contribute to its control.
Published: 2017
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49. Lower Free Thyroxin Associates with a Less Favorable Metabolic Phenotype in Healthy Pregnant Women

Author: Francis de Zegher, Maria Mar García-González, María Martínez-Pascual, Pilar Soriano-Rodríguez, Abel López-Bermejo, Judit Bassols, Joanna Reid, Anna Prats-Puig, Lourdes Ibáñez, and Fátima Mateos-Comerón
Subjects: Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Deiodinase, Thyroid Gland, Thyrotropin, Blood lipids, Thyroid Function Tests, Biochemistry, Thyroid function tests, Endocrinology, Insulin resistance, Pregnancy, Internal medicine, Humans, Medicine, Euthyroid, Triiodothyronine, biology, medicine.diagnostic_test, Adiponectin, business.industry, Biochemistry (medical), Thyroid, medicine.disease, Thyroxine, Cross-Sectional Studies, Phenotype, medicine.anatomical_structure, biology.protein, Women's Health, Female, Insulin Resistance, business, hormones, hormone substitutes, and hormone antagonists
Abstract: Context: A lower free T4 (fT4), within the euthyroid range, has been shown in adults to associate with an adverse metabolic phenotype. Thyroid physiology changes significantly during gestation and affects maternal and fetal well-being. Objective: The aim of the study was to test the hypothesis that a lower serum fT4 in healthy euthyroid pregnant women is related to a less favorable metabolic phenotype and to fetal or placental weight. Design, Setting, Patients, and Outcome Measures: We examined associations of thyroid function tests (TSH and fT4) and the free T3 (fT3)-to-fT4 ratio (as a proxy of deiodinase activity) with a metabolic profile [preload and postload glucose, glycosylated hemoglobin (HbA1c), high molecular-weight (HMW)-adiponectin, homeostasis model of assessment for insulin resistance (HOMA-IR), and serum lipids] in 321 healthy pregnant women. All women were euthyroid and had negative anti-thyroid peroxidase antibodies. None received thyroid hormone replacement. Blood tests were performed in women between 24 and 28 wk gestation. Placentas and newborns were weighed at birth. Results: Circulating TSH did not relate to metabolic parameters, but decreasing fT4 and increasing fT3-to-fT4 ratio associated with a less favorable metabolic phenotype, as judged by higher postload glucose, HbA1c, fasting insulin, HOMA-IR, and triglycerides, and by a lower HMW-adiponectinemia (all P ≤ 0.005). In multiple regression analyses, fT4 was independently associated with HbA1c (β = −0.135; P = 0.038), HMW-adiponectin (β = 0.218; P < 0.001), and placental weight (β = −0.185; P < 0.005), whereas the fT3-to-fT4 ratio was independently associated with maternal body mass index (β = 0.265; P < 0.001), HMW-adiponectinemia (β = −0.237; P < 0.002), HOMA-IR (β = 0.194; P = 0.014), and placental weight (β = 0.174; P = 0.020). Conclusion: In pregnant women without a history of thyroid dysfunction, lower concentrations of fT4 and a higher conversion of fT4 to fT3, as inferred by changes in the fT3-to-fT4 ratio, were found to be associated with a less favorable metabolic phenotype and with more placental growth.
Published: 2011
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50. Soluble fatty acid synthase relates to bone biomarkers in prepubertal children

Author: Carmen Sitjar, Anna Prats-Puig, Abel López-Bermejo, Teresa Puig, Marta Mas-Parareda, Lourdes Ibáñez, Pilar Soriano-Rodríguez, P. Grau-Cabrera, Mercè Montesinos-Costa, J. Bassols, F. de Zegher, and Marta Díaz
Subjects: Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Osteocalcin, Blood lipids, Adipose tissue, Bone and Bones, Collagen Type I, Bone remodeling, Insulin resistance, N-terminal telopeptide, Internal medicine, medicine, Humans, Vitamin D, Child, Anthropometry, biology, Adiponectin, business.industry, Alkaline Phosphatase, medicine.disease, Fatty Acid Synthase, Type I, Fatty acid synthase, Endocrinology, Adipose Tissue, Solubility, biology.protein, Female, Energy Metabolism, Peptides, business, Biomarkers
Abstract: Circulating soluble fatty acid synthase (FASN, a key enzyme in de novo biosynthesis of fatty acids, expressed in both adipocytes and osteoblasts) is clinically related to a less favorable bone profile in healthy prepubertal children. Soluble FASN may participate in the reciprocal regulation between fat and bone metabolism. Fatty acid synthase (FASN), a key enzyme in de novo biosynthesis of fatty acids, is expressed in adipocytes and osteoblasts. We hypothesized that FASN may participate in the crosstalk between fat and bone. To this aim, we studied the relation between circulating soluble FASN (an extracellular FASN that reflects previously intracellular enzymatic activity) and adipose tissue and bone biomarkers in prepubertal children. Circulating soluble FASN, total and high molecular weight (HMW) adiponectin, bone biomarkers [osteocalcin (OC), uncarboxylated osteocalcin (ucOC), C-terminal cross-linked telopeptide of type I collagen (CTX), bone-specific alkaline phosphatase (BSAP)], and a profile of energy metabolism [body fat, insulin resistance and secretion (HOMA), serum lipids] were assessed in 84 asymptomatic prepubertal children (44 girls, 40 boys, age 6.8 ± 0.1 year). Serum 25-OH Vitamin D (Vit D) was additionally measured. Circulating soluble FASN increased with increasing HMW adiponectin (r = 0.29, p = 0.01) and decreasing serum Vit D (r = −0.21, p < 0.05), and was related to a less favorable bone profile, showing negative associations with bone-derived metabolic parameters [total OC (r = −0.33, p = 0.002) and ucOC (r = −0.37, p < 0.0001)] and a positive association with the CTX-to-BSAP ratio (r = 0.31, p < 0.01). These correlations were not explained by age, gender, body fat, insulin resistance or secretion or serum lipids; however, they were predominant in those subjects with Vit D levels below the population median. Circulating soluble FASN relates to both adipose tissue and bone biomarkers in prepubertal children, with associations that are dependent on Vit D concentrations. These findings suggest that FASN may participate in the crosstalk between fat and bone metabolism.
Published: 2011
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