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1. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis.

Author

Wannan, Cassandra, Nelson, Barnaby, Addington, Jean, Allott, Kelly, Anticevic, Alan, Arango, Celso, Baker, Justin, McGorry, Patrick, Mittal, Vijay, Nordentoft, Merete, Nunez, Angela, Pasternak, Ofer, Pearlson, Godfrey, Perez, Jesus, Perkins, Diana, Powers, Albert, Roalf, David, Sabb, Fred, Schiffman, Jason, Shah, Jai, Smesny, Stefan, Spark, Jessica, Stone, William, Strauss, Gregory, Tamayo, Zailyn, Torous, John, Upthegrove, Rachel, Vangel, Mark, Verma, Swapna, Wang, Jijun, Rossum, Inge, Wolf, Daniel, Wolff, Phillip, Wood, Stephen, Yung, Alison, Agurto, Carla, Alvarez-Jimenez, Mario, Amminger, Paul, Armando, Marco, Asgari-Targhi, Ameneh, Cahill, John, Carrión, Ricardo, Castro, Eduardo, Cetin-Karayumak, Suheyla, Mallar Chakravarty, M, Cho, Youngsun, Cotter, David, DAlfonso, Simon, Ennis, Michaela, Fadnavis, Shreyas, Fonteneau, Clara, Gao, Caroline, Gupta, Tina, Gur, Raquel, Gur, Ruben, Hamilton, Holly, Hoftman, Gil, Jacobs, Grace, Jarcho, Johanna, Ji, Jie, Kohler, Christian, Lalousis, Paris, Lavoie, Suzie, Lepage, Martin, Liebenthal, Einat, Mervis, Josh, Murty, Vishnu, Nicholas, Spero, Ning, Lipeng, Penzel, Nora, Poldrack, Russell, Polosecki, Pablo, Pratt, Danielle, Rabin, Rachel, Rahimi Eichi, Habiballah, Rathi, Yogesh, Reichenberg, Avraham, Reinen, Jenna, Rogers, Jack, Ruiz-Yu, Bernalyn, Scott, Isabelle, Seitz-Holland, Johanna, Srihari, Vinod, Srivastava, Agrima, Thompson, Andrew, Turetsky, Bruce, Walsh, Barbara, Whitford, Thomas, Wigman, Johanna, Yao, Beier, Yuen, Hok, Ahmed, Uzair, Byun, Andrew, Chung, Yoonho, Do, Kim, Hendricks, Larry, Huynh, Kevin, Jeffries, Clark, Lane, Erlend, and Langholm, Carsten

Subjects
clinical high risk, consortium, early detection, prediction, prevention, psychosis, Humans, Psychotic Disorders, Schizophrenia, Prospective Studies, Adult, Prodromal Symptoms, Young Adult, International Cooperation, Adolescent, Research Design, Male, Female
Abstract

This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.

Published
2024

2. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Author

Barth, Claudia, Kelly, Sinead, Nerland, Stener, Jahanshad, Neda, Alloza, Clara, Ambrogi, Sonia, Andreassen, Ole A, Andreou, Dimitrios, Arango, Celso, Baeza, Inmaculada, Banaj, Nerisa, Bearden, Carrie E, Berk, Michael, Bohman, Hannes, Castro-Fornieles, Josefina, Chye, Yann, Crespo-Facorro, Benedicto, de la Serna, Elena, Díaz-Caneja, Covadonga M, Gurholt, Tiril P, Hegarty, Catherine E, James, Anthony, Janssen, Joost, Johannessen, Cecilie, Jönsson, Erik G, Karlsgodt, Katherine H, Kochunov, Peter, Lois, Noemi G, Lundberg, Mathias, Myhre, Anne M, Pascual-Diaz, Saül, Piras, Fabrizio, Smelror, Runar E, Spalletta, Gianfranco, Stokkan, Therese S, Sugranyes, Gisela, Suo, Chao, Thomopoulos, Sophia I, Tordesillas-Gutiérrez, Diana, Vecchio, Daniela, Wedervang-Resell, Kirsten, Wortinger, Laura A, Thompson, Paul M, and Agartz, Ingrid

Subjects
Brain Disorders, Serious Mental Illness, Pediatric, Biomedical Imaging, Clinical Research, Neurosciences, Mental Health, Schizophrenia, Mental health, Good Health and Well Being, Female, Humans, Male, Adolescent, White Matter, Diffusion Tensor Imaging, Brain, Psychotic Disorders, Anisotropy, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset

Published
2023

3. Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Author

Constantinides, Constantinos, Han, Laura KM, Alloza, Clara, Antonucci, Linda Antonella, Arango, Celso, Ayesa-Arriola, Rosa, Banaj, Nerisa, Bertolino, Alessandro, Borgwardt, Stefan, Bruggemann, Jason, Bustillo, Juan, Bykhovski, Oleg, Calhoun, Vince, Carr, Vaughan, Catts, Stanley, Chung, Young-Chul, Crespo-Facorro, Benedicto, Díaz-Caneja, Covadonga M, Donohoe, Gary, Plessis, Stefan Du, Edmond, Jesse, Ehrlich, Stefan, Emsley, Robin, Eyler, Lisa T, Fuentes-Claramonte, Paola, Georgiadis, Foivos, Green, Melissa, Guerrero-Pedraza, Amalia, Ha, Minji, Hahn, Tim, Henskens, Frans A, Holleran, Laurena, Homan, Stephanie, Homan, Philipp, Jahanshad, Neda, Janssen, Joost, Ji, Ellen, Kaiser, Stefan, Kaleda, Vasily, Kim, Minah, Kim, Woo-Sung, Kirschner, Matthias, Kochunov, Peter, Kwak, Yoo Bin, Kwon, Jun Soo, Lebedeva, Irina, Liu, Jingyu, Mitchie, Patricia, Michielse, Stijn, Mothersill, David, Mowry, Bryan, de la Foz, Víctor Ortiz-García, Pantelis, Christos, Pergola, Giulio, Piras, Fabrizio, Pomarol-Clotet, Edith, Preda, Adrian, Quidé, Yann, Rasser, Paul E, Rootes-Murdy, Kelly, Salvador, Raymond, Sangiuliano, Marina, Sarró, Salvador, Schall, Ulrich, Schmidt, André, Scott, Rodney J, Selvaggi, Pierluigi, Sim, Kang, Skoch, Antonin, Spalletta, Gianfranco, Spaniel, Filip, Thomopoulos, Sophia I, Tomecek, David, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, van Amelsvoort, Therese, Vázquez-Bourgon, Javier, Vecchio, Daniela, Voineskos, Aristotle, Weickert, Cynthia S, Weickert, Thomas, Thompson, Paul M, Schmaal, Lianne, van Erp, Theo GM, Turner, Jessica, Cole, James H, ENIGMA Schizophrenia Consortium, Dima, Danai, and Walton, Esther

Subjects
ENIGMA Schizophrenia Consortium, Brain, Humans, Magnetic Resonance Imaging, Prospective Studies, Schizophrenia, Aging, Adolescent, Adult, Aged, Middle Aged, Female, Male, Young Adult, Mental Health, Serious Mental Illness, Brain Disorders, Neurosciences, Biomedical Imaging, Clinical Research, Behavioral and Social Science, Neurological, Mental health, Good Health and Well Being, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.

Published
2023

4. Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Author

Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A, Arango, Celso, Arolt, Volker, Auzias, Guillaume, Ayesa-Arriola, Rosa, Banaj, Nerisa, Banaschewski, Tobias, Bandeira, Cibele, Başgöze, Zeynep, Cupertino, Renata Basso, Bau, Claiton HD, Bauer, Jochen, Baumeister, Sarah, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Brem, Silvia, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R, Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carmona, Susanna, Carr, Vaughan J, Catts, Stanley V, Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G, Conzelmann, Annette, Craven, Alexander R, Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Dannlowski, Udo, Davey, Christopher G, Deruelle, Christine, Díaz-Caneja, Covadonga M, Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T, Fedor, Jennifer, Fitzgerald, Jacqueline, Foran, William, Ford, Judith M, Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Gao, Bingchen, Gao, Si, Goikolea, Jose M, Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J, Green, Melissa, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Haavik, Jan, Hahn, Tim, Harrison, Ben J, Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J, Hilland, Eva, Hoekstra, Pieter J, Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M, Ipser, Jonathan C, Jahanshad, Neda, Jakobi, Babette, Jansen, Andreas, Janssen, Joost, Jonassen, Rune, Kaiser, Anna, Kaleda, Vasiliy, Karantonis, James, King, Joseph A, Kircher, Tilo, Kochunov, Peter, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, and Lawrie, Stephen

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Neurosciences, Genetics, Mental Health, Serious Mental Illness, Mental Illness, Women's Health, Brain Disorders, Preterm, Low Birth Weight and Health of the Newborn, Pregnancy, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Behavioral and Social Science, Prevention, Schizophrenia, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Neurological, Reproductive health and childbirth, Mental health, Good Health and Well Being, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Bipolar Disorder, Cerebral Cortex, Child, Depressive Disorder, Major, Female, Humans, Infant, Newborn, Magnetic Resonance Imaging, Premature Birth, Cortical growth, Cortical surface area, Mental illness, Neurodevelopment, Neurogenesis, Psychiatric disorders, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences
Abstract

BackgroundMorphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life.MethodsInterregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed.ResultsAcross the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth.ConclusionsOur findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

Published
2022

5. A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes

Author

Guirgis, Faheem W, Black, Lauren Page, Henson, Morgan, Labilloy, Guillaume, Smotherman, Carmen, Hopson, Charlotte, Tfirn, Ian, DeVos, Elizabeth L, Leeuwenburgh, Christiaan, Moldawer, Lyle, Datta, Susmita, Brusko, Todd M, Hester, Alexis, Bertrand, Andrew, Grijalva, Victor, Arango-Esterhay, Alexander, Moore, Frederick A, and Reddy, Srinivasa T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Atherosclerosis, Cardiovascular, Sepsis, Hematology, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Infection, Good Health and Well Being, Aged, Antioxidants, Biomarkers, Cohort Studies, Female, Humans, Hypolipoproteinemias, Intensive Care Units, Lipoproteins, Longitudinal Studies, Male, Middle Aged, Multiple Organ Failure, Organ Dysfunction Scores, Outcome Assessment, Health Care, Phenotype, Prospective Studies, Protective Factors, Inflammation, Lipids, Lipoprotein, Quality of life, Shock, Medical and Health Sciences, Emergency & Critical Care Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveApproximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We sought to characterize lipoprotein predictive ability for poor outcomes and contribution to sepsis heterogeneity.DesignProspective cohort study with independent replication cohort.SettingEmergency department and surgical ICU at two hospitals.PatientsSepsis patients presenting within 24 h.MethodsMeasures included cholesterol levels (total cholesterol, high density lipoprotein cholesterol [HDL-C], low density lipoprotein cholesterol [LDL-C]), triglycerides, paraoxonase-1 (PON-1), and apolipoprotein A-I (Apo A-I) in the first 24 h. Inflammatory and endothelial markers, and sequential organ failure assessment (SOFA) scores were also measured. LASSO selection assessed predictive ability for outcomes. Unsupervised clustering was used to investigate the contribution of lipid variation to sepsis heterogeneity.Measurements and main results172 patients were enrolled. Most (~ 67%, 114/172) rapidly recovered, while ~ 23% (41/172) developed CCI, and ~ 10% (17/172) had early death. ApoA-I, LDL-C, mechanical ventilation, vasopressor use, and Charlson Comorbidity Score were significant predictors of CCI/early death in LASSO models. Unsupervised clustering yielded two discernible phenotypes. The Hypolipoprotein phenotype was characterized by lower lipoprotein levels, increased endothelial dysfunction (ICAM-1), higher SOFA scores, and worse clinical outcomes (45% rapid recovery, 40% CCI, 16% early death; 28-day mortality, 21%). The Normolipoprotein cluster patients had higher cholesterol levels, less endothelial dysfunction, lower SOFA scores and better outcomes (79% rapid recovery, 15% CCI, 6% early death; 28-day mortality, 15%). Phenotypes were validated in an independent replication cohort (N = 86) with greater sepsis severity, which similarly demonstrated lower HDL-C, ApoA-I, and higher ICAM-1 in the Hypolipoprotein cluster and worse outcomes (46% rapid recovery, 23% CCI, 31% early death; 28-day mortality, 42%). Normolipoprotein patients in the replication cohort had better outcomes (55% rapid recovery, 32% CCI, 13% early death; 28-day mortality, 28%) Top features for cluster discrimination were HDL-C, ApoA-I, total SOFA score, total cholesterol level, and ICAM-1.ConclusionsLipoproteins predicted poor sepsis outcomes. A Hypolipoprotein sepsis phenotype was identified and characterized by lower lipoprotein levels, increased endothelial dysfunction (ICAM-1) and organ failure, and worse clinical outcomes.

Published
2021

6. Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome

Author

Davies, Robert W, Fiksinski, Ania M, Breetvelt, Elemi J, Williams, Nigel M, Hooper, Stephen R, Monfeuga, Thomas, Bassett, Anne S, Owen, Michael J, Gur, Raquel E, Morrow, Bernice E, McDonald-McGinn, Donna M, Swillen, Ann, Chow, Eva WC, van den Bree, Marianne, Emanuel, Beverly S, Vermeesch, Joris R, van Amelsvoort, Therese, Arango, Celso, Armando, Marco, Campbell, Linda E, Cubells, Joseph F, Eliez, Stephan, Garcia-Minaur, Sixto, Gothelf, Doron, Kates, Wendy R, Murphy, Kieran C, Murphy, Clodagh M, Murphy, Declan G, Philip, Nicole, Repetto, Gabriela M, Shashi, Vandana, Simon, Tony J, Suñer, Damiàn Heine, Vicari, Stefano, Scherer, Stephen W, Bearden, Carrie E, and Vorstman, Jacob AS

Subjects
Biomedical and Clinical Sciences, Health Sciences, Genetics, Schizophrenia, Serious Mental Illness, Behavioral and Social Science, Prevention, Brain Disorders, Clinical Research, Mental Health, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Adult, Aged, Child, Child, Preschool, Cognitive Dysfunction, Cohort Studies, DiGeorge Syndrome, Female, Genetic Variation, Humans, Intellectual Disability, Male, Middle Aged, Multifactorial Inheritance, Phenotype, Risk Factors, Young Adult, International 22q11.2 Brain and Behavior Consortium, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

The 22q11.2 deletion syndrome (22q11DS) is associated with a 20-25% risk of schizophrenia. In a cohort of 962 individuals with 22q11DS, we examined the shared genetic basis between schizophrenia and schizophrenia-related early trajectory phenotypes: sub-threshold symptoms of psychosis, low baseline intellectual functioning and cognitive decline. We studied the association of these phenotypes with two polygenic scores, derived for schizophrenia and intelligence, and evaluated their use for individual risk prediction in 22q11DS. Polygenic scores were not only associated with schizophrenia and baseline intelligence quotient (IQ), respectively, but schizophrenia polygenic score was also significantly associated with cognitive (verbal IQ) decline and nominally associated with sub-threshold psychosis. Furthermore, in comparing the tail-end deciles of the schizophrenia and IQ polygenic score distributions, 33% versus 9% of individuals with 22q11DS had schizophrenia, and 63% versus 24% of individuals had intellectual disability. Collectively, these data show a shared genetic basis for schizophrenia and schizophrenia-related phenotypes and also highlight the future potential of polygenic scores for risk stratification among individuals with highly, but incompletely, penetrant genetic variants.

Published
2020

7. Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

Author

Villalón-Reina, Julio E, Martínez, Kenia, Qu, Xiaoping, Ching, Christopher RK, Nir, Talia M, Kothapalli, Deydeep, Corbin, Conor, Sun, Daqiang, Lin, Amy, Forsyth, Jennifer K, Kushan, Leila, Vajdi, Ariana, Jalbrzikowski, Maria, Hansen, Laura, Jonas, Rachel K, van Amelsvoort, Therese, Bakker, Geor, Kates, Wendy R, Antshel, Kevin M, Fremont, Wanda, Campbell, Linda E, McCabe, Kathryn L, Daly, Eileen, Gudbrandsen, Maria, Murphy, Clodagh M, Murphy, Declan, Craig, Michael, Emanuel, Beverly, McDonald-McGinn, Donna M, Vorstman, Jacob AS, Fiksinski, Ania M, Koops, Sanne, Ruparel, Kosha, Roalf, David, Gur, Raquel E, Eric Schmitt, J, Simon, Tony J, Goodrich-Hunsaker, Naomi J, Durdle, Courtney A, Doherty, Joanne L, Cunningham, Adam C, van den Bree, Marianne, Linden, David EJ, Owen, Michael, Moss, Hayley, Kelly, Sinead, Donohoe, Gary, Murphy, Kieran C, Arango, Celso, Jahanshad, Neda, Thompson, Paul M, and Bearden, Carrie E

Subjects
Paediatrics, Biomedical and Clinical Sciences, Neurosciences, Pediatric, Biomedical Imaging, Mental Health, Clinical Research, Brain Disorders, Mental health, Adolescent, Adult, Anisotropy, Child, DiGeorge Syndrome, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, White Matter, Young Adult, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

22q11.2 deletion syndrome (22q11DS)-a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22-is associated with an elevated risk of psychosis and other developmental brain disorders. Prior single-site diffusion magnetic resonance imaging (dMRI) studies have reported altered white matter (WM) microstructure in 22q11DS, but small samples and variable methods have led to contradictory results. Here we present the largest study ever conducted of dMRI-derived measures of WM microstructure in 22q11DS (334 22q11.2 deletion carriers and 260 healthy age- and sex-matched controls; age range 6-52 years). Using harmonization protocols developed by the ENIGMA-DTI working group, we identified widespread reductions in mean, axial and radial diffusivities in 22q11DS, most pronounced in regions with major cortico-cortical and cortico-thalamic fibers: the corona radiata, corpus callosum, superior longitudinal fasciculus, posterior thalamic radiations, and sagittal stratum (Cohen's d's ranging from -0.9 to -1.3). Only the posterior limb of the internal capsule (IC), comprised primarily of corticofugal fibers, showed higher axial diffusivity in 22q11DS. 22q11DS patients showed higher mean fractional anisotropy (FA) in callosal and projection fibers (IC and corona radiata) relative to controls, but lower FA than controls in regions with predominantly association fibers. Psychotic illness in 22q11DS was associated with more substantial diffusivity reductions in multiple regions. Overall, these findings indicate large effects of the 22q11.2 deletion on WM microstructure, especially in major cortico-cortical connections. Taken together with findings from animal models, this pattern of abnormalities may reflect disrupted neurogenesis of projection neurons in outer cortical layers.

Published
2020

8. Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard, Elsa, Nannya, Yasuhito, Hasserjian, Robert P, Devlin, Sean M, Tuechler, Heinz, Medina-Martinez, Juan S, Yoshizato, Tetsuichi, Shiozawa, Yusuke, Saiki, Ryunosuke, Malcovati, Luca, Levine, Max F, Arango, Juan E, Zhou, Yangyu, Solé, Francesc, Cargo, Catherine A, Haase, Detlef, Creignou, Maria, Germing, Ulrich, Zhang, Yanming, Gundem, Gunes, Sarian, Araxe, van de Loosdrecht, Arjan A, Jädersten, Martin, Tobiasson, Magnus, Kosmider, Olivier, Follo, Matilde Y, Thol, Felicitas, Pinheiro, Ronald F, Santini, Valeria, Kotsianidis, Ioannis, Boultwood, Jacqueline, Santos, Fabio PS, Schanz, Julie, Kasahara, Senji, Ishikawa, Takayuki, Tsurumi, Hisashi, Takaori-Kondo, Akifumi, Kiguchi, Toru, Polprasert, Chantana, Bennett, John M, Klimek, Virginia M, Savona, Michael R, Belickova, Monika, Ganster, Christina, Palomo, Laura, Sanz, Guillermo, Ades, Lionel, Della Porta, Matteo Giovanni, Elias, Harold K, Smith, Alexandra G, Werner, Yesenia, Patel, Minal, Viale, Agnès, Vanness, Katelynd, Neuberg, Donna S, Stevenson, Kristen E, Menghrajani, Kamal, Bolton, Kelly L, Fenaux, Pierre, Pellagatti, Andrea, Platzbecker, Uwe, Heuser, Michael, Valent, Peter, Chiba, Shigeru, Miyazaki, Yasushi, Finelli, Carlo, Voso, Maria Teresa, Shih, Lee-Yung, Fontenay, Michaela, Jansen, Joop H, Cervera, José, Atsuta, Yoshiko, Gattermann, Norbert, Ebert, Benjamin L, Bejar, Rafael, Greenberg, Peter L, Cazzola, Mario, Hellström-Lindberg, Eva, Ogawa, Seishi, and Papaemmanuil, Elli

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Hematology, Stem Cell Research, Cancer, Clinical Research, Rare Diseases, Genetics, 2.1 Biological and endogenous factors, Aetiology, Alleles, Cohort Studies, DNA Copy Number Variations, DNA Mutational Analysis, Female, Gene Frequency, Genomic Instability, Humans, Loss of Heterozygosity, Male, Mutation, Myelodysplastic Syndromes, Phenotype, Prognosis, Survival Analysis, Treatment Outcome, Tumor Suppressor Protein p53, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

Tumor protein p53 (TP53) is the most frequently mutated gene in cancer1,2. In patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease3,4, rapid transformation to acute myeloid leukemia (AML)5, resistance to conventional therapies6-8 and dismal outcomes9. Consistent with the tumor-suppressive role of TP53, patients harbor both mono- and biallelic mutations10. However, the biological and clinical implications of TP53 allelic state have not been fully investigated in MDS or any other cancer type. We analyzed 3,324 patients with MDS for TP53 mutations and allelic imbalances and delineated two subsets of patients with distinct phenotypes and outcomes. One-third of TP53-mutated patients had monoallelic mutations whereas two-thirds had multiple hits (multi-hit) consistent with biallelic targeting. Established associations with complex karyotype, few co-occurring mutations, high-risk presentation and poor outcomes were specific to multi-hit patients only. TP53 multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring System (IPSS-R)11. Surprisingly, monoallelic patients did not differ from TP53 wild-type patients in outcomes and response to therapy. This study shows that consideration of TP53 allelic state is critical for diagnostic and prognostic precision in MDS as well as in future correlative studies of treatment response.

Published
2020

9. Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups

Author

Boedhoe, Premika SW, van Rooij, Daan, Hoogman, Martine, Twisk, Jos WR, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anikin, Anatoly, Anticevic, Alan, Arango, Celso, Arnold, Paul D, Asherson, Philip, Assogna, Francesca, Auzias, Guillaume, Banaschewski, Tobias, Baranov, Alexander, Batistuzzo, Marcelo C, Baumeister, Sarah, Baur-Streubel, Ramona, Behrmann, Marlene, Bellgrove, Mark A, Benedetti, Francesco, Beucke, Jan C, Biederman, Joseph, Bollettini, Irene, Bose, Anushree, Bralten, Janita, Bramati, Ivanei E, Brandeis, Daniel, Brem, Silvia, Brennan, Brian P, Busatto, Geraldo F, Calderoni, Sara, Calvo, Anna, Calvo, Rosa, Castellanos, Francisco X, Cercignani, Mara, Chaim-Avancini, Tiffany M, Chantiluke, Kaylita C, Cheng, Yuqi, Cho, Kang Ik K, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Dale, Anders M, Dallaspezia, Sara, Daly, Eileen, Denys, Damiaan, Deruelle, Christine, Di Martino, Adriana, Dinstein, Ilan, Doyle, Alysa E, Durston, Sarah, Earl, Eric A, Ecker, Christine, Ehrlich, Stefan, Ely, Benjamin A, Epstein, Jeffrey N, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas J, Faraone, Stephen V, Fedor, Jennifer, Feng, Xin, Feusner, Jamie D, Fitzgerald, Jackie, Fitzgerald, Kate D, Fouche, Jean-Paul, Freitag, Christine M, Fridgeirsson, Egill A, Frodl, Thomas, Gabel, Matt C, Gallagher, Louise, Gogberashvili, Tinatin, Gori, Ilaria, Gruner, Patricia, Gürsel, Deniz A, Haar, Shlomi, Haavik, Jan, Hall, Geoffrey B, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hirano, Yoshiyuki, Hoekstra, Pieter J, Hoexter, Marcelo Q, Hohmann, Sarah, Høvik, Marie F, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, Jalbrzikowski, Maria, James, Anthony, Janssen, Joost, Jaspers-Fayer, Fern, Jernigan, Terry L, Kapilushniy, Dmitry, and Kardatzki, Bernd

Subjects
Attention Deficit Hyperactivity Disorder (ADHD), Behavioral and Social Science, Clinical Research, Mental Health, Neurosciences, Pediatric, Autism, Intellectual and Developmental Disabilities (IDD), Brain Disorders, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Neurological, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Cerebrum, Child, Female, Human Development, Humans, Male, Neuroimaging, Obsessive-Compulsive Disorder, Organ Size, Psychopathology, Research Report, Systems Analysis, ENIGMA ADHD working group, ENIGMA ASD working group, ENIGMA OCD working group, Attention Deficit Hyperactivity Disorder, ENIGMA, Structural MRI, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveAttention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data.MethodsStructural T1-weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients with ADHD (N=2,271), ASD (N=1,777), and OCD (N=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. The authors examined subcortical volume, cortical thickness, and cortical surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults, using linear mixed-effects models adjusting for age, sex, and site (and intracranial volume for subcortical and surface area measures).ResultsNo shared differences were found among all three disorders, and shared differences between any two disorders did not survive correction for multiple comparisons. Children with ADHD compared with those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller intracranial volume than control subjects and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared with adult control subjects and other clinical groups. No OCD-specific differences were observed across different age groups and surface area differences among all disorders in childhood and adulthood.ConclusionsThe study findings suggest robust but subtle differences across different age groups among ADHD, ASD, and OCD. ADHD-specific intracranial volume and hippocampal differences in children and adolescents, and ASD-specific cortical thickness differences in the frontal cortex in adults, support previous work emphasizing structural brain differences in these disorders.

Published
2020

10. Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA

Author

Radua, Joaquim, Vieta, Eduard, Shinohara, Russell, Kochunov, Peter, Quidé, Yann, Green, Melissa J, Weickert, Cynthia S, Weickert, Thomas, Bruggemann, Jason, Kircher, Tilo, Nenadić, Igor, Cairns, Murray J, Seal, Marc, Schall, Ulrich, Henskens, Frans, Fullerton, Janice M, Mowry, Bryan, Pantelis, Christos, Lenroot, Rhoshel, Cropley, Vanessa, Loughland, Carmel, Scott, Rodney, Wolf, Daniel, Satterthwaite, Theodore D, Tan, Yunlong, Sim, Kang, Piras, Fabrizio, Spalletta, Gianfranco, Banaj, Nerisa, Pomarol-Clotet, Edith, Solanes, Aleix, Albajes-Eizagirre, Anton, Canales-Rodríguez, Erick J, Sarro, Salvador, Di Giorgio, Annabella, Bertolino, Alessandro, Stäblein, Michael, Oertel, Viola, Knöchel, Christian, Borgwardt, Stefan, du Plessis, Stefan, Yun, Je-Yeon, Kwon, Jun Soo, Dannlowski, Udo, Hahn, Tim, Grotegerd, Dominik, Alloza, Clara, Arango, Celso, Janssen, Joost, Díaz-Caneja, Covadonga, Jiang, Wenhao, Calhoun, Vince, Ehrlich, Stefan, Yang, Kun, Cascella, Nicola G, Takayanagi, Yoichiro, Sawa, Akira, Tomyshev, Alexander, Lebedeva, Irina, Kaleda, Vasily, Kirschner, Matthias, Hoschl, Cyril, Tomecek, David, Skoch, Antonin, van Amelsvoort, Therese, Bakker, Geor, James, Anthony, Preda, Adrian, Weideman, Andrea, Stein, Dan J, Howells, Fleur, Uhlmann, Anne, Temmingh, Henk, López-Jaramillo, Carlos, Díaz-Zuluaga, Ana, Fortea, Lydia, Martinez-Heras, Eloy, Solana, Elisabeth, Llufriu, Sara, Jahanshad, Neda, Thompson, Paul, Turner, Jessica, van Erp, Theo, collaborators, ENIGMA Consortium, Glahn, David, Pearlson, Godfrey, Hong, Elliot, Krug, Axel, Carr, Vaughan, Tooney, Paul, Cooper, Gavin, Rasser, Paul, Michie, Patricia, Catts, Stanley, Gur, Raquel, Gur, Ruben, Yang, Fude, Fan, Fengmei, Chen, Jingxu, and Guo, Hua

Subjects
Brain Disorders, Biomedical Imaging, Mental Health, Schizophrenia, Neurosciences, Mental health, Adult, Algorithms, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Meta-Analysis as Topic, Middle Aged, Neuroimaging, Young Adult, Brain, Cortical thickness, Gray matter, Mega-analysis, Volume, ENIGMA Consortium collaborators, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address this heterogeneity with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power. We conducted random-effects meta-analyses, mixed-effects mega-analyses and ComBat mega-analyses to compare cortical thickness, surface area and subcortical volumes between 2897 individuals with a diagnosis of schizophrenia and 3141 healthy controls from 33 sites. Specifically, we compared the imaging data between individuals with schizophrenia and healthy controls, covarying for age and sex. The use of ComBat substantially increased the statistical significance of the findings as compared to random-effects meta-analyses. The findings were more similar when comparing ComBat with mixed-effects mega-analysis, although ComBat still slightly increased the statistical significance. ComBat also showed increased statistical power when we repeated the analyses with fewer sites. Results were nearly identical when we applied the ComBat harmonization separately for cortical thickness, cortical surface area and subcortical volumes. Therefore, we recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work. We provide easy-to-use functions in R that work even if imaging data are partially missing in some brain regions, and they can be trained with one data set and then applied to another (a requirement for some analyses such as machine learning).

Published
2020

11. Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness.

Author

Bergé, Daniel, Mané, Anna, Lesh, Tyler A, Bioque, Miquel, Barcones, Fe, Gonzalez-Pinto, Ana Maria, Parellada, Mara, Vieta, Eduard, Castro-Fornieles, Josefina, Rodriguez-Jimenez, Roberto, García-Portilla, Maria Paz, Usall, Judith, Carter, Cameron S, Cabrera, Bibiana, Bernardo, Miguel, Janssen, Joost, Mezquida, Gisela, Amoretti, Silvia, Pina-Camacho, Laura, Arango, Celso, González-Ortega, I, García, S, De-la-Cámara, C, Fayed, N, Sanjuan, Julio, Aguilar, EJ, Guo, Joyce Y, Salgado, Purificación, Raduà, Joquim, Sánchez-Moreno, J, de la Serna, Elena, Baeza, Ima, Contreras-Fernández, Fernando, Saiz-Masvidal, C, González-Blanco, L, Jiménez-Treviño, L, Dompablo, M, Torío, I, Butjosa, A, Rubio-Abadel, E, Sarró, S, and Pomarol-Clotet, E

Subjects
Clinical Research, Prevention, Neurosciences, Schizophrenia, Mental Health, Brain Disorders, Serious Mental Illness, Biomedical Imaging, 2.1 Biological and endogenous factors, Aetiology, Mental health, Adolescent, Adult, Body Water, Child, Cross-Sectional Studies, Female, Gray Matter, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Psychotic Disorders, White Matter, Young Adult, PEPs group, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Recent diffusion imaging studies using free-water (FW) elimination have shown increased FW in gray matter (GM) and white matter (WM) in first-episode psychosis (FEP) and lower corrected fractional anisotropy (FAt) in WM in chronic schizophrenia. However, little is known about the longitudinal stability and clinical significance of these findings. To determine tissue-specific FW and FAt abnormalities in FEP, as part of a multicenter Spanish study, 132 FEP and 108 healthy controls (HC) were clinically characterized and underwent structural and diffusion-weighted MRI scanning. FEP subjects were classified as schizophrenia spectrum disorder (SSD) or non-SSD. Of these subjects, 45 FEP and 41 HC were longitudinally assessed and rescanned after 2 years. FA and FW tissue-specific measurements were cross-sectional and longitudinally compared between groups using voxel-wise analyses in the skeletonized WM and vertex-wise analyses in the GM surface. SSD and non-SSD subjects showed (a) higher baseline FW in temporal regions and in whole GM average (P.adj(SSD vs HC) = .003, P.adj(Non-SSD vs HC) = .040) and (b) lower baseline FAt in several WM tracts. SSD, but not non-SSD, showed (a) higher FW in several WM tracts and in whole WM (P.adj(SSD vs HC)= .049) and (b) a significant FW decrease over time in temporal cortical regions and in whole GM average (P.adj = .011). Increased extracellular FW in the brain is a reliable finding in FEP, and in SSD appears to decrease over the early course of the illness. FAt abnormalities are stable during the first years of psychosis.

Published
2020

12. The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium

Author

Holleran, Laurena, Kelly, Sinead, Alloza, Clara, Agartz, Ingrid, Andreassen, Ole A, Arango, Celso, Banaj, Nerisa, Calhoun, Vince, Cannon, Dara, Carr, Vaughan, Corvin, Aiden, Glahn, David C, Gur, Ruben, Hong, Elliot, Hoschl, Cyril, Howells, Fleur M, James, Anthony, Janssen, Joost, Kochunov, Peter, Lawrie, Stephen M, Liu, Jingyu, Martinez, Covadonga, McDonald, Colm, Morris, Derek, Mothersill, David, Pantelis, Christos, Piras, Fabrizio, Potkin, Steven, Rasser, Paul E, Roalf, David, Rowland, Laura, Satterthwaite, Theodore, Schall, Ulrich, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J, Uhlmann, Anne, Voineskos, Aristotle, Zalesky, Andrew, van Erp, Theo GM, Turner, Jessica A, Deary, Ian J, Thompson, Paul M, Jahanshad, Neda, and Donohoe, Gary

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Prevention, Neurosciences, Behavioral and Social Science, Clinical Research, Brain Disorders, Serious Mental Illness, Schizophrenia, Mental Health, Mental health, Adult, Anisotropy, Brain, Case-Control Studies, Cognition, Diffusion Tensor Imaging, Factor Analysis, Statistical, Female, Healthy Volunteers, Humans, Intelligence, Male, Middle Aged, Neural Pathways, Principal Component Analysis, Schizophrenic Psychology, Wechsler Scales, White Matter, ENIGMA, Meta-Analysis, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

ObjectiveSchizophrenia has recently been associated with widespread white matter microstructural abnormalities, but the functional effects of these abnormalities remain unclear. Widespread heterogeneity of results from studies published to date preclude any definitive characterization of the relationship between white matter and cognitive performance in schizophrenia. Given the relevance of deficits in cognitive function to predicting social and functional outcomes in schizophrenia, the authors carried out a meta-analysis of available data through the ENIGMA Consortium, using a common analysis pipeline, to elucidate the relationship between white matter microstructure and a measure of general cognitive performance, IQ, in patients with schizophrenia and healthy participants.MethodsThe meta-analysis included 760 patients with schizophrenia and 957 healthy participants from 11 participating ENIGMA Consortium sites. For each site, principal component analysis was used to calculate both a global fractional anisotropy component (gFA) and a fractional anisotropy component for six long association tracts (LA-gFA) previously associated with cognition.ResultsMeta-analyses of regression results indicated that gFA accounted for a significant amount of variation in cognition in the full sample (effect size [Hedges' g]=0.27, CI=0.17-0.36), with similar effects sizes observed for both the patient (effect size=0.20, CI=0.05-0.35) and healthy participant groups (effect size=0.32, CI=0.18-0.45). Comparable patterns of association were also observed between LA-gFA and cognition for the full sample (effect size=0.28, CI=0.18-0.37), the patient group (effect size=0.23, CI=0.09-0.38), and the healthy participant group (effect size=0.31, CI=0.18-0.44).ConclusionsThis study provides robust evidence that cognitive ability is associated with global structural connectivity, with higher fractional anisotropy associated with higher IQ. This association was independent of diagnosis; while schizophrenia patients tended to have lower fractional anisotropy and lower IQ than healthy participants, the comparable size of effect in each group suggested a more general, rather than disease-specific, pattern of association.

Published
2020

13. Distinct and shared contributions of diagnosis and symptom domains to cognitive performance in severe mental illness in the Paisa population: a case-control study

Author

Service, Susan K, Upegui, Cristian Vargas, Ramírez, Mauricio Castaño, Port, Allison M, Moore, Tyler M, Umanes, Marfred Munoz, Arango, Luis Guillermo Agudelo, Díaz-Zuluaga, Ana M, Espejo, Juanita Melo, López, María Cecilia, Palacio, Juan David, Sánchez, Sergio Ruiz, Valencia, Johanna, Teshiba, Terri M, Espinoza, Alesandra, Loohuis, Loes Olde, De la Hoz Gomez, Juan, Brodey, Benjamin B, Sabatti, Chiara, Escobar, Javier I, Reus, Victor I, Jaramillo, Carlos Lopez, Gur, Ruben C, Bearden, Carrie E, and Freimer, Nelson B

Subjects
Biological Psychology, Psychology, Applied and Developmental Psychology, Depression, Behavioral and Social Science, Bipolar Disorder, Neurosciences, Mental Health, Clinical Research, Brain Disorders, Schizophrenia, Serious Mental Illness, 2.1 Biological and endogenous factors, Aetiology, 2.3 Psychological, social and economic factors, 2.4 Surveillance and distribution, Mental health, Good Health and Well Being, Adult, Case-Control Studies, Cognition, Cognition Disorders, Colombia, Depressive Disorder, Major, Female, Humans, Linear Models, Male, Middle Aged, Schizophrenic Psychology, Young Adult, Clinical Sciences, Public Health and Health Services, Clinical sciences, Applied and developmental psychology, Clinical and health psychology
Abstract

BackgroundSevere mental illness diagnoses have overlapping symptomatology and shared genetic risk, motivating cross-diagnostic investigations of disease-relevant quantitative measures. We analysed relationships between neurocognitive performance, symptom domains, and diagnoses in a large sample of people with severe mental illness not ascertained for a specific diagnosis (cases), and people without mental illness (controls) from a single, homogeneous population.MethodsIn this case-control study, cases with severe mental illness were ascertained through electronic medical records at Clínica San Juan de Dios de Manizales (Manizales, Caldas, Colombia) and the Hospital Universitario San Vicente Fundación (Medellín, Antioquía, Colombia). Participants were assessed for speed and accuracy using the Penn Computerized Neurocognitive Battery (CNB). Cases had structured interview-based diagnoses of schizophrenia, bipolar 1, bipolar 2, or major depressive disorder. Linear mixed models, using CNB tests as repeated measures, modelled neurocognition as a function of diagnosis, sex, and all interactions. Follow-up analyses in cases included symptom factor scores obtained from exploratory factor analysis of symptom data as main effects.FindingsBetween Oct 1, 2017, and Nov 1, 2019, 2406 participants (1689 cases [schizophrenia n=160; bipolar 1 disorder n=519; bipolar 2 disorder n=204; and major depressive disorder n=806] and 717 controls; mean age 39 years (SD 14); and 1533 female) were assessed. Participants with bipolar 1 disorder and schizophrenia had similar impairments in accuracy and speed across cognitive domains. Participants with bipolar 2 disorder and major depressive disorder performed similarly to controls, with subtle deficits in executive and social cognition. A three-factor model (psychosis, mania, and depression) best represented symptom data. Controlling for diagnosis, premorbid IQ, and disease severity, high lifetime psychosis scores were associated with reduced accuracy and speed across cognitive domains, whereas high depression scores were associated with increased social cognition accuracy.InterpretationCross-diagnostic investigations showed that neurocognitive function in severe mental illness is characterised by two distinct profiles (bipolar 1 disorder and schizophrenia, and bipolar 2 disorder and major depressive disorder), and is associated with specific symptom domains. These results suggest the utility of this design for elucidating severe mental illness causes and trajectories.FundingUS National Institute of Mental Health.

Published
2020

14. Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

Author

Ravell, Juan C, Matsuda-Lennikov, Mami, Chauvin, Samuel D, Zou, Juan, Biancalana, Matthew, Deeb, Sally J, Price, Susan, Su, Helen C, Notarangelo, Giulia, Jiang, Ping, Morawski, Aaron, Kanellopoulou, Chrysi, Binder, Kyle, Mukherjee, Ratnadeep, Anibal, James T, Sellers, Brian, Zheng, Lixin, He, Tingyan, George, Alex B, Pittaluga, Stefania, Powers, Astin, Kleiner, David E, Kapuria, Devika, Ghany, Marc, Hunsberger, Sally, Cohen, Jeffrey I, Uzel, Gulbu, Bergerson, Jenna, Wolfe, Lynne, Toro, Camilo, Gahl, William, Folio, Les R, Matthews, Helen, Angelus, Pam, Chinn, Ivan K, Orange, Jordan S, Trujillo-Vargas, Claudia M, Franco, Jose Luis, Orrego-Arango, Julio, Gutiérrez-Hincapié, Sebastian, Patel, Niraj Chandrakant, Raymond, Kimiyo, Patiroglu, Turkan, Unal, Ekrem, Karakukcu, Musa, Day, Alexandre Gr, Mehta, Pankaj, Masutani, Evan, De Ravin, Suk S, Malech, Harry L, Altan-Bonnet, Grégoire, Rao, V Koneti, Mann, Matthias, and Lenardo, Michael J

Subjects
Rare Diseases, Hematology, Clinical Research, Autoimmune Disease, Cancer, Lymphoma, 2.1 Biological and endogenous factors, Aetiology, Antigens, CD, Autoimmune Lymphoproliferative Syndrome, CD4-CD8 Ratio, Cation Transport Proteins, Female, Glycosylation, Humans, Magnesium Deficiency, Male, X-Linked Combined Immunodeficiency Diseases, Genetic diseases, Glycobiology, Immunology, Proteoglycans, Medical and Health Sciences
Abstract

X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), and increased CD4-CD8-B220-TCRαβ+ T cells (αβDNTs), in addition to the previously described features of an inverted CD4/CD8 ratio, CD4+ T lymphocytopenia, increased B cells, dysgammaglobulinemia, and decreased expression of the natural killer group 2, member D (NKG2D) receptor. EBV-associated B cell malignancies occurred frequently in EBV-infected patients. We studied patients with XMEN and patients with autoimmune lymphoproliferative syndrome (ALPS) by deep immunophenotyping (32 immune markers) using time-of-flight mass cytometry (CyTOF). Our analysis revealed that the abundance of 2 populations of naive B cells (CD20+CD27-CD22+IgM+HLA-DR+CXCR5+CXCR4++CD10+CD38+ and CD20+CD27-CD22+IgM+HLA-DR+CXCR5+CXCR4+CD10-CD38-) could differentially classify XMEN, ALPS, and healthy individuals. We also performed glycoproteomics analysis on T lymphocytes and show that XMEN disease is a congenital disorder of glycosylation that affects a restricted subset of glycoproteins. Transfection of MAGT1 mRNA enabled us to rescue proteins with defective glycosylation. Together, these data provide new clinical and pathophysiological foundations with important ramifications for the diagnosis and treatment of XMEN disease.

Published
2020

15. Dietary Interventions for Autism Spectrum Disorder: A Meta-analysis.

Author

Fraguas, David, Díaz-Caneja, Covadonga M, Pina-Camacho, Laura, Moreno, Carmen, Durán-Cutilla, Manuel, Ayora, Miriam, González-Vioque, Emiliano, de Matteis, Mario, Hendren, Robert L, Arango, Celso, and Parellada, Mara

Subjects
Humans, Fatty Acids, Omega-3, Vitamins, Dietary Supplements, Adolescent, Adult, Child, Female, Male, Randomized Controlled Trials as Topic, Autism Spectrum Disorder, Medical and Health Sciences, Psychology and Cognitive Sciences, Pediatrics
Abstract

ContextDietary interventions such as restrictive diets or supplements are common treatments for young people with autism spectrum disorder (ASD). Evidence for the efficacy of these interventions is still controversial.ObjectiveTo assess the efficacy of specific dietary interventions on symptoms, functions, and clinical domains in subjects with ASD by using a meta-analytic approach.Data sourcesOvid Medline, PsycINFO, Embase databases.Study selectionWe selected placebo-controlled, double-blind, randomized clinical trials assessing the efficacy of dietary interventions in ASD published from database inception through September 2017.Data extractionOutcome variables were subsumed under 4 clinical domains and 17 symptoms and/or functions groups. Hedges' adjusted g values were used as estimates of the effect size of each dietary intervention relative to placebo.ResultsIn this meta-analysis, we examined 27 double-blind, randomized clinical trials, including 1028 patients with ASD: 542 in the intervention arms and 486 in the placebo arms. Participant-weighted average age was 7.1 years. Participant-weighted average intervention duration was 10.6 weeks. Dietary supplementation (including omega-3, vitamin supplementation, and/or other supplementation), omega-3 supplementation, and vitamin supplementation were more efficacious than the placebo at improving several symptoms, functions, and clinical domains. Effect sizes were small (mean Hedges' g for significant analyses was 0.31), with low statistical heterogeneity and low risk of publication bias.LimitationsMethodologic heterogeneity among the studies in terms of the intervention, clinical measures and outcomes, and sample characteristics.ConclusionsThis meta-analysis does not support nonspecific dietary interventions as treatment of ASD but suggests a potential role for some specific dietary interventions in the management of some symptoms, functions, and clinical domains in patients with ASD.

Published
2019

16. Aquaporin-4 serostatus does not predict response to immunotherapy in neuromyelitis optica spectrum disorders

Author

Mealy, Maureen A, Kim, Su-Hyun, Schmidt, Felix, López, Reydmar, Arango, Jorge A Jimenez, Paul, Friedemann, Wingerchuk, Dean M, Greenberg, Benjamin M, Kim, Ho Jin, and Levy, Michael

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Adolescent, Adult, Aged, Aquaporin 4, Child, Female, Humans, Immunologic Factors, Immunosuppressive Agents, Immunotherapy, Magnetic Resonance Imaging, Male, Middle Aged, Mycophenolic Acid, Neuromyelitis Optica, Predictive Value of Tests, Retrospective Studies, Rituximab, Young Adult, Devic's disease, immunosuppression, relapse, neuromyelitis optica, rituximab, mycophenolate, Devic’s disease, Neurosciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

BackgroundDebate exists about whether neuromyelitis optica spectrum disorder seronegative disease represents the same immune-mediated attack on astrocytic aquaporin-4 as in seropositive disease.ObjectiveWe investigated whether response to common treatments for neuromyelitis optica spectrum disorder differed by serostatus, as assessed by change in annualized relapse rate.MethodsWe performed a multicenter retrospective analysis of 245 patients with neuromyelitis optica spectrum disorder who were treated with either rituximab or mycophenolate mofetil as their first-line immunosuppressive treatment for disease prevention. Patients were followed for a minimum of 6 months following treatment initiation.ResultsIn those started on rituximab, the pre-treatment annualized relapse rates for seropositive and seronegative patients were 1.81 and 1.93, respectively. On-treatment annualized relapse rates significantly declined to 0.32 (seropositive; p

Published
2018

17. Feasibility study of a cell phone intervention to promote mental health among deported mexican migrants.

Author

Bojorquez, Letza, Aguilera-Guzmán, Rosa María, Aguilera, Adrián, and Mejía-Arango, Silvia

Subjects
Humans, Feasibility Studies, Depression, Emotions, Mental Health Services, Adult, Transients and Migrants, Patient Participation, Female, Male, Relaxation Therapy, Surveys and Questionnaires, Undocumented Immigrants, Cell Phone, Cognitive Behavioral Therapy, Public Health, Public Health and Health Services
Published
2018

18. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S, Jahanshad, N, Zalesky, A, Kochunov, P, Agartz, I, Alloza, C, Andreassen, OA, Arango, C, Banaj, N, Bouix, S, Bousman, CA, Brouwer, RM, Bruggemann, J, Bustillo, J, Cahn, W, Calhoun, V, Cannon, D, Carr, V, Catts, S, Chen, J, Chen, J-X, Chen, X, Chiapponi, C, Cho, Kl K, Ciullo, V, Corvin, AS, Crespo-Facorro, B, Cropley, V, De Rossi, P, Diaz-Caneja, CM, Dickie, EW, Ehrlich, S, Fan, F-M, Faskowitz, J, Fatouros-Bergman, H, Flyckt, L, Ford, JM, Fouche, J-P, Fukunaga, M, Gill, M, Glahn, DC, Gollub, R, Goudzwaard, ED, Guo, H, Gur, RE, Gur, RC, Gurholt, TP, Hashimoto, R, Hatton, SN, Henskens, FA, Hibar, DP, Hickie, IB, Hong, LE, Horacek, J, Howells, FM, Hulshoff Pol, HE, Hyde, CL, Isaev, D, Jablensky, A, Jansen, PR, Janssen, J, Jönsson, EG, Jung, LA, Kahn, RS, Kikinis, Z, Liu, K, Klauser, P, Knöchel, C, Kubicki, M, Lagopoulos, J, Langen, C, Lawrie, S, Lenroot, RK, Lim, KO, Lopez-Jaramillo, C, Lyall, A, Magnotta, V, Mandl, RCW, Mathalon, DH, McCarley, RW, McCarthy-Jones, S, McDonald, C, McEwen, S, McIntosh, A, Melicher, T, Mesholam-Gately, RI, Michie, PT, Mowry, B, Mueller, BA, Newell, DT, O'Donnell, P, Oertel-Knöchel, V, Oestreich, L, Paciga, SA, Pantelis, C, Pasternak, O, Pearlson, G, Pellicano, GR, Pereira, A, and Pineda Zapata, J

Subjects
Neurosciences, Brain Disorders, Mental Health, Serious Mental Illness, Biomedical Imaging, Schizophrenia, Clinical Research, Mental health, Adult, Aged, Aged, 80 and over, Brain, Cohort Studies, Corpus Callosum, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, White Matter, Young Adult, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

Published
2018

19. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia.

Author

Chatterjee, Saion, Peters, Sanne AE, Woodward, Mark, Mejia Arango, Silvia, Batty, G David, Beckett, Nigel, Beiser, Alexa, Borenstein, Amy R, Crane, Paul K, Haan, Mary, Hassing, Linda B, Hayden, Kathleen M, Kiyohara, Yutaka, Larson, Eric B, Li, Chung-Yi, Ninomiya, Toshiharu, Ohara, Tomoyuki, Peters, Ruth, Russ, Tom C, Seshadri, Sudha, Strand, Bjørn H, Walker, Rod, Xu, Weili, and Huxley, Rachel R

Subjects
Humans, Dementia, Vascular, Dementia, Diabetes Mellitus, Type 2, Risk Factors, Prospective Studies, Sex Factors, Aged, Aged, 80 and over, Middle Aged, Female, Male, Vascular, Diabetes Mellitus, Type 2, and over, Endocrinology & Metabolism, Medical and Health Sciences
Abstract

ObjectiveType 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia.Research design and methodsA systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses.ResultsStudy-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45-1.80]; men: pooled RR 1.58 [95% CI 1.38-1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86-2.94) in women and 1.73 (95% CI 1.61-1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35-1.73) in women and 1.49 (95% CI 1.31-1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08-1.30]; P < 0.001).ConclusionsIndividuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.

Published
2016

20. Genetic neuropathology of obsessive psychiatric syndromes.

Author

Jaffe, AE, Deep-Soboslay, A, Tao, R, Hauptman, DT, Kaye, WH, Arango, V, Weinberger, DR, Hyde, TM, and Kleinman, JE

Subjects
Prefrontal Cortex, Humans, Tic Disorders, Genetic Predisposition to Disease, Cohort Studies, Obsessive-Compulsive Disorder, Anorexia Nervosa, Gene Expression Regulation, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Reference Values, Adolescent, Adult, Middle Aged, Female, Male, Bulimia Nervosa, Young Adult, Genetic Association Studies, Psychology, Clinical Sciences, Public Health and Health Services
Abstract

Anorexia nervosa (AN), bulimia nervosa (BN) and obsessive-compulsive disorder (OCD) are complex psychiatric disorders with shared obsessive features, thought to arise from the interaction of multiple genes of small effect with environmental factors. Potential candidate genes for AN, BN and OCD have been identified through clinical association and neuroimaging studies; however, recent genome-wide association studies of eating disorders (ED) so far have failed to report significant findings. In addition, few, if any, studies have interrogated postmortem brain tissue for evidence of expression quantitative trait loci (eQTLs) associated with candidate genes, which has particular promise as an approach to elucidating molecular mechanisms of association. We therefore selected single-nucleotide polymorphisms (SNPs) based on candidate gene studies for AN, BN and OCD from the literature, and examined the association of these SNPs with gene expression across the lifespan in prefrontal cortex of a nonpsychiatric control cohort (N=268). Several risk-predisposing SNPs were significantly associated with gene expression among control subjects. We then measured gene expression in the prefrontal cortex of cases previously diagnosed with obsessive psychiatric disorders, for example, ED (N=15) and OCD/obsessive-compulsive personality disorder or tics (OCD/OCPD/Tic; N=16), and nonpsychiatric controls (N=102) and identified 6 and 286 genes that were differentially expressed between ED compared with controls and OCD cases compared with controls, respectively (false discovery rate (FDR)

Published
2014

21. Jumping to conclusions, general intelligence, and psychosis liability: Findings from the multi-centre EU-GEI case-control study

Author

Fabio Seminerio, Andrei Szöke, Antonio Lasalvia, Diego Quattrone, Domenico Berardi, Jean-Paul Selten, Ilaria Tarricone, Peter B. Jones, Graham K. Murray, Miguel Bernardo, José Luis Santos, Pierre-Michel Llorca, Alexander Richards, Caterina La Cascia, Celso Arango, Manuel Arrojo, Victoria Rodriguez, Lieuwe de Haan, Craig Morgan, Crocettarachele Sartorio, Michael Conlon O'Donovan, Andrea Tortelli, Laura Ferraro, Julio Sanjuán, Robin M. Murray, Hannah E. Jongsma, Marta Di Forti, Cristina Marta Del-Ben, Eva Velthorst, Jim van Os, Daniele La Barbera, Bart P. F. Rutten, Julio Bobes, Sarah Tosato, Pak C. Sham, James B. Kirkbride, Paulo Rossi Menezes, Charlotte Gayer-Anderson, Giada Tripoli, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Tripoli G., Quattrone D., Ferraro L., Gayer-Anderson C., Rodriguez V., La Cascia C., La Barbera D., Sartorio C., Seminerio F., Tarricone I., Berardi D., Szoke A., Arango C., Tortelli A., Llorca P.-M., De Haan L., Velthorst E., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Del-Ben C.M., Menezes P.R., Selten J.-P., Jones P.B., Jongsma H.E., Kirkbride J.B., Lasalvia A., Tosato S., Richards A., O'donovan M., Rutten B.P.F., Os J.V., Morgan C., Sham P.C., Murray R.M., Murray G.K., Di Forti M., Adult Psychiatry, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Tripoli, Giada, Quattrone, Diego, Ferraro, Laura, Gayer-Anderson, Charlotte, Rodriguez, Victoria, La Cascia, Caterina, La Barbera, Daniele, Sartorio, Crocettarachele, Seminerio, Fabio, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Lui, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Lasalvia, Antonio, Tosato, Sarah, Richards, Alex, O'Donovan, Michael, Rutten, Bart Pf, Os, Jim van, Morgan, Craig, Sham, Pak C, Murray, Robin M, Murray, Graham K, Di Forti, Marta, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), and MUMC+: Hersen en Zenuw Centrum (3)

Subjects
Male, MISCOMPREHENSION, Intelligence, DELÍRIO, 0302 clinical medicine, Cognition, SCHIZOPHRENIA, psychotic-like experience, jumping to conclusions, Applied Psychology, Problem Solving, RISK, education.field_of_study, Middle Aged, 16. Peace & justice, Cognitive bias, 3. Good health, First episode psychosis, IQ, polygenic risk score, psychotic-like experiences, symptom dimensions, Psychiatry and Mental health, BIAS, Schizophrenia, RELIABILITY, Female, Original Article, jumping to conclusion, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Clinical psychology, Adult, Psychosis, Adolescent, DISORDERS, Population, REEXAMINATION, Delusions, 03 medical and health sciences, Young Adult, PEOPLE, medicine, Humans, Cognitive Dysfunction, education, DELUSIONAL IDEATION, Cognitive deficit, business.industry, Case-control study, medicine.disease, First episode psychosi, 030227 psychiatry, Psychotic Disorders, Case-Control Studies, Jumping to conclusions, business, 030217 neurology & neurosurgery
Abstract

This study was funded by the Medical Research Council, the European Community’s Seventh Framework Program grant [agreement HEALTH-F2-2009-241909 (Project EU-GEI)], São Paulo Research Foundation (grant 2012/0417-0), the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust and King’s College London, the NIHR BRC at University College London and the Wellcome Trust (grant 101272/Z/12/Z)., Tripoli, G., Quattrone, D., Ferraro, L., Gayer-Anderson, C., Rodriguez, V., La Cascia, C., La Barbera, D., Sartorio, C., Seminerio, F., Tarricone, I., Berardi, D., Szöke, A., Arango, C., Tortelli, A., Llorca, P.-M., De Haan, L., Velthorst, E., Bobes, J., Bernardo, M., Sanjuán, J., Santos, J.L., Arrojo, M., Del-Ben, C.M., Menezes, P.R., Selten, J.-P., Jones, P.B., Jongsma, H.E., Kirkbride, J.B., Lasalvia, A., Tosato, S., Richards, A., O'donovan, M., Rutten, B.P.F., Os, J.V., Morgan, C., Sham, P.C., Murray, R.M., Murray, G.K., Di Forti, M.

Published
2021

22. The effect of priming and duration of oestradiol benzoate treatment before progesterone administration on embryo development and survival in anestrous recipient mares

Author

Pedro S. Oquendo, Elisa S. M. Silva, Fabiana M. G. Oquendo, Juan Cuervo‐Arango, Marcelo E. Beletti, UCH. Departamento de Medicina y Cirugía Animal, and Producción Científica UCH 2022

Subjects
Estradiol, Horses - Reproduction - Hormone therapy, Caballos - Aparato genital, Embryonic Development, Horses - Generative organs, Embryo Transfer, Hormonas sexuales, Estrus, Endocrinology, Hormones, Sex, Estro, Horses - Reproduction - Endocrine aspects, Caballos - Reproducción - Tratamiento hormonal, Animals, Female, Animal Science and Zoology, Horses, Progesterone, Caballos - Reproducción - Aspectos endocrinológicos, Biotechnology
Abstract

Este artículo se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/epdf/10.1111/rda.14220 The effect of three different hormonal protocols to prepare anestrous recipient mares on embryo survival was evaluated. The first group consisted of only progesterone administration (NE) 4 days before embryo transfer, while the recipients from the other two groups received a single administration of 2.5 mg of oestradiol benzoate (SE) 2 days earlier or 8 mg of oestradiol split in increasing doses for 5 consecutive days (LE) ending 3 days before progesterone treatment. The likelihood of recovering an embryo 2 days after transfer was 46.1% (6/13), 62.5% (5/8) and 85.7% (6/7) for recipient mares from the no oestrus, short and long oestrous groups respectively (p = .09). In conclusion, the presence and duration of oestradiol treatment before progesterone administration tended to influence the embryo survival in anestrous recipients 2 days after transfer. The surviving embryos recovered from the three different groups of recipients did not show any difference in size and morphology.

Published
2022

23. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Author

Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole A. Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E. Bearden, Michael Berk, Hannes Bohman, Josefina Castro-Fornieles, Yann Chye, Benedicto Crespo-Facorro, Elena de la Serna, Covadonga M. Díaz-Caneja, Tiril P. Gurholt, Catherine E. Hegarty, Anthony James, Joost Janssen, Cecilie Johannessen, Erik G. Jönsson, Katherine H. Karlsgodt, Peter Kochunov, Noemi G. Lois, Mathias Lundberg, Anne M. Myhre, Saül Pascual-Diaz, Fabrizio Piras, Runar E. Smelror, Gianfranco Spalletta, Therese S. Stokkan, Gisela Sugranyes, Chao Suo, Sophia I. Thomopoulos, Diana Tordesillas-Gutiérrez, Daniela Vecchio, Kirsten Wedervang-Resell, Laura A. Wortinger, Paul M. Thompson, and Ingrid Agartz

Subjects
Male, Pediatric, Psychiatry, Adolescent, Psychology and Cognitive Sciences, Neurosciences, Brain, Biological Sciences, Serious Mental Illness, White Matter, Medical and Health Sciences, Brain Disorders, Cellular and Molecular Neuroscience, Psychiatry and Mental health, Diffusion Tensor Imaging, Mental Health, Good Health and Well Being, Psychotic Disorders, Clinical Research, Schizophrenia, Humans, Anisotropy, Biomedical Imaging, Female, Molecular Biology
Abstract

Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset d = 0.37), posterior corona radiata (d = 0.32), and superior fronto‐occipital fasciculus (d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.

Published
2023

24. Global population attributable fraction of potentially modifiable risk factors for mental disorders: a meta-umbrella systematic review

Author

Elena Dragioti, Joaquim Radua, Marco Solmi, Celso Arango, Dominic Oliver, Samuele Cortese, Peter B. Jones, Jae Il Shin, Christoph U. Correll, Paolo Fusar-Poli, Dragioti, Elena [0000-0001-9019-4125], Solmi, Marco [0000-0003-4877-7233], Arango, Celso [0000-0003-3382-4754], Oliver, Dominic [0000-0002-8920-3407], Jones, Peter B [0000-0002-0387-880X], Il Shin, Jae [0000-0003-2326-1820], Fusar-Poli, Paolo [0000-0003-3582-6788], and Apollo - University of Cambridge Repository

Subjects
Psychiatry, Incidence, Mental Disorders, Psykiatri, Cellular and Molecular Neuroscience, Psychiatry and Mental health, Psychotic Disorders, Meta-Analysis as Topic, Pregnancy, Risk Factors, Humans, Female, Prospective Studies, Child, Molecular Biology
Abstract

Numerous risk factors for mental disorders have been identified. However, we do not know how many disorders we could prevent and to what extent by modifying these risk factors. This study quantifies the Population Attributable Fraction (PAF) of potentially modifiable risk factors for mental disorders. We conducted a PRISMA 2020-compliant (Protocol: https://osf.io/hk2ag) meta-umbrella systematic review (Web of Science/PubMed/Cochrane Central Register of Reviews/Ovi/PsycINFO, until 05/12/2021) of umbrella reviews reporting associations between potentially modifiable risk factors and ICD/DSM mental disorders, restricted to highly convincing (class I) and convincing (class II) evidence from prospective cohorts. The primary outcome was the global meta-analytical PAF, complemented by sensitivity analyses across different settings, the meta-analytical Generalised Impact Fraction (GIF), and study quality assessment (AMSTAR). Seven umbrella reviews (including 295 meta-analyses and 547 associations) identified 28 class I-II risk associations (23 risk factors; AMSTAR: 45.0% high-, 35.0% medium-, 20.0% low quality). The largest global PAFs not confounded by indication were 37.84% (95% CI = 26.77-48.40%) for childhood adversities and schizophrenia spectrum disorders, 24.76% (95% CI = 13.98-36.49%) for tobacco smoking and opioid use disorders, 17.88% (95% CI = not available) for job strain and depression, 14.60% (95% CI = 9.46-20.52%) for insufficient physical activity and Alzheimers disease, 13.40% (95% CI = 7.75-20.15%) for childhood sexual abuse and depressive disorders, 12.37% (95% CI = 5.37-25.34%) for clinical high-risk state for psychosis and any non-organic psychotic disorders, 10.00% (95% CI = 5.62-15.95%) for three metabolic factors and depression, 9.73% (95% CI = 4.50-17.30%) for cannabis use and schizophrenia spectrum disorders, and 9.30% (95% CI = 7.36-11.38%) for maternal pre-pregnancy obesity and ADHD. The GIFs confirmed the preventive capacity for these factors. Addressing several potentially modifiable risk factors, particularly childhood adversities, can reduce the global population-level incidence of mental disorders. Funding Agencies|Wellcome Trust [ENTER: 215793/Z/19/Z]; Spanish Ministry of Science and Innovation; Instituto de Salud Carlos III [SAM16PE07CP1, PI16/02012, PI19/024]; ERDF Funds from the European Commission, "A way of making Europe", CIBERSAM; Madrid Regional Government, European Union Structural Funds [B2017/BMD-3740 AGES-CM-2]; European Union [FP7-4-HEALTH-2009-2.2.1-2-241909, FP7- HEALTH-2013-2.2.1-2-603196, FP7- HEALTH-2013-2.2.1-2-602478]; European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking [115916, 777394]; Fundacion Alicia Koplowitz; Fundacion Familia Alonso

Published
2022

25. Measurement of stigma and associated characteristics in people with tuberculosis in Medellín, Colombia: a cross-sectional study

Author

Iader Rodríguez-Márquez, Fernando Montes, Luz D Upegui-Arango, Nilton Montoya, Nelly E Vargas, Abelardo Rojas, Gloria C Valencia, Claudia M Álvarez, Catalina Marceló-Díaz, and Jesus Ochoa

Subjects
Male, Cross-Sectional Studies, Infectious Diseases, Ill-Housed Persons, Social Stigma, Public Health, Environmental and Occupational Health, Humans, Tuberculosis, Female, Parasitology, General Medicine, Colombia, Aged
Abstract

Background Stigma towards tuberculosis (TB) delays diagnosis and compromises adherence to treatment. We measured the degree of stigma and identified the sociodemographic and clinical characteristics that were associated with a higher degree of stigma in patients with pulmonary and extrapulmonary TB in Colombia. Methods We conducted a cross-sectional study with 232 participants included in the TB control program in 2017. Sociodemographic and clinical variables were measured. The stigma component was measured through a validated scale and a multiple linear regression was used. Results The study analysed 232 patients, of which 52.2% were men, 53.5% were between 27 and 59 y of age and 66.8% had a basic–medium education level. Two characteristics were significantly related to a higher stigma score: the basic–medium education level and homeless status. Homeless status increased the stigma score by 0.27. In contrast, the adjusted stigma score decreased by 0.07 if the patient's health status was perceived as ‘healthy’. Conclusion Stigma is maximized in homeless patients and patients with a low education level. It is minimized in patients who perceive their state of health as ‘healthy’.

Published
2022

26. The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)

Author

Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, De Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., Van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Hubbard, Kathryn, Beards, Stephanie, Reininghaus, Ulrich, Tripoli, Giada, Stilo, Simona A., Roldán, Laura, López, Gonzalo, Matteis, Mario, Rapado, Marta, González, Emiliano, Martínez, Covadonga, Cuadrado, Pedro, Solano, José Juan Rodríguez, Carracedo, Angel, Costas, Javier, Bernardo, Enrique García, Sánchez, Emilio, Olmeda, Ma Soledad, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Jamain, Stéphane, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Sideli, Lucia, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Loureiro, Camila Marcelino, Shuhama, Rosana, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Gayer-Anderson, Charlotte [0000-0003-1636-889X], Apollo - University of Cambridge Repository, Gayer-Anderson C., Jongsma H.E., Di Forti M., Quattrone D., Velthorst E., de Haan L., Selten J.-P., Szoke A., Llorca P.-M., Tortelli A., Arango C., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Parellada M., Tarricone I., Berardi D., Ruggeri M., Lasalvia A., Ferraro L., La Cascia C., La Barbera D., Menezes P.R., Del-Ben C.M., Hubbard K., Beards S., Reininghaus U., Tripoli G., Stilo S.A., Roldan L., Lopez G., Matteis M., Rapado M., Gonzalez E., Martinez C., Cuadrado P., Solano J.J.R., Carracedo A., Costas J., Bernardo E.G., Sanchez E., Olmeda M.S., Cabrera B., Lorente-Rovira E., Garcia-Portilla P., Jimenez-Lopez E., Franke N., van Dam D., Termorshuizen F., van der Ven E., Messchaart E., Leboyer M., Schurhoff F., Baudin G., Ferchiou A., Pignon B., Jamain S., Richard J.-R., Charpeaud T., Tronche A.-M., Frijda F., Sideli L., Seminerio F., Sartorio C., Marrazzo G., Loureiro C.M., Shuhama R., Tosato S., Bonetto C., Cristofalo D., Rutten B.P., van Os J., Jones P.B., Murray R.M., Kirkbride J.B., Morgan C., Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, de Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Lui, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, MUMC+: Hersen en Zenuw Centrum (3), ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and APH - Mental Health

Subjects
Male, Health (social science), Epidemiology, Ethnic group, Ethnic Group, Gene-environment interactions, Environment–environment interactions, 0302 clinical medicine, Ethnicity, 10. No inequality, First episode, RISK, biology, Incidence (epidemiology), Incidence, CANNABIS, Middle Aged, Case-control, First-episode psychosis, 3. Good health, Europe, Psychiatry and Mental health, Case–control Environment–environment interactions EU-GEI First-episode psychosis Gene–environment interactions Incidence, Case–control, EU-GEI, Gene–environment interactions, Schizophrenia, Cohort, Female, Psychology, Case-Control Studie, Brazil, Human, Adult, medicine.medical_specialty, Social Psychology, Adolescent, Study Protocols and Samples, DISORDERS, Environment–environment interaction, Representativeness heuristic, 03 medical and health sciences, Young Adult, PSYCHOSIS, AGE, First-episode psychosi, Environment-environment interactions, medicine, Humans, Gene–environment interaction, Settore MED/25 - Psichiatria, METAANALYSIS, biology.organism_classification, medicine.disease, 030227 psychiatry, Case-Control Studies, Gene-Environment Interaction, Cannabis, CHILDHOOD ADVERSITIES, 030217 neurology & neurosurgery, Demography
Abstract

Funder: FP7 Ideas: European Research Council; doi: http://dx.doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2010-241909, Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.

Published
2020

27. Colorectal cancer inhibition by BET inhibitor JQ1 is MYC-independent and not improved by nanoencapsulation

Author

Thibaut Fourniols, Valentina Maggio, Diana Rafael, Ariana Colaco, Elia García Vidal, Alessandra Lopes, Simo Schwartz, Águeda Martínez-Barriocanal, Veronique Preat, and Diego Arango

Subjects
Mice, Inbred BALB C, Proteins, Pharmaceutical Science, Antineoplastic Agents, Azepines, General Medicine, Triazoles, Proto-Oncogene Proteins c-myc, Mice, Drug Delivery Systems, Cell Line, Tumor, Liposomes, Animals, Humans, Nanoparticles, Female, Colorectal Neoplasms, Infusions, Intravenous, Biotechnology
Abstract

Bromodomain and extraterminal domain protein inhibitors (BETi) for cancer treatment did not convince during their first clinical trials. Their epigenetic mechanism of action is still not well understood, even if MYC is generally considered as its main downstream target. In this context, we intended to assess two new nanoformulations of the BETi JQ1 for the treatment of colorectal cancer (CRC). JQ1 was encapsulated at 10 mg/mL in lipid nanocapsules (LNC) or polymeric micelles (PM), both compatible for an intravenous administration. Their effect was compared with free JQ1 on several CRC cell lines in vitro and with daily intraperitoneal cyclodextrin (CD)-loaded JQ1 on the CT26 CRC tumor model in vivo. We showed that LNC preferentially accumulated in tumor, liver, and lymph nodes. LNC-JQ1 and CD-JQ1 similarly delayed tumor growth and increased median survival from 15 to 23 or 20.5 days. JQ1 altered MYC in only two among four CRC cell lines. This MYC-independence found in CT26 was confirmed in vivo by PCR and immunohistochemistry. The main explanation of the JQ1 anticancer effect was an increase in apoptosis. The investigation of its impact on the tumor microenvironment did not show significant effects. Finally, JQ1 association with irinotecan did not synergize in vivo with JQ1 nanoformulations. In conclusion, we demonstrated that the JQ1 anticancer effect was not improved by nanoencapsulation even if their tumor delivery was probably higher. MYC inhibition was not associated to JQ1 efficacy in the case of the CT26 CRC murine model.

Published
2022

28. Predicting the severity of peer victimization and bullying perpetration among youth with interpersonal problems: A 6‐month prospective study

Author

Alejandra, Arango, Michael, Clark, and Cheryl A, King

Subjects
Male, Adolescent, Social Psychology, Bullying, Bayes Theorem, United States, Psychiatry and Mental health, Adolescent Behavior, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, Humans, Female, Prospective Studies, Child, Crime Victims
Abstract

Peer victimization is prevalent and associated with adverse outcomes. In this prospective study of youth who self-reported interpersonal problems, we examined school connectedness, school behavioral difficulties, academic difficulties, and internalizing problems (social anxiety, self-esteem, depression) as predictors of peer victimization and bullying perpetration severity. We also examined the moderating effects of gender.Participants were 218 youth (66.5% female), ages 12-15 years (M = 13.5, SD = 1.1), who screened positive for peer victimization, bullying perpetration, and/or low social connectedness using self-report measures. Youth were recruited from an emergency department in the United States as part of an intervention trial. Youth identified primarily as African American (53.7%) and Caucasian (31.7%). Youth completed a 6-month follow-up assessment (75% retention). Separate Bayesian regression models were used to examine the effects of baseline school connectedness, school behavioral difficulties, academic difficulties, and internalizing problems on the severity of 6-month peer victimization and bullying perpetration.Baseline depression was positively related to both peer victimization and bullying perpetration severity. Baseline behavioral problems were positively related to bullying perpetration severity. Interactions indicated that gender moderated the relationship between school connectedness and peer victimization.Given the adverse outcomes linked with peer victimization and bullying perpetration, an improved understanding of factors that predict victimization and perpetration severity may be helpful in defining intervention targets.

Published
2022

29. Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis

Author

Kate Merritt, Andrew J. Lawrence, Arsime Demjaha, Kie W Nam, Roberto Rodriguez-Jimenez, Gareth J. Barker, Marina Díaz-Marsá, Brian V. Broberg, Richard Drake, Antje A. T. S. Reinders, Iris E. C. Sommer, Silvana Galderisi, Covadonga M. Díaz-Caneja, Birte Glenthøj, Kyra-Verena Sendt, Alice Egerton, Egill Rostrup, Armida Mucci, Inge Winter van Rossum, Neeltje E.M. van Haren, W. Wolfgang Fleischhacker, Lone Baandrup, Paola Dazzan, Shôn Lewis, René S. Kahn, Celso Arango, Bjørn H Ebdrup, Rocío Pérez-Iglesias, Mark Weiser, Philip McGuire, Christos Pantelis, Joost Janssen, Dazzan, P., Lawrence, A. J., Reinders, A. A. T. S., Egerton, A., Van Haren, N. E. M., Merritt, K., Barker, G. J., Perez-Iglesias, R., Sendt, K. -V., Demjaha, A., Nam, K. W., Sommer, I. E., Pantelis, C., Wolfgang Fleischhacker, W., Van Rossum, I. W., Galderisi, S., Mucci, A., Drake, R., Lewis, S., Weiser, M., Martinez Diaz-Caneja, C. M., Janssen, J., Diaz-Marsa, M., Rodriguez-Jimenez, R., Arango, C., Baandrup, L., Broberg, B., Rostrup, E., Ebdrup, B. H., Glenthoj, B., Kahn, R. S., Mcguire, P., Child and Adolescent Psychiatry / Psychology, Clinical Cognitive Neuropsychiatry Research Program (CCNP), and Movement Disorder (MD)

Subjects
Adult, Male, medicine.medical_specialty, Psychosis, Time Factors, Adolescent, medicine.medical_treatment, Schizoaffective disorder, Young Adult, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, Outcome Assessment, Health Care, Humans, Medicine, Schizophreniform disorder, Antipsychotic, cortical thickne, Gyrification, first episode, Cerebral Cortex, First episode, medicine.diagnostic_test, business.industry, Remission Induction, Magnetic resonance imaging, gyrification, trial, cortical thickness, medicine.disease, Magnetic Resonance Imaging, OPTiMiSE, 030227 psychiatry, schizophrenia, Psychiatry and Mental health, Psychotic Disorders, Schizophrenia, Female, Nerve Net, business, 030217 neurology & neurosurgery, Regular Articles, Antipsychotic Agents, Follow-Up Studies, MRI
Abstract

Individuals with psychoses have brain alterations, particularly in frontal and temporal cortices, that may be particularly prominent, already at illness onset, in those more likely to have poorer symptom remission following treatment with the first antipsychotic. The identification of strong neuroanatomical markers of symptom remission could thus facilitate stratification and individualized treatment of patients with schizophrenia. We used magnetic resonance imaging at baseline to examine brain regional and network correlates of subsequent symptomatic remission in 167 medication-naïve or minimally treated patients with first-episode schizophrenia, schizophreniform disorder, or schizoaffective disorder entering a three-phase trial, at seven sites. Patients in remission at the end of each phase were randomized to treatment as usual, with or without an adjunctive psycho-social intervention for medication adherence. The final follow-up visit was at 74 weeks. A total of 108 patients (70%) were in remission at Week 4, 85 (55%) at Week 22, and 97 (63%) at Week 74. We found no baseline regional differences in volumes, cortical thickness, surface area, or local gyrification between patients who did or did not achieved remission at any time point. However, patients not in remission at Week 74, at baseline showed reduced structural connectivity across frontal, anterior cingulate, and insular cortices. A similar pattern was evident in patients not in remission at Week 4 and Week 22, although not significantly. Lack of symptom remission in first-episode psychosis is not associated with regional brain alterations at illness onset. Instead, when the illness becomes a stable entity, its association with the altered organization of cortical gyrification becomes more defined.

Published
2021

30. Associations of Social Network Characteristics With Gait Speed in Older Women From Physical Activity Community Groups

Author

Carlos Mario Arango-Paternina, Annie Tibaduiza-Romero, Jhon Fredy Ramírez-Villada, and Leonardo Rodríguez-Perdomo

Subjects
medicine.medical_specialty, Physical activity, Psychological intervention, Physical Therapy, Sports Therapy and Rehabilitation, Logistic regression, Social Networking, Adult women, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Humans, 030212 general & internal medicine, Social isolation, Exercise, Gait, Aged, Social network, business.industry, Rehabilitation, Popularity, Walking Speed, Gait speed, Cross-Sectional Studies, Female, Geriatrics and Gerontology, medicine.symptom, business, Psychology, human activities, Gerontology, 030217 neurology & neurosurgery
Abstract

The identification of social network factors associated with gait speed may offer different perspectives for improving community and clinical interventions for older adults. The objective of this study was to explore the associations of the social network of friends with gait speed. This was a cross-sectional study conducted in a sample of 128 older adult women recruited in community groups of physical activity. Clinical screening, social network questions, body composition evaluation, and gait speed test were applied to the participants. Logistic regression models were used to analyze associations between characteristics of the social network of friends and high gait speed. Findings indicated that social isolation was not associated with high gait speed and that popularity and proportion of friends with high gait speed were significantly associated with high gait speed. Findings suggested that there was a relationship between social network factors and the ability to perform high gait speed.

Published
2021

31. The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings from the Multinational EU-GEI Study

Author

Andrea Tortelli, Peter B. Jones, Jim van Os, Caterina La Cascia, Bart P. F. Rutten, Eva Velthorst, Baptiste Pignon, Celso Arango, Sarah Tosato, Lieuwe de Haan, Julio Sanjuán, Marion Leboyer, James B. Kirkbride, Antonio Lasalvia, Diego Quattrone, Cristina Marta Del-Ben, Andrei Szöke, Grégoire Baudin, Charlotte Gayer-Anderson, Pierre-Michel Llorca, Paulo Rossi Menezes, Robin M. Murray, Julio Bobes, Hannah E Jongsma, Miguel Bernardo, Mohamed Lajnef, Jean-Paul Selten, Hugo Peyre, Jean-Romain Richard, Franck Schürhoff, Craig Morgan, Marta Di Forti, Ilaria Tarricone, Mauro Braca, Manuel Arrojo, Aziz Ferchiou, Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.-R., Baudin, G., Tosato, S., Jongsma, H., De Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuán, J., Selten, J.-P., Tortelli, A., Llorca, P.-M., Van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szöke, A., Schürhoff, F., Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Adult Psychiatry, APH - Mental Health, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Pignon B., Lajnef M., Kirkbride J.B., Peyre H., Ferchiou A., Richard J.-R., Baudin G., Tosato S., Jongsma H., De Haan L., Tarricone I., Bernardo M., Velthorst E., Braca M., Arango C., Arrojo M., Bobes J., Del-Ben C.M., Di Forti M., Gayer-Anderson C., Jones P.B., La Cascia C., Lasalvia A., Menezes P.R., Quattrone D., Sanjuan J., Selten J.-P., Tortelli A., Llorca P.-M., Van Os J., Rutten B.P.F., Murray R.M., Morgan C., Leboyer M., Szoke A., Schurhoff F., Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), and RS: MHeNs - R3 - Neuroscience

Subjects
Male, stressful life events, Schizotypy, positive subclinical symptom, Ethnic group, Social Environment, subclinical psychosis, positive subclinical symptoms, 0302 clinical medicine, Adverse Childhood Experiences, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, SINTOMAS PSÍQUICOS, subclinical psychosi, 10. No inequality, COMMUNITY ASSESSMENT, Subclinical infection, GENERAL-POPULATION, psychotic symptom, Depression, Confounding, Social Discrimination, depressive subclinical symptom, stressful life event, ETHNIC-GROUPS, 3. Good health, Psychiatry and Mental health, NEIGHBORHOOD CHARACTERISTICS, ADULT PSYCHIATRIC-DISORDERS, psychotic symptoms, Adverse Childhood Experience, Female, psychosocial stress, Psychology, Psychosocial, Human, Clinical psychology, negative subclinical symptom, psychosocial stre, Adult, Psychosis, Sibling, LIFE EVENTS, schizotypy, Psychotic Disorder, 03 medical and health sciences, Community Assessment of Psychic Experiences (CAPE), THREATENING EXPERIENCES, medicine, Humans, European Union, Settore MED/25 - Psichiatria, childhood trauma, Siblings, Stressor, medicine.disease, PERCEIVED DISCRIMINATION, negative subclinical symptoms, 030227 psychiatry, PSYCHOMETRIC PROPERTIES, Psychotic Disorders, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, dis crimination, social capital, depressive subclinical symptoms, Stress, Psychological, 030217 neurology & neurosurgery, Regular Articles, discrimination
Abstract

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment-environment (ExE) interactions between these factors. Data were drawn from the EUGEI study, in which healthy controls (N = 1497) and siblings of subjects with a psychotic disorder (N = 265) were included in six countries. The association between psychosocial stressors and subclinical psychosis dimensions (positive, negative and depressive dimension as measured by the Community Assessment of Psychic Experiences (CAPE) scale) and possible ExE interactions were assessed using linear regression models. After adjusting for sex, age, ethnicity, country, and control/sibling status, childhood trauma (beta for positive dimension: 0.13, negative: 0.49, depressive: 0.26) and stressful life events (positive: 0.08, negative: 0.16, depressive: 0.17) were associated with the three dimensions. Lower social capital was associated with the negative and depression dimensions (negative: 0.26, depressive: 0.13), and self-reported discrimination experiences with the positive dimension (0.06). Our findings are in favor of independent, cumulative and non-specific influences of social adversities in subclinical psychosis in non-clinical populations, without arguments for E * E interactions. © The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Published
2021

32. The profession of neuropsychologist in Canada: Findings of a national survey

Author

Diego Rivera, Sebastien Monette, Juan Carlos Arango-Lasprilla, Josie-Anne Bertrand, Daniela Ramos-Usuga, and Elisabeth Perreau-Linck

Subjects
Adult, Male, Employment, Canada, medicine.medical_specialty, Referral, medicine.medical_treatment, Population, Neuropsychological Tests, Arts and Humanities (miscellaneous), Neuropsychology, Surveys and Questionnaires, Developmental and Educational Psychology, medicine, Humans, Child, education, education.field_of_study, Rehabilitation, business.industry, Public sector, Clinical supervision, Psychiatry and Mental health, Clinical Psychology, Clinical neuropsychology, Neuropsychology and Physiological Psychology, Family medicine, Female, business, Psychology, Neurocognitive
Abstract

The purpose of this study was to investigate the demographic characteristics, academic training and types of professional activities of clinical neuropsychologists in Canada. 282 participants completed an online-based survey. Respondents were women for the most part and had a mean age of 43 years. They typically had doctoral-level training (85%) and about one-quarter had postdoctoral training (23%). Nearly half (47%) had a lifespan practice, over one-third (37%) had an adults-only practice, and about one-sixth (16%) had an exclusively pediatric practice. Most worked full-time (79%). Respondents were almost evenly split three ways between those who worked in the public sector, those who worked in the private sector, and those who worked in both. The most common professional activities related to assessment (95%), although clinical supervision (43%) and rehabilitation (42%) were also quite frequent, whereas research (27%) and teaching (18%) were less so. The most common reason for referral was to determine a diagnosis (79%). Pediatric neuropsychologists worked primarily with individuals with neurodevelopmental disorders and neuropsychologists working with adult populations worked primarily with individuals with emotional disorders, acquired neuropsychological disorders (traumatic brain injury, stroke/vascular), and neurocognitive disorders (dementia). At time of study, Canadian neuropsychologists seemed to enjoy a fairly balanced situation: Their level of training and the ratio of neuropsychologists per population were both high. However, these varied widely across Canada. This suggests that the profession and public interest would stand to gain from seeing training standardized to some extent nationwide.

Published
2021

33. Treatment of Locally Advanced Cervical Cancer With Kidney Failure and Comorbidities

Author

Eder, Arango Bravo, Tatiana, Carmona, Denisse, Castro-Eguiluz, Dolores, Gallardo-Rincón, Emilio, Flores, and Lucely Del Carmen, Cetina-Pérez

Subjects
Cancer Research, Oncology, Carcinoma, Squamous Cell, Humans, Uterine Cervical Neoplasms, Female, Neoplasm Invasiveness, Renal Insufficiency, Middle Aged
Abstract

A woman aged 63 years presented at the gynecological oncology outpatient clinic with the following medical history: smoking history (smoking index of 10); systemic arterial hypertension diagnosed 6 years ago; menarche at 16 years; menopause at 52 years; 4 pregnancies, 4 deliveries; beginning of active sexual life at 18 years; 3 sexual partners; and no early cancer detection method in her life. Her performance status per ECOG criteria was 1. The patient presented with transvaginal bleeding with 5 months of evolution. Upon physical exploration, a 5 x 5 cm tumor in the cervix was detected, with the following characteristics: exophytic, friable, bleeding, with invasion to the lower third of the vagina, affection to the cul-de-sac and parametria, and bilaterally fixed to the pelvic wall. A biopsy of the cervix showed moderately differentiated invasive squamous cell carcinoma.

Published
2021

34. Phase 3, Randomized, 20-Month Study of the Efficacy and Safety of Bimatoprost Implant in Patients with Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 2)

Author

Bacharach, J., Tatham, A., Ferguson, G., Belalcazar, S., Thieme, H., Goodkin, M. L., Chen, M. Y., Guo, Q., Liu, J., Robinson, M. R., Bejanian, M., Wirta, D. L., Alezzandrini, A., Bercovich, G., Deromedis, P., Furno Sola, F., Gentile, C., Lerner, S., Lupinacci, A., Zeolite, C., Birt, C., Crichton, A., Gagne, S., Giunta, M., Harasymowycz, P., Jinapriya, D., Nicolela, M., Nixon, D., Saurel, P., Yan, D., Yuen, D., Arango, S., Martinez, A., Parra Restrepo, J. C., Korda, V., Kadlecova, J., Svacinova, J., Khairy, H., El Ibiary, H., El Sanabary, Z., Bell, K., Greslechner, R., Koch, J., Lorenz, K., Oberacher-Velten, I., Schmickler, S., Schuart, C., Bandello, F., Cagini, C., Figus, M., Mastropasqua, L., Rossetti, L., Uva, M. G., Thayanithi, S., Wells, A., Husain, R., Koh, V., Lim, D., Tin, A., Gous, P., Venter, L., Kee, C., Kook, M., Park, K. -H., Eraslan, M., Kayikcioglu, O., Yildirim, N., Bourne, R., Choudhary, A., Cordeiro, F., Dubois, V., Kirwan, J., Lim, S., Martin, K., Nithy, A., Prabhu, A., Amir, A., Barnebey, H., Beck, A., Bergstrom, L., Borisuth, N., Branch, J. D., Briggs, J., Bylsma, S., Chang, P., Christie, W., Cotter, F., Depenbusch, M., Goldberg, D. F., Greiner, J., Gupta, S., Gutmark, R., Han, Y., Heersink, S., Kahook, M., Khouri, A., Kim, J., Kushnick, H., Lin, C., Luchs, J., Maharaj, A., Mansberger, S. L., Mares, F., Miller-Ellis, E., Modi, S., Paul, M., Pitha, I., Saltzmann, R., Sato, M., Savestsky, M., Segal, B., Segal, Z., Serle, J., Sherwood, M., Singh, I., Smith, S. E., Song, J., Sorenson, R., Tenkman, L., Tekwani, N., Tubbs, C., Tyson, F., Vizzeri, G., Vold, S., Vu, Q., Warren, K. S., and Wirta, D.

Subjects
Adult, Male, medicine.medical_specialty, Intraocular pressure, genetic structures, Corneal Touch, Ocular hypertension, Glaucoma, Timolol, Young Adult, Double-Blind Method, Ophthalmology, Clinical endpoint, Humans, Medicine, Pharmacology (medical), Original Research Article, Antihypertensive Agents, Intraocular Pressure, Aged, Aged, 80 and over, Drug Implants, Dose-Response Relationship, Drug, Bimatoprost, business.industry, Middle Aged, medicine.disease, eye diseases, Female, Ocular Hypertension, sense organs, Implant, Ophthalmic Solutions, business, Glaucoma, Open-Angle, medicine.drug
Abstract

Objective To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 and 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 patients with OAG or OHT and an open iridocorneal angle inferiorly in the study eye. Study eyes were administered 10 or 15 µg bimatoprost implant on day 1, week 16, and week 32, or twice-daily topical timolol maleate 0.5%. Primary endpoints were IOP and IOP change from baseline through week 12. Safety measures included treatment-emergent adverse events (TEAEs) and corneal endothelial cell density (CECD). Results Both 10 and 15 µg bimatoprost implant met the primary endpoint of noninferiority to timolol in IOP lowering through 12 weeks. Mean IOP reductions from baseline ranged from 6.2–7.4, 6.5–7.8, and 6.1–6.7 mmHg through week 12 in the 10 µg implant, 15 µg implant, and timolol groups, respectively. IOP lowering was similar after the second and third implant administrations. Probabilities of requiring no IOP-lowering treatment for 1 year after the third administration were 77.5% (10 µg implant) and 79.0% (15 µg implant). The most common TEAE was conjunctival hyperemia, typically temporally associated with the administration procedure. Corneal TEAEs of interest (primarily corneal endothelial cell loss, corneal edema, and corneal touch) were more frequent with the 15 than the 10 µg implant and generally were reported after repeated administrations. Loss in mean CECD from baseline to month 20 was ~ 5% in 10 µg implant-treated eyes and ~ 1% in topical timolol-treated eyes. Visual field progression (change in the mean deviation from baseline) was reduced in the 10 µg implant group compared with the timolol group. Conclusions The results corroborated the previous phase 3 study of the bimatoprost implant. The bimatoprost implant met the primary endpoint and effectively lowered IOP. The majority of patients required no additional treatment for 12 months after the third administration. The benefit-risk assessment favored the 10 over the 15 µg implant. Studies evaluating other administration regimens with reduced risk of corneal events are ongoing. The bimatoprost implant has the potential to improve adherence and reduce treatment burden in glaucoma. Clinicaltrials.gov Identifier NCT02250651. Supplementary Information The online version contains supplementary material available at 10.1007/s40265-021-01624-9.

Published
2021

35. Seguridad de la anestesia neuroaxial en mujeres con embarazo gemelar y síndrome de transfusión feto-fetal, sometidas a fotocoagulación láser. Estudio de cohorte retrospectiva

Author

Natalia Satizábal-Padridín, Akemi Arango-Sakamoto, Luis Felipe Laverde-Martínez, Leidy Johanna López-Erazo, Einar Sten Billefals-Vallejo, Laura Marcela Zamudio-Castilla, and Yuliana Angélica Orozco-Peláez

Subjects
embarazo gemelar, Anesthesia, Epidural, medicine.medical_specialty, Fetofetal transfusion, Gestational Age, fotocoagulación láser, anesthesia, transfusión feto-fetal, anestesia, fetofetal transfusion, Pregnancy, medicine, Humans, Prospective Studies, Investigación Original, epidural anesthesia, spinal anesthesia, Retrospective Studies, Gynecology, Laser Coagulation, business.industry, Fetoscopy, Lasers, anestesia epidural, Obstetrics and Gynecology, Spinal anesthesia, Gynecology and obstetrics, anestesia raquídea, general anesthesia, fetoscopia, RG1-991, Pregnancy, Twin, Female, business, Monozygotic twins
Abstract

To describe the clinical characteristics and the frequency of maternal, fetal and neonatal complications in accordance with the neuraxial anesthesia (NA) technique in women with twin-totwin transfusion syndrome (TTTS) treated with laser photocoagulation.Descriptive retrospective cohort study of pregnant patients with TTTS treated with laser photocoagulation under NA at Fundación Valle del Lili, Cali (Colombia), between 2013-2017. Patients with Quintero stage V TTTS were excluded. The protocol was approved by the institutional ethics committee.Of the participants, 32 met the inclusion and exclusion criteria. The study population consisted of young, multiparous women. Urgent interventions were performed in 87.5% of cases; 43.7% were Quintero stage III and epidural anesthesia was used in 56.2% of the women. Maternal hemodynamic variables were similar, in accordance with the timing of surgery and the neuraxial technique used. Sustained hypotension occurred in 65.6% of the pregnant women and 9.3% developed pulmonary edema. Pre-term delivery occurred in 65.6% of the patients and 18.7% had premature rupture of membranes. There were 14 fetal demises and five neonatal deaths. There were no cases of maternal mortality.In patients with TTTS requiring laser photocoagulation, the use of epidural, spinal or combined anesthesia is likely associated with similar maternal hemodynamic variables at the time of surgery. Practitioners providing care to these pregnant women must be aware of the frequent occurrence of maternal, fetal and neonatal complications. Prospective studies to assess the safety and effectiveness of the different neuraxial anesthesia techniques in patients with TTTS are required.describir las características clínicas y la frecuencia de complicaciones maternas, fetales y neonatales, según técnica de anestesia neuroaxial (AN) en mujeres con síndrome de transfusión feto-fetal (STFF) tratadas con fotocoagulación láser (FL).estudio de cohorte retrospectiva descriptivo. Se incluyeron gestantes con STFF tratadas con FL y AN en la Fundación Valle del Lili, Cali (Colombia) entre 2013-2017. Se excluyeron pacientes con STFF estadio-V de Quintero. Se usó estadística descriptiva. El protocolo fue aprobado por el Comité de Ética de la institución.32 participantes cumplieron con los criterios de inclusión y de exclusión. La población estuvo constituida por mujeres jóvenes, multíparas. En el 87,5% de los casos se realizó intervención de urgencia. El 43,7% presentaba el estadio-III de Quintero y en el 56,2 % de las gestantes se utilizó anestesia epidural. Las variables hemodinámicas maternas exhibieron un comportamiento similar, acorde al momento de la cirugía y la técnica neuoraxial implementada. El 65,6 % de las gestantes presentó hipotensión sostenida y el 9,3 % desarrolló edema pulmonar. El 65,6 % de las pacientes experimentó parto pretérmino y el 18,7 % ruptura prematura de membranas. Se registraron 14 muertes fetales y cinco neonatales. No se registraron casos de mortalidad materna.en pacientes con STFF que requieren FL, el uso de la anestesia epidural, espinal o combinada probablemente se asocia con un comportamiento similar al de las variables hemodinámicas maternas, durante los momentos de la cirugía. Los profesionales que brindan atención a estas gestantes deben estar alerta ante la frecuente aparición de complicaciones maternas, fetales y neonatales. Se requieren estudios prospectivos que evalúen la seguridad y la efectividad de las diferentes técnicas de anestesia neuroaxial en pacientes con STFF.

Published
2021

36. Moderate, Little, or No Improvements in Neurobehavioral Symptoms among Individuals with Long COVID: A 34-Country Retrospective Study

Author

Daniela Ramos-Usuga, Paul B. Perrin, Yelena Bogdanova, Laiene Olabarrieta-Landa, Elisabet Alzueta, Fiona C. Baker, Stella Iacovides, Mar Cortes, Juan Carlos Arango-Lasprilla, Universidad Pública de Navarra. Departamento de Ciencias de la Salud, and Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila

Subjects
Adult, Male, Long COVID, SARS-CoV-2, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Infant, Newborn, COVID-19, Neurobehavioral symptoms, neurobehavioral symptoms, risk factors, Oxygen, COVID-19 Testing, Post-Acute COVID-19 Syndrome, Risk factors, Quality of Life, Humans, Female, Retrospective Studies
Abstract

(1) Background: Some people with COVID-19 develop a series of symptoms that last for several months after infection, known as Long COVID. Although these symptoms interfere with people’s daily functioning and quality of life, few studies have focused on neurobehavioral symptoms and the risk factors associated with their development; (2) Methods: 1001 adults from 34 countries who had previously tested positive for COVID-19 completed the Neurobehavioral Symptom Inventory reporting the symptoms before their COVID-19 diagnosis, during the COVID-19 infection, and currently; (3) Results: Participants reported large-sized increases before vs. during COVID-19 in all domains. Participants reported a medium-sized improvement (during COVID-19 vs. now) in somatic symptoms, a small-sized improvement in affective symptoms, and very minor/no improvement in cognitive symptoms. The risk factors for increased neurobehavioral symptoms were: being female/trans, unemployed, younger age, low education, having another chronic health condition, greater COVID-19 severity, greater number of days since the COVID-19 diagnosis, not having received oxygen therapy, and having been hospitalized. Additionally, participants from North America, Europe, and Central Asia reported higher levels of symptoms across all domains relative to Latin America and Sub-Saharan Africa; (4) Conclusions: The results highlight the importance of evaluating and treating neurobehavioral symptoms after COVID-19, especially targeting the higher-risk groups identified. General rehabilitation strategies and evidence-based cognitive rehabilitation are needed in both the acute and Long COVID phases. Daniela Ramos Usuga was supported by a predoctoral fellowship from the Basque Government (PRE_2019_1_0164).

Published
2022
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37. Persistent negative symptoms in recent-onset psychosis: Relationship to treatment response and psychosocial functioning

Author

Paola Bucci, Paola Dazzan, Giulia Maria Giordano, Carmen Aiello, Silvana Galderisi, Celso Arango, Lone Baandrup, Inge Winter van Rossum, René S. Kahn, Roberto Rodriguez-Jimenez, Arsime Demjaha, Covadonga M. Díaz-Caneja, Robert W. Buchanan, Stefan Leucht, A. Vignapiano, Birte Glenthøj, Philip McGuire, Armida Mucci, Bucci, P., Mucci, A., van Rossum, I. W., Aiello, C., Arango, C., Baandrup, L., Buchanan, R. W., Dazzan, P., Demjaha, A., Diaz-Caneja, C. M., Giordano, G. M., Glenthoj, B. Y., Leucht, S., Mcguire, P., Rodriguez-Jimenez, R., Vignapiano, A., Kahn, R. S., and Galderisi, S.

Subjects
Adult, Male, medicine.medical_specialty, Psychosis, Treatment response, Schizoaffective disorder, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Extrapyramidal symptoms, Internal medicine, medicine, Humans, Pharmacology (medical), Biological Psychiatry, Depression (differential diagnoses), Clozapine, Outcome, Pharmacology, business.industry, Persistent negative symptoms, medicine.disease, 030227 psychiatry, First-episode schizophrenia, Psychosocial Functioning, Psychiatry and Mental health, Treatment Outcome, Psychotic Disorders, nervous system, Neurology, Schizophrenia, Female, Schizophrenic Psychology, Neurology (clinical), medicine.symptom, business, Psychosocial, 030217 neurology & neurosurgery, Antipsychotic Agents, medicine.drug
Abstract

Negative symptoms are associated with poor clinical and psychosocial outcome in schizophrenia. Their prevalence and identification in first-episode patients remains controversial. In a large cohort of patients in the early stage of schizophrenia, schizophreniform or schizoaffective disorder, we investigated, over the different phases of the OPTiMiSE trial (baseline, 4, 10 and 22 weeks of treatment), the prevalence of negative symptoms of moderate severity, unconfounded by depression and extrapyramidal symptoms at baseline. Moreover, we assessed symptomatic remission, attrition rate and psychosocial functioning in subjects with short-term (4 weeks) persistent unconfounded negative symptoms (PNS) and in those with negative symptoms that did not persist at follow-up and/or were confounded at baseline (N-PNS). Negative symptoms of moderate severity were observed in 59% of subjects at baseline. They were associated with worse psychosocial functioning and longer duration of psychosis at intake in the study. Eleven percent of subjects had PNS unconfounded at baseline and 7.9% had PNS unconfounded at both baseline and end of 4-week treatment. Psychosocial functioning was comparable in PNS and N-PNS subjects at baseline but it was significantly worse in the former group after 4-weeks. PNS subjects showed lower remission and higher attrition rates at the end of all treatment phases. Fifty-six percent of subjects completing phase 3 (clozapine treatment) had PNS, and 60% of them were non-remitters at the end of this phase. The presence of short-term PNS during the first phases of psychosis was associated with poor clinical outcome and resistance to antipsychotic treatment, including clozapine.

Published
2020

38. Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure

Author

Michael R. Zile, Marc A. Pfeffer, Lars Lund, John J.V. McMurray, Antonio S. Sibulo, Gerard C.M. Linssen, Lars Køber, Victor Shi, Juan Luis Arango, Dragos Vinereanu, Brian Claggett, Martin Lefkowitz, Milton Packer, Jean L. Rouleau, Michele Senni, Scott D. Solomon, Adel R. Rizkala, Inder S. Anand, Chen Huan Chen, Karl Swedberg, Nancy K. Sweitzer, Muthiah Vaduganathan, Béla Merkely, Sergey Boytsov, Akshay S. Desai, Solomon, S, Vaduganathan, M, L Claggett, B, Packer, M, Zile, M, Swedberg, K, Rouleau, J, A Pfeffer, M, Desai, A, Lund, L, Kober, L, Anand, I, Sweitzer, N, Linssen, G, Merkely, B, Luis Arango, J, Vinereanu, D, Chen, C, Senni, M, Sibulo, A, Boytsov, S, Shi, V, Rizkala, A, Lefkowitz, M, and Mcmurray, J

Subjects
Male, medicine.medical_specialty, Ventricular Ejection Fraction, Tetrazoles, Angiotensin-Converting Enzyme Inhibitors, Ventricular Function, Left, clinical efficacy, Angiotensin Receptor Antagonists, Physiology (medical), Internal medicine, Humans, Medicine, Clinical efficacy, Aged, Heart Failure, Ejection fraction, business.industry, Aminobutyrates, Biphenyl Compounds, Stroke Volume, Middle Aged, medicine.disease, Drug Combinations, Treatment Outcome, sacubitril/valsartan, Heart failure, ventricular ejection fraction, Cardiology, Valsartan, Female, Cardiology and Cardiovascular Medicine, business, Sacubitril, Valsartan
Abstract

Background: While disease-modifying therapies exist for heart failure (HF) with reduced left ventricular ejection fraction (LVEF), few options are available for patients in the higher range of LVEF (>40%). Sacubitril/valsartan has been compared with a renin-angiotensin-aldosterone–system inhibitor alone in 2 similarly designed clinical trials of patients with reduced and preserved LVEF, permitting examination of its effects across the full spectrum of LVEF. Methods: We combined data from PARADIGM-HF (LVEF eligibility≤40%; n=8399) and PARAGON-HF (LVEF eligibility≥45%; n=4796) in a prespecified pooled analysis. We divided randomized patients into LVEF categories: ≤22.5% (n=1269), >22.5% to 32.5% (n=3987), >32.5% to 42.5% (n=3143), > 42.5% to 52.5% (n=1427), > 52.5% to 62.5% (n=2166), and >62.5% (n=1202). We assessed time to first cardiovascular death and HF hospitalization, its components, and total heart failure hospitlizations, all-cause mortality, and noncardiovascular mortality. Incidence rates and treatment effects were examined across categories of LVEF. Results: Among 13 195 randomized patients, we observed lower rates of cardiovascular death and HF hospitalization, but similar rates of noncardiovascular death, among patients in the highest versus the lowest groups. Overall sacubitril/valsartan was superior to renin-angiotensin-aldosterone–system inhibition for first cardiovascular death or heart failure hospitalization (Hazard Ratio [HR] 0.84 [95% CI, 0.78–0.90]), cardiovascular death (HR 0.84 [95% CI, 0.76–0.92]), heart failure hospitalization (HR 0.84 [95% CI, 0.77–0.91]), and all-cause mortality (HR 0.88 [95% CI, 0.81–0.96]). The effect of sacubitril/valsartan was modified by LVEF (treatment-by-continuous LVEF interaction P =0.02), and benefit appeared to be present for individuals with EF primarily below the normal range, although the treatment benefit for cardiovascular death diminished at a lower ejection fraction. We observed effect modification by LVEF on the efficacy of sacubitril/valsartan in both men and women with respect to composite total HF hospitalizations and cardiovascular death, although women derived benefit to higher ejection fractions. Conclusions: The therapeutic effects of sacubitril/valsartan, compared with a renin-angiotensin-aldosterone–system inhibitor alone, vary by LVEF with treatment benefits, particularly for heart failure hospitalization, that appear to extend to patients with heart failure and mildly reduced ejection fraction. These therapeutic benefits appeared to extend to a higher LVEF range in women compared with men. Clinical Trial Registration: https://www.clinicaltrials.gov . Unique identifiers: NCT01920711 (PARAGON-HF), NCT01035255 (PARADIGM-HF).

Published
2020

39. Rehabilitation and outcomes after complicated vs uncomplicated mild TBI: results from the CENTER-TBI study

Author

Howe E. I., Zeldovich M., Andelic N., von Steinbuechel N., Fure S. C. R., Borgen I. M. H., Forslund M. V., Hellstrom T., Soberg H. L., Sveen U., Rasmussen M., Kleffelgaard I., Tverdal C., Helseth E., Lovstad M., Lu J., Arango-Lasprilla J. C., Tenovuo O., Azouvi P., Dawes H., Roe C., Akerlund C., Amrein K., Andreassen L., Anke A., Antoni A., Audibert G., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B. -M., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Carbayo Lozano G., Carbonara M., Cavallo S., Chevallard G., Chieregato A., Citerio G., Clusmann H., Coburn M., Coles J., Cooper J. D., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Dark P., De Keyser V., Degos V., DellaCorte F., denBoogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G. -L., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P. A., Gratz J., Gravesteijn B., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Helbok R., Horton L., Huijben J., Hutchinson P. J., Jacobs B., Jankowski S., Jarrett M., Jiang J. -Y., Johnson F., Jones K., Karan M., Kolias A. G., Kompanje E., Kondziella D., Kornaropoulos E., Koskinen L. -O., Kovacs N., Kowark A., Lagares A., Lanyon L., Laureys S., Lecky F., Ledoux D., Lefering R., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Maas A. I. R., Castano-Leon A. M., Maegele M., Majdan M., Manara A., Manley G., Martino C., Marechal H., Mattern J., McMahon C., Melegh B., Menon D., Menovsky T., Mikolic A., Misset B., Muraleedharan V., Murray L., Negru A., Nelson D., Newcombe V., Nieboer D., Nyiradi J., Olubukola O., Oresic M., Ortolano F., Palotie A., Parizel P. M., Payen J. -F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Pisica D., Ples H., Polinder S., Pomposo I., Posti J. P., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Helmrich I. R., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roise O., Rosand J., Rosenfeld J. V., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez-Porras R., Sandor J., Schafer N., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Singh R. D., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stevens R., Stewart W., Steyerberg E. W., Stocchetti N., Sundstrom N., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Ao B. T., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Unterberg A., Vajkoczy P., Vallance S., Valeinis E., Vamos Z., van der Jagt M., Van der Steen G., van der Naalt J., van Dijck J. T. J. M., van Erp I. A. M., van Essen T. A., Van Hecke W., van Heugten C., Van Praag D., van Veen E., Vyvere T. V., van Wijk R. P. J., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K. K. W., Whitehouse D., Wiegers E., Williams G., Wilson L., Winzeck S., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F. A., Zelinkova V., Ziverte A., Zoerle T., Apollo - University of Cambridge Repository, Ragauskas, Arminas, Rocka, Saulius, Tamosuitis, Tomas, Vilcinis, Rimantas, „Springer Nature' grupė, Ročka, Saulius, Tamošuitis, Tomas, Molecular Neuroscience and Ageing Research (MOLAR), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Seventh Framework Programme, FP7, European Commission, EC: 602150, Sigrid Juséliuksen Säätiö, Pécsi Tudományegyetem, PTE, OT has received funding from consultancy for NeuroTraumaSciences Ltd. and from Sigrid Juselius Foundation. The other authors declare no competing interests., CENTER-TBI was supported by the European Union 7th Framework programme (EC grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA), and from Integra LifeSciences Corporation (USA). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report., Hungarian Brain Research Program - Grant No. KTIA_13_NAP-A-II/8, University of Pécs, Pécs, Hungary 88, European Project: 602150,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,CENTER-TBI(2013), Howe, E, Zeldovich, M, Andelic, N, von Steinbuechel, N, Fure, S, Borgen, I, Forslund, M, Hellstrom, T, Soberg, H, Sveen, U, Rasmussen, M, Kleffelgaard, I, Tverdal, C, Helseth, E, Lovstad, M, Lu, J, Arango-Lasprilla, J, Tenovuo, O, Azouvi, P, Dawes, H, Roe, C, Akerlund, C, Amrein, K, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Carbayo Lozano, G, Carbonara, M, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, De Keyser, V, Degos, V, Dellacorte, F, Denboogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Kornaropoulos, E, Koskinen, L, Kovacs, N, Kowark, A, Lagares, A, Lanyon, L, Laureys, S, Lecky, F, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Lingsma, H, Maas, A, Castano-Leon, A, Maegele, M, Majdan, M, Manara, A, Manley, G, Martino, C, Marechal, H, Mattern, J, Mcmahon, C, Melegh, B, Menon, D, Menovsky, T, Mikolic, A, Misset, B, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Nyiradi, J, Olubukola, O, Oresic, M, Ortolano, F, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Pisica, D, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Helmrich, I, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schafer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Singh, R, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Stevens, R, Stewart, W, Steyerberg, E, Stocchetti, N, Sundstrom, N, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Ao, B, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Vallance, S, Valeinis, E, Vamos, Z, van der Jagt, M, Van der Steen, G, van der Naalt, J, van Dijck, J, van Erp, I, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, van Veen, E, Vyvere, T, van Wijk, R, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Whitehouse, D, Wiegers, E, Williams, G, Wilson, L, Winzeck, S, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Zelinkova, V, Ziverte, A, and Zoerle, T

Subjects
Male, Mild TBI, PROM, rehabilitation, Health Policy, Rehabilitation, Glasgow Outcome Scale, Brain Injuries, Traumatic/psychology, Traumatic/psychology, SDG 3 - Good Health and Well-being, Brain Injuries, Brain Injuries/complications, Brain Injuries, Traumatic, Quality of Life, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Brain Concussion
Abstract

Background Despite existing guidelines for managing mild traumatic brain injury (mTBI), evidence-based treatments are still scarce and large-scale studies on the provision and impact of specific rehabilitation services are needed. This study aimed to describe the provision of rehabilitation to patients after complicated and uncomplicated mTBI and investigate factors associated with functional outcome, symptom burden, and TBI-specific health-related quality of life (HRQOL) up to six months after injury. Methods Patients (n = 1379) with mTBI from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study who reported whether they received rehabilitation services during the first six months post-injury and who participated in outcome assessments were included. Functional outcome was measured with the Glasgow Outcome Scale – Extended (GOSE), symptom burden with the Rivermead Post Concussion Symptoms Questionnaire (RPQ), and HRQOL with the Quality of Life after Brain Injury – Overall Scale (QOLIBRI-OS). We examined whether transition of care (TOC) pathways, receiving rehabilitation services, sociodemographic (incl. geographic), premorbid, and injury-related factors were associated with outcomes using regression models. For easy comparison, we estimated ordinal regression models for all outcomes where the scores were classified based on quantiles. Results Overall, 43% of patients with complicated and 20% with uncomplicated mTBI reported receiving rehabilitation services, primarily in physical and cognitive domains. Patients with complicated mTBI had lower functional level, higher symptom burden, and lower HRQOL compared to uncomplicated mTBI. Rehabilitation services at three or six months and a higher number of TOC were associated with unfavorable outcomes in all models, in addition to pre-morbid psychiatric problems. Being male and having more than 13 years of education was associated with more favorable outcomes. Sustaining major trauma was associated with unfavorable GOSE outcome, whereas living in Southern and Eastern European regions was associated with lower HRQOL. Conclusions Patients with complicated mTBI reported more unfavorable outcomes and received rehabilitation services more frequently. Receiving rehabilitation services and higher number of care transitions were indicators of injury severity and associated with unfavorable outcomes. The findings should be interpreted carefully and validated in future studies as we applied a novel analytic approach. Trial registration ClinicalTrials.gov NCT02210221.

Published
2022

40. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Author

Nepogodiev, Dmitri, Simoes, Joana FF, Elizabeth, Li, Picciochi, Maria, Glasbey, James C, Baiocchi, Glauco, Blanco‐colino, Ruth, Chaudhry, Daoud, Alameer, Ehab, El‐boghdadly, Kariem, Wuraola, Funmilola, Ghosh, Dhruva, Gujjuri, Rohan R, Harrison, Ewen M, Lule, Herman, Kaafarani, Haytham, Khosravi, Mohammad, Kronberger, Irmgard, Leventoğlu, Sezai, Mann, Harvinder, Mclean, Kenneth A, Mengesha, Mengistu Gebreyohanes, Modolo, Maria Marta, Ntirenganya, Faustin, Norman, Lisa, Outani, Oumaima, Pius, Riinu, Pockney, Peter, Qureshi, Ahmad Uzair, Roslani, April Camilla, Satoi, Sohei, Shaw, Catherine, Bhangu, Aneel, Omar, Omar M, Ahmed, Waheed‐ul‐rahman, Argus, Leah, Ball, Alasdair, Bywater, Edward P, Brar, Amanpreet, Dawson, Brett E, Duran, Irani, Elhadi, Muhammed, Jones, Conor S, Kamarajah, Sivesh K, Keatley, James M, Lawday, Samuel, Marson, Ella J, Ots, Riinu, Santos, Irène, Taylor, Elliott H, Trout, Isobel M, Varghese, Chris, Venn, Mary L, William, Xu, Dajti, Irida, Gjata, Arben, Kacimi, Salah Eddine Oussama, Boccalatte, Luis, Cox, Daniel, Townend, Philip, Aigner, Felix, Kronberger, Irmgard Elisabeth, Samadov, Elgun, Alderazi, Amer, Hossain, Kamral, Padmore, Greg, Ramshorst, Gabrielle, Lawani, Ismaïl, Cerovac, Anis, Delibegovic, Samir, Gomes, Gustavo Mendonça Ataíde, Buarque, Igor Lima, Gohar, Muhammad, Slavchev, Mihail, Nwegbu, Chukwuemeka, Agarwal, Arnav, Martin, Janet, Ng‐kamstra, Joshua, Olivos, Maricarmen, Lou, Wenhui, Ren, Dong‐lin, Calvache, Jose Andres, Perez Rivera, Carlos J, Hadzibegovic, Ana Danic, Kopjar, Tomislav, Mihanovic, Jakov, Jiménez, Pablo Mijahil Avilés, Gouvas, Nikolaos, Klat, Jaroslav, Novysedlák, René, Amisi, Nicolas, Christensen, Peter, El‐hussuna, Alaa, Batista, Sylvia, Lincango‐naranjo, Eddy, Emile, Sameh, Sandoval, Danilo Alfonso Arévalo, Dhufera, Hailu, Hailu, Samuel, Mengesha, Mengistu G, Kauppila, Joonas H, Arnaud, Alexis P, Demetrashvili, Zaza, Albertsmeier, Markus, Lederhuber, Hans, Löffler, Markus W., Acquah, Daniel Kwesi, Ofori, Bernard, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Aguilera‐arevalo, Maria‐lorena, Recinos, Gustavo, Mersich, Tamás, Wettstein, Dániel, Kembuan, Gabriele, Milan, Peiman Brouki, Khosravi, Mohammad Hossein, Mozafari, Masoud, Hilmi, Ahmed, Mohan, Helen, Zmora, Oded, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Fujimoto, Yuki, Kuroda, Naoto, Abou Chaar, Mohamad K., Ayasra, Faris, Fakhradiyev, Ildar, Hamdun, Intisar Hisham Said, Jin‐young, Jang, Jamal, Mohammad, Karout, Lina, Gulla, Aiste, Rasoaherinomenjanahary, Fanjandrainy, Samison, Luc Hervé, Sánchez, Iran Irani Durán, Gonzalez, Diana Samantha, Martinez, Laura, Martínez, María José, Nayen, Alejandra, Medina, Antonio Ramos‐De, Nunez, Jade, Nashidengo, Pueya Rashid, Shah, Rakesh, Shrestha, Ashish Lal, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, Wright, Deborah, Abdur‐rahman, Lukman, Ademuyiwa, Adesoji, Adisa, Adewale, Osinaike, Babatunde, Seyi‐olajide, Justina, Williams, Omolara, Williams, Emmanuel, Pejkova, Sofija, Al Balushi, Zainab, Sayyed, Raza, Mohsen, Mustafa Abo, Abukhalaf, Sadi A., Cukier, Moises, Gomez‐fernandez, Hugo, Yip, Sebastian Shu, Ojeda, Ximena Paola Vasquez, Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel F., Zarour, Ahmad, Bonci, Eduard‐alexandru, Negoi, Ionut, Efetov, Sergey, Kochetkov, Viktor, Litvin, Andrey, Ingabire, Jc Allen, Bucyibaruta, Georges, Faustin, Ntirenganya, Habumuremyi, Sosthene, Imanishimwe, Alphonsine, Dieu, Haragirimana Jean, Munyaneza, Emmanuel, Ncogoza, Isaie, Ndong, Abdourahmane, Radenkovic, Dejan, Chew, Min Hoe, Koh, Frederick, Ngu, James, Panyko, Arpád, Bele, Uros, Košir, Jurij Aleš, Daoud, Hassan, Bravo, Ana Maria Minaya, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Adam, Mohammed Elmujtba Adam Essa, Rutegård, Martin, Sund, Malin, Adamina, Michel, Gialamas, Eleftherios, Horisberger, Karoline, Alshaar, Muhammad, Huang, Abel, Lohsiriwat, Varut, Charles, Shane, Jlassi, Haithem, Isik, Arda, Lekuya, Hervé Monka, Kopetskyi, Slava, Alsaadi, Hayder, Alshryda, Sattar, Alser, Osaid, Bankhead‐kendall, Brittany, Breen, Kerry, Mashbari, Hassan, Cal, Fernando Bonilla, Al‐naggar, Hamza, Maimbo, Mayaba, Mazingi, Dennis, Abbott, Tom, Akhbari, Melika, Benson, Ruth, Bhanderi, Shivam, Biccard, Bruce, Caruana, Edward, Chakrabortee, Sohini, Chapatwala, Reema, Costas‐chavarri, Ainhoa, Demetriades, Andreas K, Desai, Anant, Di Saverio, Salomone, Drake, Thomas, Edwards, John, Evans, Jonathan, Fiore, Marco, Ford, Samuel, Fotopoulou, Christina, Fowler, Alexander, Futaba, Kaori, Ganly, Ian, James, Harelimana Grace, Griffiths, Ewen, Gronchi, Alessandro, Hutchinson, Peter, Hyman, Gabriella Yael, Incorvia, Joseph, Jain, Ritu, Jenkinson, Michael, Khan, Tabassum, Knight, Stephen Richard, Kolias, Angelos, Kudsk‐iversen, Søren, Kwan, Tsun Yu, Leung, Elaine, Mayol, Julio, Mckay, Siobhan, Meara, John G., Mills, Emily, Moug, Susan, Patel, Akshay, Perinotti, Roberto, Rice, Henry E., Roberts, Keith, Schache, Andrew, Shaw, Richard, Smart, Neil, Stephens, Matthew, Stewart, Grant D., Teasdale, Ella, Vaughan‐shaw, Peter, Vidya, Raghavan, Wright, Naomi, Zimmelman, Natalie, Agastra, Ervis, Thereska, Dariel, Lucchini, Sergio Martin, Laudani, Veronica, Chwat, Carina, Salazar, Ivana Ines Pedraza, Pantoja Pachajoa, Diana Alejandra, Duro, Agustin, Arancibia, José Alfredo Calderón, D’Aulerio, Giuliana, Dudi‐venkata, Nagendra, Egoroff, Natasha, Farik, Shebani, Lott, Natalie, Moss, Jana‐lee, Rennie, Sarah, Tan, Lorwai, Uyen Giao, Vo, Watson, David, Watters, David, Bright, Tim, Hollington, Paul, Zhou, Xuanyu, Kroon, Hidde M, Farfus, Anthony, Barker, John, Watson, Eleanor, Stevens, Sean, Latif, Haider, Dawson, Amanda Caroline, Chuan, Alwin, Muralidharan, Vijayaragavan, Wong, Enoch, Ackermann, Travis, Pacilli, Maurizio, Hodgson, Russell, Heriot, Alexander, Choong, Peter, Brown, Wendy, Lidder, Surjit, Yeung, Justin, Traeger, Luke, Regalo, Guillermo, Gourlay, Ralph, Badiani, Sarit, Koh, Cherry, Putnis, Soni, Haider, Fayza, Mitul, Ashrarur Rahman, Komen, Niels, Dhondt, Bert, Cappeliez, Serge, Pigeolet, Manon, Schoneveld, Martijn, Stijns, Jasper, Oosterlinck, Wouter, Flamey, Nicolas, Kpangon, Cyrille, Agbadebo, Mouhamed, Tobome, Smèvo Romaric, Barros, Aldo Vieira, Júnior, Samuel Aguiar, Amaral Campos, Heloisa Galvão, Gross, Jefferson, Coimbra, Felipe José Fernandez, Kowalski, Luiz Paulo, Makdissi, Fabiana, Nakagawa, Suely, Neto, Joao Pedreira Duprat, Vartanian, Jose Guilherme, Yazbek, Guilherme, Zequi, Stenio C, Flumignan, Ronald, Jaworska, Natalia, Dell, Angela, Shanthanna, Harsha, Behzadi, Abdollah, Nessim, Carolyn, Mozel, Michelle, St‐germain, Pascal, Russell, Crispin, Groot, Gary, Safieddine, Najib, Wijeysundera, Duminda, Eskander, Antoine, Chadi, Sami, Mackenzie, Shawn, Flexman, Alana, Heredia, Fernando, Villanueva, Julio, Waissbluth, Sofia, Macchiavello, Roberto, Escudero, Mario I, Fuentes, Tyare, Mimica, Ximena, Saenz, Dinimo Bolivar, Caicedo, Lina, Alzate, Juan Pablo, Luna, Joaquin, Alonso, Nestor Fabian Pedraza, Silva, Camilo Ortiz, Rodriguez, Juliana, Silva‐igua, Liliana, Torres, Martha Luz, Trujillo, Lina María, Calvache, Albaro José Nieto, Balanta‐melo, Julián, Figueroa‐casanova, Rafael, García‐montoya, Oscar‐julián, Toro, Carlos Andres Marulanda, Botero, Marcela Velez, Arango, Maria Clara Mendoza, Martinez, Eneida Diaz, Perdomo, Valentina Gutiérrez, Montenegro, Emileth, Rodriguez‐abreu, Julia, Mejía, Dolores, Abouelnagah, Galal, Shehata, Sameh, Rida, Ahmed Hossam Eldin Fouad, Hassan, Ramy A., Saad, Mahmoud M., Loaloa, Mohamed Reda, Mostafa, Badr, Qassem, Mohamed, Fahmy, Mohamed, Abozied, Hesham, Azzam, Ahmed Y, Ghozy, Sherief, Sallam, Asser, Shehta, Ahmed, Abdelkhalek, Mohamed, Samaka, Rehab, Morsy, Amr, Sherif, Ahmed Elshawadfy, Negussie, Abraham, Fisseha, Tigist, Shumbash, Kibruyisfaw, Abebe, Metasebia, Yasin, Seid Mohammed, Akililu, Yemisirach Bizuneh, Megersa, Abebe, Tefera, Teshome, Assefa, Melatework, Atnafu, Bahru, Tsegaye, Bereket, Bezabih, Yoseph Solomon, Sisay, Silamlak, 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Christopher, Bork, Ulrich, Fluegen, Georg, Horch, Raymund E., Schmedding, Andrea, Schnitzbauer, Andreas, Eberbach, Helge, Schlager, Daniel, Spelsberg, Fritz, Keppler, Lena, Hecker, Andreas, Wolfer, Susanne, Ronellenfitsch, Ulrich, Nitschke, Christine, Peiper, Christian, Hakami, Ibrahim, Welter, Stefan, Nikolaieva, Karine, Roth, Andreas, Lindert, Judith, Gousias, Konstantinos, Rissmann, Anke, Linz, Valerie Catherine, Rahbari, Nuh, Rassweiler‐seyfried, Marie‐claire, Gut, Anna Eleonora, Gempt, Jens, Reim, Daniel, Wagner, Arthur, Keppler, Alexander M., Stoleriu, Mircea Gabriel, Saier, Tim, Stadler, Josef, Kaiser, Julia Christina, Brunner, Stefan M., Pfister, Karin, Herzberg, Jonas, Nowak, Kai, Reinhard, Tobias, Stavrou, Gregor A., Königsrainer, Alfred, Konrads, Christian, Quante, Markus, Laban, Simon, Pusch, Silke, Hirschburger, Markus, Doerner, Johannes, Wiegering, Armin, Tampaki, Ekaterini Christina, Ruiz, Alitza Gutiérrez, Rodas, Alejandra, Portilla, Ana Lucía, Carrera, Jacqueline, 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Maji, Suvendu, Basu, Somprakas, Mahakalkar, Chandrashekhar, Kannan, Ravi, Mehraj, Asif, Ranganath, N, Phadnis, Ashish, Yadev, I, Kavalakat, Alfie, Mittal, Rohin, Vallam, Karthik Chandra, Akhavizadegan, Hamed, Maleki, Esmaeil Rezghi, Kandevani, Naser Yousefzadeh, Ikele, Hilary, Mcnestry, Catherine, Fleming, Christina, O’Brien, Stephen, Elwahab, Sami Abd, Davis, Niall, Javadpour, Mohsen, Mcdonnell, Brendan, Connor, Clare O, Bolger, Jarlath, Clancy, Cillian, Croghan, Stefanie M, Donlon, Noel, Cullinane, Carolyn, Creavin, Ben, Muheilan, Muheilan, Earley, Helen, Kabir, Syed Mohammad Umar, Fahadullah, Muhammad, Ryan, Éanna, Connelly, Tara, Hashimoto, Daisuke, Alqudah, Majdi Ali, Alajalen, Amer, Omari, Rand Y., Qasem, Abdulrahman, Alawneh, Yazan, Ahmad, Amer, Aladawi, Omar, Alrayes, Bourhan, Haidar, Hanan, Husain, Shatha, Qassem, Faisal, Sumadi, Adnan, Salhiyeh, Ala’a Abu, Al‐manaseer, Balqees Mahmoud, Alsunna, Zaid, Ra’Ed, Hazim, Hamad, Faten Reyad Bani, Abuleil, Amro, Jimaale, Elmi Ahmed Mohamed, Abu‐mehsen, Marah, Olaywah, Noor, Wafi, Omar, Ababneh, Hazim, Abu‐ismail, Luai, Khamees, Almu’Atasim, Alkhatib, Ahmad, Bolatbekova, Raikhan, Kulimbet, Mukhtar, Nurgozhin, Talgat, Saliev, Timur, Zhussupov, Baurzhan, Almabayev, Ydyrys, Kaidarova, Dilyara, Tamoos, Khalil, Aqeelah, Ahmed, Mohammed, Alsnosy Abdullah Khalefa, Al Maadany, Faraj, Alkadeeki, Ghadah, Gahwagi, Milad, Aldressi, Wafa, Amnaina, Mohamed, Alansari, Arowa Hassan Abdulrahman, Alkaseek, Akram, Yagoub, Ghozlan, Amer, Anass Ben, Salem, Marwa, Almugaddami, Ayman, Burgan, Dania, Abdelkabir, Mohammed, Alshareef, Khayriyah, Islam Ben Jouira, Rayet, Meelad, Ayman, Bouhuwaish, Ahmad, Dwaga, Sumayya Essayah, Khalifa, Houda, Almiqlash, Bushray, Suliaman, Taha, Alawami, Mohammed, Elhajdawe, Fras, Aboazamazem, Hajir, Ellojli, Ibrahim, Msherghi, Ahmed, Saleh, Ismail Ali, Alayan, Mohammed, Ndayishyigikiye, Marcel Didier, Munyika, Akutu, Plarre, Philipp, Borowski, David W, Wells, Cameron, Teague, Rebecca, Elliott, Brodie, Kieser, David, Mohyieldin, Omar, Mcintosh, Nick, Haran, Cheyaanthan, King, Jasmin, Jeong, Ha, Mcguinness, Matthew James, Adesanya, Opeoluwa, Olaogun, Julius, Akinmade, Akinola, Bwala, Kefas, Agbonrofo, Peter, Afolabi, Akinwale, Usang, Usang, Ekenze, Sebastian, Olori, Samson, Lawal, Taiwo Akeem, Okunlola, Abiodun, Kache, Stephen, Sale, Danjuma, Anyanwu, Lofty‐john, Okereke, Chukwuma, Tolani, Musliu Adetola, Filipce, Venko, Todorovic, Lazar, Stavridis, Sotir, Massoud, John George, Alsibai, Sareyah, Sultan, Rizwan, Altaf, Humera Naz, Bhatti, Abu Bakar Hafeez, Waqar, Shahzad Hussain, Aziz, Aliya, Kerawala, Asad Ali, Rai, Lajpat, Anwer, Mariyah, Tariq, Aiman, Ayub, Bushra, Niazi, Sami Ullah, Naseem, Muhammad Yasir, Sarwar, Muhammad Zeeshan, Khokhar, Muhammad Imran, Zahid, Imdad Ahmad, Majid, Haroon Javaid, Talat, Nabila, Asif, Muhammad, Chaudhary, Muhammad Hamid, Farooq, Umer, Ahmad, Siddique, Mabood, Waleed, Bukhari, Syed Imran, Tariq, Muhammad, Yaqoob, Eesha, Javed, Saad, Malik, Muhammad 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Ionescu, Sebastian, Ginghina, Octav, Costea, Radu, Zarnescu, Narcis Octavian, Drasovean, Radu, Dimofte, Mihail‐gabriel, Porumb, Vlad, Kirov, Mikhail, Molitvin, Yegor, Pykhteev, Vadim, Raevskaya, Marianna, Butyrskii, Aleksandr, Alshahrani, Mushabab, Althumairi, Azah, Alzerwi, Nasser, Al Ameer, Ahmed, Madkhali, Tariq, Almulhim, Abddulrahman Saleh, Ghazwani, Salman, Ayoub, Abdu, Iskander, Othman, Ghunaim, Mohammed, Alharthi, Mohammed, Alzaidi, Turki M, Alyami, Mohammad, Al Amri, Abdulrahman, Alfakhri, Abdullah, Alhefdhi, Amal, Chowdhury, Sharfuddin, Nouh, Thamer, Alshehri, Ameen, Alzahrani, Abdulrahman, Alalawi, Yousef, Awad, Selmy, Konate, Ibrahima, Tendeng, Jacques, Teo, Nan Zun, Aqil, Sabra, López, Cristina Barrena, Mozo, Ana Sánchez, Infante, Antonio Rodriguez, Vivancos, Patricia Caja, Prieto, Mikel, Roman, Igor Alberdi San, Fernandez, Laura Gomez, Vives, Josep Maria Muñoz, Carreras‐castañer, Anna, Díaz‐feijoo, Berta, Sieira‐gil, Ramon, Turrado‐rodriguez, Victor, López, Anna Sánchez, Sánchez‐cabús, Santiago, Toscano, Marta Jimenez, Sin, MªPilar Canals, Laura, Saura García, Sole, Oriol Martin, Bellver, Pedro Palazon, Pérez‐bertólez, Sonia, Prat‐ortells, Jordi, Martínez, Mireia Riba, Rubio‐palau, Josep, Tarrado, Xavier, Nuñez, Jorge, Mendoza, Veronica Alonso, Bescós, Coro, Espin‐basany, Eloy, Espinosa‐bravo, Martin, Gil‐sala, Daniel, González‐suárez, Susana, Estruch, Nuria Montferrer, Mariño, Lucia Porteiro, Rodríguez‐tesouro, Ana, Portilla, Fabian Rojas, Pérez, M Pilar Tormos, Vives, Inmaculada, De Cortazar, Unai Garcia, Tudela, Kiara, Landaluce‐olavarria, Aitor, Gómez, Mercedes Estaire, Almoguera, Jorge, Ugarte‐sierra, Bakarne, Jimenez, Virginia, Bertrand, Marta, Puiggrós, Laura Cárdenas, Delisau‐puig, Olga, Garcia‐adamez, Jorge, Bergkvist, David Julià, Maldonado‐marcos, Eloy, García, Lucia Diego, Golet, Marta Roldón, Soto‐darias, Iván, Rahy‐martín, Aida Cristina, Enjuto, Diego, Ramos‐luengo, Adolfo, Fernandez, Juan Delgado, Duarte, Carolina Lugo, Thies, Cristina 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Xaviour, Okedi Francis, Turinawe, Gaston, Mubezi, Isaac, Sikakulya, Franck K., Kakeeto, Andrew, Kabweru, Wilberforce M., Kiweewa, Ronald, Matovu, Paul, Isaac, Otolia, Mashhour, Mohamed, El Helw, Amin, Kherani, Safeena, Mohamed, Awadelkarim, Abbas, Ferial Mohamed Ali, Mohammed, Diary, Aldlyami, Ehab, Kundra, Rakesh, Michael, Antony Louis Rex, Khalil, Kareem S., Dbeis, Rachel, Shaikh, Shafaque, Ferry, Jenny, Jamal, Aiman, Siddique, Haleema, Das, Rishi, Ponugoti, Nikhil, Rattanasirivilai, Pornjittra, Sultana, Asma, Mosley, Frances, Chan, Matthew, Bateman, Antony, Davies‐jones, Gareth, Georgiades, Fanourios, Ahmadi, Navid, Coonar, Aman, Baig, Mariam, Khatri, Chetan, Surendran, Arthika, Sonksen, Julian, Sinnerton, Robert, Brennan, Caitlin, Faulkner, Gemma, Greenhalgh, Michael, Emerson, Hannah, Singisetti, Kiran, Totty, Joshua, Wilson, Michael, Terence, Lo, Corbett, Harriet, Okonkwo, Ijeoma, Arbane, Gill, Kerawala, Cyrus, Parmar, Chetan, Bath, Michael, Odejinmi, Funlayo, Sagar, Jayesh, 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Moller, Cea‐cea, Neo, Eu Nice, Neo, Eu Ling, Nguyen, Alain, Prasad, Shalvin, Roy, Jennifer, Russell, Christine, Sammour, Tarik, Smith, Nicholas, Smith, Richard, Stranz, Conrad, Tourani, Saam, Tran, Steven, Van de Ven, Lucinda, Warren, Leigh, Whitfield, Robert, Wormald, Jamie, Yin, Yijie, Bierton, Christopher, Cribb, Benjamin, Foley, Katarina, Ong, Daniel, Watson, Matthew, Hampton, Jacob, Karam, James, Rugendyke, Anya, Zhang, Tyson, Vasey, Carolyn, Apellaniz, Eduardo, Frankel, Adam, Gahan, Lara, Guerra, Glen R, Liesegang, Amanda, Lutton, Nicholas, Maurice, Andrew, Miron, Scott, Prasad, Aveechal, Sercombe, Ashleigh, Sivapalan, Thanusan, Ahmad, Syed Danial Syed, Tee, Chin Li, Yaksich, Lachlan, Batstone, Martin, Breik, Omar, Young, Thomas, Field, Michael, Scott, Benjamin, Charlton, Gabriella, Chen, Si, Cheung, Henry Yan Chi, Gauri, Neha, Hayhurst, Ross, James, Sophie, Jang, Seyoung, Jia, Fangzhi, Zhang, Helen, Aujla, Randeep, Finsterwald, Michael, Percy, Digby, Tanaya, Alvin, Trivedi, Anand, Aylett, Andrew, Grills, Richard, Holmes, Angela, Kwok, Matthew Ming Kei, Lambers, Anton, Lambers, Leo, Lok, Evania, Nagra, Sonal, Page, Richard, Paltoglou, Nicholas, Panuganti, Vishwakar, Riddell, Sophie, Rudock, Gareth, Tan, Hannah, Underwood, Kirk, Youssef, Daniel, Amoils, Ricci, Bahtigur, Nazli, Bengeri, Savitha, Builth‐snoad, Lily, Cheah, Hock Ping, Chen, Paul, Chew, Kenneth, Chong, Alyssa, Clark, Sara, Kaul, Rhea Darbari, Devan, Eliya, Ewington, Christina, Fatima, Aleeza, Fitt, Sophia, Gaul, John, Ghosal, Paloma, Gojnich, Amy, Gunawardena, Indu, Hamer, Peter, Holmes, Samuel, Hou, Zhen, Jolly, Danielle, Kane, James Dimitri, Kaufman, Micayla, Khandelwal, Tanishq, Khanijaun, Sukhwant, Kwok, Kelvin, Latif, Edward, Laura, Sharon, Lee, Vivian, Leung, Catherine, Liang, Ina, Lin, Peter, Lun, Elizabeth Weng Yan, Luo, Haili, Victor, Ly, Jolande, Ma, Macnab, Brooke, Mcgee, Richard, Miles, Stephanie, Munro, William, Narroway, Harry, Ngan, Tin Yau, Noor, Anthony, Pahalawatta, Upuli, Park, Melissa, Parkin, Cameron, Poon, Rita, Somasundaram, Shanmugam S, Saab, Claudia, Simpson, Renwick, Steinel, Dana, Taylor, Emily, Tchen, Adrian, Thong, Shu, Tran, Kelvin, Tree, Kevin, Vance, Lucille, Wong, Ken, Victor, Yu, Zhang, Michael, Cox, Aram, Tan, David Chi Hau, Thani, Nova, Das, Shefali, Macdonald, Taigh, Salama, Paul, Sandhu, Gagandeep, Shadbolt, Rachel, Phan, Du, Townend, David, Eunmaro, Ju, Lee, Sang Mi, Barnett, Stephen, Kheslat, Hajar Hasan, Higgins, Andrew, Jamieson‐grigg, Chloe, Jenkins, Victoria, Larner, Brett, Perini, Marcos, Proud, David, Qin, Kirby, Riddiough, Georgina, Seevanayagam, Sivendran, Damien M., Wu, Zhao, Chris, Aggarwal, Sonali, Vinna, An, Battershell, Melanie, Chan, Elliot, Cheung, King Tung, Drake, Anna, Goonawardena, Janindu, Hunt, Benjamin, Christopher, Ip, Iyer, Vikram, Jain, Anshini, Kealey, Joshua, Lew, Chen, Lim, Christopher Seng Hong, Luck, Tara, Mackay, Sean, Maher, Natalie, Maroske, Georgia, Roubos, Nicholas, Sengupta, Shomik, Steen, Christopher, Tsigaras, Zac, Tuttle, Zachary, Ward, Salena, Williams, Marli, Yeap, Evie, Zhou, Jessie, Coates, Amy, Mutalima, Nora, Tran, Ton, Nataraja, Ramesh, Sharpin, Claire, Bird, David, Choy, Kay Tai, Condron, Sarah, Daruwalla, Jurstine, Anjos, Isabela, El‐khoury, Hanna, Fabian, Robert, Gillard, Andrew, Greenop, Rebecca, Issa, Michael, Lee, Sharon, Mori, Krinal, Petrakis, Nikki, Qureshi, Maryum, Sabella, Danielle, Satasivam, Prassannah, Sathianathen, Niranjan, Seow, Sean Ezekiel, Shen, Amanda, Shi, Margaret, Tabassum, Meher, Teixeira, Rodrigo, Vivian‐taylor, Josephine, Wheatley, Jennifer, Shepherd, Sally, Soucisse, Mikael, King, Sebastian, O’Connor, Brendan, Teague, Warwick, Banting, Simon, Chong, Lynn, Clatworthy, Sharnel, Cochrane, Angela, Fox, Adrian, Hii, Michael Wei, Isaacs, Anna, Johnson, Mary Ann, Knowles, Brett, Newcomb, Andrew, Price, Veronique, Raman, Jaishankar, Read, Matthew, Rowcroft, Alistair, Taylor, Lillian, Wright, Gavin, Chana, Prem, Shaw, Kalai, Bock, Jacob, Cory, Jordan, Drummond, Katharine, Lahy, Jack, Mcintire, Thomas, Price, Benjamin, Stark, Claire, Besson, Alex, Gartrell, Richard, Lauritz, Brianne, Nguyen, Ha My Ngoc, Ong, Chui Foong, Pitcher, Meron, Scullion, Lorna, Tang, Howard, Taylor, Danielle, Wolf, Brigid, Wichmann, Matthias, Davis, Amelia, Maurel, Amelie, Raubenheimer, Kyle, Campbell, Cassidy, Colaco, Ashley, Machado, Maria Julia Corbetta, Heffernan, Abbie, Karihaloo, Costa, Ludbrook, Isabella, Park, Sean SW, Peerally, Bibi Nabeeha, Singhai, Camila, Stevens, Heidi, Vavilov, Sergey, Aubin, Anne‐marie, Harris, Margaret, Lim, Zhi Ying, Spring, Rebecca, Stieler, Melissa, Barnes, Nicholas Adamson, Alam, Ahmad Seraj, Alsoudani, Ali, Amico, Francesco, Anning, Rebecca, Balogh, Zsolt J., Blatt, Alison, Cairns, Scott, Carroll, Jesse, Caterson, Andrew, Christie, Adam, Cope, Daron, Dale, Tyson, Dennis, Grace, Duggal, Anchal, Ennis, Brendan, Fenton, Mark, Yi Xin Joanna, Fu, Galevska‐dimitrovska, Ana, Gani, Jonathan, Gelzinnis, Scott, Gramlick, Madelyn, Hadlow, Claudia, Hardstaff, Ruth, Heer, Munish, Holmes, Merran, Hone, Bridget, Sophie, Hu, Huang, Linna, Iqbal, Ramiz, Jefferson, Niall, Kasthurirathne, Dimithi, Kuo, Stephen, Lau, Wayne Yan, Liang, Hsin‐ping, Lim, Daniel, Lin, Rosalina, Mcdonogh, Jack, Mcilwain, Elysse, Ming, Yan Joyce, O’Neill, Christine, Ocsan, Ryan James, Oosthuizen, Benjamin, Organ, Nicole, Otieno, James, Park, Felicity, Paterson, Amanda, Cerdeira, Marisol Perez, Peters, Luke, Petersson, Josefin, Rubbo, Sonia, Siribaddana, Venesa, Thurairajah, Kabilan, Ting, Caleb, Watson, Antonia, Way, Teagan, Wiadji, Elvina, Willoughby, Ellisha, Bailey, Ashley, Broadbent, Samuel, Narayanan, Viswanathan, Stephens, Samuel, Wilkes, Anna, Zhao, Jie, Ballal, Mohammed, D’Souza, Carl, Forbes, Clara, Goss, Matthew, Haddleton, Monique, Harty, Jacinda, Hayne, Dickon, Hew, Nicole, Koh, Wee Ling, Lee, Shawn, Malik, Shahbaz S, Abdul, Naseer Mohammed, Richards, Toby, Seow, Yi Th Ng, Wong, James, Archer, Leigh, Azaman, Nur Sabrina Binti Babe, Dilevska, Tina, Foo, Jonathan, Hans, Tasvinder, Jansen, Shirley, Kumar, Mohit, Leeson, Christopher, Pham, Terence, Pineda, Fernando Picazo, Rajakumar, Saravanan, Suk‐udom, Supisara, Tan, Jonathan, Thurston, Benjamin, Zhao, Bichen, Gupta, Shivangi, Hou, Lachlan, Jeyamanoharan, Nivedan, Leigh, James, Poh, Wei Shearn, Sala, Michael, Crothers, Rebecca, Dravid, Madhulika, Harrison, Ben, Islam, Sumayya, Mccartney, Conor, Nel, Henco, Pearson, Natasha, Apostolou, Christos, Berney, Christophe, Chou, Richard, Hanna, Sam, Lam, Andrew, Vanessa, Ma, Phanse, Salonee Shubhen, Elliott, Michael, Phung, Daniel, Barry, Jessica, Clark‐mackay, Eleanore, Cope, Jennifer, Halliwell, Richard, Chen, Ji, De Robles, Marie Shella, Llorando, Alyssa, Mahin, Humaira Haider, Rao, Dominic, Syed, Faisal, Abulafia, Daniel, Buckland, Benjamin, Cordingley, Timothy, Debiasio, Ashe, Drane, Andrew, Ireland, Patrick, Julien, Benji, Lan‐hoa, Le, Lee, Austin Yeon Suk, Loh, Eu Jhin, Middleton, Andrew, Mortimer, Brienna, Sebastian, Samuel, Short, Brooke, Stewart, Peter, Ruyven, Stephanie, Wong, Daniel, Zhang, Charry, Zhu, Bonnie, Ziaziaris, William, Leitner, Aran, Tolzman, Lukas, Zitt, Matthias, Rakos, Gergely, Székely, György, Djedovic, Gabriel, Königsrainer, Ingmar, Allmer, Caterina, Herritsch, Barbara, Mitteregger, Martin, Schauer, Christian, Seitinger, Gerald, Siebenhofer, Carmen, Uranitsch, Stefan, Duller, David, Mathew, Erwin, Skias, Christoph, Andrianakis, Alexandros, Belarmino, Armin, Brinskelle, Petra, Castellani, Christoph, Cohnert, Tina, Fediuk, Melanie, Fink, Andrea, Holzmeister, Clemens, Kahn, Judith, Kresic, Josip, Leithner, Andreas, Lindenmann, Joerg, Lumenta, David, Michelitsch, Birgit, Mikalauskas, Saulius, Nischwitz, Sebastian P., Puchwein, Paul, Roj, Andrej, Schemmer, Peter, Singer, Georg, Smolle‐juettner, Freyja‐maria, Till, Holger, Wolf, Axel, Andraschofsky, Tibor Oliver, Angerer, Rafael, Arco, Daniel, Kaufmann, Claudia, Kilic, Nura, Widschwendter, Peter, Angermann, Reinhard, Bauer, Marlies, Bergmann, Nicole, Freyschlag, Christian, Gisinger, Martin, Gollmann‐tepeköylü, Can, Graber, Michael, Haim, Alexander, Harasser, Carina, Härter, Bettina, Hirsch, Jakob, Hofer, Markus, Holfeld, Johannes, Huber, Anna Lena, Kralinger, Martina, Krappinger, Dietmar, Kuen, Marlene, Liebensteiner, Michael, Messner, Franka, Messner, Alex, Naegele, Felix, Ninkovic, Marijana, Nowosielski, Yvonne, Osl, Antonia, Ower, Cornelia, Pölzl, Leo, Rauchegger, Teresa, Reimer, Daniel, Riecke, Johannes, Schwabegger, Anton H., Sokolovski, Filipp, Strimmer, Anna, Süss, Markus, Thaler, Martin, Umlauft, Julian, Zehetner, Claus, Zeimet, Alain G., Allerstorfer, Jakob, Haslhofer, David, Hofer, Daniel, Luger, Matthias, Pisecky, Lorenz, Poier, Nikolaus, Rubicz, Nina, Schmolmüller, Christoph, Zwittag, Paul, Rossmann, Tobias, Ruiz‐navarro, Francisco, Stefanits, Harald, Elsayed, Hend, Habertheuer, Peter, Hajkova, Tereza, Loidl, Wolfgang, Luger, Ferdinand, Windischbauer, Amadeus, Fischer, Ines, Függer, Reinhold, Kirchweger, Patrick, Saini, Thomas, Berger, Julian, Fraz, Wolfgang, Nia, Arastoo, Kenez, Mihaly, Nichita, Margit, Magele, Astrid, Mayr, Thomas, Noe, Chiara, Bittner, Reinhard, Borhanian, Kurosch, Dornauer, Isabella, Emmanuel, Klaus, Gabersek, Ana, Gantschnigg, Antonia, Grechenig, Michael, Gruber, Ricarda, Hutter, Jörg, Jäger, Tarkan, Koch, Oliver, Lechner, Michael, Manzenreiter, Lisa, Mayer, Franz, Muehlbacher, Iris, Presl, Jaroslav, Rezaie, Daniel, Schredl, Philipp, Varga, Martin, Weitzendorfer, Michael, Wimmer, Angela, Brunner, Eberhard, Cillia, Michael, Gruber, Michaela, Grünbart, Martin, Heinrich, Elmar, Hoi, Hannes, Kemmetinger, Vanessa, Mittermair, Christof, Mosshammer, Victoria, Obrist, Christian, Paal, Peter, Roesch, Judith, Russe, Elisabeth, Schaetz, Tobias, Schirnhofer, Jan, Schwaiger, Karl, Wechselberger, Gottfried, Weiss, Helmut, Lanner, Maximilian, Binder, Alf‐dorian, Gürtler, Thomas, Fink, Marcus, Reichhold, Daniel, Stoyanova, Radoslava, Beitl, Klara, Bernardi, Martin H., Datler, Philip, Dawoud, Christopher, Farr, Alex, Foessleitner, Philipp, Grimm, Christoph, Harpain, Felix, Hoda, Mir Alireza, Holawe, Simone, Kranawetter, Marlene, Ott, Johannes, Perricos, Alexandra, Pesta, Maximilian, Pillerstorff, Robert, Reiterer, Christian, Riss, Stefan, Rosta, Klara, Scheriau, Georg, Tschernko, Edda, Wenzl, Rene, Wiedemann, Dominik, Wohlrab, Peter, Zapletal, Bernhard, Zimmermann, Matthias, Zimpfer, Daniel, Findl, Oliver, Fisus, Andreea, Ruiss, Manuel, Komaz, Melanie, Meindl, Nikolaus, Primavesi, Florian, Stadlbauer, Karl Heinz, Stättner, Stefan, Steiner, Florian, Cerny, Ondrej, Falkensammer, Eva, Knotzer, Hans, Köglberger, Paul, Poidinger, Bernhard, Wiesinger, Clemens Georg, Burtscher, Johannes, Rath, Sebastian, Trivik‐barrientos, Felipe, Aliyeva, Gunay, Behbudov, Vuqar, Muslumov, Gurbankhan, Zeynalov, Natiq, Alam, Mahmood, Alfayez, Fatema, Hasan, Batool, Mahdi, Maryam, Mulla, Husain, Qader, Kawthar, Saeed, Amr, Shirazi, Ahmed, Albastaki, Aysha, Birido, Nuha, Chagla, Hiba Hameed, Dawaishan, Abdulla, Dawaishan, Baheya, Farhan, Abeer, Juma, Isam, Khan, Asher, Patel, Aqsa Mohammad Eqbal, Srinivasan, Madhu, Deen, Fatema Waheed Akbar Mohamad Akbar Nawab, Abdulqadir, Seemal, Jabr, Abdulla, Maqsood, Fauzia, Almoosa, Noora, Naseer, Mai, Alam, Mohammed Shadrul, Basher, AKM Khairul, Islam, Shahnoor, Islam, S. M. Nazmul, Karim, Sabbir, Faisel, Muntasir, Khan, Sadia, Mannan, Iftekhar Ibne, Nazia, Nawshin, Bentham, Malissa, Corbin, Sasha, Doyle, Alex, Eastmond, Asha, Haynes, Amelia, O’Shea, Margaret, Phillips, Emil, Walkes, Keisha, Artyushkov, Evgeniy L., Kaplan, Mark L., Straltsov, Vladislav, Litvina, Yauheniya, Lyzikov, Alexei, Tihmanovich, Victor E., Borges, Mafalda, Brits, Tim, De Hous, Nicolas, De Wachter, Stefan, Menovsky, Tomas, Mortiers, Xavier, Vermeulen, Dorien, Vleminckx, Nils, Ysebaert, Dirk, Bontinck, Julie, Bulthé, Danny, Rasschaert, Ricky, Van Haver, Anne‐sophie, Van Belle, Koen, Verstraeten, Laurence, Vounckx, Manon, D’Ulisse, Sébastien, De Bruyne, Yasmine, El Nakadi, Badih, Heloise, Tessely, Luisetto, Matteo, Marinakis, Sotirios, Maton, Maxime, Viste, Claire, Van Daele, Elke, Vandeputte, Mathieu, Duinslaeger, Marc, Jacobs‐tulleneers‐thevissen, Daniel, Jansen, Yanina, Janssens, Ward, Kunda, Rastislav, Messaoudi, Nouredin, Ruyssers, Michael, Van Eetvelde, Ellen, Vanhoeij, Marian, Van den Eynde, Jef, Van den Eynde, Raf, Chaoui, Ahmed M., Akpla, Marcellin, Lawani, Souliath, Agossou, Hermann, Behanzin, Hulrich Aouagbe, Bokossa, Covalic, Dewanon, Hubert, Yome, Hugues, Boukari, Alassan, Gbehade, Oswald, Tobome, Sèmèvo Romaric, Amossou, Labissi Francois, Dossou, Francis, Barišić, Tatjana, Boras, Miran, Brekalo, Zdrinko, Blagojević, Ivana Čuljak, Damjanović, Ana, Dragisic, Vedran, Šimić, Ana Dugandžić, Gunaric, Filip, Kajic, Martin, Knežević, Darko, Krešić, Tanja, Lasić, Valentina, Letica, Ludvig, Martinovic, Vlatka, Mikulic, Iva, Miskovic, Josip, Pehar, Hrvoje, Rastović, Pejana, Sesar, Irena, Šetka‐čuljak, Violeta, Soljic, Martina, Tiric, Dejan, Tomić, Vajdana, Vasilj, Anja, Hudic, Igor, Oliver, Renato Aguera, Lamonica, Felipe Azenha, De Medeiros, Jorge, Florindo, Henrique Donizetti Bianchi, Filho, Rodolfo Jose Favaretto, Pereira, Fernanda Costa, Rodrigues, Rodrigo, Junior, Antonio Antunes Rodrigues, Andrade, Fernanda Ruiz, Salvetti, Maisa, Campioto, Débora Schalge, Lamonica, Mayra Tuboi, Urbano, Gustavo, Prado, Ricardo Villela, Alonso, Nivaldo, Santos, Carlos Ferreira, Tonello, Cristiano, Pires, Robinson Esteves, Rezende, Ricardo Fernandes, Reis, Igor, Marson, Fernando Augusto Lima, Ferreira, Erick Pires, Palamim, Camila Vantini Capasso, Brandao, Marcelo, Souza, Tiago Henrique, Maunsell, Rebecca, Neto, Alfeu Accorsi, Accorsi, Guilherme, Fernandes, Murilo Francisco, Machareth, Camila, Moura, Barbara Viegas, Dias, Vanessa, Guarienti, Luciano, Sampaio, Lia Regina, Vendrame, Cristiano, Coelho, Tatiane Amorim, Becker, Karin, Dias, Andre, Fachin, Camila Girardi, Gomes‐da‐silva, Monica Maria, Moraes, Isabela, Pinto, Amanda, Stychnicki, Adriano Seikiti, Julio, Nathalia Siqueira, Santos, José Mauro, Junior, Humberto Fenner Lyra, Oliveira, João Carlos Costa, Onzi, Tiago Rafael, Gerber, Marlus Tavares, Coelho, Filipe Osni, Silva, Janaína Carla, Panis, Carolina, Rech, Daniel, Avelino, Melissa, Botacin, Lais, Gonçalves, Mateus Capuzzo, Santos Leite, Amanda Lira, Pol‐fachin, Laercio, Bezerra, Tainá Santos, Santos Junior Alcimar, Alcimar Lavareda, Amorim, Robson, Leão, Maria Eduarda Bellotti, Bergamasco, João José Corrêa, Pinheiro, Cintia Cardoso, Neto, Rubem Alves Da Silva, De Araújo, Elaine Francisca, Guimaraes, Lilian, Liborio‐kimura, Tatiana, Camara, Isabelle Melo, Siqueira, Victor Ripardo, Rodriguez, Juan, Silva, Jeancarllo, Junior, Rubem Alves Silva, Cardoso, Cláudio, Guimaraes, Andre, Alves, Wislene Sarajane Moreira, Menezes, Agna Soares Da Silva, Araujo, Marcelo, Brito, Kattiucy, Albuquerque, Josie Marcelle Lira, Dussan‐sarria, Jairo Alberto, Souza, Andressa, Stüker, Andre Ricardo, Bresciani, Tiago, Stefani, Luciana Cadore, Cavazzola, Leandro Totti, Costa, Tainá, Dasqueve, Matheus, Marangon, Gustavo De Bacco, Martins, Otávio Ritter Silveira, Rodrigues, Josy, Cardoso, Guilherme Roloff, Neto, Brasil Silva, Soares, Tilaê, Zanella, Aline, Filippi, Lucas Torelly, Guerra, Enilde Eloena, Cruz, Ricardo Pedrini, Kalil, Antonio Nocchi, Laporte, Gustavo, Salem, Moacyr, Lima Brazan, Murilo, Campos Prado, Caio Antonio, Moises, Elaine Christine Dantas, Suto, Hilda Satie, Yasuda, Alice Gadotti, Zani, Ana Carolina Tagliatti, Santos, Roberto Cardoso Cardoso, Duarte, Geraldo, Joviliano, Edwaldo Edner, Santos, Carolina Lourenço Gomes, Quintana, Silvana Maria, Tamashiro, Edwin, Valera, Fabiana Cardoso Pereira, Zaccaro, Marília Veccechi Bijos, Andreotti, Isis, Lima, Leonardo, Salgado, Wilson, Cunha Viana Júnior, Alonço, Moutinho, Lana, Oliveira, Cora Pichler, Martins, Isabela Trindade, Toledo, Isabela Vieira, Guimaraes‐filho, Marco Antonio Correa, Arrivabeno, Rodrigo, Murta, Claudio Bovolenta, Said, Danniel Frade, Junior, Jose Pontes, Pugliesi, Felipe Guimarães, Gregorio, Paulo, Mariani, Alessandro, Minamoto, Fabio, Silva, Juliana Lourenço, Muller, Bruno, Zanon, Caio, Carvalho, Vladimir C., Lima, Ana Lucia Munhoz, Oliveira, Priscila R, Santos Silva, Jorge, Teixeira, Mariana Faccini, Kulcsar, Marco, Matos, Leandro, Nunes, Kamilla Schmitz, Junior, Joel Abdala, Abdallah, Emne, Carvalho, Genival Barbosa, Farias, Igor Correia, Silva, Cassia, Eloi Pinto, Fabio Fernando, Facure, Luciana, Godoy, André, Kupper, Bruna, Leite, Fernanda, Melo Lôbo, Matheus, Mantoan, Henrique, Marques, Narimã, Marques, Tomas, Medici, João Paulo, Torres, Silvio Melo, Garcia, Katheryne Merlos, Meduna, Rafael Ribeiro, Herbst, Ana Carolina Scintini, Santos, Silvana Soares Dos, Gonçalves, Bruna Tirapelli, Antonini, Marcelo, Brienze, Carolina, Farah, José Francisco, Gonçalves, Rodrigo, Machado, Vinicius, Nadal, Luis Roberto, Rodrigues, Danilo Nadal, Pansani, Adrieli, Rocha, Maria Luiza, Simonsen, Marcelo, Tsuchiya, Daniela, Vasques, Rafaela, Amorim, Jorge, Carvalho, Ana Alyra, Correia, Rebeca, Santos, Brena Costa, Neto, Henrique Jorge Guedes, Nakano, Luis, Pereda, Mariana, Vasconcelos, Vladimir, Awada, Jamile Barakat, Gava, Guilherme, Ijichi, Tiago Riuji, Kim, Nam Jin, Nunes, Rafael, Pinto, Fabio, Pereira, Thiago Henrique Sigoli, Volpe, Gustavo Jardim, Gatti, Arthur, Nardi, Caroline, Oliva, Ramon, Oliveira, Layze Braz, Carvalho, Herica Emilia Félix, Ribeiro, Ivonizete Pires, Rodrigues, Gabriel Renan Soares, Sousa, álvaro Francisco Lopes, Chebel, Michel, Sousa Fernandes, Paulo Henrique, Freitas, Marcelo Augusto Faria, Cunha, Juliano Rodrigues, Ather, Zeenia, Dimitrov, Dobromir, Filipov, Emil, Gyokova, Elitsa, Ilieva, Ivelina, Ivanov, Tsvetomir, Karamanliev, Martin, Neykov, Vasil, Atanasov, Boyko, Belev, Nikolay, Kamenova, Paolina, Tonev, Kaloyan, Yotsov, Tsanko, Hristova, Evguenia, Spassov, Kolyo, Tsankov, Tsanko, Dardanov, Dragomir, Gribnev, Petar, Sokolov, Manol, Brown, James, Tanyi, John, Hurdle, Heather, Maclean, Anthony, Sander, Michael, Al Riyami, Salim, Bali, Krittika, Bigam, David, Dajani, Khaled, Anvari, Mehran, Bolis, Rafik, Choi, David, Ellis, Susan, Gupta, Michael, Hanna, Wael, Hong, Dennis, Horner, Cynthia, Luketic, Lea, Moisiuk, Peter, Shargall, Yaron, Alfaro, Hilda, Alkhamesi, Nawar, Allen, Laura, Brackstone, Muriel, Chan, Eunice, Cheng, Davy, Chui, Jason, Gonzalez, Nelson, Lanting, Brent, Macneil, S. Danielle, Mayer, Robert, Mcgee, Jacob, Nagappa, Mahesh, Power, Nicholas, Prempeh, Agya, Qiabi, Mehdi, Razvi, Hassan, Schemitsch, Emil, Sehmbi, Herman, Shah, Ushma, Subramani, Yamini, Vasarhelyi, Edward, Vogt, Kelly, Yang, Homer, Abdehgah, Ali Ghorbani, Balvardi, Saba, Feldman, Liane, Fiore, Julio Flavio, Hanson, Melissa, Hopkins, Brent, Kaneva, Pepa, Lee, Lawrence, Leonard, Julia, Abou‐khalil, Jad, Martel, Andre, Stevenson, James, Lee, Susan, Merchant, Richard, Avoine, Samuel, Belanger, Laurence, Belanger, Mathieu, Belzile, Etienne, Blais, Anne‐sophie, Boucher‐kovalik, Sofia, Boulanger‐gobeil, Cindy, Cardinal, Etienne, Champagne, Pierre‐olivier, Cloutier, Jonathan, Corriveau‐durand, Simon, Cote, Mathieu, Cote, Maxime, Côté, Mathilde, Courval, Valérie, Demers, Suzanne, Desbiens, Christine, El Ouazzani, Mehdi, Girard, Karine, Girard, Ève‐marie, Gosselin, Karo, Khuong, Helene, Labrecque, Nathalie, Langlais, Eve‐lyne, Larouche, Audrey, Lavallée, Andréane, Lemyre, Madeleine, Maheux‐lacroix, Sarah, Marien, Melissa, Marin, Patrick, Mauger, Julie, Milot, Genevieve, Nadeau, Sylvie, Nguyen, Sebastien, Paris, Mélinda, Pelet, Stéphane, Plante, Marie, Plante, Carole, Pouliot, Frederic, Renaud, Marie Claude, Sarlabous, Mathilde, Schmit, Isabelle, St‐germain, Raphaël, Johnston, Brian, Labine, Nicole, Persad, Amit, Pham, Hong, Wood, Melissa, Azam, Riordan, Atrey, Amit, Beckett, Andrew, Cohen, Daniel, Das, Sunit, Daza, Julian, Dunkerton, Cheryl, Ellenbogen, Yosef, Hanley, Ciara, Kellett, Sorcha, Khoshbin, Amir, Ladha, Karim, Mcfarlan, Amanda, Montgomery, Spencer, Pazmino‐canizares, Janneth, Suresh, Hrishikesh, Vasdev, Ravleen, Ahmed, Maira, Gentili, Fred, Kalyvas, Aristotelis, Millesi, Matthias, Sarica, Can, Shaikh, Taariq, Leslie, St, Jacques, Null, Tabasinejad, Raha, Zadeh, Gelareh, Hsiao, Marvin, Jedrzejko, Nicole, Black, Peter, Broe, Claire, Dandurand, Charlotte, Grey, Rebecca, Leung, Philemon, Lindberg, Andrew, Gutierrez, Juan Mata, Mayson, Kelly, Meneghetti, Adam, Phillips, Drew, Street, John, Calderón, Carolina Carvajal, Pizarro, Daniel Alejandro Donoso, Fernández, Esteban, Molero, Ángela, Mutarello, Nastassja, Lucic, Jorge Núñez, Gaete, Katherine Ochoa, Lopez, Catalina Ruiz, Sepúlveda, Rina, Ulloa, Camila, Barreda, Mauricio, Dallaserra, Matias, Wood, Matías Günther, Tobar, Mauricio Sandoval, Garcia‐huidobro, Francisco, Dona, Jimena, Diez, Carolina Soto, Igor, Daniel, Mena, Javier, Reyes, José Tomás, Soto, Catalina Arredondo, Campos, Jose, Gonzalez, Javier, Rivera, Barbara, Altamirano‐villarroel, Jaime, Cohn, David, Amesti, Luis Marin, Recabal, Pedro, Sandoval, Camilo, Fonseca, Bruno Catoia, Contador, Monica, Hodali, Andres, Pincheira, Camila, Mantilla, Andrea Ramos, Garrido, Claudio Salas, Torres, Janina, Valenzuela, Marco, Chen, Zehua, Jiankun, Hu, Tao, Jin, Yang, Kun, Zhang, Yuexin, Chen, Yuan, Cunchuan, Wang, Yang, Wah, Bai, Xueli, Liang, Tingbo, Tao, Ma, Ning, Pu, Yin, Hanlin, Caicedo, Camilo, Beltran, Diego Felipe Tellez, Escobar, Alejandro, Granados, Carolina Perez, Pinzon, Lisbeth Alexandra Urueña, Bonilla, Carlos, Santana, Diana, Serrano, Oscar, Garcia, Andrea, Luque, Fernando Giron, Patino‐jaramillo, Nasly G., Baquero, Laura Giselle Contreras, Botero, Nestor Augusto Muñoz, Castellanos, Jhoana Andrea Murillo, Calvera, Andrea Juliana Vega, Acosta Buitrago, Lina M., Bohórquez‐tarazona, Maria Paz, Rivera, Paulo Andrés Cabrera, Felipe Casas, J, Alfaro, Valeria Cormane, Corso, Julian, Guerra, Bayron, Guerrero‐becerra, Albert Franz, Abiyomaa, Akram Kadamani, Montes, Felix Ramon, Paz, Manuel Santiago Mosquera, Sandoval, Camilo Andrés Polanía, Quintana, Natalia, Ortega, Carlos Fernando Roman, Santacruz, Carlos, Téllez, Manuela, Sánchez, Camilo Alejandro Velandia, Arias‐amézquita, Fernando, Vargas, Luis Felipe Cabrera, Murgueitio, Natalia Cortes, Escorcia, Elkin, Ghotme, Kemel Ahmed Ghotme, Gomez‐mayorga, Jorge Luis, Vergel, Alvaro Felipe Guerrero, Herrera‐almario, Gabriel, Londono‐schimmer, Eduardo, Mejia, Juan A., Monsalve, Guillermo, Rodriguez, Camilo, Niño, Juan Nicolas Rodriguez, Ortegón, Luis Martín Rodríguez, Sanabria, Daniel, Alvarez, Andres, Andrade, Arnulfo, Ardila‐montealegre, Javier, Baquero, David, Vidales, Edgar Mauricio Barrios, Giraldo, María Alejandra Caicedo, Carvajal, María Camila, Castillo, Maria, Florez, Maria Carolina Castillo, Cendales, María Angelica, Monroy, Danny Conde, Cortes, Henry, Daniel, Mario, De la Peña, Jairo, Delgado‐nieto, Elena Leonor, Espitia, Hernando, Avendaño, Carlos Figueroa, Burgos, Edgar Oswaldo Hernandez, Isaza‐restrepo, Andres, Londono, German, Maldonado, Margarita Maria, Montenegro, Andrea, Navarro, Juan Carlos, Navarro‐alean, Jorge, Abaunza, Katherine Parra, Pulido, Eliana, Ramírez Amaya, Erika M., Chaves, Carlos Eduardo Rey, Rincón, Natalia Andrea Rivera, Castillo, William Mauricio Riveros, Sanchez, Lizeth Rodriguez, Rubiano, Wilson, Russi, Maria, Olarte, Juan Carlos Sabogal, Tovar, Javier Mauricio Salgado, Sanchez, Maria Juliana, Varela, David Mauricio Solano, Gomez, Paula Torres, Trillos, Marcial, Patiño, Ana María Vargas, Vargas‐barato, Felipe, Leon, Juan Pablo Villate, Useche, María Alejandra Wagner, Acosta, Jesus, Almeciga, Adriana, Mendez, Luis Becerra, Beltran, Rafael Jose, Bonilla, Ana, Buitrago, Miguel, Cabrera, Marino, Quiroz, Pedro Hernando Calderon, Camacho‐nieto, Diego, Fierro, Carlos Andrés Carvajal, Bonilla, Sergio Cervera, Diaz, Sandra, Facundo, Helena, Forero, Jorge, Mora, Mauricio Garcia, Tirado, Karena Victoria Garcia, Perez, German Fabian Godoy, Gonzalez, Felipe, Guevara, Oscar, Hernandez, Jairo Alonso, Mora, David Ricardo Herrera, Lalinde, Juan David, Lehmann, Carlos, Llanos, Eduardo Leon, Lopez, Byron Eduardo Lopez De Mesa, Mariño, Ivan, Medina, Monica, Morales, Raúl Eduardo Pinilla, Puerto, Angela, Null, Ma, Quintero‐ortíz, Andrea, Hernández, Juliana Rendón, Cortés, Elio Fabio Sánchez, Hernández, Alvaro Eduardo Sánchez, Suarez, Raul, Suescun, Oscar, Vanegas, Marco, Varela, Rodolfo, Bernal, Jorge Luis Velez, Viveros‐carreño, David, Gómez, Daniela Camargo, Fletcher, Angelica, Merchan, Abel, Luna, Euler Javier Burbano, Cujiño, Indira, Galvis, Mauricio Velasquez, Galliadi, Lina Maria Vergara, Gonzalez, Orlando Abonia Gonzalez Abonia, Saravia, Maria Fernanda Acuna, Arroyave, Roberto, Angulo, Jose Maria Barreto, Bonilla‐escobar, Francisco Javier, Cardona, Uriel, Giacometto, Ivan Castañeda, Castillo, José Luis, Castillo‐cobaleda, Diego Fernando, Garcia, Diego Jose Caycedo, Tello, Brenda Marcela Coll, Dueñas‐ramirez, Juan Carlos, Vidarte, Oscar Andres Escobar, Figueroa, Luis, Garcia‐perdomo, Herney, Gomez, Alden, Gomez, Laura, Gomez, Alejandro, Grande‐gil, Ana María, Guarin, David, Guzman, Natalia, Castañeda, Enrique Herrera, Hinaoui, Marisol, Escobar, Anuar Armando Idrobo, Kammerer, Christian Kammerer, Leon, Sergio, Lucero, Carlos Antonio Llanos, López, Angie, Martinez‐blanco, Alexander Maximiliano, Casella, Antonio José Montoya, Corredor, Ricardo Andres Niño, Ordoñez, Sebastian, Uribe, Diego Alfredo Palta, Serna, Andrea Carolina Perea, Ríos, July, Ríos‐samper, Gabriel, Garcia, Juan David Rivera, Moreno, Juan Camilo Salcedo, Sandoval, John, Ramirez, Guillermo Alberto Sarmiento, Romero, Paola Andrea Tabares, Urzola, Ricardo, Valdes‐duque, Iliana Maria, Velasquez, Miguel, Villegas, Lina Maria, Zapata‐copete, James, Lara, José Omar Zorrilla, Zuluaga, Mauricio Zuluaga, Moreno, Alejandra Echeverri, Figueroa, Juan Sebastian, Ortiz, Adolfo Enrique Gómez, Mosos, Maria Fernanda Gonzalez, González‐orozco, Alejandro, Roncancio, Juan Jose Jaramillo, Martínez, María Camila Leyva, Mosos, Monica, Ramirez, Juan Sebastian, Rodríguez, Henry Andrés, Henao, Juan David Saavedra, Varón, María Alejandra Torrado, Ramírez, Leidy Natalia Idarraga, Ocampo, Lorena, Marin, Monica Cardona, Gonzalez, Ana Maria Marin, Mejia, David Alejandro, Vanegas, Luis Emiro, Martinez, Yicel Alvarez, Vesga, Sandra Aruachan, Fuentes, Dayana Vanessa Baron, Salas, Alejandra Caballero, Estrada, Gustavo Antonio Martinez, Campo, Kelly Viloria, Alvarez, Juan Antonio Corralez, Regino, Cesar David Galindo, Velasquez, Angela Maria Giraldo, Moreno, Carlos Enrique Melo, Tejada, Jorman H., Tovar, Jesus Hernan, Tovar, German Alirio, Hernández, Edison Alexander Benavides, Orozco‐chamorro, Claudia Milena, Angel, Gustavo Adolfo, Buesaquillo, Christian Ali, Montaño, Victor David Olave, Sánchez‐gómez, Andrés, Ureche, Daniela Patricia Escalante, Garrido, Jairo Martinez, Genda, Eben‐ezer, Eboma, Fabrice, Bitunjac, Kristina, Grulović, Karlo, Vučković, Marijana, Šantak, Goran, Borovic, Emanuel, Versic, Ana Bosak, Hasandić, Damir, Grabar, Natasa Poldan, Medancic, Suzana Srsen, Brkic, Lucija, Cokarić, Sara, Palac, Petra Pavic, Samac, Zeljka, Tomić, Josipa, Vrdoljak, Marija, Bacic, Ivan, Bakmaz, Bernarda, Vučičić, Nikolina Bratošević, Brzic, Domagoj, Canovic, Samir, Dijan, Emilio, Dragicevic, Maja Grgec, Karlo, Robert, Konjevoda, Suzana, Kovačević, Petra, Kovačić, Ivan, Markulić, Frane, Matak, Luka, Morović, Domagoj, Perišić, Gordan, Simic, Andrea, Skitarelić, Neven, Veršić, Matea, Žufić, Vanja, Zuzul, Matea, Anzic, Srdan Ante, Carevic, Iva, Litvic, Dubravka Heli, Markov‐glavas, Duska, Jovanovic, Tatjana Savic, Augustin, Goran, Biloš, Jerko, Biočina, Bojan, Biosic, Vedrana, Bobovec, Dino, Botica, Iva, Bumber, Boris, Čerina, Petra, Vukovic, Katarina Duric, Gasparovic, Hrvoje, Gatin, Lucija, Grsic, Kresimir, Radojković, Ika Gugić, Jelčić, Ivan, Kastelan, Zeljko, Kolak, Juraj, Kulis, Tomislav, Kunjko, Kristian, Maric, Marjan, Kavanagh, Marcel Marjanović, Milicic, Borna, Morić, Trpimir, Pasini, Miram, Penezić, Luka, Prgomet, Drago, Prstacic, Ratko, Prtorić, Andreja, Radojković, Rudolf, Romić, Ivan, Sečan, Tomislav, Šoša, Dora škrljak, Slipac, Juraj, Tomic, Mislav, Zedelj, Jurica, Zekulić, Toni, Zimak, Zoran, Lorencin, Mia, Luksic, Ivica, Mamic, Matija, Espinsa, Norberto Miranda, Cruz, Ailén Sánchez, Antoniou, Stavros A., Kakas, Michael, Panayiotou, Yiannis, Almezghwi, Heyam, Arslan, Kalbim, Besim, Hasan, Özant, Ali, Özçay, Necdet, Kokkinos, Georgios, Papatheodorou, Panayiotis, Pozotou, Ioanna, Stavrinidou, Olga, Yiallourou, Anneza, Burda, Lukáš, Dosoudil, Michal, Martinek, Lubomir, Gawel, Wladyslaw B., Lerch, Milan, Peteja, Matúš, Žatecký, Jan, Daniel, Toman, Formánek, Martin, Javurkova, Veronika, Kepičová, Markéta, Macečková, Nicole, Matousek, Petr, Simetka, Ondrej, Vavra, Petr, Zelenik, Karol, Černý, Jan, Khan, Sami, Lischke, Robert, Přibyl, Martin, Younus, Temoore, Amarasena, Yenuksha, Klíma, Karel, Pirmorad, Setareh, Hotová, Zuzana, Mladěnka, Aleš, Bozo, Nulvin, Harbjerg, Julie Lykke, Hviid, Louise, Kristensen, Helle ø, Mekhael, Mira, Nielsen, Mette Fugleberg, Paulsen, Laerke, Sinimäki, Saija, Mogensen, Louise Zinck, Bonde, Peter, Ebbehøj, Anders Lyng, Fenger, Anne‐sophie, Haugstvedt, Aleksander Fjeld, Hansen, Christine Hangaard, Jönsson, Maria Lovisa, Jorgensen, Lars N, Krarup, Peter‐martin, Lihn, Anne‐louise, Meyhoff, Christian, Otte, Helena, Amar, Anas Ould Si, Palm, Henrik, Schlesinger, Nis, Smith, Henry, Tryggedsson, Ida, Axelsen, Anne Reiss, Bælum, Jens Kristian, Ellebaek, Mark Bremholm, Ellebæk, Signe Bremholm, Hogh, Anders, Acosta, Maria, Acosta, Yancy, Baez, Pedro, Betances, Luis Alfredo, Bonilla, Luis Rodolfo, Cabreja, Daniel, Cruz, Wilton Cabrera, Expósito, María Mabel Collado, Crespo, Aldo, Cruz‐pineda, Octavio, D’óleo García, Claudio Samuel, Díaz, Pedro, Escoto, Remberto, Figueroa, Jatnna, Garcia, Luis, Rodriguez, U Garcia‐Dubus, Gomez, Humberto, Grullon, Adrian, Guerrero, Fatherin, Guzman, Lillian, Mosquea, Thelma Rocío Jiménez, Lazala, Engels, Lopez, Ariela, Francisco, Leeany Maletta, Mercado, Jhomayri, Munoz, Herisardy, Paulino, Jeffrey, Fernandez, Maricely Ambar Perez, Reyes, Rudeily, Guilamo, Lilia Rosa Reyes, Rivas, Ruben, Torres, Claudia Alejandra Rivas, Rodríguez, Ada, Villa, Madelin Tamar Rosario, Santana, Eleazar, Soto, Joel, Tactuk, Nassin, Sardiñas, Cristina Kristel Tonos, Ubinas, Raul, Victoria, Jose, Villegas, Aaron, Acra‐tolari, Ricardo, Beltran, Larissa, Betances, Luis Fernand, Blaubach, Alejandro, Mejía, Denisse Idalia Campos, Capellan, Nathalia, Bruzual, María Fernanda Cedeño, Spencer, Saray Cordero, Lantigua, Gabriella Cuevas, De Jesus, Luis, Díaz, Gabriela, Vásquez, Pedro Pablo Díaz, Disla, Karla, Uceta, Jesús Antonio Echavarría, Jimenez, Paola Irina Eusebio, Fernandez, Damaris, Camilo, Marlin Fernandez, Germosen, Jiomar Manuel Figueroa, Fortunato, Maruel, Fernández, Leyla Gabriel, Dihmes, Alicia German, Herrera, Héctor, Cuevas, Elizabeth Leon, Mata, Jose Alejandro, De La Cruz, Mirian Mateo, De la Cruz, Dolores Mejia, Mirambeaux, Marcos, De La Cruz, Fabio Ortiz, Paulino, Henry, Pelletier, Gabriela, Pichardo, Merycarla, Enrique, Rodriguez Pumarol Próspero, Rivas, Julio, Marmolejos, Ann Stephany Sanchez, Santana, Roman Santana, Almanzar, Irina Suero, Sánchez, María Magdalena Vásquez, Campuzano, Nicolás, Ocampo, José Ricardo Negrete, Armas, Maria, Guerra, Alvaro Santiago LeMarie, Vizcaya, Gustavo León, Abdelwahab, Omar Ahmed, Elmehrath, Ahmed O., Mostafa, Mohammed Ezzat, Amira, Gamal, Sallam, Ibrahim, Sherief, Mohamed, Abdelmajeed, Ahmed, Abdou, Mostafa, Shanab, Ahmed Abo, Abodeeb, Aya, Aboelkhel, Roger, Abosamak, Nour Eldin, Bakr, Amna Abou, Aboubakr, Samar, Abouelnagah, Yossof, Aboumadawy, Omar, Adel, Dina, Afifi, Nermeen, Ahmed, Sara, Ahmed, Abedelrahman, Sayed, Mohamed AL, Alberkamy, Abdelrahman, Aldahma, Mohamed, Ali, Ahmed, Ali, Mostafa, Bakr, Mohamed Amin, Anter, Alaa, Asal, Doaa, Ashoush, Fouad, Ashraf, Olfat, Ashraf, Abdel Rahman, Atta, Rewan, Badr, Salma, Bahaaeldin, Mohamed, Bastawesy, Mostafa, Darwish, Sara, El Kharashy, Rasha, Elassar, Ziad, Elbadawy, Seifeldin, Elkhity, Dina, Elsaka, Alromisaa, Elsayed, Manal, Hewalla, Mostafa Elsayed Elsayed, Elshafey, Mohamed, Eshac, Youssof, Eshac, Fares, Essameldin, Amr, Ewedah, Moataz, Ezz, Yara, Farag, Mohamed, Gadelkarim, Inas, Gadelrab, Ziyad, Gamal, Dina, Ghaly, Mira, Girgis, Nathalie, Gouda, Omar, El Goweini, Nancy H., Hafez, Nour, Hafez, Youssef, Abdin, Abdelkader Hamed, Hanno, Rodina, Hassanin, Aliaa, Hassanin, Mohamed, Hemead, Hanan M., Hemida, Abdelrahman, Hosain, Maher, Hossam, Ahmed, Aly, Hamza Hussein Aly Salama, Ibrahim, Mohamed, Ibrahim, Abdelrahman, Ibrahim, Nourhan, Hamouda, Noha Mohamed Salah Ibrahim Moussa, Iskander, Monica, Khalifa, Islam, Kotb, Mostafa, Mahmoud, Nada, Shabana, Alaa Mahmoud Abo, Mamdouh, Nora, Metwalli, Maram, Metwally, Khaled, Moghazy, Mahmoud, Mohamed, Moustafa, Mourad, Mohamed, Moustafa, Esraa, Mubarek, Kamilia, Nader, Nour Eldin, Nasser, Ahmed, Omar, Samaa, Qatora, Mostafa Shehata, Ragab, Mohamed, Ragal, Marawan, Ramadan, Dina, Ramadan, Rana, Ramadan, Sara, Romany, John, Sabry, Ahmed, Said, Yasmeen, Salamah, Sara, Saleh, Ahmed Mostafa, Elkaffas, Mona Saleh Mesbah Mohamed, Salem, Alaa, Salim, Hashem, Samih, Ahmed, Abdelaal, Ahmed Samir, Shaheen, Ahmed, Mohammed, Yassmeen Sharafeldin, Shehata, Abdelrahman, Shemeis, Mohamed, Shenit, Karim, Sheta, Mennatallah, Soffar, Asmaa, Tanas, Yousef, Tarek, Ahmed, Yehia, Nermin, Eid, Omar Khaled Mohamed, Abdulfattah, Ammar Yasser, Elsaghir, Ahmed, Elganainy, Mohamed Fouad, Elsayed, Omar Ibrahim, Elmandouh, Omar, Hamam, Omar, Shehata, Mostafa Ahmed, Abdelaziz, Areej A., Abbas, Ahmed M., El‐ghani, Wael Abd, Abd Elazeem, Hossam Aldein S., Elsayed, Mustafa Abd, Abd‐elkariem, Ahmed Yassien, Abdalla, Shimaa, Abdel‐aleem, Mahmoud, Abdelazeem, Khaled, Abdelfattah, Mahmoud, Abdelhafez, Mohammed, Abdelkarem, Mohamed M., Abdelraouf, Ali, Abdullaha, Lamess, Abubeih, Hossam, Ahmed, Moaiad Eldin, Ahmed, Nagm Eldin Abu Elnga, Ahmed, Ahmed, Saad, Sarah Ahmed, Alaa, Sherif, Alhussaini, Ali, Ali, Abdelrahman Ahmed Abdelrahman, Ali, Ibrahim, Ali, Wagdi, Mohamed, Mohamed Ali, Ashraf, Mohamed, Bassiouni, Muhammad, El‐adawy, Mohamed G., El‐sharkawi, Mohammad, Elkhayat, Hussein, Elmaghraby, Khaled, Elsdfy, Shady, Elsharkawy, Mohamed, Eltayeb, Almoutaz, Mohamed, Mohamed Esmat, Essam, Esraa, Fahd, Mahmoud, Farouk, Osama, Gadelkareem, Rabea, Ghoneim, Ahmed, Takrouney, Mohammed Hamada, Hamdan, Ahmed, Hamed, Abd El‐Rahman, Hasan, Ahmad, Hassanin, Mohamed Abdelghafor, Hawal, Islam, Henes, Kerollos, Herdan, Mohamed Omar, Hetta, Helal F., Ibrahem, Omar, Ibrahim, Mostafa, Ibrahim, Islam H., Kamel, Mahmoud, Khallaf, Mohamed, Elghazaly, Shrouk M., Mahfouz, Abobakr, Mahmoud, Osman, Mahran, Wesam, Mahrous, Doha, Marsis, Abadeer, Mohamed, Ayman, Hussein, Aliae Mohamed, Sayed, Amr Mohamed, Mohammed, Mahmoud M, Mokhtar, Ahmed, Monib, Fatma A., Nageeb, Ahmed, Nageh, Mariam Albatoul, Nageh, Mohammed, Omar, Nehal Gamal, Ragab, Abdelrahman, Ramadan, Abdelrahman, Temerik, Abdallah Rashad, Sabry, Aya, Safwat, Hadeer, Salah, Omar, Mahmoud, Ahmed Elhussiny Salah, Saleh, Ahmed, Sallam, Mahmoud, Samir, Ahmed, Sayad, Reem, Sayed, Esraa, Sedik, Ahmed S., Shahine, Mohammed, Soliman, Antonios, Soliman, Wael, Taher, Mohamed Gamal, Wanees, Randa, Yousof, Ebrahim Ahmed, Youssef, Ahmed, Elabedeen, Omar Zein, Hassan, Ahmed Emad Sayed, Fattah, Shrouk Abdel, Abostate, Ahmed, Ali, Samar, Salama, Saad Ali Saad, Allam, Mohamed, Alsadek, Ahmed, Arafa, Ebrahim, Barakat, Ahmed, El Sherpiny, Mohammed, Elbehairy, Gehad, Eleisawy, Mahmoud, Elgendy, Abdelrahman, Elhawary, Rewan, Eltregy, Sherif, Hamdy, Mahmoud, Hassan, Gehad, Khalifa, Aya, Mahmoud, Ahmed, Altukhy, Ahmed Mohamed, Noah, Kareem, Noureldin, Yasser, Nowar, Mostafa, Saad, Moustafa, Elsaeidy, Ahmed Saad, Elsaeidy, Khaled Saad, Sabry, Hesham, Sameh, Mostafa, Said‐elnaby, Ahmed Tarek, Zahed, Mohamed, Zahran, Mohamed, Zaid, Abdelrahman, Zoghary, Ahmed Zaki, Atef, Mohamed, Mohamed, Ahmed, Youssef, Mohamed, Abdelhamid, Mahmoud Hossameldin Saad, Alazab, Emad, Awad, Ahmed K., Darwesh, Amr, El Fiky, Lobna, Elgarhy, Ibrahim, Nassef, Mohamed Adel, Shaban, Mahmoud, Shalaby, Mahmoud Mohamed Mohamed, Wahba, Abdelrahman, Fouad, Omar Youssif Omar, Elsadek, Menan, Gad, Dalia, Abdelsamed, Ahmed, Bayomy, Abdulhakeem, Elsalhy, Mohamed, Fahim, Ahmed, Seleim, Ahmed, Afifi, Eman, Gamal, Fatma Alzahraa, Gamal, Mennatullah, Eldesouky, Omnia, Eldwini, Mohamed Hatem Elmetwalli Eldwini, Fahmy, Mostafa Medhat Fahmy, Hussein, Ahmed, Ouf, Abdallah, Sami, Omar, Shaat, Salem, Bahi, Abdullah Wael Mostafa Khalil, Atea, Abdurhman, Gamal, Ibrahim, El Kassas, Mohamed, Omar, Wael, Tawheed, Ahmed, Al‐oribi, Saeid, Aly, Nuran Khaled, Elfiky, Mahmoud, Elmaghraby, Alaa Eldine, Elrahmany, Abdulrahman, Elsherbeeny, Motaz, Helmy, Youssef, Nabil, Ahmed, Farahat, Ahmed Samir, Soliman, Mostafa, Wassef, Amr, Abdelrahman, Abdelrahman, Elsaban, Seif, Ghaly, Galal, Hamdy, Rana, Mondy, Hamada, Abdallah, Lubna, Darwish, Abdelrhman KZ, Rabea, Mohamed, Azab, Mohammed A, Abbas, Alzhraa Salah, El‐deeb, Marwa, Fawzy, Mohamed, Ibraheem, Maher, Bakry, Abdelrahman, Elnems, Sarah, Elsheikh, Randa, Gbreel, Mohamed Ibrahim, Hafez, Mahmoud, Jammal, Mohamed, Hamam, Khaled M, Makram, Abdelrahman M, Makram, Omar Mohamed, Rabie, Salma, Askalany, Sherine Yousery, Abushanab, Mokhtar Mohamed Ibrahim, Eid, Abdulrahman, El Ghalid, Mohammed Refaat Ibrahiem Amin, Abdelaty, Ahmed Adel, Fayad, Elsayed A., Radwan, Asmaa, Sallam, Moataz, Shokry, Ahmad, Farouk, Ahmed Mohamed, Elfallal, Ahmed, Elfeki, Hossam, Elsaeed, Mohamed, Elsaid, Mahmoud, Makroum, Amany, Elsaid, Dina Mohamed, Mostafa, Mohamed, Omar, Mohamed W, Rezk, Mohamed, Sakr, Ahmed, Sanad, Aly, Shalaby, Mostafa, Shawqy, Mohammed, Shetiwy, Mohamed, Shoma, Ashraf, Tawakl, Noura, Yunes, Asmaa, Abouzid, Amr, Atallah, Khalid, Elmorsi, Rami, Elsherbini, Ahmed, Gaballa, Khaled, Hamdy, Omar, Hamdy, Mohamed, Metwally, Islam Hany, Refky, Basel, Shetiwy, Mosab, Zuhdy, Mohammed, Zahran, Mohammed A, Abdellah, Fatima, Abdelmawla, Ahmed, Abdrabou, Ahmed, Abubakr, Asmaa, Al Gohary, Rawda, Al‐shazly, Mohammed Hamdy, Ali, Mohamed, Allam, Abdallah R, Aposaeeda, Aya, Asfour, Mohammed, Ayman, Ammar, Omran, Abdelrahman Azzam, Daghash, Ibrahim Tawfiq, Ebada, Mahmoud Ahmed, Eid, Taher, El Kelany, Ahmed, El Shemy, Esraa, El‐hag‐aly, Mohammed, Elgamal, Omar, Elghoury, Mahmoud, Elkased, Ahmed Farag, Ellakwa, Takwa Hamed, Ellakwa, Hamed, Elmeanawy, Amr, Elnoamany, Salma, Elsabagh, Alaa, Elsawey, Abdelrahman, Elshabrawy, Enas, Elshakhs, Seliman, Elsoudy, Naira, Ezzat, Esraa, Fawzy, Ahmed, Gamal, Abrar, Gameel, Ahmed, Gharbia, Khaled, Ghonaim, Mohamed, Ghonaim, Alaa, Hafez, Ahmed, Hafez, Abdelrahman, Ismail, Zainab, Khaled, Mohamed, Meselhy, Mohammed, Mikhail, Pola, Mohamed, Mervat, Mougahed, Mohamed, Mustafa, Abdulla, Nada, Ahmed, Omran, Janna, Ebiad, Mohamed S., Saleh, Ibrahiem, Salem, Nourhan, Salem, Osama, Selim, Salma, Shalaby, Ghada, Sherif, Hoda, Soltan, Hatem, Wahbah, Mahmoud, Abdelbary, Eman Zakaria, Zayan, Ahmad Helmy, Afify, Abdelrahman, Hadiya, Hossam Ali, Elshref, Mohamed Jamal, Ahmed, Mostafa Mohamed, Nasser, Nourhan, Abdeldayem, Hesham, Salama, Ibrahim Abdelkader, Ammar, Khaled, Ayoub, Islam, Aziz, Amr, Badawy, Mohammad Taha, Balabel, Mohamed, Fayed, Yahya, Gad, Emad Hamdy, Gomaha, Maher, Hammad, Essam, Hegazy, Osama, Hegazy, Elsayed, Ibrahim, Tarek, Kallaf, Mostafa, Macshut, Mahmoud, Magdy, Ammar, Oteem, Ahmed, Sallam, Ahmed, Samaan, Samy, Sharshar, Mohamed, Shoreem, Hany, Soliman, Elsayed, Soliman, Hossam Eldeen, Yassein, Taha, Zakaria, Hazem, Eldaly, Abdullah, Mashaly, Sarah, Abd‐elsalam, Sherief, Abdel‐elsalam, Wafaa, Shaalah, Ahmed Abdullah, Elbahnasawy, Mohamed, Elhalaby, Ismael, Hamada, Mohamed, Soliman, Sarah Hamdy, Hawila, Ahmed, Morsy, Mohamed Sherif, Naieem, Mohmed, Nasreddin, Mohammed, Salman, Samar, Sarsik, Sameh, Shabana, Ahmed, Tolba, Engy, Zagho, Mohamed, Kams, Liisa, Rätsep, Tõnu, Riips, Karolin, Abdurehman, Oumer, Admasu, Azarias, Berhea, Ataklitie, Eado, Yegeremu, Hailu, Nebiyou, Kidane, Meklit, Mohammed, Abdurezak, Mohammed, Khalid, Tibelt, Admasu, Woldemariam, Mersha Abebe, Yonael, Lydya, Alemu, Megersa, Aklilu, Abenezer Tirsit, Asele, Frehun, Assefa, Solomon, Azmach, Dawit, Bekele, Philimon, Mamo, Mickyas, Maru, Nahom, Mekuria, Haile, Menkir, Abel, Mikru, Filagot, Siraw, Eyerusalem, Suga, Hilkiah, Sumoro, Natnael, Teka, Aklilu, Thomas, Efeson, Woldemariam, Dereje, Wubishet, Estifanos, Abebe, Engida, Abebe, Kirubel, Asfaw, Fitsum, Bergene, Eyerusalem, Eshete, Mahder, Gebrehiwot, Fitsum Gebreegziabher, Gedefaw, Yetsedaw, Mengesha, Mulualem Wondafrash, Mengiste, Netsanet, Menjeta, Abeje, Muleta, Mahteme Bekele, Sefera, Sena, Tedla, Yonatan, Teklu, Daniel, Teshome, Henok, Tirfe, Leake, Tsegabrhan, Sahle, Tsehaye, Milkias, Worku, Bereket, Molla, Million, Supha, Melka, Taye, Tewodros, Abebe, Nebyou, Alemu, Berhanu, Chanie, Abera, Degefu, Hailegebriel, Desalegn, Dawit, Gebre, Hiwot, Hussen, Husnia, Kassa, Dawit, Laeke, Tsegazeab, Mammo, Tihitena Negussie, Negash, Samuel, Sahlu, Abat, Tiruneh, Abraham Genetu, Wolde, Amanuel, Woldeselassie, Hanna Getachew, Ahmed, Mnewer Y., Zewdneh, Betelhem, Fentaw, Jibril, Salia, Shemsedin, Tabore, Ketema, Gurara, Addisalem, Abreha, Tassew, Abrha, Teklebirhan, Beyene, Gaym, Hailu, Niguse, Weldu, Mulu Atsbaha, Abdissa, Desalegn, Tesfaw, Mequannet, Wolle, Melatework, Asmamaw, Dawit, Assefa, Biniam Zemedu, Bedane, Dereje, Bekele, Ephrem, Getie, Aderaw, Melkamu, Solomon, Mengesha, Workineh, Shumye, Getachew, Tagele, Gashaye, Tesfa, Abrham Amare, Workneh, Wubshet, Genetu, Sileshi, Mebratu, Eneyew, Chanyalew, Lidya, Deresse, Tilahun, Girma, Adissu, Seid, Marta, Shimelash, Dagim, Shitaw, Abrham, Ayalew, Tewabe, Diress, Tesfaye, Kassahun, Berhanu, Kassaye, Bersabeh, Mulugeta, Esubalew, Tesfaw, Getasew, Yimenu, Beminet, Benecha, Semir, Aman, Mudesir, Ibrahim, Adem, Mekete, Alem, Tesemma, Abdi, Mohammed, Adnan Abdulkadir, Abdullahi, Yasir Younis, Adem, Ephrem, Ahmedin, Mahlet, Assefa, Yared, Ayde, Fitsum, Berhe, Alazar, Gebremeskel, Zersenay, Siyoum, Eneyew Getachew, Teresa, Sintayehu, Wude, Zinaye, Yemer, Fasika, Yohannes, Dagnachew, Zeleke, Ewunetu, Zerihun, Gulilat, Degefe, Derje Worku, Derilo, Hankore Tamirat, Eliyas, Nebiyu, Bayissa, Firew, Deressa, Yadani, Gemechu, Lidya, Gurmu, Tegenu, Kasaye, Ashenafi, Melese, Lemi, Muleta, Lemesa, Mulugeta, Gersam, Taye, Seifu, Teshome, Abraham, Tesso, Birhanu, Gebrekirstos, Gebreagziabher, Haile, Mhreteab, Kassa, Haftamu, Saddik, Mohammed, Mengist, Alemneh, Heikkinen, Juuso, Helminen, Olli, Huhta, Heikki, Kotkavaara, Tommi, Mosorin, Matti‐aleksi, Pitkänen, Joel, Qian, Cheng, Sinikumpu, Jaakko, Sova, Henri, Tastula, Mikko, Virta, Ville P, Bettoni, Jérémie, Dakpé, Stéphanie, Devauchelle, Bernard, Lavagen, Nolwenn, Bastard, François, Bin, Kim, Breheret, Renaud, Fouquet, Olivier, Gueutier, Alexandre, Henric, Nicolas, Kahn, Alexis, Kün‐darbois, Jean‐daniel, Moukoko, Didier, Pineau, Anna, Podevin, Guillaume, Schmitt, Françoise, Alshawared, Fadi, Beyrne, Carlos Daniel, Lugans, Laurene, Marie‐macron, Lysa, Doussot, Alexandre, Ahmed, Omar, Alnajjar, Louy, Mis, Tommaso Cipolat, Fliss, Souha, Giocanti‐auregan, Audrey, Gregory, Thomas, Guiraudet, Patrice, Le Fouler, Adrien, Martinod, Emmanuel, Onorati, Ilaria, Peretti, Marine, Quilichini, Julien, Radu, Dana, Trésallet, Tresallet, Andro, Christophe, Maffert, Alexis, Chapman, Tracy, Halden, Maxime, Fayon, Julie, Mattevi, Catherine, Marion, Herjean, Bendjemar, Lynda, Lionel, Charre, Mikhael, Elie, Macías, Rosa Montero, Villefranque, Vincent, Volpin, Enrico, Trilling, Bertrand, Boleslawski, Emmanuel, Constance, Houlzé‐laroye, Drubay, Vincent, El Amrani, Mehdi, Eveno, Clarisse, Lecolle, Katia, Martin, Louis, Noiret, Barbara, Piessen, Guillaume, Truant, Stephanie, Zerbib, Philippe, Aubry, Estelle, Denimal, Franck, Lamblin, Antoine, Barrat, Benjamin, Caire, François, Christou, Niki, Fourcade, Laurent, Laloze, Jerome, Bouv‐hez, Margaux Mekann, Salle, Henri, Taibi, Abdelkader, Tricard, Jeremy, Usseglio, Julie, Chopinet, Sophie, Gregoire, Emilie, Delpont, Marion, Blanchard, Claire, Crenn, Vincent, Vergie, Stéphane, Denis, Waast, Fragnaud, Henri, Regenet, Nicolas, Rigaud, Jerome, Varenne, Yoann, Anract, Philippe, Barat, Maxime, Biau, David, Dautry, Raphaël, Dohan, Anthony, Idier, Louis, Lang, Elena, Thouny, Camille, Tzedakis, Stylianos, Audenet, François, Cazelles, Antoine, Chamouni, Alexandre, Karoui, Mehdi, Mejean, Arnaud, Clermidi, Pauline, Langlais, Tristan, Leonelli, Lorenzo, Maisonneuve, Emeline, Nicolas, Beaud, Perrot, Ophelie, Prost, Doriane, Thomin, Anne, Thouement, Thouement, Athiel, Yoann, Berry, Richard, Boddaert, Guillaume, Bonnet, Stéphane, Cathala, Nathalie, Conso, Christel, Denet, Christine, Laforest, Anaïs, Levy‐zauberman, Yael, Macek, Petr, Mombet, Annick, Ollat, Didier, Scamporlino, Adriana, Zadegan, Frederic, Amine, Chamakhi Ahmed, Baratte, Baratte, Chartier‐kastler, Emmanuel, Chereau, Nathalie, Colas, Pierre‐antoine, Duquesne, Igor, Genser, Laurent, Petit, Gaëlle Godiris, Goumard, Claire, Hasani, Ariola, Lim, Chetana, Martellotto, Sophie, Melot, Charlotte, Menegaux, Fabrice, Pinar, Ugo, Pocard, Marc, Roupret, Morgan, Scatton, Olivier, Seisen, Thomas, Séverine, Noullet, Turco, Célia, Chouillard, Elie, Beganton, Paul, Frasca, Denis, Kerforne, Thomas, Corbiere, Lisa, Gasmi, Anis, Ghemame, Marwane, Guérin, Sonia, Khene, Zine‐eddine, Livin, Marie, Mahmoud, Fedy, Maillot, Betty, Merdrignac, Aude, Mouriaux, Frederic, Robin, Fabien, Sulpice, Laurent, Vazeux, Charles, Bertheuil, Nicolas, Bonneau, Soline, Cazemajou, Clément Thierry, Cousin, Ianis, Defert, Coralie, Fustec, Elisa, Juricic, Melodie, Lavoue, Vincent, Mevel, Gwenaël, Timoh, Krystel Nyangoh, Renault, Annaëlle, Violas, Philippe, Schwarz, Lilian, Tuech, Jean Jacques, Morichau‐beauchant, Tristan, Sauvat, Frederique, Haddad, Elie, Vermersch, Sophie, Patrizi, Andrea, Roux, Alexia, Aimé, Adeline, Malgras, Brice, Cherkaoui, Zineb, D’Urso, Antonio, Felli, Emanuele, Gonzalez, Cristians Alejandro, Ignat, Mihaela, Mutter, Didier, Pessaux, Patrick, Vix, Michel, Gornes, Hugo, Vergriete, Kélig, Berthoumieu, Pierre, Genre, Ludivine, Le Gall, Hélène, Pierre, Trocard, Chalhoub, Marc, Del, Mathilde, Martinez, Alejandra, Fuchs‐buder, Thomas, Vancon, Antoine, Faya, Camara Abraham, Asaph, Elvam, Baruwa, Elisee, Hofman, Gwen, Machemedze, Solomon, Idiata, Michael Mayombo, Muhemi, Roger, Ndizeye, Olivier, Nkunzimana, Elysé, O’Connor, Jennifer, O’Connor, Zachary, Tchoba, Simplice, Boumas, Natacha, Devidze, Grigol, Pisarevi, Givi, Baumgarten, Sabine, Grüßer, Linda, Hölzle, Frank, Kowark, Pascal, Kowark, Ana, Rossaint, Rolf, Schäfer, Benedikt, Wallqvist, Julia, Winnand, Philipp, Ziemann, Sebastian, Anthuber, Matthias, Broecheler, Tobias, Edlinger, Florian, Goßlau, Yvonne, Hyhlik‐duerr, Alexander, Maksymiw, Florian, Shiban, Ehab, Sommer, Florian, Sommer, Björn, Zerwes, Sebastian, Beyer, Katharina, Lauscher, Johannes Christian, Lee, Lucas D., Loch, Florian N, Schineis, Christian, Aghalarov, Ilgar, Belyaev, Orlin, Braumann, Chris, Enste, Annika, Fahlbusch, Tim, Herzog, Torsten, Horn, Julian, Jedanowski, Julia, Knipschild, Julia, Luu, Andreas Minh, Mohan, Prem Vignesh, Siemen, Leonie, Slobodkin, Illya, Strotmann, Johanna Josefine, Uhl, Waldemar, Wolf, Katerina, Coburn, Mark, Egger, Eva, Eichhorn, Klaus, Enderes, Jana, Far, Frederick, Franzen, Alina, Güresir, Erdem, Hadjiathanasiou, Alexis, Kalff, Jörg C., Kohistani, Zaki, Manekeller, Steffen, Mustea, Alexander, Probst, Chris, Randau, Thomas, Recker, Florian, Schuss, Patrick, Straßberger‐nerschbach, Nadine, Strieth, Sebastian, Treede, Hendrik, Beekum, Cornelius J., Vatter, Hartmut, Velten, Markus, Vilz, Tim O., Wirtz, Dieter, Wittmann, Maria, Behr, Michael, Bulian, Dirk Rolf, Marche, Benedikt, Moczko, Tobias, Otchwemah, Robin, Schulz, Sissy‐amelie, Thomaidis, Panagiotis, Bruns, Christiane, Cursiefen, Claus, Domröse, Christian, Fuchs, Hans, Heindl, Ludwig Maximilian, Mallmann, Michael R., Mallmann, Christoph, Ratiu, Dominik Alexander, Canzler, Ulrich, Distler, Marius, Korn, Sandra, Meisel, Cornelia, Meusel, Marcus, Petzold, Andrea, Praetorius, Christian, Renesse, Janusz, Weitz, Juergen, Wimberger, Pauline, Alkhanji, Nour, Fung, Stephen, Jaber, Kefah, Knoefel, Wolfram Trudo, Vay, Christian, Clonda, Octavian, Cottin, Tatiana, Juodiene, Evelina, Juodis, Domantas, Petrovic, Biljana, Solodarenko, Oleksandra, Binder, Johannes, Grützmann, Robert, Hackner, Danilo, Junker, Stefanie, Arsalan, Mani, Banek, Severine, Chun, Felix, Faqar‐uz‐zaman, Sara Fatima, Keese, Daniel, Kluth, Luis, Rolle, Udo, Van Linden, Arnaud, Walther, Thomas, Bayer, Jörg, Beck, Jürgen, Fung, Christian, Kraus, Luisa Mona, Leiber, Christian, Neidert, Nicolas, Sandkamp, Richard, Schnell, Oliver, Schulte, Antonia, Strähle, Jakob, Jarmusch, Stefanie, Novotny, Helmut Franz Georg, Becker, Johannes, Fulghum, Christian, Gonschor, Bernhard, Herbolzheimer, Marit, Nicolaiciuc, Sina, Trulson, Alexander, Vogelsang, Holger, Zimmermann, Benno, Akbari, Amir Ali, Boening, Andreas, Edinger, Fabian, Hecker, Matthias, Knitschke, Michael, Koch, Christian, Reichert, Martin, Schmidt, Götz, Schneck, Emmanuel, Uhl, Eberhard, Nóbrega, Silvia Flachs, Kauffmann, Philipp, Miller, Clemens, Nemeth, Marcus, Sievers, Denise, Kisser, Ulrich, Kleeff, Jorg, Klose, Johannes, Lorenz, Kerstin, Papendick, Nancy, Plontke, Stefan, Seiwerth, Ingmar, Steer, Susanne, Thomssen, Christoph, Ukkat, Jörg, Dumpies, Christian W., Fischer, Isabel, Gessner, Michael, Hanke, John, Klauke, Friederike, Leuschner, Sebastian, Mendel, Thomas, Müller, Katharina, Schmidt, Birte, Schreiter, Valentin, Stosberg, Peter, Vinz, Franziska, Herbig, Beate, Sander, Johannes, Schulte, Thilo Maria, Betz, Christian Stephan, Bewarder, Julian, Bier, Johannes, Böttcher, Arne, Burg, Simon, Busch, Chia‐jung, Bußmann, Lara, Gosau, Martin, Heuer, Annika, Izbicki, Jakob, Klatte, Till Orla, König, Daniela, Köpke, Leon‐gordian, Moeckelmann, Nikolaus, Praetorius, Mark, Priemel, Matthias, Stadlhofer, Rupert, Stangenberg, Martin, Uzunoglu, Faik G., Wittig, Lukas, Zech, Henrike, Zeller, Nina, Roux, Frederic, Spaeth, Tsiona, Fricker, Roland, Müller, Thomas, Schröder, Lars, Alasmari, Mohammed, Boeker, Clara, Hakami, Ibrahim Abdullah, Mall, Julian W, Kyritsis, Ioannis, Graeb, Christian, Huber‐strößner, Kristin, Branzan, Daniela, Doss, Markus, Gockel, Ines, Jödicke, Carolin, Osterhoff, Georg, Pempe, Christina, Sucher, Robert, Adler, Tina, Kelly, Kathrin, Merkle, Janica, Siebert, Julia, Hirche, Christoph, Kneser, Ulrich, Tapking, Christian, Agrawal, Rachit, Qureischie, Homeira, Croner, Roland, Koslowski, Lisa, Krause, Hardy, Meyer, Frank, Turial, Salmai, Al‐nawas, Bilal, Battista, Marco Johannes, Goedeke, Jan, Hasenburg, Annette, Heider, Julia, Mueller, Lena Katharina, Zeller, Simon, Jentschura, Sina Louisa Patrizia, Kowalewski, Karl‐friedrich, Kriegmair, Maximilian, Männle, David, Reissfelder, Christoph, Rotter, Nicole, Scherl, Claudia, Seyfried, Steffen, Kirschniak, Andreas, Rolinger, Jens, Wilhelm, Peter, Bader, Franz G., Ottl, Stephanie, Behr, Alexandra Viktoria, Diamantis, Alexandros, Fichter, Andreas, Grill, Florian, Heck, Matthias, Jira, Daniel, Kallmayer, Michael, Koll, Florestan, Luhne, Stefan, Meyer, Bernhard, Patachia, Robert, Pergolini, Ilaria, Safi, Seyer, Schäffer, Christoph, Schirren, Moritz, Wegmann, Helmut, Wirth, Markus, Zhu, Zhaojun, Aghamaliyev, Ughur, Almaghrabi, Mahmoud, Böcker, Wolfgang, Bruder, Jan, Frank, Konstantin, Herterich, Viktoria, Huber, Verena, Ilmer, Matthias, Kammerlander, Christian, Neuerburg, Carl, Ehrlich‐treuenstätt, Viktor H., Werner, Jens, Börner, Nikolaus, Fegg, Florian, Hartmann, Daniela, Ladurner, Roland, Liokatis, Paris, Patzer, Kathrin, Schlager, Justin Gabriel, Smolka, Wenko, Zimmermann, Petra, Hatz, Rudolf, Steinhart, Diana, Glowalla, Claudio, Schneidmueller, Dorien, Henkel, Karl Wilhelm, Steiner, Martin, Hölz, Katharina, Knorr, Christian, Kuehlmann, Britta, Oikonomou, Kyriakos, Prantl, Lukas, Flurschütz, Roland, Honarpisheh, Human, Kröger, Marie, Lepiorz, Dominic, Luths, Charlotte, Niemeier, Andreas, Sras, Yara, Strate, Tim, Winter, Thore, Freiman, Thomas, Gessler, Florian, Won, Sae‐yeon, Widyaningsih, Rizky, Hoffmann, Sebastian, Schäfer, Ruth Christine, Thiel, Johannes Tobias, Bertolani, Elisa, Steidle, Christoph, Überrück, Lisa, Yurttas, Can, Ziegler, Patrick, Zimmermann, Alexander, Bolenz, Christian, Dayan, Davut, Greve, Jens, Hoffmann, Thomas K., Janni, Wolfgang, Löbig, Niklas, Schochter, Fabienne, Vahl, Julius Malte, Wezel, Felix, Greif, Veronika, Schmidbauer, Stefan, Marsch, Imke, Schneider, Rolf, Boenicke, Lars, Degener, Stephan, Dreger, Nici Markus, Horstmeier, Franz Christian, Kruschwitz, Jakob, Rombach, Adrian, Schmidt, Nele, Seiberth, Rose, Singh, Jaswinder, Smit, Marieke, Rundstedt, Friedrich‐carl, Zirngibl, Hubert, Diessner, Joachim, Friedrich, Sabine, Germer, Christoph‐thomas, Helmer, Philipp, Herrmann, Johannes, Kranke, Peter, Kübler, Hubert, Lock, Johan, Lotz, Christopher, Meffert, Rainer, Meybohm, Patrick, Müller, Sophie, Notz, Quirin, Popp, Maria, Schlegel, Nicolas, Schlesinger, Tobias, Schmid, Benedikt, Sitter, Magdalena, Steinisch, Andreas, Treutlein, Agnes, Berg, Anne, Wurmb, Thomas Erik, Agyeman‐duah, Nana Kwaku, Appiah, Enoch, Armah, Ralph, Asare, Christopher, Awere‐kyere, Lawrence, Daary, Dennis, Gakpetor, Delali, Allah, Stephen Minlah, Obbeng, Ambe, Osei‐poku, Dorcas, Puozaa, Diana, Tackie, Enoch, Adu‐aryee, Nii Armah, Agboadoh, Nelson, Asare, Offei, Bowan, Antoinette Bediako, Brown, George Darko, Clegg‐lamptey, Joe‐nat, Dedey, Florence, Dery, Cedric, Fenu, Benjamin Sena, Harrison, Marian Abedua, Kumassah, Philemon, Kuuzie, Ekins, Nsaful, Josephine, Olayiwola, David Olatayo, Smith, Cecilia, Banka, Charles, Hussey, Romeo, Azize, Diallo Abdoul, Aniakwo, Luke Adagrah, Adofo‐asamoah, Yvonne, Agbeno, Evans Kofi, Agyapong, Meshach Manu, Agyen, Thomas, Mensah, Kwasi Agyen, Alhassan, Baba Alhaji Bin, Amoako‐boateng, Mabel, Appiah‐thompson, Peter, Gyimah, Nita Asamoa‐Manu, Asante‐bremang, Moses, Asante‐asamani, Alvin, Atawurah, Henry, Appiah, Anthony Baffour, Baidoo, Richard Ogirma, Baidoo, Ebikela Ivie, Boakye, Benedict, Boateng, Abigail, Dadoe, Dora, Dayie, Makafui Seth Caleb‐Joshua Kwasi, Debrah, Samuel, Doku, Kingsley, Enti, Enti, Ken‐amoah, Sebastian, Koggoh, Patience, Kpangkpari, Richard, Maison, Patrick, Mensah, Samuel, Mensah, Philip, Mensah, Teresa Aba, Morna, Martin Tangnaa, Nimako‐mensah, Jilac, Nkrumah, John, Nortey, Michael, Ofori, Emmaunel Owusu, Opandoh, Isabella Naa Morkor, Osei‐tutu, Ethel, Adae, Jefferson Owusu, Quansah, Kofi, Quartson, Elizabeth, Rahman, Ganiyu Adebisi, Walawah, David, Yigah, Makafui, Yussif, Safia, Jiagge, Nuna, Nachelleh, Emmanuel, Acquaye, Jane, Agbedinu, Kwabena, Agyei, Fareeda, Agyemang‐prempeh, Akosua, Amo‐antwi, Kwabena, Amoah, Michael, Amoah, George, Amoako, Yaw A, Aning, Daniel Gyawu, Ankobea‐kokroe, Frank, Mintah, Dominic Annor, Anyitey‐kokor, David, Appiah‐kubi, Adu, Arthur, Joshua, Ativor, Vincent, Barnor, Isaac, Braimah, Yasmine, Darko‐asante, Regina, Davor, Anthony, Issahalq, Mohammed Duah, Dzogbefia, Mawutor, Emile, Tano, Fiifi‐yankson, Papa, Gaveh, Valerie, Gudugbe, Senyo, Gyabaah, Solomon, Gyamfi, Frank Enoch, Gyedu, Adam, Gyimah, Derrick, Hammond, Bernard, Jonathan, Boakye‐yiadom, Joseph, Yorke, Konney, Thomas Okpoti, Konney, Anna, Kusi, Kwasi, Kyei, Ishmael, Lovi, Agbenya, Naabo, Nuhu, Nimako, Boateng, Nyadu, Beauty, Nyarko, Obed Ofori, Ofosu‐barko, Ben Blay, Oppong, Philip Peprah, Osabutey, Anita, Poku, Martha, Sagoe, Robert, Yifieyeh, Abiboye, Ansong, George, Abass, Adam, Abdul‐mumin, Alhassan, Adjeso, Theophilus, Alatiiga, John Abanga, Amadu, Munira, Annan, Nathaniel, Leal, German Azahares, Bukari, Mohammed, Buunaaim, Alexis, Cheyuo, Ernest, Salifu, Latif Daboo, Damah, Michael, Dery, Malcolm, Dzantor, Edem Kojo, Garcia, Odoniel Guerra, Baba, Yabasin Iddrisu, Issaka, Adamu, Muntaka, Abdul‐Jalilu Mohammed, Murphy, James, Agyeman, Yaa Nyarko, Amankwaa, Wisdom Opoku, Osman, Imoro, Pie, Samuel, Seidu, Anwar Sadat, Sheriff, Mohammed, Charadan, Ana Maria Simono, Titigah, Abraham, Yahaya, Mundashiru, Yakubu, Musah, Yenli, Edwin Mwintiereh Ta‐ang, Grypiotis, Ioannis, Kiriakopoulos, Nikolaos, Koliopoulos, Georgios, Kyvelos, Vasilis, Micha, Georgia, Papadopoulou, Triada, Balalis, Dimitrios, Fradelos, Evangelos, Korkolis, Dimitrios, Alexakis, Nicholas, Angelou, Kyveli, Haidopoulos, Dimitrios, Prodromidou, Anastasia, Rodolakis, Alexandros, Thomakos, Nikolaos, Psychogios, Dimitris, Antonakis, Pantelis, Bramis, Konstantinos, Chardalias, Leonidas, Contis, Ioannis, Dafnios, Nikos, Dellaportas, Dionysios, Dimitra, Papalouka, Fragkoulidis, Georgios, Gkiokas, Georgios, Gklavas, Antonios, Hadjizacharias, Theodoros, Karageorgou, Dimitra, Konstadoulakis, Manousos, Kontopoulou, Christina, Massaras, Dimitrios, Memos, Nikolaos, Papaconstantinou, Ioannis, Politis, Dimitrios, Polydorou, Andreas, Stamatis, Konstantinos, Theodosopoulos, Theodosios, Vezakis, Antonios, Avgerinos, Konstantinos, Katunin, Jevgeni, Kechagias, Aristotelis, Kelgiorgi, Dionysia, Kritikos, Neoklis, Pengermä, Pasi, Bisdas, Theodosios, Ioannidis, Argyrios, Konstantinidis, Michael, Konstantinidou, Sofia, Patelis, Nikolaos, Antonopoulou, Maria Ioanna, Deskou, Eirini, Kalles, Vasileios, Manatakis, Dimitrios K., Stamos, Nikolaos, Tasis, Nikolaos, Arkadopoulos, Nikolaos, Danias, Nikolaos, Economopoulou, Panagiota, Frountzas, Maximos, Kokoropoulos, Panagiotis, Michalopoulos, Nikolaos, Selmani, Jonida, Sidiropoulos, Theodoros, Vassiliu, Panteleimon, Paraskevas, Kosmas I., Bartziotas, Dimitrios, Bouchagier, Konstantinos, Galanis, Ilias, Kalamatianos, Theodosis, Kapiris, Stylianos, Kolinioti, Angeliki, Mavrodimitraki, Eleni, Metaxas, Panagiotis, Nikova, Alexandrina, Psarologos, Michail, Sotiropoulou, Maria, Stranjalis, George, Albanopoulos, Konstantinos, Kondilis, Panagiotis, Vrakopoulou, Gavriella Zoi, Chrysovergis, Aristeidis, Chrysovitsiotis, Georgios, Giotakis, Evangelos, Kanellopoulou, Vasiliki, Kyrodimos, Efthymios, Larentzakis, Andreas, Pantos, Pavlos, Papanikolaou, Vasileios, Potamianos, Spyridon, Theodoropoulos, Charalampos, Triantafyllou, Alexandra, Triantafyllou, Tania, Georgousi, Kleoniki, Panagiotou, Peter, Avramidis, Emmanouil, Babis, George, Zafeiris, Evangelos, Antoniou, Afroditi, Bessias, Nikolaos, Maras, Dimitris, Papas, Theofanis, Roditis, Konstantinos, Tsagkos, Ioannis, Tsiantoula, Paraskevi, Alexandrou, Andreas, Baili, Efstratia, Charalabopoulos, Alexandros, Dimitroulis, Dimitrios, Dorovinis, Panagiotis, Garoufalia, Zoe, Kanavidis, Prodromos, Karavokyros, Ioannis, Karydakis, Lysandros, Kykalos, Stylianos, Kyros, Eleandros, Machairas, Nikolaos, Mastoraki, Aikaterini, Nikiteas, Nikolaos, Papalampros, Alexandros, Schizas, Dimitrios, Skotsimara, Antonia, Stamopoulos, Paraskevas, Syllaios, Athanasios, Terras, Alexis, Tomara, Nefeli, Tsourouflis, Gerasimos, Vagios, Ilias, Zografos, Constantinos, Apostolou, Konstantinos, Georgopoulos, Nikolaos, Antoniou, Theofani, Antzaka, Christina, Falara, Areti, Fragoulis, Socrates, Ftikos, Panagiotis, Matsouka, Fedra, Perreas, Konstantinos, Rellia, Panagiota, Samara, Evangelia, Smirli, Anna, Tasouli, Androniki, Thanopoulos, Apostolos, Chalkias, Petros Loukas, Dedemadi, Georgia, Mourmouris, Panagiotis, Skolarikos, Andreas, Theochari, Nikoletta, Tzelves, Lazaros, Gaitanakis, Stylianos, Milas, Theodoros, Theodorakis, Emmanuel, Karona, Paraskevi, Kastanaki, Pagona, Tzouganakis, Angelos, Agalianos, Christos, Tsouknidas, Ioannis, Xenakis, Andreas, Chrysos, Emmanuel, Lasithiotakis, Konstantinos, Nikolouzakis, Taxiarchis, Xenaki, Sofia, Xynos, Evangelos, Lostoridis, Eftychios, Nagorni, Eleni‐aikaterini, Pujante, Antonio, Tourountzi, Paraskevi, Aggeliki, Al, Baxevanidou, Kyriaki, Bouliaris, Konstantinos, Efthimiou, Matheos, Kalfountzos, Christos, Koukoulis, Georgios, Lachanas, Vasileios, Petropoulos, Konstantinos, Tsitiridis, Ioannis, Angelis, Fragkiskos, Arnaoutoglou, Eleni, Baloyiannis, Ioannis, Bareka, Metaxia, Bouronikou, Anna, Christodoulidis, Gregory, Daponte, Alexandros, Fergadi, Maria, Gkolias, Nick, Gkrinia, Eleni, Hajiioannou, Jiannis, Kalogritsas, Nikos, Karoni, Eleni, Korais, Christos, Krestinidis, Giorgos, Ktisti, Antigoni, Magouliotis, Dimitrios, Maiou, Charikleia, Malizos, Konstantinos, Minasidou, Maria, Ntalouka, Maria, Ntziovara, Anna Maria, Palla, Effrosyni, Perivoliotis, Konstantinos, Saini, Fani, Samara, Athina, Saratziotis, Athanasios, Skoulakis, Charalampos, Solomi, Efthymios, Stamoulis, Konstantinos, Terzoudis, Christos Dimitrios, Tsironi, Evangelia, Tzovaras, George, Vallianou, Kyriaki, Zacharoulis, Dimitris, Ziogkou, Anna, Δακής, Κωνσταντί__ς, Elias, Liolis, Maroulis, Ioannis, Mulita, Francesk, Plachouri, Kerasia‐maria, Vailas, Michail, Doitsidis, Charalampos, Filo, Eva, Gkalonaki, Ioanna, Kogia, Eleni, Kontopoulou, Konstantina, Mitroudi, Magdalini, Panteli, Christina, Patoulias, Ioannis, Semkoglou, Olga Ioulia, Sfoungaris, Dimitrios, Valioulis, Ioannis, υτσ_υ μης, Γι ωργος, Astreidis, Ioannis, Christidis, Panagiotis, Ioannidis, Orestis, Loutzidou, Lydia, Mantevas, Antonis, Paraskevopoulos, Konstantinos, Tatsis, Dimitris, Athanasiadis, Apostolos, Dagklis, Themistoklis, Kalogiannidis, Ioannis, Kapetanios, Georgios, Mamopoulos, Apostolos, Margioula‐siarkou, Chrysoula, Petousis, Stamatios, Tsakiridis, Ioannis, Anthoulakis, Christos, Christou, Chrysanthos, Fantakis, Antonios, Iordanidou, Eirini, Kaselas, Christos, Panagiotidou, Sousana, Papadopoulos, Vasileios, Papavasiliou, Kyriakos, Piachas, Athanasios, Siasios, Ioannis, Spyridakis, Ioannis, Theodoridis, Theodoros, Tooulias, Andreas, Tsiridis, Eleftherios, Tsopozidi, Maria, Alemán, María, Brolo, Estuardo, Lemus, Ana Lucia, Greenberg, Jennifer, Chew, Krisna Mishel Morales, Oliva, José Rodrigo, Lima, María Alejandra De León, Muralles, Ismar Lopez, Solares, Felipe, Ajcip, Gaby, Anton, Claudia, Cojulun, Jose, Flores, Mario‐andrés, José, Noriega, Paiz, Carlos Adolfo Marroquín, Morales, Steffanía, Najera, Ramiro, Lorenzana, Eduardo Quiñónez, Rivera, Pablo, Rodas, Lesly, Santos, Victor, Sosa, Dianne, Ybarra, Natalia, Cajti, José David Pérez, Régil, Carlos, Osorio, Walter A, Arriola, Rember Rosales, Talé‐rosales, Luis‐fernando, Herrera, Danilo, Rodríguez, Servio Tulio Torres, Villeda, Sergio Alejandro, Anicetti, Joshua, Medina, Andrea Michelle Lowey, Ardebol, Javier, Barillas, Kathia, De Leon, Francis, Recinos, Salvador, Marroquin‐alpirez, Miguel‐angel, Yax, Yessica, Hon, Sophie, Liu, Yuk Ho, Liu, Alex Qinyang, Liu, Shirley, Chiu, Hei Tung Natalie, Chow, Chi Man Tom, Hau, Victor, Ho Wai, Ip, Mak, Brian, Mok, Chung Ying, Dennis, Ng, Siu, Yin Yu Eva, Wong, Kiu Fung, Jingya Jane, Pu, Yu‐xiong, Su, Au‐yeung, Kit Ying, Chan, David Yuen Chung, Chan, Albert, Chan, Shannon Melissa, Chang, Tsz Ching, Chiu, Tor Wo, Chiu, Wang Kei, Zhexi, He, Man Fung, Ho, Kevin Ki Wai, Ho, Jacky Yan Kit, Ho, Kung, Janet Wui Cheung, Lam, Cheuk Ho, Lau, Rainbow W. H., Ling, Samuel Ka Kin, Lok, Hon Ting, Mak, Tony Wing Chung, Chi‐fai, Ng, Simon, Ng, Kelvin Kwok‐Chai, Ng, Calvin S. H., Ng, Ong, Michael Tim Yun, Tan, Teresa, Tang, Sui Fan, Teoh, Jeremy Yuen‐Chun, Teoh, Anthony, Tsui, Bess Siu Yan, Wong, George Kwok Chu, Wong, Randolph, Wong, Kwok Chuen, Yee, Chi Hang, Antal, Zsuzsanna, Kalman, Attila, Voros, Peter, Bahrehmand, Kiarash, Echim, Timea, Novak, Zoltan, Sztipits, Tamás, Bihari, Laszló ádám, Hidi, László, Piros, Laszlo, Rózsa, Balazs, Sotonyi, Peter, Szatai, Lilla, Herczeg, György, Pordány, Bálint, Tornyi, Fanni, Dede, Kristof, Egyed, Tamás, Saftics, György, Kulcsicka‐gut, Judit, Sipos, Zsófia, Toth, Dezso, Patel, Bhavin, Majmudar, Hardil, Mankad, Saptak, Pathan, Sohilkhan, Sharathkumarkl, L, Sasatti, Lokesh, Mahankali, Subramanyam, Annayappa, Santhosh Kumar Sampengere, Agrawal, Tulika, Anandan, Premkumar, Baindur, Aditya, Manjunath, Bd, Savitha, C, Anitha, G S, Harigond, Sandeep, Tejeswini, K K, Kesarla, Venkatesh, Manangi, Mallikarjuna, Hareesh, P B, Ranjan, Jyothi K R, Shetty, Athish, Chikkanayakanahalli, Santhosh Shivashankar, Sunil, Tanvi, Syamala, Shreya, Tharanath, Kavya, Atal, Aditya, Rajagopal, Niranjana, Srinath, B S, Vinod, Nk, Thirumanikandan, P L, Mishra, Nitu, Shrivastava, Sushruta, Wadhwani, Rekha, Ahmad, Reyaz, Haq, Zainab Ahmad, Behera, Prateek, Dhurwe, Ritika, Haq, Rehan, Jain, Vaibhav, Jain, Anuj, Karna, Sunaina, Pushpalatha, Kameshwarachari, Raj, Sumit, Santoshi, John Ashutosh, Singh, Pooja, Verma, Virendra, Waindeskar, Vaishali, Yadav, Moorat Singh, Aziz, Zaheda, Chakraborty, Koyel, Chappity, Preetam, Das, Gurudip, Datta, Debajyoti, Jena, Saubhagya Kumar, Kar, Madhabananda, Khuntia, Susanta, Kumar, Pankaj, Kumar, Ravi, Aswathi, Kv, Mishra, Abhijeet, Mishra, Swastik, Mittal, Yash, Muduly, Dillip, Panda, Ritesh, Panigrahi, Sibasish, Parija, Sucheta, Patra, Saroj, Rout, Bikram, Sahu, Rabi, Sarkar, Saurav, Singh, Sweta, Sudha, Sanjibani, Sultania, Mahesh, Tripathy, Sujit, Varghese, Paulson, Kansay, Rajeev, Kaushik, Robin, Singh, Simrandeep, Gupta, Sunil Kumar, Khare, Siddhant, Kumar, Vishal, Mohindra, Sandeep, Patil, Ninad, Salunke, Pravin, Savlania, Ajay, Singh, Kavindra, Pradeep Krishna, Rv, Narasimhan, Gomathy, Rela, Mohamed, Appukuttan, Akhila, Goudar, Swati, Mallick, Shweta, Titus, Christi, Chidambarasamy, Ezhir Selvan, Madhavan, Devdas, Murugesan, Anandan, Narayanasamy, Kuppurajan, Barani Kumar, P B, Rajan, Firoz, Vijayaragavan, Paari, Kumar, Arvind, Borthakur, Biplob, Chauhan, Tapan Singh, Govil, Akhil, Gupta, Shubhra, Hanjoora, Vijay Mohan, Sharma, Ashish, Srivastava, Aseem, Tiwari, Saurabh, Vishwani, Vartika, Pendyala, Karuna Sree, Prasad, Navakoti, Bothra, Jyoti, Deb, Mainak, Herle, Koushik, Jayaram, Harish, Kannaiyan, Lavanya, Krithiga, Abirami, Mukta, W, Nagpal, Pooja, Pathak, Prachi, Banerjee, Sumit, Chaudhary, Ramkaran, Choudhary, Gautam Ram, Chugh, Ankita, Dixit, Pawan, Elhence, Abhay, Gahlot, Nitesh, Garg, Mayank, Ghuman, Navdeep Kaur, Jha, Deepak, Kala, Prakash, Kaur, Amanjot, Madduri, Vijay, Pandey, Himanshu, Pareek, Puneet, Pathak, Manish, Rathod, Kirtikumar J, Rodha, Mahaveer Singh, Saxena, Rahul, Sharma, Naveen, Shekhar, Shashank, Singh, Mahendra, Singh, Pratibha, Suryanarayanan, Bhaskar, Vishnoi, Jeewan Ram, Amin, Shivang, Kumar, Rohit, Sharma, Tanishq, Murugesan, Kesavan, Ramasamy, Abhinav Balachandar Subbiah, Chatterjee, Debarshi, Gerber, C Gerber, Naskar, Upasana, Aggarwal, Gaurav, Agrawal, Sanjit Kumar, Ahmed, Azaz, Gupta, Sujoy, Jain, Prateek, Jain, Deepak, Kewlani, Vishal, Pipara, Amrit, Priya, Noopur, Raja, Roopak, Shakya, Sudip, Thambudorai, Robin, Kharkongor, Dimple, Agarwal, Anjoo, Akhtar, Naseem, Anand, Akshay, Asnani, Mona, Chaturvedi, Arun, Chaurasia, Akhilanand, Enny, Loreno E., Garg, Surabhi, Gupta, Sameer, Jaiswal, Anoop Kumar, Jaiswal, Somil, Jaware, Yashpal, Kala, Navneet, Karnatak, Ruchi, Kaur, Apjit, Kumar, Vijay, Kumar, Manoj, Kumar, Ambrish, Kumar, Upander, Shrivastava, Amit Kumar, Mehrotra, Seema, Mishra, Brijesh, Mishra, Anand, Namrata, Null, Ojha, Bal Krishna, Ozair, Ahmad, Pal, Uma Shanker, Pandey, Amita, Raja, Nancy, Ramakant, Pooja, Roy, Ashutosh, Sachan, Rekha, Sankhwar, Satyanarayan, Sankhwar, Pushp, Sarin, Divya, Shukla, Ayushi, Singh, Sushil, Singh, Mohit, Singh, Kul Ranjan, Singh, Renu, Singh, Uma, Singh, Urmila, Solanki, Vandana, Sonkar, Abhinav Arun, Srivastava, Chhitij, Suryawanshi, Parijat, Tewarson, Vivek, Verma, Rajat, Verma, Manju Lata, Yadav, Awdhesh, Chand, Gyan, Chanthar, K. M. M. Vishvak, Hoysal, Dileep, Mishra, Anjali, Batra, Nitin, Bhatti, Arun, Chopra, Rupali, David, Shakina, Dhar, Tapasya, Dutt, Uma Kant, Dutta, Rohini, Gandhi, Sumir, Haque, Parvez David, Paul Sudhakar John, B, Veetil, Sreejith Kannummal, Kaur, Gurvinder, Kumar, Navneet, Luther, Anil, Mahajan, Anupam, Mahajan, Amit, Mandrelle, Kavita, Mathews, Shefin, Michael, Vishal, Mukherjee, Partho, Pargal, Pinki, Paul, Rajesh, Phillip, Anupam, Phillips, Rachel, Samuel, Abhishek, Singh, Noel, Singh, Inderjot, Singh, Abhijit, Grewal, Sarvpreet Singh, Singhania, Anusha, Thirumalai, Selven, Varghese, Ashish, Wesley, Joshua, Thomas, Josy, Zechariah, Pradeep, Ifthikar, Mariam Anjum, Mathew, Rohan Thomas, Shetty, Rohan, Vijaykumar, M Vijayakumar, Hameed, BM Zeeshan, Ibrahim, Sufyan, Jyothish, Gayathri, Krishna, Sunil, Mathew, Stanley, Kumar, Arjun Suresh, Singh, Narinder, Sinha, Piyush Kumar, Sridhar, Rachith, Agarwal, Sunny, Balasubramaniam, Srikant, Chhatrapati, Swati, Deshpande, Charulata, Dharia, Ashni, 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Priyadarshini, Suganya, S, Samuel, Habie, Samuel, Gilbert, Selvaraj, Daniel, Sharma, Srujan, Surendran, Suraj, Hariharan, T D, Thangaraj, Santhosh Kumar, Thomas, Vinotha, Thomas, Varghese, Thomas, John K, Harish, Y S, Boggavarapu, Manobhiram, Voonna, Murali Krishna, Lolobali, Marilaeta Cindryani, Ryalino, Christopher, Senapathi, Tjokorda Gde Agung, Tjokorda, Mahadewa, Widnyana, I Made Gede, Aditianingsih, Dita, Auerkari, Aino, Chandra, Susilo, Damara, Fachreza Aryo, Dilmy, Mohammad Adya Firmansha, Harzif, Achmad Kemal, Manggala, Sidharta Kusuma, Pratama, Dedy, Priyambodo, Affan, Ramlan, Andi Ade, Soenarto, Ratna Farida, Sugiarto, Adhrie, Surya, Ilham Utama, Tango, Tamara, Tantri, Aida Rosita, Zahra, Raihanita, Fachrian, Dedy, Hasyim, Andi, Susanti, Ade, Saputra, Teddy, Syarifuddin, Erwin, Islam, Andi Asadul, Pajan, Hendra, Amrullah, Ahmad Hannan, Anam, Khoirul, Hadipranata, Thirza, Sugianto, Julius Albert, Fitrisyah, Aidyl, Lestari, Mayang Indah, Lubis, Nur Rachmat, Zainal, Rizal, Zulkifli, Zulkifli, Amba, Erick Gamaliel, Lie, Warren, Thehumury, Andika Adiputra, Apriawan, Tedy, Aji, Yunus Kuntawi, Wathoni, Roidah Taqiyya Zahra, Anwar, Sumadi Lukman, Aryandono, Teguh, Harahap, Wirsma Arif, Kurniawaty, Juni, Sari, Djayanti, Wahyono, Artanto, Widyastuti, Yunita, Jufan, Akhmad Yun, Arjmand, Parisa, Etezadpour, Mohammad, Ganjeifar, Babak, Hosseinpoor, Masoumeh, Mehrad‐majd, Hassan, Rajati, Mohsen, Assadi, Reza, Noori, Ehsan, Rajaei, Parisa, Hajisadeghi, Samira, Mehdizadeh, Mohammad, Soltani, Mina, Alizadeh, Narges, Nia, Gholamreza Azarnia Azar, Heidari, Hamid, Zavareh, Seyedmohamad Hosseini Zavareh Hosseini, Pour, Ali Moazami Pour Moazami, Savaddar, Farokh, Vahedian, Mostafa, Amouzegar, Hoora, Bahadorzadeh, Mojdeh, Hemmasi, Seyedeh Homa, Kachoie, Ahmad, Karimi, Ali Karimi, Miraj, Sepideh, Mirzaie, Monireh, Mokarami, Hossein Mokarami, Salimi, Amrollah, Ahangari, Roghayyeh, Ahmadvand, Ali, Bashiri, Ali, Borhani, Morteza, Haidari, Mohammad, Khosroshahi, Mohammad Taghi Imani, Bini, Shahrokh Jahan, Koosha, Mohsen, Moslemi, Mohammad Kazem, Naghibi, Ali, Tehrani, Shahrzad, Yazdi, Zahra, Adeli, Seyyed Hassan, Alborzi, Majid, Bagheri, Hamed, Eshraghi, Mohsen, Manesh, Hassan Fatemi, Ghomeisi, Mohammad, Hejazi, Seyed Fakhreddin, Madani, Saeed, Motahaver, Nima Najafian, Norouzi, Samieh, Modarres, Mahdi Pezeshki, Shafiee, Ali, Vafaeimanesh, Jamshid, Yusefi, Hossein, Hosseini, Elahe, Medhati, Pourya, Nikoupour, Hamed, Aghazadeh, Kayvan, Bastaninejad, Shahin, Dabirmoghaddam, Payman, Erfanian, Reza, Firouzifar, Mohammadreza, Heidari, Farrokh, Irani, Shirin, Karimi, Ebrahim, Kouhi, Ali, Zarandy, Masoud Motasaddi, Anari, Mahtab Rabbani, Sandoughdaran, Saleh, Sohrabpour, Saeed, Tajdini, Ardavan, Yazdani, Nasrin, Bagheri, Nima, Javadi, Seyed Amir, Kalantar, Seyed Hadi, Keneshlou, Farzaneh, Khan, Zahid Hussain, Mortazavi, SM Javad, Ahmadi, Sayedali, Hatam, Jaber, Nabian, Mohammad Hossein, Zanjani, Leila Oryadi, Vosoughi, Fardis, Golbakhsh, Mohammadreza, Shafiei, Seyyed Hossein, Siavashi, Babak, Al‐isawi, Ali, Al‐masood, Mohammed, Al‐najjar, Dania, Gahtan, Yarub, Nabil, Sara, Hameed, Najat Abdul, Hameed, Jumana Abdul, Ahmed, Abdullah, Akadh, Ali, Hussein, Rand, Aljebur, Abbas, Hassan, Sadik, Ali, Haithem Hussein, Al‐hasani, Fahad, Ibrahim, Mustafa Wameedh, Saeed, Mubder Mohammed, Muhssein, Haidar, Akindoyin, Success, Barry, Stevie, Dewan, Nikhil, Ekwere, Bosom, Essajee, Murtaza, Langhe, Ream, Marshall, Calista, Musa, Darya, Ahmad, Zeeshan, Andrews, Emmet, Chin, Bruno Chan, Corrigan, Mark, Murphy, Amy Edwards, Foley, Niamh, Gardiner, Padraig, Hechtl, Daniel, Hsiao, Michelle, Kayyal, Mohd Yasser, Killeen, Shane, Lyons, Maria, Burke, Cathy, Hewitt, Matt, Mohamed, Marwa, Nazir, Syeda Farah, Mei Yee, Ng, Wahab, Nor Azlia Abdul, Monteith, Cathy, Oduola, Oladayo, Aljohmani, Lylas, Nugent, Timothy, Corr, Paula, Crone, Lauren, Harris, Johnathon, Hill, Arnold, Kearney, David, Keenan, Robert Anthony, Nolan, Deirdre, Ryan, James, Hehir, Mark Philip, Regan, Carmen, Geary, Michael, Malone, Fergal, Mccarthy, Claire, O’Connor, Donal B, Considine, Shane, Donohoe, Emma, Herron, Caroline, Larkin, John, Lynch, Thomas Hugh, Maguire, Barry, Manecksha, Rustom, Carthy, Andrea Mc, Nagassima, Katharina, O’Sullivan, Erica, Rohan, Pat, Roopnarinesingh, Ryan, Salloum, Salloum, Aherne, Thomas, Barry, Mary, Bowen, Gareth John, Boyle, Ellen, Dowdall, Joseph, Hanly, Ann, Hassanin, Ahmed, Heneghan, Helen, Hurson, Conor, Kelly, Orlaith, Kennelly, Rory, Kiernan, Aoife, Martin, Sean T, Masarani, Nawar, Mccartan, Damian, Mcdermott, Enda W, Murphy, Ben, Kin Cheung, Ng, Njeze, Nwabundo, O’Neill, Aine, Prichard, Ruth S, Quirke, Ned, Reynolds, Ian Sean, Winter, Des, Casey, Rowan, Elamin, Mutaz, Gillis, Amy, Kavanagh, Dara, Kelly, Michael, Mcnamee, Áine, Neary, Paul, Owens, Patrick, Ravi, Akshaya, Ridgway, Paul, Carroll, Paul, Collins, Chris, Dhannoon, Amenah, Fowler, Amy, Hogan, Aisling, Lowery, Aoife, Mcanena, Peter, Timon, Charlie, Walsh, Stewart, Al‐ramli, Wisam, Azeem, Imran, Bahadoor, Muhammad Usaama, Bodnar, Zsolt, Elmusharaf, Hassan, Hassan, Faisal Saeed, Hingum, Adam, Huan, Huilun, Jennings, Seamus, Khalid, Mohamed Hamed, Kuteva, Mariya, Mujtaba, Syed Nadeem, Peeriyah, Shanell, Rehman, Hina, Sarwar, Muhammad Assam, Shaju, Tony, Stephens, Ian, Sugrue, Michael, Thomas, Joseph, Varzgalis, Manvydas, Zeeshan, Saqib, Jaffer, Alisha, Jones‐whiting, Larne, Peirce, Colin, Johnston, Sean, Lim, Seantee, Abdelgadir, Alwaleed, Al‐mukhaizeem, Youssef, Cooke, Fiachra, Crowley, Clare, Cullen, Ivor, Flanagan, Michael, Fogarty, Amy, Glynn, Orna, Martinez, Claudia Guerrero, Hamza, Mohamed Alfatih, Hassan, Mekki, Hegazy, Ibrahim, Hill, Rhodri, Kazim, Amr, Khalid, Azriny Shaziela, Khalid, Muhammad Abdullah, Majeed, Zubair, Manning, Aidan, Mccullough, Peter, Murphy, Seamus, Neary, Peter, Noone, Anthony, O’Donoghue, Gerrard, O’Kelly, John, Odonnell, Eddie, Osman, Elaf, Ryan, Jessica, Saeed, Rafeh, Arar, Ahmad Abo, Abed, Arsan Abu, Dykman, Daniel, Elnassasra, 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Martines, Gennaro, Papagni, Vincenzo, Picciariello, Arcangelo, Magnone, Stefano, Pisano, Michele, Poiasina, Elia, Alberici, Laura, Antonacci, Filippo, Arena, Alessandro, Belvedere, Angela, Bernagozzi, Fabio, Bernante, Paolo, Bertoglio, Pietro, Bianchi, Lorenzo, Bisulli, Maria, Bonfanti, Barbara, Boussedra, Safia, Brandolini, Jury, Cacciapuoti, Crescenzo, Cardelli, Stefano, Casadei, Riccardo, Cescon, Matteo, Cipolli, Alessandro, Cipriani, Riccardo, Contu, Luca, Costa, Francesco, Daddi, Niccolo, De Crescenzo, Eugenia, De Iaco, Pierandrea, De Palma, Alessandra, Del Gaudio, Massimo, Gatta, Anna Nunzia Della, Dolci, Giampiero, Dondi, Giulia, Droghetti, Matteo, Parri, Sergio Nicola Forti, Garelli, Elena, Gelati, Chiara, Germinario, Giuliana, Giorgini, Federico A., Ingaldi, Carlo, Jovine, Elio, Kawamukai, Kenji, Lanci, Antonio Lanci, Lombardi, Raffaele, Miralles, Maria Elisa Lozano, Marchetti, Claudio, Masetti, Michele, Minni, Francesco, Morezzi, Daniele, Parlanti, Daniele, Pellegrini, Alice, Perrone, Anna Myriam, Pezzuto, Anna Paola, Pignatti, Marco, Pilu, Gianluigi, Pinto, Valentina, Poggioli, Gilberto, Puglisi, Silvana Bernadetta, Raimondo, Diego, Ravaioli, Matteo, Ricci, Claudio, Ricciardi, Sara, Ricotta, Francesco, Rizzo, Roberta, Romano, Angela, Rottoli, Matteo, Schiavina, Riccardo, Seracchioli, Renato, Serenari, Matteo, Serra, Margherita, Solli, Piergiorgio, Sorbi, Gioia, Taffurelli, Mario, Tanzanu, Marta, Tarsitano, Achille, Tesei, Marco, Vago, Gabriele, Violante, Tommaso, Zanotti, Simone, Aspide, Raffaele, Bertolini, Giacomo, Bortolotti, Carlo, Carretta, Alessandro, Caruso, Ambra, Conti, Alfredo, De Vita, Carla, Friso, Filippo, La Corte, Emanuele, Mazzatenta, Diego, Pirina, Alessandro, Rosetti, Vittoria, Sturiale, Carmelo, Vincenzi, Matteo, Zoli, Matteo, Castagnini, Francesco, Donati, Davide Maria, Frisoni, Tommaso, Lucchini, Stefano, Palmerini, Emanuela, Traina, Francesco, Baietti, Anna Maria, Berselli, Bruno, Bolognesi, Silvia, Fabbri, Erich, Farnia, Francesco, 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Scandura, Carmen Emanuela, Barca, Ida, Carnevali, Adriano, Carpino, Antonio, Cristofaro, Maria Giulia, De Paola, Gilda, Giannaccare, Giuseppe, Novembre, Daniela, Sammarco, Giuseppe, Scorcia, Vincenzo, Angeli Christy, Yu, D’Andrea, Marcello, Mongardi, Lorenzo, Tosatto, Luigino, Barone, Mirko, Mucilli, Felice, Muraglia, Angelo, Caserini, Ottavia, Giuliani, Domenico Benvenuto, Monti, Marco, Morello, Alessia, Segalini, Edoardo, Borghi, Felice, Cianflocca, Desiree, Daniele, Alberto, Donati, Danilo, Gelarda, Enrico, Giraudo, Giorgio, Giuffrida, Maria Carmela, Marano, Alessandra, Olearo, Elena, Ciarello, Vincenzo Pruiti, Puppo, Andrea, Testa, Valentina, Giacometti, Marco, Zonta, Sandro, Monti, Eleonora, Porta, Andrea, Sambucci, Daniele, Birindelli, Arianna, Carrara, Barbara, Compagnoni, Bruno, Del Giudice, Roberto, Dester, Sara Elisabetta, Lomiento, Daniele, Ruggiero, Silvia, Taglietti, Lucio, Viotti, Fabio, Lacavalla, Domenico, Occhionorelli, Savino, Rubbini, Michele, Bernabei, Massimiliano, Fabbri, Nicolò, Fazzin, Marta, Feo, Carlo V., Torchiaro, Marco, Costi, Renato, Virgilio, Edoardo, Arlia, Lorenzo, Barbato, Giuseppe, Bartolini, Ilenia, Bottari, Andrea, Bruno, Chiara, Bruscino, Alessandro, Checcucci, Carlotta, Cianchi, Fabio, Coratti, Francesco, De Vincenti, Rosita, Di Bella, Annamaria, Fambrini, Massimiliano, Fortuna, Laura, Gallo, Oreste, Gigliucci, Giacomo, Locatello, Luca Giovanni, Maltinti, Gherardo, Martellucci, Jacopo, Prosperi, Paolo, Ringressi, Maria Novella, Sorbi, Flavia, Staderini, Fabio, Taddei, Antonio, Anastasi, Alessandro, Canonico, Giuseppe, Chisci, Emiliano, Gabellini, Linda, Masciello, Fabrizio, Michelagnoli, Stefano, Nelli, Tommaso, Tirloni, Luca, Alemanno, Giovanni, Arminio, Armando, Beck, Renata, Bergamini, Carlo, Cotoia, Antonella, Lizzi, Vincenzo, Maccagnano, Giuseppe, Pesce, Vito, Sarni, Antonio Luciano, Tartaglia, Nicola, Vovola, Fernanda, Avanzolini, Andrea, Bocchino, Antonio, Bova, Raffaele, Cavaliere, Davide, D’Acapito, Fabrizio, Ercolani, 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Antonino Francesco, Mazzeo, Carmelo, Bertoglio, Camillo Leonardo, De Martini, Paolo, Ferrari, Giovanni, Giani, Alessandro, Lombardi, Pietro Maria, Mazzola, Michele, Baldari, Ludovica, Bissacco, Daniele, Boni, Luigi, Cassinotti, Elisa, Domanin, Maurizio, Pignataro, Lorenzo, Torretta, Sara, Trimarchi, Santi, Armellin, Daniele, Basato, Silvia, Bernardi, Laura, Bunino, Francesca, Capretti, Giovanni, Carrano, Francesco Maria, Castoro, Carlo, Colombo, Giovanni, Costantino, Andrea, De Lucia, Francesca, De Virgilio, Armando, Di Bari, Matteo, Ferreli, Fabio, Gaino, Francesca, Gramellini, Marco, La Raja, Carlotta, Malvezzi, Luca, Marano, Salvatore, Mercante, Giuseppe, Milana, Flavio, Nappo, Gennaro, Peros, Georgios, Pirola, Francesca, Rossi, Vanessa, Russo, Elena, Spriano, Giuseppe, Tamburello, Sara, Zerbi, Alessandro, Aiolfi, Alberto, Bona, Davide, Sozzi, Andrea, Adamoli, Laura, Ansarin, Mohssen, Bertolaccini, Luca, Cenciarelli, Sabine, Chu, Francesco, De Berardinis, Rita, Romario, Uberto 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Ferdinando, Sileri, Pierpaolo, Spina, Alfio, Vignali, Andrea, Barberio, Cristina, Beretta, Luigi, Cavenago, Francesca, Di Tomasso, Nora, Fresilli, Stefano, Landoni, Giovanni, Lazzari, Stefano, Lombardi, Gaetano, Marmiere, Marilena, Monaco, Fabrizio, Todaro, Gabriele, Turi, Stefano, Zangrillo, Alberto, Bertolina, Francesca, Bogani, Giorgio, Bonomi, Stefano, Cadenelli, Pierfrancesco, Chiappa, Valentina, Cioffi, Stefano Piero Bernardo, Citterio, Davide, Comini, Lara Valentina, Cortinovis, Umberto, Cosimelli, Maurizio, Ditto, Antonino, Gennaro, Massimiliano, Giannini, Lorenzo, Guaglio, Marcello, Guzzo, Marco, Leva, Andrea, Macchi, Alberto, Manzo, Elena, Martinelli, Fabio, Mattavelli, Ilaria, Mazzaferro, Vincenzo Maria, Raspagliesi, Francesco, Rolli, Luigi, Sala, Laura, Salvioni, Roberto, Santinami, Mario, Segattini, Silvia, Sorrentino, Luca, Zaborra, Carlotta, Anesi, Alexandre, Pattacini, Gianmaria Casoni, Di Bartolomeo, Mattia, Pecchini, Francesca, Pellacani, Arrigo, Piccoli, Micaela, Fusini, Federico, Gattolin, Andrea, Migliore, Marco, Rimonda, Roberto, Sasia, Diego, Travaglio, Elisabetta, Brunetti, Federica, Cereda, Marco, Ceresoli, Marco, Cigagna, Luca, Dell’Oro, Cristina, Fogliati, Alessandro, Fruscio, Robert, Grassi, Tommaso, Isabella, Maini Marzia, Nespoli, Luca Carlo, Oldani, Massimo, Ornaghi, Sara, Tamini, Nicolò, Antropoli, Carmine, Castaldi, Antonio, Palumbo, Alessio, Altieri, Gaia, Bracale, Umberto, Corcione, Francesco, De Luca, Marcello, De Palma, Giovanni Domenico, Di NUZZO, Maria Michela, Lionetti, Ruggero, Bue, Dalila Loredana Lo, Luglio, Gaetano, Pagano, Gianluca, Peltrini, Roberto, Pirozzi, Nello, Tropeano, Francesca Paola, Aversano, Alessia, Belli, Andrea, D’Amico, Maria, Delrio, Paolo, Izzo, Francesco, Patrone, Renato, Rega, Daniela, Maida, Pietro, Marra, Ester, Marte, Gianpaolo, Tufo, Andrea, Bianco, Francesco, Cappiello, Antonio, Gili, Simona, Incollingo, Paola, Novi, Alessandra, Bagaglini, Giulia, Iovino, Claudio, Tasselli, Francesco Menegon, 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Andreani, Lorenzo, Antonio, Darienzo, Aprile, Vittorio, Balestri, Riccardo, Benettini, Giacomo, Berrettini, Stefano, Bruschini, Luca, Chiarugi, Massimo, Coccolini, Federico, Colangeli, Simone, Cremonini, Camilla, Mencacci, Lodovica Cristofani, Dallan, Iacopo, De Santi, Silvia, Di Franco, Gregorio, Di Girolami, Lorena, Fiacchini, Giacomo, Furbetta, Niccolò, Korasidis, Stylianos, Lucchi, Marco, Morandi, Andrea, Morelli, Luca, Musetti, Serena, Neri, Carlo Maria, Palmeri, Matteo, Picariello, Miriana, Porcelli, Francesco, Puccini, Marco, Roffi, Nicolo, Statuti, Erica, Tartaglia, Dario, Tonelli, Alberto, Vianini, Matteo, Baronio, Gianluca, Montuori, Mauro, Pinotti, Enrico, Basso, Stefano Maria Massimiliano, Maffeis, Federica, Ubiali, Paolo, Aguzzoli, Lorenzo, Coiro, Saverio, Falco, Giuseppe, Mandato, Vincenzo Dario, Mastrofilippo, Valentina, Mele, Simone, Baldi, Caterina, Corbellini, Carlo, Sampietro, Gianluca Matteo, Dugo, Massimo, Garino, Mauro, Marafante, Chiara, Masciandaro, Antonio, Moggia, Elisabetta, Murgese, Alessandra, Agro, Felice Eugenio, Capolupo, Gabriella Teresa, Carannante, Filippo, Caricato, Marco, Denaro, Vincenzo, Mazzotta, Erica, Papalia, Rocco, Pascarella, Giuseppe, Strumia, Alessandro, Zampogna, Biagio, Cinquepalmi, Matteo, Colasanti, Marco, Del Basso, Celeste, Falaschi, Federica, Guglielmo, Nicola, Meniconi, Roberto Luca, Pecoraro, Alessandra, Usai, Sofia, Crescentini, Giacomo, Larcinese, Antonella, Picone, Emanuele, Sinibaldi, Giovanni, Agnes, Annamaria, Agnes, Salvatore, Alfieri, Sergio, Belia, Francesco, Bianchi, Valentina, Bianco, Giuseppe, Biondi, Alberto, Campennì, Paola, Cozza, Valerio, D’Archi, Sabatino, D’Ugo, Domenico, De Simone, Veronica, Di Grezia, Marta, Di Lorenzo, Sofia, Ferracci, Federica, Fico, Valeria, Franceschini, Gianluca, Fransvea, Pietro, Gasparini, Giulio, Gordini, Luca, La Greca, Antonio, Litta, Francesco, Lombardi, Celestino Pio, Marra, Angelo Alessandro, Parello, Angelo, Pascale, Marco Maria, Patini, Romeo, Pepe, Gilda, Persiani, Roberto, Puccioni, Caterina, Ratto, Carlo, Rosa, Fausto, Saponaro, Gianmarco, Scardina, Lorenzo, Silvia, Tedesco, Tropeano, Giuseppe, Benevolo, Maria, Bugada, Daniele, Campo, Flaminia, Dona, Maria Gabriella, Manciocco, Valentina, Marchesi, Paolo, Mastroianni, Riccardo, Mazzola, Francesco, Moretto, Silvia, Pellini, Raul, Petruzzi, Gerardo, Pichi, Barbara, Simone, Giuseppe, Tuderti, Gabriele, Zocchi, Jacopo, Cosentino, Luigi Marino, Sagnotta, Andrea, Angelico, Roberta, Bellato, Vittoria, Campanelli, Michela, Franceschilli, Marzia, Grande, Michele, Lisi, Giorgio, Manzia, Tommaso Maria, Petagna, Lorenzo, Sensi, Bruno, Sica, Giuseppe, Siragusa, Leandro, Tisone, Giuseppe, Assenza, Marco, Binda, Barbara, Biondi, Massimo, Brachini, Gioia, Bruzzaniti, Placido, Casagrande, Mauro, Ciccarone, Flavia, Cicerchia, Pierfranco Maria, Cirillo, Bruno, Crocetti, Daniele, D’Ambrosio, Giancarlo, D’Andrea, Vito, De Felice, Francesca, De Toma, Giorgio, Rocca, Carlo Della, Duranti, Giulia, Familiari, Pietro, Fiori, Enrico, Fonsi, Giovanni Battista, Frati, Alessandro, La Rocca, Stefania, La Torre, Filippo, Lapolla, Pierfrancesco, Marruzzo, Giovanni, Meneghini, Simona, Mingoli, Andrea, Picchetto, Andrea, Polimeni, Antonella, Ribuffo, Diego, Salvati, Maurizio, Santoro, Antonio, Sapienza, Paolo, Simonelli, Luigi, Valentini, Valentino, Zambon, Martina, Zancana, Giuseppa, Zuppi, Emma, D’Annunzio, Simone, De Nunzio, Cosimo, Fiorelli, Silvia, Ibrahim, Mohsen, Loffredo, Chiara, Massullo, Domenico, Menna, Cecilia, Monica, Rocco, Pelli, Massimiliano, Rendina, Erino Angelo, Teodonio, Leonardo, Tubaro, Andrea, Argenio, Giulio, Accarino, Giulio, Giancarlo, Accarino, Giordano, Antonio Nicola, Cardinali, Luca, Sebastiani, Elisa, Travaglini, Grazia, Andreatta, Erika, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele, Bonavina, Luigi, Froiio, Caterina, Lovece, Andrea, Copelli, Chiara, Manfuso, Alfonso, Di Maio, Pasquale, Giudice, Marco, Iocca, Oreste, Cennamo, Rosario, Cornali, Tommaso, Di Marzo, Francesco, Altana, Cristian, Bussu, Francesco, Capobianco, Giampiero, Carta, Anna Giacomina, Ciccarello, Sandro, Cossu, Maria Laura, Cottu, Pietrina, De Riu, Giacomo, Dessole, Salvatore, Dessole, Francesco, Dettori, Salvatora, Doria, Carlo, Fancellu, Alessandro, Feo, Claudio F, Ginesu, Giorgio Carlo, Giuliani, Giuliana, Iannuccelli, Marco Giuseppe, Madonia, Massimo, Mancino, Roberto, Massarelli, Olindo, Meloni, Gianfranco, Milia, Fabio, Mulliri, Andrea, Perra, Teresa, Petrillo, Marco, Piras, Antonio, Piredda, Franco, Pisanu, Francesco, Porcu, Alberto, Rizzo, Davide, Sanna, Angelino, Scanu, Antonio Mario, Scognamillo, Fabrizio, Soma, Damiano, Tanca, Anna Rita, Tedde, Alessandro, Tedde, Matteo, Vaira, Luigi Angelo, Pazzi, Andrea Bartalini Cinughi, Samorani, Osvaldo Carpineto, Fusario, Daniele, Marano, Luigi, Oldrà, Gaia, Pesce, Anna Lisa, Piccioni, Stefania Angela, Resca, Luca, Ricchiuti, Vincenzo, Roviello, Franco, Savelli, Vinno, Abrate, Alberto, Bordoni, Pierpaolo, Bosio, Lorenzo, Clarizia, Guglielmo, Fleres, Francesco, Franzini, Marco, Fratto, Antonio, Giumelli, Pierluigi, Grechi, Alessandro, Longhini, Alessandro, Lorusso, Fabrizio, Scarnecchia, Elisa, Scolari, Federica, Spolini, Alessandro, Maiuri, Vincenzo, Papandrea, Matteo, Roncone, Arturo, Conti, Lorenzo, Rizzi, Andrea, Rovagnati, Marco, Brolese, Alberto, Cai, Tommaso, Ciarleglio, Francesco Antonio, Dalprà, Francesca, Malossini, Gianni, Mereu, Liliana, Tamanini, Irene, Tateo, Saverio, Viel, Giovanni, Battistella, Enrico, Rizzo, Paolo Boscolo, Fabbris, Cristoforo, Massani, Marco, Spinato, Giacomo, Tutino, Roberta, Grossi, Ugo, Iacomino, Alessandro, Novello, Simone, Romano, Maurizio, Rossi, Serena, Santoro, Giulio, Zanus, Giacomo, Trungu, Sokol, Aizza, Giada, Bellio, Gabriele, Bogoni, Selene, Bortul, Marina, Casagranda, Biagio, Cortinovis, Sara, Manzini, Nicolò, Drigo, Davide, Germani, Paola, Mastronardi, Manuela, Paiano, Lucia, Palmisano, Silvia, Filosso, Pier Luigi, Guerrera, Francesco, Marro, Matteo, Rinaldi, Mauro, Ruffini, Enrico, Salizzoni, Stefano, Bardelli, Laura, Berselli, Mattia, Borroni, Giacomo, Cocozza, Eugenio, Desio, Matteo, Elisa, Bottazzoli, Ietto, Giuseppe, Iori, Valentina, Iovino, Domenico, Livraghi, Lorenzo, Marchionini, Valentina, Megna, Stefano, Nahal, Emma Amal, Palumbo, Mara, Quintodei, Valeria, Zullo, Alessandra, D’Alimonte, Lucrezia, Pirozzolo, Giovanni, Vignotto, Chiara, Campagnaro, Tommaso, Caravati, Andrea, Conci, Simone, De Cristofaro, Carlotta, Gecchele, Gabriele, Giuliani, Tommaso, Graziosi, Jacopo, Guglielmi, Alfredo, Paiella, Salvatore, Pedrazzani, Corrado, Pollini, Tommaso, Rattizzato, Simone, Ruzzenente, Andrea, Salvia, Roberto, Turri, Giulia, Bacchion, Matilde, Butturini, Giovanni, Casaril, Andrea, Giardino, Alessandro, Impellizzeri, Harmony, Inama, Marco, Isabella, Frigerio, Moretto, Gianluigi, De Zuanni, Marco, Deiana, Enrica, Guglielmo, Mario, Broglia, Alessandro, Casarini, Claudia, Zingaretti, Caterina Costanza, Bonaldi, Marta, Cesana, Giovanni, Mastriale, Francesco, Olmi, Stefano, Fukami, Matteo Uccelli Yasuyuki, Saito, Takuya, Sano, Tsuyoshi, Hirai, Naoki, Hirota, Kazuyoshi, Kushikata, Tetsuya, Oyama, Tasuku, Saito, Junichi, Ishibashi, Katsuhiko, Kamiyama, Mizue, Son, Kyongsuk, Tarao, Kentaroh, Yamada, Takayuki, Shiga, Toshiya, Aze, Chisaki, Deguchi, Yoshihiko, Hasegawa, Hirotoshi, Hoshino, Tatsuki, Innami, Yasushi, Inoue, Hiroyuki, Ito, Shingo, Nomura, Takeshi, Ogihara, Tomomi, Okada, Reina, Ouchi, Takashi, Sekiya, Yuri, Tachibana, Keikoku, Takano, Emi, Yamamoto, Masae, Matsuda, Shuko, Matsuki, Yuka, Shigemi, Kenji, Hiraki, Teruyuki, Inoue, Yui, Jotaki, Shosaburo, Abe, Tatsuro, Eto, Masatoshi, Inokuchi, Junichi, Kashiwagi, Eiji, Kinoshita, Fumio, Kobayashi, Satoshi, Lee, Ken, Matsumoto, Takashi, Monji, Keisuke, Naganuma, Hidekazu, Shiota, Masaki, Takeuchi, Ario, Obara, Shinju, Takatsuki, Saori, Tanaka, Saori, Iida, Koji, Kagawa, Kota, Neshige, Shuichiro, Chaki, Tomohiro, Hirata, Naoyuki, Kazuma, Satoshi, Kimizuka, Motonobu, Kumita, Sho, Nishihara, Noriaki, Satoshi, Sato, Sawada, Atsushi, Tachibana, Shunsuke, Yamakage, Michiaki, Nakamura, Yuta, Sato, Kozo, Irie, Tomoya, Irisawa, Tomoko, Kanemaru, Eiki, Koga, Yuko, Chiba, Yoshihiko, Makino, Jun, Ohama, Shinnosuke, Okada, Shinichiro, Teruaki, Kano, Kida, Tatsuya, Takei, Tomohide, Hanazaki, Kazuhiro, Kitagawa, Hiroyuki, Namikawa, Tsutomu, Mizota, Toshiyuki, Takeda, Chikashi, Yagi, Shintaro, Imai, Hiroshi, Ishitobi, Makoto, Kato, Manabu, Nishikawa, Kouhei, Sasaki, Takeshi, Yonekura, Hiroshi, Kanaya, Akihiro, Irimada, Daisuke, Ishikawa, Haruka, Kaiho, Yu, Ida, Mitsuru, Kawaguchi, Masahiko, Kawamura, Kenji, Ogawa, Munehiro, Okada, Hiroshi, Endo, Shunji, Fujiwara, Yoshinori, Higashida, Masaharu, Kubota, Hisako, Okada, Toshimasa, Tanaka, Hironori, Ueno, Tomio, Yoshimatsu, Kazuhiko, Kikukawa, Motohiro, Kuriyama, Akira, Matsushime, Susumu, Hidehiko, Hishikawa, Hino, Haruaki, Hisamatsu, Yoji, Kamiya, Akio, Kinoshita, Hidefumi, Kita, Masato, Kobayashi, Toshinori, Michiura, Taku, Miki, Hirokazu, Murakawa, Tomohiro, Okada, Hidetaka, Saito, Tomohito, Saito, Ryoichi, Sugi, Motohiko, Sumi, Genichiro, Yamaki, So, Yamamoto, Tomohisa, Yoshida, Aya, Kambara, Tatsuya, Kanematsu, Sayaka, Satoshi, Okazaki, Hijikawa, Takeshi, Kitade, Hiroaki, Yanagida, Hidesuke, Fujita, Tomoyuki, Fukushima, Satsuki, Tadokoro, Naoki, Furukawa, Taku, Iizuka, Yusuke, Otsuka, Yuji, Sanui, Masamitsu, Sawada, Ikumi, Iwahashi, Hideki, Miyamoto, Morikazu, Takano, Masashi, Mieda, Tsutomu, Ando, Chihiro, Isada, Tetsuro, Ishizaki, Taku, Amer, Qaed Bani, Ishida, Sachi, Kobayashi, Yasuma, Kuratani, Norifumi, Sakurai, Tomoe, Takada, Misa, Iba, Yutaka, Tsukagoshi, Junji, Yamada, Akira, Amano, Yuki, Fumoto, Kentaro, Noro, Shusaku, Fujimoto, Ayataka, Tomoto, Kyoichi, Okamura, Yukiyasu, Sugiura, Teiichi, Uesaka, Katshuhiko, Takemura, Natsuki, Kuroda, Kento, Hayashi, Megumi, Kaneko, Satoi, Kawagoe, Izumi, Kochiyama, Tsukasa, Yamaguchi, Ai, Abe, Nobutsugu, Ando, Tadao, Chinzei, Mieko, Hirano, Kouichi, Kobayashi, Yoichi, Matsuki, Ryota, Matsumoto, Hironori, Motoyasu, Akira, Nakazawa, Harumasa, Noguchi, Hikari, Okamura, Kaio, Ono, Motoaki, Seki, Hiroyuki, Sunami, Eiji, Tajima, Atsushi, Tanigaki, Shinji, Uzawa, Kohji, Watanabe, Hidenobu, Furuhata, Yukari, Toyama, Satoshi, Uchida, Tokujiro, Enomoto, Yutaka, Furukawa, Yuri, Hasumi, Yoko, Hirota, Jinso, Iida, Katsuyuki, Ikeda, Shingo, Ikeda, Tatsuhiko, Kawamata, Natsuko, Kawasaki, Yosuke, Koizumi, Minako, Kono, Yoshiharu, Kuzuhara, Shigeki, Maeda, Junichi, Moriyama, Mai, Nagamoto, Shoichi, Nakanishi, Rinako, Noda, Michio, Seichi, Atsushi, Takahashi, Shintaro, Takashi, Kobayashi, Takeda, Misuzu, Tanakura, Kenta, Terajima, Katsuyuki, Tsuji, Munechika, Ueshima, Chiharu, Yamamoto, Naoya, Yamamoto, Mari, Yokota, Toshiya, Yoshioka, Yuki, Yuri, Sakoh, Iwata, Shintaro, Kawai, Akira, Osaki, Shuhei, Ishikawa, Masashi, Iwasaki, Masae, Morita, Tomonori, Hirooka, Reina, Nakata, Yoshinori, Sawamura, Shigehito, Ishida, Yusuke, Kawachi, Aya, Kobayashi, Takayuki, Nagashima, Fumiaki, Suzuki, Naoki, Ando, Kohei, Miyazawa, Noriko, Tanaka, Yukio, Abuissa, Khatab, Aljabali, Alaa, Almasri, Amal, Alrabadi, Mera, Alshara, Rana, Alzghoul, Yasmeen, Alzughoul, Ahmed, Freihat, Ali, Jeitan, Emran, Owais, Qais, Smadi, Aseel, Abukhadra, Mahmoud, Abunawas, Huthifa, Al‐azzam, Abdallah Ahmed Mezel, Aladaileh, Ammar, Albadawi, Ismail, Alhawatmeh, Mohammad, Alkhaza’Leh, Mohannad Yaser, Alneimat, Roaa Salem Jwaid, Alwahedy, Saba, Alwardat, Abdel Rahman Mohannad Ahmad, Dhoon, Slsabela, El‐qawaqzeh, Khaled, Hrerat, Tarteel, Jaradat, Enas, Mubaydeen, Teeba, Sarayrah, Husam, Tarawneh, Mohammad Abdel Elah A., Karasneh, Mohammad Yousef, Zurgan, Amany, Alassaf, Mohammad, Alzraikat, Sayel H., Amarin, Justin Z., Hijjawi, Ahmed, Suradi, Haya H., Zaghlol, Louay Y., Abdalah, Ahmad, Abdallah, Ghaida, Tarieh, Ammar Abu, Abu‐libdeh, Tareq, Abualteen, Faisal, Al Abdallah, Murad, Al Bdour, Zakaria, Al Dahabrh, Seif, Al‐kasaji, Farah, Ali, Zaid Al‐sheikh, Al‐thaher, Mohammad, Alnajjar, Tareq, Alqedrh, Mohannad, Alsaleh, Mohammad, Alzaatreh, Mohammad, Amayreh, Ghandi, Ayasra, Yazeed, Eid, Ahmad, Ghayada, Ibrahim, Moh’d Ahmed Hasanein, Khaled, Hassouneh, Anas, Hijazeen, Raid, Hmeidan, Majedah, Khaled, Ahmed, Khasawneh, Barihan, Kifayeh, Omar, Lafi, Yasser, Seba, Jasem, Semrin, Qusai, Sma, Fda, Theab, Mohammad, Tumeh, Haitham, Zaid, Muna Aba, Abazeed, Alaa, Abbad, Bader, Abbadi, Osaid, Abu‐ishkerih, Nizar, Al‐osta, Malk, Al‐zyadat, Reham, Alawneh, Bashar Omar Falah, Alhattab, Majd, Alkurdieh, Mohd Mujahed, Awwad, Ziad, Hammouri, Mohammad, Hussein, Hamzeh, Khader, Sereen, Khalil, Mariam, Mansour, Omar, Othman, Ahmad, Qandeel, Haitham, Saleem, Mohammad, Souri, Fouad, Tahboub, Ahmad, Tayyem, Raed, Abdallah, Munir, Abdel‐hafez, Ibrahim, Obead, Hamza Abu, Abudari, Hadeel, Abuhamour, Ehab, Abusadah, Samer, Al‐azzeh, Nimer, Al‐adwan, Sofian, Al‐darabah, Ali, Al‐qannas, Mohammad, Albaba, Basil, Alradawneh, Qutaiba, Amaireh, Mohammad, Ashour, Subhi, Chabaan, Reem, Eskander, Ammar, Fawzi, Ahmad, Haij, Manal, Hamad, Hisham, Hamdan, Haya, Hamss, Ahmed, Hassouneh, Esraa, Hyasat, Ayah, Ibrahim, Zainab, Jamaliah, Saja, Khalil, Mohammed, Massad, Anas, Mohamed, Ishak, Qandeel, Mahmoud, Qasrawi, Dalia, Raggad, Mahmoud, Rifai, Ebaa, Semreen, Nedal, Shehada, Reham, Shorman, Marwan, Al‐shibi, Abdallah, Alsa’Afin, Shatha, Bani‐hani, Morad, Nimer, Bahaa, Nofal, Sandra, Qaraqe, Layth, Salameh, Mohammed, Saleh, Ma’Moun, Sanjuq, Ghaidaa, Sharabi, Alaa, Sweiti, Alaa, Yaghmour, Jamal, Zaza, Sabri, Alhindi, Rahaf, Baninasr, Eman, Al‐masri, Mahmoud, Al‐najjar, Hani, Alawneh, Fade, Al‐latayfeh, Motasem, Al‐shudifat, Abdel‐ellah, Ahmad, Abd Almonem Shaikh, Abdeljalil, Abdelkarim, Abdelrahman, Haneen, Abdulmalek, Abdulmalek, Abedalqader, Lina, Abed, Laith Abu, Al Smadi, Omar, Alarood, Salameh, Allouzi, Mohammad, Almansour, Maha, Almi’Ani, Sari, Alsaiad, Abdulhakim, Alshaikh, Khaled, Androus, Farah, Awbakh, Mirna, Azzam, Belal, Yasin, Hammam Bany, Daoud, Maher, Dawod, Lujain, Dawod, Omar, Elmusa, Reem, Fadli, Saba, Hammad, Farah, Hunaiti, Majd, Muhtaseb, Mahmoud, Owaimer, Rawan, Qulaghassi, Zaki, Romman, Saleh, Saket, Rawand, Sharawi, Said, Tawalbeh, Alaa, Al‐howthi, Mohammed, Ababneh, Laila, Ababneh, Roba, Za’Nouneh, Faris Jamal Abu, Al DHOUN, Sajedah, Al Khassawneh, Ahmad, Al Sharie, Ahmed, Al Shraideh, Ayah Ahmad, Al‐dabaa, Tawfik, Al‐jarrah, Salsabeel, Al‐jarrah, Hothaifa, Al‐othman, Hadeel, Alaradi, Zuhair, Alshannaq, Qutaiba, Alsulaiman, Rima, Alzaqh, Motasem, Alzu’Bi, Yazan, Audat, Ziad, Bahhour, Mohammad, Bdour, Saja, Khatatbeh, Roa, Marji, Fares, Mazahreh, Tagleb, Nail, Dina, Nuseir, Amjad, Rabab’Ah, Asmaa, Sawadi, Taher, Zidan, Ghina, Muhfouz, Dima Abu, Nael, Abdullah, Qasim, Ahmad, Al‐jarrah, Amar, Rawagah, Faisal, Abu Ismail, Dima Y, Al‐dolat, Wedad, Alzoubi, Mai, Alzoubi, Malak, Alzu’Bi, Mu’Taz, Asha, Ruba, Guboug, Ali, Hussein, Hasan, Rawashdeh, Shireen, Sanwar, Mohammad, Ababneh, Adnan, Abu‐eisheh, Basil, Alhami, Haneen Ahmad, Al Dwairi, Saif Aldeen, Al Shurman, Hana’, Al Yahya, Zakaria, Al‐atiyah, Hussam, Al‐balas, Hasan, Aljaiuossi, Anas, Alqawasmi, Shatha, Alqudah, Sadeel, Alshourman, Mahmoud, Hamad, Abdulsalam Bani, Issa, Anas Bany, Ennab, Raed, Hamdoni, Sara, Hijazi, Zaid, Khafaja, Ali, Mraiyan, Mohamed, Obeidat, Riyad, Olaywah, Dina, Qudah, Mohamad, Talal, Mhamdd, Aidarov, Askar, Sarmenova, Aisulu, Kodasbaev, Almat, Sakhov, Orazbek, Tanabayeva, Shynar, Amrayev, Sultan, Dzhumabekov, Berik, Malgazhdarov, Maulen, Tezekbaev, Kanat, Kukubassov, Yerlan, Satanova, Alima, Mwachiro, Michael, Parker, Robert, Simel, Ian, Mohammedali, Shamshuddin, Mwaria, Claude, Obure, Ralph, Shah, Sayed Shah Nur Hussein, Hirani, Chetan, Kibunyi, Muthoni, Mailu, Claire, Mwangi, Victor, Ogenya, Roy, Osea, Lydia, Cheruiyot, Davies, Hirsi, Omar, Muiru, Carolyne, Wanjara, Samuel, Kim, Chang Woo, Lee, Suk Hwan, Almulla, Ahmad, Dashti, Mustafa, Elghany, Omar, Sultan, Abdullah, Al‐mahmeed, Husain, Alabbad, Jasim, Albader, Ibtisam, Aldalal, Shuaib, Baba, Mahdi, Abdulsalam, Fareed, Alhajri, Naser, Alwael, Athari, Ayele, Brook, Marie, Hatem, Zaitoun, Ahmed, Alali, Ahmad M., Alkhamis, Ahmed, Alozairi, Ous, Almazeedi, Sulaiman, Alsabah, Salman, Abdelkarim, Mostafa, Al Rashed, Asmaa, Al Subaie, Saud, Al‐shaiji, Tariq, Al‐terki, Abdullatif, Alhunaidi, Omar, Aljewaied, Ali, Alzamel, Khaled, Farag, Ahmed, Hayati, Hussein, Termos, Salah, Wood, Sarah, Al‐gilani, Maha, Al‐sihan, Mutlaq, Alotaibi, Haifa, Lobovs, Dmitrijs, Pcolkins, Andrejs, Sivins, Armands, Apse, Ingus Arnolds, Berga, Annija Evelīna, Ivanova, Anna, Demicevs, Jevgenijs, Ivanovs, Igors, Kaminskis, Aleksejs, Opincans, Janis, Pāvulāns, Jānis, Rudzāts, Agris, Udre, Anna, Dbouk, Samer, Farfour, Imadeddine, Rakka, Mohamad, Antonios, Ingrid, El Hage, Joe, Hage, Stephanie, Haiby, Lea, Kahi, Hiba, Lichaa, Anthony, Moussa, Rita Milan, Salameh, Michel, Sarkis, Riad, Albaini, Obey, Haykal, Tony, Safadi, Bassem, Abou‐abbass, Hussein, Al Makari, Reem, Al Zein, Zeina, Baidoun, Mariam, Itani, Rania, Owiedat, Mustafa, Abdel Sater, Ali H., Akl, Michel, Badran, Nour, El Mustapha, Sara, Fatouh, Fathallah, Ghoussoub, Youssef, Saad, Nader, Serhan, Fatima, Souleiman, Bassem, Alame, Walid, Ghiya, Peter, Ibrahim, Firas, Abdallah, Rasha, Kassab, Mohamad B., Karout, Samar, Aya Abdul, Al, Chaaban, Hilal, Fakih, Ghinwa, Haj‐ibrahim, Huzifa, Awad, Rabih, El Assaad, Hadi, Alfeqeeh, Ahmed, Muftah, Hosam, Abdulrahman, Taha, Ahseen, Naeimah, Abunaaja, Hayat Omar, Abdulmalik, Abdulmuez, Al Gasi, Abd El Jawad, Alsaeiti, Sara, Elkhafeefi, Fatimah, Elrefai, Nasre, Ahmad, Rofida, Alhouni, Tarek, Alkarky, Safya, Alkeelani, Hana, Alkuwafi, Rauoof, Benhariz, Rema, Bettamer, Nagat, Busarira, Musa, Bushaala, Hassan, Diryaq, Tariq, Elbargathe, Osama, Eldarat, Tarik, Elfadli, Mustafa, Elfitori, Jamael, Elmahgoub, Asma, Elsahti, Reem, Hassan, Yosef, Hussain, Fathi, Mirsal, Taha, Mohammed, Marwa, Saad, Ebtesam, Hadad, Haifaa Il, Mosabha, Mostafa, Alhaje, Awatif, Haron, Aaya, Alsuwiyah, Suhir, Hamed, Mona, Khel, Samer, Omar, Sana, Yousef, Rowaida, Abdelmalik, Abubaker, Abosnaina, Yahya, Abuhlaiga, Ma’Aly, Abushahma, Ahmed Omar, Aldelensi Alzubi, Alhosen Saleh M, Aljanfi, Asma, Alnehum, Mohamed Alnaser, Alzedam, Ahmad, Delhen, Malik, Maderi, Galia, Matoug, Faisel, Mohammed, Burooj, Sawalem, Mohamed, Jahan, Alhadi, Jahan, Abdussalam, Alazabi, Basma, Alezabi, Bahauldin, Alazabi, Mona Masaud Amro, Egdeer, Amin Salem Ahmed, Sefi, Fatma, Kamoka, Elhusain, Salamah, Abdulrauf, Abdalhadi, Alya, Abdeewi, Saedah, Alhadad, Marwah, Awrayit, Ahmed, Eshnaf, Mabroka, Yahmad, Mohammad, Abudher, Abdulhafid, Elamin, Faisl, Abojeila, Farah, Aliwa, Mohamed, Jouira, Rayet Al Islam Ben, Shagour, Sana, Altobal, Ahmed, Aljuroushi, Omar, Almadani, Hadeel, Attia, Hajer, Eljali, Amal Sharif, Emran, Ayyah, Omar, Mabruka, Salim, Radhwan, Samer, Ashraf, Abulshuwashi, Nayrouz Abdullah, Ben Khalifa, Emadeddin T M, Benabdalla, Hdaya Abdalla S, Elnageh, Hatem, Hammad, Ali, Abdullah, Duha Milad, Abusalem, Marwa, Esmael, Esraa Ben, Benmasoud, Fatma, Debri, Laila, Elmokhtar, Randa, Sheta, Manal Ezeddin Kamel, Elhabashi, Bushra Sayeh Mohamed, Younis, Balkees, Elmabrouk, Amna, Momen, Ahmed, Alzoubi, Abdalrahem Essied Alzubi, Ayad, Kusay, Hasan, Ameerah Mahdi Abraheem, Musrati, Fawzie, Abusannoga, Malek, Malek, Ans, Ajaj, Hatem, Abdulwahed, Eman, Aboubeirah, Mohammed, Alqurpaa, Aya, Alshareea, Entisar, Aribi, Sarra, Aribi, Tomather, Biala, Marwa, Ghamgh, Reem, Issa, Mohannned, Lamari, Amani Hamid, Mufth, Mohammed, Abboud, Omar Sudig, Hallalah, Muad Fathi Khalleefah Abu, Abumahara, Saleh, Aburima, Sarah, Adrees, Mohammed, Ahtash, Abdurahman, Al Shukri, Asmaa, Alameen, Hind, Alarabi, Rehab, Alarabi, Alarabi, Alelwany, Aisha, Alesmail, Abdulkarim, Algadi, Noran, Almaqrahi, Khuloud, Alosta, Hadel, Alsharedi, Mohamed, Bashir, Rasha, Ghrema, Mahmoud Ben, Nour, Sari Bin, Elbarouni, Sofian, Elhadi, Ahmed, Elkhadar, Abdulmohimen A, Elkouba, Esraa, Elmsherghi, Nabiha, Gammoudi, Abdulmohimen, Ghariba, Abdulraouf, Gjam, Fatima Zayed, Haidar, Arwa, Helal, Hala, Huwaysh, Mohammed, Alhadheeri, Ahmed Khalid, Kriem, Eslam, Osman, Halim, Ossman, Mohamed Ali, Shilfeet, Marwah, Turshani, Laila, Albishty, Nouran, Alhadi, Abdulmueti, Ali, Salem, Altoumi, Manal Ahmed, Bahroun, Sumayyah Ghayth, Younes, Eman, Atarabulsi, Hana, Elshaibi, Mohamed, Othman, Abdullmujeeb, Hasan, Hayat Ben, Hasan, Najat Shaban Ben, Hasan, Rabab Shaban Ben, Barauskas, Vidmantas, Dainius, Edvinas, Dambrauskas, Zilvinas, Dauksa, Albertas, Dekeryte, Inga, Gudaityte, Rita, Jasaitis, Kristijonas, Koženiauskaitė, Akvilė, Krasauskas, Virgilijus, Lukosiute‐urboniene, Ausra, Maleckas, Almantas, Riauka, Romualdas, Šlenfuktas, Vygintas, Svagzdys, Saulius, Urbonas, Kestutis, Vanagas, Tomas, Venclauskas, Linas, Venskutonis, Donatas, Zilinskas, Justas, Ambrazevicius, Marijus, Syminas, Vilius, Aliosin, Oleg, Cizauskaite, Agne, Eismontas, Vitalijus, Jurgaitis, Jonas, Mikutaitis, Vytenis, Petrauskas, Donatas, Samalavicius, Narimantas Evaldas, Simcikas, Dainius, Slepavicius, Algirdas, Tamosiunas, Albinas, Turskis, Vaidotas, Vasiliauskas, Bernardas, Aniukstyte, Laura, Dulskas, Audrius, Januška, Gediminas, Kuliavas, Justas, Montrimaite, Margarita, Cekauskas, Albertas, Kaminskas, Azuolas Algimantas, Kozenevskis, Sarunas, Poskus, Tomas, Strupas, Kestutis, Zelvys, Arunas, Decker, Georges, Noël, Audrey, Rajaonarivony, Maheriandrianina Fanambinana Voahary, Lucas, Randimbinirina Zakarimanana, Andriantsoa, Herimampionona E, Rasamoelina, Mamisoa B, Vatosoa, Rakotonarivo Aina Andrianina, Andriamanana, Liantsoa, Finaritra, Casimir FP Rahantasoa, Raherison, Aristide Romain, Rajaobelison, Tsirimalala, Rakotoarisoa, Haritiana, Ramifehiarivo, Maharo, Ranaivoson, Solonirina Harinarindra, Randriantsoa, Hajamihamina Marina Parfaite, Razafimanjato, Narindra Njarasoa Mihaja, Razafindrahita, Jeannie BA, Solofoarimanana, Solofoarimanana, Tsiambanizafy, Guillaume Odilon, Judicaël, Rakotonaivo Mamisoa, Solo, Corinne Eulalie, Ralaizafindraibe, Tojomamy Herinjaka, Andofenohasina, Fanonjomahasoa Safiry, Rasataharifetra, Hanta, Razafindraibe, Vanona Barijaona, Herinirina, Angelin Sablon, Das, Andre, Ganapathy, Thanga, Gunarasa, Yohesuwary, Mariapan, Kalyani, Muniandy, Maathichsudhaar, Osman, Mohd Firdauss, Azmi, Mohd Azem Fathi Mohammad, Soh, Jien Yen, Zain, Wan Zainira Wan, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Chan, Kheng Hooi, Hayati, Firdaus, Johan, Syamim, Mah, Jin Jiun, Sriram, Ratha Krishnan, Subramaniam, Sentilnathan, Shahimi, Nur Shahirah Binti Muhammad, Hamdan, Khairul Hazim, Ibrahim, Mohd Razali, Muthkumaran, Guhan, Tan, Ju Ann, Thanapal, Mohana Raj, Aziz, Dayang Anita Abdul, Bastion, Mae‐lynn, Harun, Mohd Hairul Nizam, Imran, Farrah‐hani, Din, Norshamsiah Md, Zain, Ayesha Mohd, Mustapha, Mushawiahti, Nabil, Syed, Naffi, Ainal Adlin, Nazimi, Abd Jabar, Ramli, Roszalina, Soon, Bee Hong, Bal, Pavin, Cheng, Joo Qing, Draman, Mohd Rusdi, Fadzli, Ahmad Nazran, Ghauth, Sakina, Hung, Weipin, Jamaris, Suniza, Koh, Peng Soon, Krishnasamy, Sivakumar, Lee, Yeong Sing, Liew, Yew Toong, Lim, Jeffery Zk, Lim, Raymond Chung Siang, Lim, Hiong Chin, Pauzi, Siti Farhan Moh, Nah, Shireen Anne, Nair, Ashvin Krishna, Doris Sin Wen, Ng, Yong, Yuki Julius Ng We, Ramayah, Kamarajan, Saaid, Rahmah, Sanmugam, Anand, See, Mee Hoong, Seevalingam, Kanesh Kumaran, Sethi, Neha, Singaravel, Srihari, Zaidi, Syeda Nureena Syed Jafer Hussain, Tang, Chu Yik, Teoh, Li Ying, Wong, Kian Boon, Xavier, Ruben, Yahaya, Ahmad Shuib, Norhafiza, Ab, Rahman, Null, Islah Munjih, Ab, Rashid, Null, Aziz, Mohd Fahmi Abd, Rahman, Mohd Norhisham Azmi Abdul, Amjad, Nasser Muhammad, Alhadi, Shahidah Che, Elagili, Faisal, Kamarulzaman, Mohd Nazli, Nor, Azmi Md, Othman, Ahmad Faidzal, Sainal, Mohd Yusof, Sarif, Mat Salleh, Chua, Richelle, Ibrahim, Aini Fahriza, Ahmad, Abdul Rauf Bin, Lau, Yii Ling, Liew, Ka Yee, Palayan, Kandasami, Wong, Hui Yu, Zakaria, Jasiah, Aziz, Nor Azimah Abd, Rahim, Norazila Abdul, Rahman, Noorneza Abdul, Abdullah, Bahiyah, Sikkandar, Mohamed Faizal Bin, Firman, Fatin, Hazleigh, Nik Mohd, Kamarudin, Intan Kartika, Khalid, Shahril, Miswan, Mohd Fairudz Mohd, Zahid, Akmal Zulayla Mohd, Mustafa, Norasyikin, Obaid, Kadhim, Yahaya, Mohd Yusoff Bin Yahaya, Yusoff, Ahmad Ramzi, Andrejevic, Predrag, Myatt, Jeremy Borg, Brincat, Svetlana, Caruana, Clifford, Chircop, Kurt Lee, Chircop, Francesca, Chircop, Daniel Mario, Cini, Charles, Czok, Viktoria, Farrugia, Melanie, Grima, Gabriella, Almukhariq, Fatimah MJ Hassan, Muscat, Esther, Pisani, Darryl, Roshan, Mohsin Hassan Khan, Schembri, Nicholas, Shoukry, Mohamed, Spiteri, Neville, Tanti, Gilbert, Hasan, Ziad Aboharp, Soto, Alberto Bazan, Rubén, Cedillo Rodrìguez Jonathan, Zamudio, Gustavo Esteban Lugo, Gómez, David Gerardo Miranda, Meave, José Alfredo Pérez, Victor Pinto Angulo, Null, Aguilar, Antonio Rojas, Duran, Erik Efrain Sosa, Perez, Alejandro Vàzquez, Arroyo, Diego, Corona‐cruz, Jose, Martinez‐said, Hector, Medina‐franco, Heriberto, Mendez, Manuel, Suárez Ma, Teresa Moreno Y, Díaz, Dolores Orta, León Vázquez, Martha Patricia Pérez, Carvajal, Angélica Azucena Soto, Hernández, Fidel Soto, Stenner, Juan Ignacio, López, Adriana Valenzuela, Hernandez, Mauricio Rene, Romero, Rey Jesus, Hernandez, Aldo Bernal, Cortes‐flores, Ana Olivia, Valle, Carlos Jose Zuloaga Fernandez, Tinajero, Carlos Andres Colunga, Orozco‐perez, Jaime, Balboa, Laura Gabriela Peña, Yanowsky‐reyes, Guillermo, Torres, Víctor Hugo Alcalá, Camacho, Francisco José Barbosa, Perez, Irma Valeria Brancaccio, Calderon‐llamas, Miguel Angel, Gomez, Aldo Camacho, Cortes‐torres, Edgar‐joaquin, Cueva‐martinez, Esteban, Anguiano, Oscar Durán, Estrada, Isaac Esparza, Fierro‐rizo, Roberto, Becerril, Paola Flores, Orozco, Clotilde Fuentes, Castillo, Miguel García, Ojeda, Alejandro Gonzalez, Rubio, Ana Sofia Gonzalez, Rojas, Erick Alonso González‐García, Govea‐camacho, Luis Humberto, Barba, Jose Aldo Guzman, Peña, Juan Carlos Ibarrola, Martínez, César íñiguez, Llamas‐macias, Francisco Javier, Galaviz, Ruben Eduardo Morán, Nuño‐escobar, Cesar, Olvera‐flores, Oscar‐everardo, Osuna‐rubio, Jaqueline, Pérez‐navarro, Jose Victor, Prieto‐aldape, Rodrigo, Gonzalez, Luis Ricardo Ramirez, Sánchez, Marco Vinicio Ramírez, Reyes, Emilio, Romero‐limón, Olaya Moramay, Ruiz‐velasco, Carlos Beas, Martínez, José Antonio Sánchez, Sanchez‐villaseñor, Guillermo, Sedano‐portillo, Ismael, Gonzalez, Gabriela Ambriz, Moreno, Pedro Berrones Moreno Berrones, Alvarado, Ana Beatriz Calderon, Jesús Cárdenas Barón, José, Hernández, Araceli, Frutos, Francisco Javier León, Hernandez, Edgard Efren Lozada, Valencia, Eduardo Morales, Pérez, Karla Daniela, Bolanos‐morales, Francina, Herrera‐zamora, Julio, Santillan‐doherty, Patricio, Zavala, David Omar Arriaga, Campos, Salvador Francisco Campos, Carmona, Lizette, Nava, Antonio Galindo, Santos, Blanca, Cisneros, Juan Roberto Torres, Bozada‐gutiérrez, Katya, Herrera, Jose Jesus, Portillo, Mucio Moreno, López, Francisco Pérez, Trejo‐avila, Mario, Salazar, Carlos Valenzuela, Alvarez, Maria Regina, Cordera, Fernando, Rosa Abaroa, Marco Antonio, Gómez‐pedraza, Antonio, Hernandez, Roberto, Maffuz‐aziz, Antonio, Posada, José Antonio, Vidal, Carlos Robles, Beristain‐hernandez, Jose‐luis, Sada, Blas Eduardo Quintero, Heredia, Nicolás Uxmal Soruco, Anaya, Ernesto, Arceo‐olaiz, Ricardo, Sougarret, Bernardo Gutiérrez, Flores, Sonia Lopez, Ochoa Carrillo, Francisco J., Uribe, Raymundo Alfredo Pérez, Silva, Ludwigvan Adriano Bustamante, Lupián‐angulo, Arianne I, Martínez, Christian Enrique Soulé, García, Francisco César Becerra, Casillas, Ernesto Javier Guerrero, Uribe, Edgar, Arias, Nereida Esparza, Hernández‐nava, J. Mindy, Isla‐ortiz, David, Melchor‐ruan, Javier, Bañuelos, Esmeralda Romero, Salcedo‐hernández, Rosa, Vilar‐compte, Diana, Peniche, Paola Zinser, Aguilar Frasco, Jorge L., Alfaro‐goldaracena, Alejandro, Buerba, Gabriela Alejandra, Castro, Emma, Chan, Carlos, Cortes, Ruben, Dominguez‐rosado, Ismael, Lechuga, Daniel Garay, Herrera, Miguel, Hinojosa, Carlos, Lopez‐pena, Gabriel, Martos, Edgar, Mercado, Miguel ángel, Velázquez, Paulina Moctezuma, Moguel, Roberto, Oropeza, Mariano, Portugal, Emmanuel Peña Gómez, Posadas‐trujillo, Oscar Emmanuel, Salgado‐nesme, Noel, Jasso, Oscar Santes, Sarre, Catherine, Skewes, Karla Yareli Hernandez, Jimenez, Cristian, Licona‐meníndez, Roque Delfino, Montiel, Guillermo, Navarrete‐peón, Alberto, Ortega, Shannat, Lechuga, Fernanda Romero, Roque, Oscar, Sevilla, Fernando, González‐lópez, Rogelio, Núñez‐gonzález, Roberto ángel, Ortega‐jiménez, José Antonio, Alvarado, Antonio, Orendain, Alfonso Alvarez Manilla, Pesquera, José Alberto Atristain, Frutos, Diego, Garcia, Felipe, León, Juan Antonio González, Guzman, Marlin, Herappe, Dorihela, Miranda, Jesús Giovanni Inzunza, Botello, Miguel Angel Jimenez, Lerma, Ricardo, Pedraza, Fabián Hilario Mendoza, Castillo, Monica Noguez, Resendiz, Jose Anatolio, García, Oscar Alejandro Sánchez, Rios, Laura Elena Fernandez, Frigerio, Pamela, Garcia, Iset, Frías, Gloria Isela Mendoza, Moreno, Emmanuel, Quiroga, Raquel, Mendoza, Alejandra Anzures, Hinojosa, Arantza Govela, Izaguirre, Aldo, Miguelena, Luis Hdez, Vazquez, Jose Manuel Luna, Rodriguez, Indalecio Barcelata, Mange, Raul Ramos, Utrera, Carlos Reyes, Saenz, David Zarate, Gonzalez, Miguel Angel Zavala, González, Francisco Andrade, Cortes, Ludivina, Roman, David, Sanchez, Aaron, Gurghiș, Radu, Rojnoveanu, Gheorghe, Vozian, Marin, Caraja, Petru, Croitor, Gheorghe, Mosneaga, Roman, Erdene, Sarnai, Ganbold, Lundeg, Orgoi, Sergelen, Orsoo, Soyombo, Sainbayar, Altanchimeg, Sandag, Erdene, Sanjaa, Burmaa, Benhamou, Rita Ait, El Azhari, Abdessamad, Ghita, Bennis, Lhassani, Sara, Louraoui, Sidi Mamoun, Rghioui, Mounir, Saaf, Sarra, Gadouali, Taha, Gouazar, Iltimass, Korch, Moniba, Letrache, Ahmed, Louari, Amina, Zamame, Anas, Ousouss, Samia, Zekhnini, Meryem, Abderrazaq, Hafni, Abichou, Wijden, Ahlaou, Hamza, Baicha, Amal, Baroudi, Salma, Chaoui, Ghita, El Azzazi, Hind, El Masaoudi, Saja, Hassoun, Chiraz, Moujtahid, Hajar, Riyahi, Anas, Zaim, Ouijdane, Aji, Narjiss, Ammouze, Imane, Arkha, Yasser, Bechri, Hajar, Belabbes, Meryem Benchekroun, Benslimane, Zaineb, Boualila, Lina, Bouanani, Othmane, El Ouahabi, Abdessamad, Hossyni, Leila Essakalli, Malik, Boulaadas, Oudrhiri, Mohammed Yassaad, Sefrioui, Taha Ismail, Tagmouti, Adam, Bensghir, Mustapha, Elkoundi, Abdelghafour, Belarabi, Othman, Belkhadir, Zakaria Houssaïn, Benkabbou, Amine, Boutayeb, Saber, El Ahmadi, Brahim, El Bouazizi, Yassine, Ghannam, Abdelilah, Kabbaj, Taha, Majbar, Anass Mohammed, Mohsine, Raouf, Souadka, Amine, Kone, Badra Aliou, Ndatewapo, Fillipus, Njuki, Peter Ngungi, Abrahams, Jenevive, Jeketera, Clara, Yeboah, Kwasi, Abebrese, John Tabiri, Mureko, Alfred, Quayson, Francis William, Shikongo, Justina, Bhusal, Subarna, Dwa, Yam, Joshi, Ashoo, Berkeveld, Eva, Bloemers, Frank, Borgstein, Alexander, Gisbertz, Suzanne, Mikdad, Sarah, Berge Henegouwen, Mark, Bakx, Roel, Besselink, Marc, Lemmers, Daniel HL, Roelofs, Anne‐jasmin, Amstel, Paul, Helsdingen, Claire, Smeele, Ludi, Harlaar, Niels, Jonker, Frederik, Burg, Sjirk, Oostendorp, Justin Y., Ombashi, Saranda, Voort, Tim, Geldorp, Martijn, Posma‐bouman, Lisanne, Boer, Hans Donald, Olieman, Annette, Smid‐nanninga, Henriette, De Vries, Jean‐Paul P. M., Hogenbirk, Rianne, Derksen, Tyche, Franken, Josephine, Oosterling, Steven, Nolte, Peter, List, Jelle, Alwayn, Ian, Bijlstra, Okker, Braat, Andries, Bulder, Ruth, Kok, Michèle, Faber, Robin, Goudsmit, Ben, Hamming, Jaap, Mieog, Sven, Vahrmeijer, Alexander, Leemkolk, Fenna E. M., Vorst, Joost, Schaik, Jan, Verhagen, Merel, Albers, Kim, Gawria, Larsa, Van Goor, Harry, Warle, Michiel, Ginhoven, Tessa M., Viëtor, Charlotte, Boerma, Evert‐jan, Lallitsch, Lara, Schweitzer, Donald, Leclercq, Wouter, Sijmons, Julie, Vancoillie, Peter‐jan, Konsten, Joop, Heinsbergen, Maarten, Dekker, Nicole, Boer, Frank, Dimech, Julian, Djamali, Kaveh, Fowler, Carolyn, Ghamri, Naji, Houston, Helen, Joseph, Reece, Kantroo, Astha, Kwun, Jin, Lie, Samuel, Lightfoot, Nicholas, Maccormick, Andrew, Olliff, Sue, Trilokekar, Natasha, Wood, Daniel, Ekanayaka, Aruna, Furkert, Chris, Nanayakkara, Asanga, Panesar, Divyansh, Waddell, Oliver, Bidois, Lauren, Clifford, Zoe, Frizelle, Frank, Glyn, Tamara, Lim, Eric, Lyons, Oliver, Mclauchlan, Jared, Nicholas, Ella, O’Grady, Michael, Roake, Justin, Singh, Harsh, Ailabouni, Ramez, Rietveld, John, Alqassab, Mohammed, Amer, Mostafa, Chan, Annie, Egbuji, John, Fullarton, Mairi, Haddow, James, Hawkins, Robyn, Vui Teck, Lu, Oliver, Thomas, Saw, Kai Sheng, Sugunesegran, Ramanen, Wilkins, James, Woodfield, Esther, Baker, Joseph, Cama, Jitoko, Field, Xavier, Fulivai, Alamea, Hossain, Ruhella, Kelly, Ben, Jasen, Ly, Mckelvie, James, Meiyappan, Vivek, Cindy Xin Yi, Ou, Singh, Vidit, Hedley, Alex, Temara, Hinerangi, Aitken, Jake, Frunt, Brytt, Boys, Max Hardie, Lakshman, Prashant, Pinfold, Esther, Cowan, Sarah, Henderson, Nigel, Leary, Jessica, Castle, Cameron, Gaston, Matt, Haimona, Maira, Jury, Steffanie, Lahood, Zoe, Lim, Matthew, Macintyre, Dillon, Mak, Josephine, Neal, Annelise, Shelker, William, Weeratunga, George, Ferguson, Liam, Harmston, Christopher, Heaven, Chelsea L, Watt, Imogen, Cahill, Henry Witcomb, Abdurrazzaaq, Abdussemee, Abdussalam, Hameedat Opeyemi, Adebanjo, Ademola, Ahmed, Aminat Olayinka, Borokinni, Opeyemi Busayo, Fasiku, Olushola Kayode, Gwaram, Usman, Okoye, Onyedika, Olaomi, Oluwole, Adeyeye, Ademola, Enoch, Elizabeth, Fayose, Samuel, Kayode‐nissi, Victor, Kadiri, Innih, Oduah, Stella, Abdull, Mohammed, Abdullahi, Mohammed Kabir, Kwankiyel, Auwal Babayo, Umar, Shahir Bello, Hassan, Sulaiman, Ja’Afar, Abubakar Bappah, Ja’Afaru, Umma Hani, Kadas, Saidu, Liman, Haruna, Makama, Baje, Mohammad, Aminu Mohammad, Kirfi, Abdullahi Musa, Oyediji, Funmilayo, Mohammed, Husseini Yakubu, Akpoghor, Oghenevwegba, Arekhandia, Alexander, Dawodu, Oseyi, Edetanlen, Ekaniyere, Efobi, Chizoba, Egbor, Esezobor, Enaruna, Nosakhare, Ezeanochie, Michael, Ezenwa, Ekene, Ijekeye, Ferdinand, Imumoren, Joe, Iribhogbe, Oseihie, Irowa, Omorodion, Momoh, Moses, Nwashilli, Nnamdi, Obahiagbon, Osarobo, Obuekwe, Ozoemene, Odai, Emeka Danielson, Odigie, Vincent, Odutola, Oluwatomi, Okhakhu, Amina, Okugbo, Stanley, Oni, Samson, Onyeagwara, Ngozi, Oseghale, Eustace, Osemwegie, Osarenkhoe, Osho, Philip, Ugwi, Veronica, Uwagboe, Charles, Yusuf, Sofiat, Abiodun, Adekunle, Akinloa, Olufemi, Shodipo, Moses, Abdullahi, Alhassan, Lawal, Ishak, Echieh, Chidiebere Peter, Nwagboso, Chimaobi, Udoh, Ubong, Akanni, Bolaji, Anyimba, Solomon, Chukwu, Isaac, Ezomike, Uchechukwu, Gold, Ikponmwosa, Nnabugwu, Ikenna, Nwafor, Ikechukwu, Okolie, Louis, Okoro, Kelechukwu, Okwara, Blasius, Onyemaechi, Ndubuisi, Abdulsalam, Khalifa, Arogundade, Abayomi, Kura, Mohammed, Nwosu, David, Abdullahi, Habiba, Agida, Eyaofun, Aisuodionoe‐shadrach, Oseremen, Ajibola, Hafees, Akaba, Godwin, Ale, Omolabake, Atim, Terkaa, Emeka, Malachy Ayogu, Benard, Adeka, Buba, Amina, Chinda, John, Edino, Stephen, Eniola, Sefiu, Garba, Stephen, Isah, Aliyu, Isah, Dennis Anthony, Joshua, Zaman, Mbajiekwe, Ndubuisi, Mshelbwala, Philip, Muhammad, Rafat, Offiong, Richard, Olute, Anne, Osagie, Olabisi, Ogolekwu, Idoko Pius, Sulaiman, Bilal, Suleiman, Salisu, Umar, Aminu, Abayomi, Olukayode, Abdus‐salam, Rukiyat, Adebayo, Sikiru A., Adeleye, Amos, Ademola, Samuel, Afuwape, Oludolapo, Ajao, Akinlabi, Akinsola, Sanusi, Aladelusi, Timothy, Ayandipo, Omobolaji, Baiyewu, Lateef Ayodele, Balogun, Mosimabale, Daodu, Israel, Egbuchulem, Ifeanyichukwu Kelvin, Elemile, Peter, Ezeme, Constantine, Fasunla, Ayotunde James, Gbolahan, Olalere, Iwuagwu, Ifeanyi, Michael, Afieharo, Morhason‐bello, Jemiludeen, Nwaorgu, Onyekwere, Obadan, Izegaegbe, Odeyemi, Olubunmi, Ogundoyin, Omowonuola, Ogundoyin, Olakayode, Ogunkeyede, Segun Ayodeji, Ogunrewo, Tolulope, Okere, Oghenekevwe, Oladejo, Titilola, Oladiran, Ajibola, Olagunju, Naomi, Olaoye, Ifedolapo, Olawoye, Olayinka, Olulana, Dare, Olusanya, Adeola, Omigbodun, Akinyinka, Onakoya, Paul, Orji, Mathias, Oyelakin, Oyeleye, Oyewole, Olugboyega, Sule, Samuel, Takure, Augustine O, Ugwu, Ebere, Afolabi, Bosede, Ajayi, Peter, Akinajo, Opeyemi, Alakaloko, Felix, Atoyebi, Oluwole, Belie, Orimisan, Bode, Chris, George, Ihediwa Chibuike, Elebute, Olumide, Ezenwankwo, Francis, Fatuga, Adedeji, Ladipo‐ajayi, Oluwaseun, Makanjuola, Ayomide, Makwe, Christian, Mofikoya, Bolaji, Ohazurike, Ephraim, Ojewola, Rufus Wale, Okunade, Kehinde, Okunowo, Adeyemi, Olajide, Thomas Olagboyega, Oni, Oluwafemi, Tijani, Kehinde, Ugburo, Andrew, Ugwu, Aloy Okechukwu, Abiola, Paul, Abiyere, Henry, Adebara, Idowu, Adeniyi, Adebayo, Adeyemo, Olabisi, Ariyibi, Abimbola, Babalola, Olakunle, Bakare, Adewumi, Banjo, Oluseyi, Egharevba, Peter, Obateru, John, Ojo, Owolabi, Olajide, Adewale, Oluwafemi, Fatudimu, Oyeleye, Oluwole, Salawu, Adedayo, Babatunde, Bakare Tajudeen Ishola, Abdulsalam, Moruf, Adelaja, Aderinsola, Adeniran, Abimbola, Ajai, Olalekan, Atobatele, Kazeem, Ayodele, Olabamidele, Bello, Funmi, Faboya, Omolara, Idowu, Olufemi, Idowu, Jeuel, Mustapha, Muntaqa, Omisanjo, Olufunmilade, Osuoji, Roland, Vitowanu, Julius, Abe, Anthonia, Aderounmu, Adewale, Adesunkanmi, Abdulhafiz, Ajekwu, Temitope, Ajekwu, Samuel, Ajiboye, Olalekan, Aderogba, Adeleke Akeem, Alatise, Olusegun Isaac, Babatunde, Mustapha, Balogun, Simon, Ijarotimi, Adebimpe, Lawal, Adedayo, Ojo, Olugbenga, Olasehinde, Olalekan, Olugbami, Adebayo, Ubom, Akaninyene Eseme, Agbaje, Ademola, Mohammed, Tajudeen, Adeniran, Abiodun, Adesola, Muideen, Afolabi, Abdulrahman O., Aremu, Isiaka, Ayinmode, Iyehunwa, Bello, Jibril, Ezeoke, Grace, Gwadabe, Sadiya, Ibraheem, Gbadebo, Ibrahim, Saidu, Ijaiya, Munir’Deen, Nasir, Abdulrasheed, Odeyemi, Peter Olalekan, Ogunade, Olukayode, Olabinjo, Afusat, Olatoke, Samuel Adegboyega, Olowogbayi, Tope, Onjefu, Stephen, Popoola, Ademola, Raji, Hadijat Olaide, Salawu, Nasiru, Salawu, Hafeez, Sayomi, Tolulope Olayinka, Segun‐busari, Segun, Uche‐okonkwo, Kenechukwu, Abiola, Olajide, Anipole, Olalekan, Ogunlaja, Olumuyiwa, Adesina, Oluwaseyi, Alayande, Barnabas, Ebenezer, John, Enwerem, Kenneth, Isichei, Christian, Isichei, Mercy, Luku, Pwaluke, Omiragi, Paul, Onyeji, John, Adze, Joel, Aghadi, Ifeanyi, Auta, Akawu, Duniya, Sharon, Gyuro, Joseph, Lawal, Jamila, Makama, Jerry Godfrey, Mohammed, Garba, Mohammed‐durosinlorun, Amina, Salisu, Kabiru, Taingson, Matthew, Yusuf, Nuhu, Amos, Happy, Daniel, James, Takai, Idris Usman, Abdullahi, Lawal, Abdullahi, Sani, Abdulrahman, Mamuda, Abubakar, Mohammed Kabir, Adikaibe, Valentine, Ahmad, Misbahu, Ahmad, Jameel Ismail, Aji, Sani Ali, Aliyu, Mohammed Salele, Danagundi, Maryam Babba, Bako, Yusuf Halidu, Bello‐muhammad, Nafisatu, Garzali, Ibrahim Umar, Hasheem, Muhammad Ghazali, Hassan, Ismail, Hassan, Sadiq, Usman, Mustapha Ibrahim, Ismail, Nasiru, Jibril, Yasir Nuhu, Kurawa, Musbahu, Magashi, Mahmoud Kawu, Martins, Bardi, Bello, Usman Mohammed, Muhammad, Saminu, Muhammad, Abubakar Bala, Muhammad, Shamsuddeen, Daneji, Sulaiman Muhammad, Mukhtar, Ibrahim Aliyu, Adamu, Kabir Musa, Nwachukwu, Callistus, Omeje, Uchenna Kelvin, Orji, Ifeanyi James, Sheshe, Abdurrahman Abba, Suleiman, Ibrahim, Yunusa, Sani Abdullahi, Maryam, A, Abubakar, Kabiru Bello, Habib, Saudat Garba, Mahmood, Farrukh, Alabi, Ibrahim Abolaji, Arojuraye, Soliudeen, Salihu, Mohammed, Alade, Samuel, Kumolalo, Felix, Mogbo, Chiedozie, Adebayo, Olaolu, Ige, Oluwasuyi, Jones, Gbenga, Odunafolabi, Tunde, Olubayo, Oluniyi Oyetunde, Akani, Chris, Alasia, Datonye, Alegbeleye, Justina Omoikhefe, Aria, Oti Nimi, Awopeju, Abimbola, Edonkumoh, Kemebradikumo, Ekeke, Onyeanunam, Fyneface‐ogan, Sotonye, John, Celestine, Kasso, Terhemen, Korubo, Inye, Mato, Christie, Ogu, Rosemary, Okpani, Charles, Okpani, Anthony, Onwuagha, Ijeoma, Oppah, Ijeoma, Oputa, Victory, Oranu, Emmanuel, Orazulike, Ngozi, Otokwala, Job, Ugboma, Henry A. A, Ajayi, Adekunle, Ogundele, Ibukunolu, Salami, Babatunde, Ajagha, Okeoghene, Ali, Yakubu, Awaisu, Mudi, Daniyan, Muhammad, Fidelis, Lovely, Nwabuoku, Stanley Emeka, Ogunsua, Oluseyi, Oyelowo, Nasir, Sholadoye, Tunde T., Yakubu, Alfa, Rendevski, Vladimir, Shuntov, Blagoj, Shuntov, Natalija Cokleska, Georgieva, Gordana, Jovanoski, Tomislav, Jovanovska, Katerina, Nikolovska, Bisera, Peev, Igor, Srbov, Blagoja, Trajkova, Andrijana, Trenchev, Viktor, Dohcev, Sasho, Janchulev, Josif, Saidi, Skender, Stankov, Oliver, Trifunovski, Aleksandar, Draz, Najib Abu, Al Ajmi, Khalil, Al Ajmi, Ghadeer, Al Amri, Ayman, Al Badaai, Ghalib, Al Balushi, Nawf, Al Bassam, Wameedh, Al Farsi, Maather, Al Ghafri, Wadha, Al Ghafry, Alaa, Al HOSNI, Mohammed, Al Kalbani, Moza, Al Kalbani, Maha, Al Kharusi, Lamya, Al Kharusi, Safiya, Al Mutani, Mohammed, Al Qadhi, Hani, Al Raisi, Amani, Al Riyami, Nihal, Al Sabti, Hilal, Al Shaibi, Maha, Al‐abri, Rashid, Al‐mujaini, Abdullah, Al‐rashdi, Aya, Alajmi, Suha, Albadi, Zamzam, Albusaidi, Hanadi, Alhadeethi, Ahmed, Aljabri, Noor, Alkazrooni, Muhannad, Alkharousi, Nadiya, Alkharusi, Al‐salt, Alkiyumi, Khadija, Almaharbi, Noof, Alsaadi, Sabaa, Alsharji, Marwa, Alsharqi, ALi Hamed, Alshehhi, Fatma, Alsulaimani, Thuwaiba, Alward, Mustafa, Alwashahi, Mohammed, Alyafii, Hussain, Alzadjali, Adil, Basi, Tayseer, Dalmar, Khadija, Dawud, Bashar, Gargouri, Mohamed Mourad, Kariyattil, Rajeev, Kenawy, Ahmed Omer, Kochummen, Koshy, Kolethekkat, Arif, Pillai, Mahesh Krishna, Sureshkannan, Ks, Laghari, Farman Ali, Manjunatha, Attibele Palaksha, Mathew, Joseph Kunju, Muzaffar, Rahil, Nair, Asha, Naiya, Hafsa Ismail Ibrahim, Nazar, Zuhail, Pillai, Silja, Rahim, Ferdous, Rahman, Khalid, Sheik, Shahila, Siddiqi, Mohammad Salman, Stephen, Edwin, Younas, Shahzad, Fatima, Mishal, Javed, Ayesha, Khan, Muhammad Ahsan, Shakir, Fatima Tuz Zahra, Siddiqui, Riaz Hussain, Syed, Danish, Rehman, Ishtiaq Ur, Warraich, Shahrukh, Amir, Mohammed, Asghar, Saleha Yurf, Bangash, Ali Haider, Latif, Sehrish, Naqvi, Wajih, Abdullah, Muhammad Tariq, Abdullah, Saleha, Ahmed, Arooj, Ahsan, Muhammad Fahim Ahsan, Akhtar, Fahad, Ali, Sana, Ansar, Mehwish, Aqib, Muhammad, Arslan, Muhammad, Ashraf, Sumaira, Ayubi, Azaz, Azam, Tayyab, Bhatti, Hamza, Huda, Shahab, Irshad, Abeer, Ishaque, Nazia, Khaliq, Tanwir, Khan, Farheen, Khan, Mumtaz Ahmad Khan, Mahmood, Namrah, Malik, Ali Raza, Malik, Tahir, Malik, Komail, Mehmood, Manzer, Mustafa, Fatima, Noor, Fazal, Nubair, Sarwar, Rashid, Isbah, Saeed, Waqar, Sajid, Hannan, Shah, Sajid, Shami, Ali, Siraj, Minhaj Us Siraj, Tareen, Mariam, Haq, M Burhan Ul, Abbas, Manzar, Zaidi, Syeda Maria Ahmad, Ahmed, Iffat, Ahmed, Shahnoor, Ahsan, Kunwar Armash, Akhtar, Munazza, Akhund, Ramsha, Manji, Adil Al‐Karim, Arshad, Hajra, Awan, Muhammad Ozair, Aziz, Humaira, Bhutto, Shameen, Aamir, Faiqa Binte, Biyabani, Syed Raziuddin, Chishti, Uzma, Chundrigar, Mohsin, Ghaloo, Shayan Khalid, Haroon, Waqqas, Hashmi, Shiraz, Hassan, Murtuza, Inam, Hina, Kassam, Nausheen, Kazmi, Abbas, Khan, Majid, Khan, Muhammad Osama, Kumari, Sameeta, Malik, Muhammad Jehangir, Mansoor, Maheen, Martins, Russell Seth, Mubarik, Areeba, Munir, Muhammad Musaab, Musharraf, Muhammad Bazil, Naz, Falak, Noordin, Shahryar, Pervaiz, Arsalan, Qamar, Javeria Bilal, Rahman, M Fazlur, Rani, Pallavi, Rasheed, Yasir, Sadia, Haleema, Saeed, Marwah, Safri, Mohammad, Salim, Shaharyar, Sattar, Abida K., Shamim, Shahzad, Sherwani, Maryam, Siddiqui, Muhammad Ahsan Iqbal, Sidhwa, Astad, Tariq, Javeria, Tejani, Isbaah, Waqar, Usama, Zahid, Fahad, Jamal, Abid, Ghufran, Muhammad Ali, Memon, Amjad Siraj, Saeed, Summaya, Samo, Khursheed Ahmed, Aswani, Manisha, Manzoor, Shahneela, Muhammad, Shoaib, Arshad, Muhammad, Hussain, Syeda Namayah Fatima, Moin, Inshrah, Najjad, Muhammad Kazim Rahim, Nasir, Manal, Sohail, Osama Bin, Mangi, Ali, Markhand, Naveed, Mushtaq, Hassan, Zia, Kashif, Ahmed, Hassaan, Ahmed, Nasir, Qureshi, Talha Ahmed, Shaikh, Shafqat Ali, Anwer, Rabia, Arshad, Owais, Batool, Sehrish, Chatni, Muhammad, Chundrigar, Tariq, Dojki, Samina Saleem, Elahi, Minahil, Farooqui, Bakhtawar, Ghouri, Amna, Hassan, Nabeel, Hussain, Zainab, Hussaini, Null, Iftikhar, Fizza, Iqbal, Faizan, Javed, Anum, Javed, Dania, Kamal, Wajahat, Khan, Shifa, Mughal, Zeeshan Uddin, Murtaza, Ghulam, Nadeem, Areeba, Nasir, Areeba, Nayyer, Fatima, Nisa, Kanwal, Rauf, Yaseen, Haroon, Umer Saeed, Saleem, Shah Masabat, Seriwala, Haseeb, Shah, Aaqil, Siddiqui, Safia, Tanveer, Asher Tanweer, Tariq, Nida, Zaman, Junaid, Zamir, Mehroz, Anjum, Muhammad Ayyub, Afzal, Ameer, Ahmed, Ehsan, Ahmed, Jawad, Riaz, Shujat Ahmed, Akbar, Ali, Akbar, Bilal, Ali, Maria, Ali, Imran Ali, Ali, Abrar Ashraf, Ali, Ghazanfar, Altaf, Zahra, Ammar, Ahmed Siddique, Arif, Hafiz Muhammad Arif, Aslam, Imran, Bashir, Muhammad Mustehsan, Farooq, Usman, Farooq, Muhammad, Gondal, Khalid Masood, Iqbal, Muhammad Javed, Iqbal, Zafar, Ismail, Fahad, Jameel, Muhammad Khurram, Janjua, Muhammad Haris, Janjua, Azwa, Joshi, Prabesh, Khadam, Mamoona, Khan, Romaisa, Khawaja, Muhammad Asadullah, Manzoor, Sobia, Mohsin, Muhammad, Mumtaz, Khizra, Musaab, Muhammad, Naqi, Syed Asghar, Naumeri, Fatima, Nazir, Umer, Noureen, Sadaf, Rafi, Yaseen, Raza, Ali, Rijal, Sushil, Saleem, Irfan, Shah, Hafiz Syed Zaigham Ali, Sharif, Muhammad, Shaukat, Ayesha, Siddique, Usman, Sikandar, Hafiz Saqib, Sohail, Mohammad, Zahara, Fatima Tu, Usman, Yasmeen, Zaman, Balakh Sher, Zeb, Misbah, Afzal, Muhammad Farooq, Ahmad, Fateen, Ahmed, Waqas, Akram, Shahzad, Alam, Azhar, Ali, Danish, Ali, Ahsan, Alvi, Ammar Tariq, Asif, Suleman Asif, Aslam, Madiha, Daood, Muhammad Daood, Jawad, Muhammad, Kathia, Usama Muhammad, Khalid, Ismaeel, Khan, Anwar, Khurshid, Zain, Noman, Hamza, Raza, Ahsan, Taha, Hassan, Zubair, Muhammad, Maria, Noor Ul Huda, Janjua, DrAtif A, Ahmad, Qamar Ashfaq, Ahmad, Sheraz, Ali, Imran, Amin, Sana, Anjum, Momina, Asjad, Muhammad, Aslam, Aatif, Ayyaz, Mahmood, Bajwa, Luqman Ali, Bakhtiar, Akkasha, Bashir, Alia, Batool, Fizza, Bhatti, Samiullah, Butt, Roshan, Butt, Usman, Changazi, Shabbar Hussain, Cheema, Omer Iqbal, Chishti, Muhammad Haris, Haq, Bushra, Hashmi, Ali, Hassan, Muhammad, Hassan, Usman, Hayat, Khizar, Iqbal, Javaid, Iqbal, Ayesha, Ishaq, Amna, Javed, Sundas, Javed, Hina, Javed, Aymen, Kashif, Muhammad, Khalid, Muhammad Saud, Khan, Wasim Hayat, Khan, Rohma, Khan, Fatima, Latif, Usman, Mahmood, Arif, Majeed, Faizan, Malik, Kiren, Masood, Rumaisa, Munawwar, Fasiha, Mushtaq, Asma, Nabi, Muhammad Shoaib, Nasir, Ahmad, Naureen, Shazia, Noreen, Zahida, Qadir, Muhammad Ghulam Qadir, Raana, Gul e Raana, Rashid, Madeeha, Rehman, Abdul, Riaz, Sidra, Saboor, Arfa, Sadiq, Muhammad Hamza, Saeed, Komal, Saleem, Humaira, Sarfraz, Kiran, Shafiq, Zahid, Shafqat, Aymen, Shaukat, Hassan, Sher, Fateh, Sohail, Rubina, Suhail, Amina, Muhammad, Bilal Syed, Umair, Usama, Umar, Muhammad, Usama, Muhammad, Usman, Natasha, Waheed, Kalsoom, Farooka, Muhammad Waris, Wasim, Shafqat, Wasim, Tayyiba, Yasin, Fahad, Zafar, Zain, Zaka, Sabahat, Zaman, Salma Zaman, Azad, Junaid, Fatima, Zareen, Anwar, Muhammad Imran, Naseer, Muhammad Ahmed, Shah, Muhammad Taimoor, Ali, Ammar, Aslam, Muhammad, Aziz, Muhammad Usama, Gohar, Farhan, Humayoun, Waseem, Khan, Hassan, Naeem, Shiza, Tahir, Warda, Alvi, Kashif, Mehmood, Maria, Ali, Muhammad, Shahzad, Aniqa, Sher, Muhammad, Murtaza, Null, Siddique, Hijab, Anjum, Waleed, Ahmad, Manzoor, Alam, Muhammad, Faizi, Fouzia, Faridoon, Shehla, Hussain, Musarrat, Iftikhar, Muhammad, Jan, Yousaf, Kalim, Muhammad, Raza, Tilal Ahmed, Shah, Farrukh Ozair, Shah, Muhammad, Tahir, Imran, Khan, Hamza, Naeem, Muhammad, Ahmad, Shabir, Ahmed, Haseeb, Akbar, Hazrat Akbar, Akhtar, Muhammad Shaheer, Ali, Noman, Ali, Mehboob, Ali, Sadaf, Ali, Irfan, Amin, Hasbi Allah, Amin, Shehzadi, Ayub, Bakhtawar, Basir, Muhammad, Faraz, Ahmad, Farsi, Muhammad Salman, Gul, Ambrin, Gul, Hina, Gul, Ayaz, Gul, Sana, Haider, Sajjad L, Ikramullah, Syed Ikramullah, Jan, Kashif, Khalid, Muhammad, Khan, Salman, Khan, Muhammad Faisal, Khan, Faraz Ahmad, Mian, Iftikhar, Moeen, Aiman, Mohmand, Obaid, Rahim, Rehana, Raziq, Naila, Rehman, Riaz, Salim, Azra, Shafqat, Tanveer, Shah, Faaiz Ali, Shah, Suliman, Shakeel, Muhammad, Ullah, Tahsin, Rehman, Shams Ur, Wali, Sabaeena, Zahoor, Farnaz, Zeb, Gulmeena, Zeb, Laila, Haseeb, Null, Raza, Waqas, Amir, Zein, Arshad, Daneyal, Daud, Mashal, Chughtai, Umer Javed, Rauf, Mirza Hammad, Sajid, Zaina, Abid, Rubaba, Azam, Ayesha, Farkhanda, Tallat, Firdos, Kanwal, Khalid, Tabinda, Malik, Sobia, Mashal, Javeria, Salim, Ruqyyah, Saqib, Madiha, Shaheen, Aneela, Shahid, Madiha, Yasmeen, Irfana, Ahmed, Faryal, Ali, Aneeqa, Amjid, Zarafshan, Anwar, Muhammad Idrees, Arif, Iqtaza, Ashraf, Anam, Butt, Adam Umair Ashraf, Azhar, Faryal, Daniyal, Muhammad Daniyal, Ghazanfor, Ramlah Ghazanfor, Ishtiaq, Daniyal, Jamil, Manahil, Khalid, Ziaullah, Khan, Jahangir Sarwar Khan, Khan, Muhammad Sarfraz, Mahmood, Usama, Mahmood, Ashraf, Malik, Abdur Rehman, Nagra, Ramisha Naseer, Niazi, Fuad Ahmad Khan, Saleem, Maleeha, Saleem, Bushra, Saleem, Tayyaba, Shabbir, Raja Khalid, Shakir, Imtiaz Ahmed, Ahmad, Ashfaq, Awan, Surgeon Hafiz Riaz Hussain, Bhatti, Waqar, Shaheen, Azka, Awad, Hadeel, Mohamad, Balqees, Wafi, Dalia, Jayyab, Mustafa Abu, Toman, Hitham, Abu‐arish, Hamdoon, Al‐slaibi, Ibrahim, Alzeerelhouseini, Hussam I. A., Jobran, Fahmi, Lahlooh, Raghad, Aburayyan, Fatima, Abuzaina, Khalil, Aljuba, Ayat A., Aljunaidi, Roaa, Alzughayyar, Tareq, Amro, Adham, Amro, Sarah, Dweik, Mays, Halman, Safa, Qafisha, Qutaiba, Shaheen, Farah, Shawer, Balqis, Shehadeh, Daleen, Zalloum, Jihad, Demyati, Khaled, Hajhamad, Mohammed, Saqfalhait, Zain, Del Cid, Emmy Arrue, Rodriguez‐zentner, Homero, Abed, Francisco, Garayo, Rafael Osmar Adorno, Aguilar, Ruben, Aguilar, Ana, Maidana, Domingo Javier Aguilera, Casañas, Diego José Almada, Almiron, Teresa, Arrua, Analia, Avila, Pedro, Balmaceda, Brenda, Barreto, Alexandra, Galeano, Analy Barreto, Nuñez, Belinda Barrientos, Benegas, Magdalena, Berden, Martin, Bogarin, Amalia, Bonnin, Jorge, Barrios, Edulfo Britez, Burgos, Julio, Melgarejo, Carlos Fabián Cárdenas, Samudio, José De Jesus Casco, Cataldi, Sandra, Centurion, Jorge Augusto, Ramirex, Luz Maria Cespedes, Colina, Katerine, Almando, Gabriel Augusto Cuevas, De Bleecker, Karina, Dragotto, Antonella, Eiwa, Eiji, Enciso, Juan Carlos, Espinola, Carla, Estigarribia, Lujan, Fernandez, Celso Ariel, Ferreira, Rocio, Figueredo, Blas, Fleitas, Daniel, Fretes, Claudia, Fretes, Martin, Gonzalez, Walter Rene Fretes, Ruiz, Humberto Nicolas Galleano, Gauto, Julio, Gauto, Claudia, Gomez, Viviana, Gómez, Nadia, Insfran, Osvaldo, Karina, Liz, Legal, Christian, Llanes, Oscar, Martínez, Walter, Torres, Walter Rodrigo Martínez, Matsumura, Kiichiro, Galván, Esteban Daniel Mendoza, Noguera, Leila Mereles, Mora, Sergio, Navarro, Daniel, Roman, Lidia Noguera, Núñez, Analia, Ocampos, Lorena, Rojas, Alma Maria Ojeda, Villasboa, Derlis Joel Ojeda, Palacios, Juan, Sosa, Jessica Pamela Portillo, Ramírez, Rossana, Ramos, German, Samudio, Diego, Acosta, Jorge Eduardo Sisa, Tellez, Rodney, Urquhart, Porfiria, Vera, Beatriz, Florentin, Jorge David Vera, Vidallet, Daniel, Villalba, Gilce Teresita, Vömel, Jacob, Aquino, Laura, Martinez, Marisa Natalia, Patiño, Cesareo Saldivar, Aguayo, Omar, Aguilera, Maria Esther Ferreira, García, Federico, Giangreco, Maria, Osorio, Derlis, Sosa, Cynthia Marlene Rodríguez, Villanueva, Paulo, Rolon, Sandra Elizabeth Centurion, Ohara, Rozana, Portillo, Juan Marcelo, Cano, Ruben Milciades Varela, Melgarejo, Juan Manuel Baez, Candia, Francisco Vidal, Chirico, Carlos, Pineda, Sofia Belen Diaz, Vera, Diego Alfonso Paiva, Valdovinos, Ayrton Facundo, Velazquez, Dahiana Fatima, Arriola, Diego Raul Abente, Britos, Analia, Cantero, Daniel, Centurión, Jessica, Bareiro, Ricardo Ignacio Olmedo, Duarte, Dayhana, Paredes, Susana, Rojas, Carlos Pfingst, Delgado, Angel Luis Agüero, Godoy, Juan Marcelo Delgado, Lohse, Helmut Alfredo Segovia, Benitez, Oscar, Luraschi, Victor, Molinas, Joel, Añasco, Dulce, Barreto, Alejandro Arévalo, Rivaldi, Cristhian Chavez, Chenu, Martin, Garcia, Luz, Godoy, Rosana, Gustavo Miguel Machain, V, Velázquez, Maria Jose Martinez, Alvarenga, Brayan David Pedroso, Gonzalez, Agustin Rodriguez, Sánchez, Rosa, Sánchez, María Liz, Lohse, Herald Rene Segovia, Segovia, Cesar Giuliano Sisa, Cuenca, Osmar, Melgarejo, Sara, Ferreira, Ever David Sosa, Anaya, Estefany Angela Flores, Huallanca, Evy Yamil Huaman, Palma, Karla Melissa Marchan, Palomino, Liliam, Ordemar, Jorge, Quiroz, Manuel, Sarabia, Victor Diego Caballero, Lozano, Christian, Torres, David, Castro, Henry Rafael Acosta, Bayona‐alvarado, Gabriel, Cruz, Joao, Lizzetti, Grecia, Morales, Victor Vasquez, Ormeño, Martin, Ortiz, Liz, Roca, Kewin Quispe, Quispe‐cruz, Darwin Artidoro, Sanz, Edgar, Poma, Katherine Tataje, Seto, Gaby Susana Yamamoto, Palacios, Carlos, Mejia, Juan Francisco Pintado, Barandiaran, Jose Maria Silva, Huaman, Eduardo, Gamonal, Guillermo Enrique Reyes, Carmelo, Claudia Suazo, Condori, Diana Lizet Cruz, Valverde, Jose Vasquez, Cabrera, Cesar Alberto Vergel, Diaz, Consuelo, Caturiny, Angie Paredes, Salazar, Adolfo, Estupiñan, Joel Jesús Sánchez, Vaez, Marco Sandoval, Arangoytia, Roy, Berrospi, Francisco, Polo, Jorge Luis Bustamante, Coaquira, Jimmy Cárdenas, Escalante, Fernando Cárdenas, Armestar, Darwin Oliver Desposorio, Mora, Sheyla Katherine Diaz, Laura, Jheff, Blanco, Aldo Lopez, Garcia, Karoll Tatiana Meza, Moreno, Jaime, Payet, Eduardo, Villena, Joan Perez, Cardenas, Daniel, Barrionuevo, Luis Alcides García, Valencia, Miguel Roberto Li, Doria, Percy Mansilla, Escalante, Fiorella Palomino, Coronado, Mónica Falcón, Rocha, Pamela Valderrama, Edinson, Ulbar, Huarcaya, Vladimir Laureano Velasquez, Abella, Andrei Cesar, Andal, Carmela, Anoso, Willmar, Bejasa, Monica Maria, Cuasay, Aldrin, Fernandez, Jesus, Mercado, Eunice, Moreno, Amabelle, Palines, Alejandro, Regalado, Trina, Unira, Cristeta, Yacapin, Clarence Pio Rey, Cajucom, Carlo Angelo, Cueto, Mary Anne Carol, Ramos, Charmagne Loren, David, Avril, Merin, John Isaac, Roxas, Alberto, Candelario, Nipseey Pauloe, Lopez, Marc Paul, Ramos, Ramon Alberto, Violago, Khrissa Lea Elisa, Benosa, Yvann Kenneth, De Leon, Louie Czelline, Esguerra, Marlow, Filarca, Rene Luis, Gaddi, Corina, Gagno, Patrick Jovan, Guerra, Jeffy, Morla, Angelica Aubrey, Opano, Rivero, Penserga, Edgardo, Tesil, Mark Jheric, Turingan, Hazel, Aldana, Joel, Almelor, Alyssa Carmina, Almora, Jaime JR, Ang, Angeli Anne, Arada, Maria Angelica, Arbizo, Jeric, Barretto, Diana, Baticulon, Ronnie, Chan, Kevin Ivan P., Cruz, Elmer Jason, Grano, Pauleen, De Leon, Juan Gabriel, De Pano, Jojiemar, Dealino, Maria Angela, Mundo, Daryl Anne, Del Mundo, Hans Jesper, Dela Victoria, Czarlo, Delgado, Juan Miguel Roberto, Detran, Jan Erik, Diaz, Robert Zaid, Dinoy, Edward Arlu, Domingo, Efren, Dulnuan, Heather Grace, Patricio, Dumlao, Elises, Carlo, Estrella, Emmanuel, Flor, Joan Marie, Gana, Grace, Bynlee Stuart, Go, Hilvano‐cabungcal, Ana Melissa, Cesar, Jacinto, Lacuata, Jan Alexeis, Lapitan, Marie Carmela, Laudato, Renee Leen, Legaspi, Gerardo, Ryle, Li, Lobo, Liana Mae, Lukban, Claudine, Macapugay, Christopher John, Magsanoc, Nikko, Manalang, Enrique, Montemayor, Jon‐alexis, Notario, Jaysonnel, Santos, Jan Armelynn, Sarmiento, Abigail, Serrano, Dennis, Siahetiong, Samantha, Solis, Krisniel Florence, Sotalbo, Denorson, Tongol, Erik, Ursabia, Germaine, Patricia Ann, Uy, Valeros, Charmaine Grace, Velasco, Karen Joyce, Venida, Vincent, Yap, Hans Edison, Zamora, Mario Angelo, Agoncillo, Anika Johanna, Antonio, David Vincent, Bangayan, Nicole Robyn, Castro, Marinelle, Estanislao, Grace Lynn, Ganal‐antonio, Anne Kathleen, Ibrahim, Faiyazudin Amado, Jarin, Peter, Ching, Laine Valerie Kongsun, Lim, Josephine Alexandra, Nazal, Mariles, Vaño, Amanda May Ong, Racelis, Louie, Ramos, Kirsten, Reyes, Jeryl Anne Silvia, Rivera, Ron Daniel, Salud, Jose Antonio, Sarte, Elva Marita, Dale Kingsley, Sy, Tancinco, Eileen Grace, Torio, Anna Mariel, Avegail Niña, Uy, Abary, Ryan Rainiel, Jesus, Dabalos, Siquian, Vincent, Yabut, Kenneth, Barcelon, Jose Carlos, Carballo, Inez, Chiu, Jo Ann, Nacion, Aeris Jane D., Pędziwiatr, Michał, Rymarowicz, Justyna, Bobiński, Marcin, Kotarski, Jan, Rasoul‐pelińska, Karolina, Futyma, Konrad, Miotla, Pawel, Rechberger, Ewa, Koczy, Bogdan, Szyluk, Karol, Botelho, Pedro, Lopes, Mariana Branco, Cismasiu, Brigitta, Costa, Paulo Matos, Fallah, Jean‐michel, Freitas, Gonçalo Teodoro Fernandes, Ferreira, Filipa, Nobre, José Guilherme Gonçalves, Henriques, Susana, Lino, Rui, Macedo, Alexandre, Mendes, Cláudia, Barreira, Ana Lúcia Preto, Ramos, Nuno, Rodrigues, Susana Candeias, Santos, Catarina Rolo, Pedro, Ricardo São, Silva, Melissa, Sousa, Carla, Ribeiro, Rui, Santos, José, Alves, Ricardo, Teles, Tobias, Sousa, Liliana B., Carvalho Carvalho, Dulce Helena Ferreira, Soares, Rui Costa, Costeira, Cristina, Graveto, João, Jordão, Daniel Martins, Paiva‐santos, Filipe, Parreira, Pedro, Sousa Salgueiro Oliveira, Anabela, Azevedo, Constança, Machado, Daniela, Semião, Miguel, Bolota, Joana, Cinza, Ana Margarida, Cotovio, Manuel Damasio, Leandro, Sofia, Oliveira, Joana, Lima, Rita Pedroso, Pereira, Mário, Velez, Cristina, Cardoso, Nicole, Domingues, Joana Cristina, Henriques, Pedro, Manso, Maria Isabel, Martins, Ruben, Santos, Gildasio Martins, Morais, Henrique, Pereira, Rute, Revez, Tatiana, Ribeiro, Vera Inês, Ribeiro, Ricardo, Sousa, Sandra, Teixeira, João, Cabral, Ana, Rodrigues, Catarina S., Alves, Paulo, Ferreira, Gonçalo, Neves, Miguel, Rama, Nuno, Sousa, Inês, Almeida, Mafalda, Morais, Ricardo Bettencourt, Campos, Ana, Caroça, Cristina, Bártolo, Mariana Couto, Galindo, Luis, Girao, Ricardo, Pais, José, Vaz, Carlos, Messias, Jose Henrique Albuquerque, Silva, Francisca Brito, Fonseca, Filipa, Maurício, Sandra, Peyroteo, Inês, Ramos, Rodrigo, Salgado, Inês, Santos, Patrícia, Forte, Joana Patena, Santos, Ema, Costeira, Beatriz, Neves, Filipe, Ourô, Susana, Ferreira, Marisa Peralta, Fernandes, Mafalda Sousa, Almeida, Joana Isabel, Almeida Pinto, João, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), GlobalSurg Collaborative, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, AGEM - Endocrinology, metabolism and nutrition, ARD - Amsterdam Reproduction and Development, Paediatrics, Tytgat Institute for Liver and Intestinal Research, Nepogodiev, D., Simoes, J. 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S., Martinez, L., Martinez, M. J., Nayen, A., la Medina, A. R. -D., Nunez, J., Nashidengo, P. R., Shah, R., Shrestha, A. L., Jonker, P., Kruijff, S., Noltes, M., Steinkamp, P., Wright, D., Abdur-Rahman, L., Ademuyiwa, A., Adisa, A., Osinaike, B., Seyi-Olajide, J., Williams, O., Williams, E., Pejkova, S., Al Balushi, Z., Sayyed, R., Mohsen, M. A., Abukhalaf, S. A., Cukier, M., Gomez-Fernandez, H., Yip, S. S., Ojeda, X. P. V., Sacdalan, M. D., Major, P., Azevedo, J., Cunha, M. F., Zarour, A., Bonci, E. -A., Negoi, I., Efetov, S., Kochetkov, V., Litvin, A., Ingabire, J. A., Bucyibaruta, G., Faustin, N., Habumuremyi, S., Imanishimwe, A., de Dieu, H. J., Munyaneza, E., Ncogoza, I., Ndong, A., Radenkovic, D., Chew, M. H., Koh, F., Ngu, J., Panyko, A., Bele, U., Kosir, J. A., Daoud, H., Bravo, A. M. M., Jayarajah, U., Wickramasinghe, D., Adam, M. E. A. E., Rutegard, M., Sund, M., Adamina, M., Gialamas, E., Horisberger, K., Alshaar, M., Huang, A., Lohsiriwat, V., Charles, S., Jlassi, H., Isik, A., Lekuya, H. M., Kopetskyi, S., Alsaadi, H., Alshryda, S., Alser, O., Bankhead-Kendall, B., Breen, K., Mashbari, H., Cal, F. B., Al-Naggar, H., Maimbo, M., Mazingi, D., Abbott, T., Akhbari, M., Benson, R., Bhanderi, S., Biccard, B., Caruana, E., Chakrabortee, S., Chapatwala, R., Costas-Chavarri, A., Demetriades, A. K., Desai, A., Di Saverio, S., Drake, T., Edwards, J., Evans, J., Fiore, M., Ford, S., Fotopoulou, C., Fowler, A., Futaba, K., Ganly, I., James, H. G., Griffiths, E., Gronchi, A., Hutchinson, P., Hyman, G. Y., Incorvia, J., Jain, R., Jenkinson, M., Khan, T., Knight, S. R., Kolias, A., Kudsk-Iversen, S., Kwan, T. Y., Leung, E., Mayol, J., Mckay, S., Meara, J. G., Mills, E., Moug, S., Patel, A., Perinotti, R., Rice, H. E., Roberts, K., Schache, A., Shaw, R., Smart, N., Stephens, M., Stewart, G. D., Teasdale, E., Vaughan-Shaw, P., Vidya, R., Wright, N., Zimmelman, N., Agastra, E., Thereska, D., Lucchini, S. M., Laudani, V., Chwat, C., Salazar, I. I. P., Pachajoa, D. A. P., Duro, A., Arancibia, J. A. C., D'Aulerio, G., Dudi-Venkata, N., Egoroff, N., Farik, S., Lott, N., Moss, J. -L., Rennie, S., Tan, L., Vo, U. G., Watson, D., Watters, D., Bright, T., Hollington, P., Zhou, X., Kroon, H. M., Farfus, A., Barker, J., Watson, E., Stevens, S., Latif, H., Dawson, A. C., Chuan, A., Muralidharan, V., Wong, E., Ackermann, T., Pacilli, M., Hodgson, R., Heriot, A., Choong, P., Brown, W., Lidder, S., Yeung, J., Traeger, L., Regalo, G., Gourlay, R., Badiani, S., Koh, C., Putnis, S., Haider, F., Mitul, A. R., Komen, N., Dhondt, B., Cappeliez, S., Pigeolet, M., Schoneveld, M., Stijns, J., Oosterlinck, W., Flamey, N., Kpangon, C., Agbadebo, M., Tobome, S. R., Barros, A. V., Junior, S. A., do Amaral Campos, H. G., Gross, J., Coimbra, F. J. F., Kowalski, L. 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Y., Ghozy, S., Sallam, A., Shehta, A., Abdelkhalek, M., Samaka, R., Morsy, A., Sherif, A. E., Negussie, A., Fisseha, T., Shumbash, K., Abebe, M., Yasin, S. M., Akililu, Y. B., Megersa, A., Tefera, T., Assefa, M., Atnafu, B., Tsegaye, B., Bezabih, Y. S., Sisay, S., Bekele, K., Jira, M., Derilo, H., Degefa, E., Tadesse, A., Nidaw, M., Sarjanoja, E., Testelin, S., Boucher, S., Jouffret, L., Lakkis, Z., Le Bian, A. Z., Harper, L., des Deserts, M. D., Andre, B., Slim, K., Verhaeghe, R., Police, A., Girard, E., Chebaro, A., Nkembi, A. S., Arnalsteen, L., Ballouhey, Q., Mege, D., Jeandel, C., Duchalais, E., Bouche, P. -A., Manceau, G., Cretolle, C., Hervieux, E., Girard, N., Seguin-Givelet, A., Gaujoux, S., De Simone, B., Boisson, M., Bergeat, D., Fredon, F., Nappi, F., Kassir, R., Scalabre, A., Migliorelli, F., Ezanno, A. -C., Seeliger, B., Vaysse, C., Charbonneau, H., Misrai, V., Abbo, O., Angeles, M. A., Brunaud, L., Modabber, A., Wolf, S., Kamphues, C., Hohn, P., Glowka, T. 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K., Thakar, S., Jain, K., Kumar, A., Nagar, M., Mishra, T., Sekar, A., Gupta, A., Kaman, L., Karthigeyan, M., Tripathi, M., Rammohan, A., Vayoth, S. O., Rajanbabu, A., Subbian, A., Gupta, R., Raut, M., Evelyn, N., Kannaiyan, R. L., Matai, A., Misra, S., Bhende, V., Muthu, S., Ghosh, I., Sharma, A., Bajaj, A., Rajan, S., Agarwal, G., Pawar, P., Alexander, P., Vijayakumar, M. V., Hameed, Z., Badareesh, L., Chaudhry, N. K., Baliarsing, L., Dharap, S., Kulkarni, A., Thyavihally, Y., Sharma, R. D., Pramesh, C. S., Soni, R., Dube, S. K., Sharma, S., Singh, H., Bains, L., Ghodke, R., Sodhai, V., Maji, S., Basu, S., Mahakalkar, C., Kannan, R., Mehraj, A., Ranganath, N., Phadnis, A., Yadev, I., Kavalakat, A., Mittal, R., Vallam, K. C., Akhavizadegan, H., Maleki, E. R., Kandevani, N. Y., Ikele, H., Mcnestry, C., Fleming, C., O'Brien, S., Elwahab, S. A., Davis, N., Javadpour, M., Mcdonnell, B., Connor, C. O., Bolger, J., Clancy, C., Croghan, S. M., Donlon, N., Cullinane, C., Creavin, B., Muheilan, M., Earley, H., Kabir, S. M. U., Fahadullah, M., Ryan, E., Connelly, T., Hashimoto, D., Alqudah, M. A., Alajalen, A., Omari, R. Y., Qasem, A., Alawneh, Y., Ahmad, A., Aladawi, O., Alrayes, B., Haidar, H., Husain, S., Qassem, F., Sumadi, A., Salhiyeh, A. A., Al-Manaseer, B. M., Alsunna, Z., Ra'Ed, H., Hamad, F. R. B., Abuleil, A., Jimaale, E. A. M., Abu-Mehsen, M., Olaywah, N., Wafi, O., Ababneh, H., Abu-Ismail, L., Khamees, A., Alkhatib, A., Bolatbekova, R., Kulimbet, M., Nurgozhin, T., Saliev, T., Zhussupov, B., Almabayev, Y., Kaidarova, D., Tamoos, K., Aqeelah, A., Mohammed, A. A. K., Al Maadany, F., Alkadeeki, G., Gahwagi, M., Aldressi, W., Amnaina, M., Alansari, A. H. A., Alkaseek, A., Yagoub, G., Amer, A. B., Salem, M., Almugaddami, A., Burgan, D., Abdelkabir, M., Alshareef, K., al Islam Ben Jouira, R., Meelad, A., Bouhuwaish, A., Dwaga, S. 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S., Shaheen, A., Mohammed, Y. S., Shehata, A., Shemeis, M., Shenit, K., Sheta, M., Soffar, A., Tanas, Y., Tarek, A., Yehia, N., Eid, O. K. M., Abdulfattah, A. Y., Elsaghir, A., Elganainy, M. F., Elsayed, O. I., Elmandouh, O., Hamam, O., Shehata, M. A., Abdelaziz, A. A., Abbas, A. M., El-Ghani, W. A., Abd Elazeem, H. A. S., Elsayed, M. A., Abd-Elkariem, A. Y., Abdalla, S., Abdel-Aleem, M., Abdelazeem, K., Abdelfattah, M., Abdelhafez, M., Abdelkarem, M. M., Abdelraouf, A., Abdullaha, L., Abubeih, H., Ahmed, M. E., Ahmed, N. E. A. E., Saad, S. A., Alaa, S., Alhussaini, A., Ali, A. A. A., Ali, I., Ali, W., Mohamed, M. A., Ashraf, M., Bassiouni, M., El-adawy, M. G., El-Sharkawi, M., Elkhayat, H., Elmaghraby, K., Elsdfy, S., Elsharkawy, M., Eltayeb, A., Mohamed, M. E., Essam, E., Fahd, M., Farouk, O., Gadelkareem, R., Ghoneim, A., Takrouney, M. H., Hamdan, A., Hamed, A. E. -R., Hasan, A., Hassanin, M. A., Hawal, I., Henes, K., Herdan, M. O., Hetta, H. F., Ibrahem, O., Ibrahim, I. H., Kamel, M., Khallaf, M., Elghazaly, S. M., Mahfouz, A., Mahmoud, O., Mahran, W., Mahrous, D., Marsis, A., Hussein, A. M., Sayed, A. M., Mohammed, M. M., Mokhtar, A., Monib, F. A., Nageeb, A., Nageh, M. A., Nageh, M., Omar, N. G., Ragab, A., Ramadan, A., Temerik, A. R., Safwat, H., Salah, O., Mahmoud, A. E. S., Saleh, A., Sallam, M., Samir, A., Sayad, R., Sayed, E., Sedik, A. S., Shahine, M., Soliman, A., Soliman, W., Taher, M. G., Wanees, R., Yousof, E. A., Youssef, A., Elabedeen, O. Z., Hassan, A. E. S., Fattah, S. A., Abostate, A., Ali, S., Salama, S. A. S., Allam, M., Alsadek, A., Arafa, E., Barakat, A., El Sherpiny, M., Elbehairy, G., Eleisawy, M., Elgendy, A., Elhawary, R., Eltregy, S., Hamdy, M., Hassan, G., Khalifa, A., Mahmoud, A., Altukhy, A. M., Noah, K., Noureldin, Y., Nowar, M., Saad, M., Elsaeidy, A. S., Elsaeidy, K. S., Sabry, H., Sameh, M., Said-elnaby, A. T., Zahed, M., Zahran, M., Zaid, A., Zoghary, A. Z., Atef, M., Abdelhamid, M. H. S., Alazab, E., Awad, A. K., Darwesh, A., El Fiky, L., Elgarhy, I., Nassef, M. A., Shaban, M., Shalaby, M. M. M., Wahba, A., Fouad, O. Y. O., Elsadek, M., Gad, D., Abdelsamed, A., Bayomy, A., Elsalhy, M., Fahim, A., Seleim, A., Afifi, E., Gamal, F. A., Gamal, M., Eldesouky, O., Eldwini, M. H. E. E., Fahmy, M. M. F., Hussein, A., Ouf, A., Sami, O., Shaat, S., Bahi, A. W. M. K., Atea, A., Gamal, I., El Kassas, M., Omar, W., Tawheed, A., Al-oribi, S., Aly, N. K., Elfiky, M., Elmaghraby, A. E., Elrahmany, A., Elsherbeeny, M., Helmy, Y., Nabil, A., Farahat, A. S., Soliman, M., Wassef, A., Abdelrahman, A., Elsaban, S., Ghaly, G., Hamdy, R., Mondy, H., Abdallah, L., Darwish, A. K. Z., Rabea, M., Azab, M. A., Abbas, A. S., El-Deeb, M., Fawzy, M., Ibraheem, M., Bakry, A., Elnems, S., Elsheikh, R., Gbreel, M. I., Hafez, M., Jammal, M., Hamam, K. M., Makram, A. M., Makram, O. M., Rabie, S., Askalany, S. Y., Abushanab, M. M. I., Eid, A., El Ghalid, M. R. I. A., Abdelaty, A. A., Fayad, E. A., Radwan, A., Shokry, A., Farouk, A. M., Elfallal, A., Elfeki, H., Elsaeed, M., Elsaid, M., Makroum, A., Elsaid, D. M., Mostafa, M., Omar, M. W., Rezk, M., Sakr, A., Sanad, A., Shalaby, M., Shawqy, M., Shetiwy, M., Shoma, A., Tawakl, N., Yunes, A., Abouzid, A., Atallah, K., Elmorsi, R., Elsherbini, A., Gaballa, K., Hamdy, O., Metwally, I. H., Refky, B., Zuhdy, M., Zahran, M. A., Abdellah, F., Abdelmawla, A., Abdrabou, A., Abubakr, A., Al Gohary, R., Al-Shazly, M. H., Allam, A. R., Aposaeeda, A., Asfour, M., Ayman, A., Omran, A. A., Daghash, I. T., Ebada, M. A., Eid, T., El Kelany, A., El Shemy, E., El-Hag-Aly, M., Elgamal, O., Elghoury, M., Elkased, A. F., Ellakwa, T. H., Ellakwa, H., Elmeanawy, A., Elnoamany, S., Elsabagh, A., Elsawey, A., Elshabrawy, E., Elshakhs, S., Elsoudy, N., Ezzat, E., Fawzy, A., Gamal, A., Gameel, A., Gharbia, K., Ghonaim, M., Ghonaim, A., Hafez, A., Ismail, Z., Khaled, M., Meselhy, M., Mikhail, P., Mougahed, M., Mustafa, A., Nada, A., Omran, J., Ebiad, M. S., Saleh, I., Salem, N., Salem, O., Selim, S., Shalaby, G., Sherif, H., Soltan, H., Wahbah, M., Abdelbary, E. Z., Zayan, A. H., Afify, A., Hadiya, H. A., Elshref, M. J., Ahmed, M. M., Nasser, N., Abdeldayem, H., Salama, I. A., Ammar, K., Ayoub, I., Badawy, M. T., Balabel, M., Fayed, Y., Gad, E. H., Gomaha, M., Hammad, E., Hegazy, O., Hegazy, E., Ibrahim, T., Kallaf, M., Macshut, M., Magdy, A., Oteem, A., Samaan, S., Sharshar, M., Shoreem, H., Soliman, E., Soliman, H. E., Yassein, T., Zakaria, H., Eldaly, A., Mashaly, S., Abd-Elsalam, S., Abdel-Elsalam, W., Shaalah, A. A., Elbahnasawy, M., Elhalaby, I., Hamada, M., Soliman, S. H., Hawila, A., Morsy, M. S., Naieem, M., Nasreddin, M., Salman, S., Sarsik, S., Shabana, A., Tolba, E., Zagho, M., Kams, L., Ratsep, T., Riips, K., Abdurehman, O., Admasu, A., Berhea, A., Eado, Y., Hailu, N., Kidane, M., Mohammed, A., Mohammed, K., Tibelt, A., Woldemariam, M. A., Yonael, L., Alemu, M., Aklilu, A. T., Asele, F., Assefa, S., Azmach, D., Bekele, P., Mamo, M., Maru, N., Mekuria, H., Menkir, A., Mikru, F., Siraw, E., Suga, H., Sumoro, N., Teka, A., Thomas, E., Woldemariam, D., Wubishet, E., Abebe, E., Abebe, K., Asfaw, F., Bergene, E., Eshete, M., Gebrehiwot, F. G., Gedefaw, Y., Mengesha, M. W., Mengiste, N., Menjeta, A., Muleta, M. B., Sefera, S., Tedla, Y., Teklu, D., Teshome, H., Tirfe, L., Tsegabrhan, S., Tsehaye, M., Worku, B., Molla, M., Supha, M., Taye, T., Abebe, N., Alemu, B., Chanie, A., Degefu, H., Desalegn, D., Gebre, H., Hussen, H., Kassa, D., Laeke, T., Mammo, T. N., Negash, S., Sahlu, A., Tiruneh, A. G., Wolde, A., Woldeselassie, H. G., Ahmed, M. Y., Zewdneh, B., Fentaw, J., Salia, S., Tabore, K., Gurara, A., Abreha, T., Abrha, T., Beyene, G., Weldu, M. A., Abdissa, D., Tesfaw, M., Wolle, M., Asmamaw, D., Assefa, B. Z., Bedane, D., Bekele, E., Getie, A., Melkamu, S., Mengesha, W., Shumye, G., Tagele, G., Tesfa, A. A., Workneh, W., Genetu, S., Mebratu, E., Chanyalew, L., Deresse, T., Girma, A., Seid, M., Shimelash, D., Shitaw, A., Ayalew, T., Diress, T., Kassahun, B., Kassaye, B., Mulugeta, E., Tesfaw, G., Yimenu, B., Benecha, S., Aman, M., Mekete, A., Tesemma, A., Mohammed, A. A., Abdullahi, Y. Y., Adem, E., Ahmedin, M., Assefa, Y., Ayde, F., Berhe, A., Gebremeskel, Z., Siyoum, E. G., Teresa, S., Wude, Z., Yemer, F., Yohannes, D., Zeleke, E., Zerihun, G., Degefe, D. W., Derilo, H. T., Eliyas, N., Bayissa, F., Deressa, Y., Gemechu, L., Gurmu, T., Kasaye, A., Melese, L., Muleta, L., Mulugeta, G., Taye, S., Teshome, A., Tesso, B., Gebrekirstos, G., Haile, M., Kassa, H., Saddik, M., Mengist, A., Heikkinen, J., Helminen, O., Huhta, H., Kotkavaara, T., Mosorin, M. -A., Pitkanen, J., Qian, C., Sinikumpu, J., Sova, H., Tastula, M., Virta, V. P., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Bastard, F., Bin, K., Breheret, R., Fouquet, O., Gueutier, A., Henric, N., Kahn, A., Kun-Darbois, J. -D., Moukoko, D., Pineau, A., Podevin, G., Schmitt, F., Alshawared, F., Beyrne, C. D., Lugans, L., Marie-Macron, L., Doussot, A., Ahmed, O., Alnajjar, L., Mis, T. C., Fliss, S., Giocanti-Auregan, A., Gregory, T., Guiraudet, P., Le Fouler, A., Martinod, E., Onorati, I., Peretti, M., Quilichini, J., Radu, D., Tresallet, T., Andro, C., Maffert, A., Chapman, T., Halden, M., Fayon, J., Mattevi, C., Marion, H., Bendjemar, L., Lionel, C., Mikhael, E., Macias, R. M., Villefranque, V., Volpin, E., Trilling, B., Boleslawski, E., Constance, H. -L., Drubay, V., El Amrani, M., Eveno, C., Lecolle, K., Martin, L., Noiret, B., Piessen, G., Truant, S., Zerbib, P., Aubry, E., Denimal, F., Lamblin, A., Barrat, B., Caire, F., Christou, N., Fourcade, L., Laloze, J., Bouv-Hez, M. M., Salle, H., Taibi, A., Tricard, J., Usseglio, J., Chopinet, S., Gregoire, E., Delpont, M., Blanchard, C., Crenn, V., de Vergie, S., Denis, W., Fragnaud, H., Regenet, N., Rigaud, J., Varenne, Y., Anract, P., Barat, M., Biau, D., Dautry, R., Dohan, A., Idier, L., Lang, E., Thouny, C., Tzedakis, S., Audenet, F., Cazelles, A., Chamouni, A., Karoui, M., Mejean, A., Clermidi, P., Langlais, T., Leonelli, L., Maisonneuve, E., Nicolas, B., Perrot, O., Prost, D., Thomin, A., Thouement, T., Athiel, Y., Berry, R., Boddaert, G., Bonnet, S., Cathala, N., Conso, C., Denet, C., Laforest, A., Levy-Zauberman, Y., Macek, P., Mombet, A., Ollat, D., Scamporlino, A., Zadegan, F., Amine, C. A., Baratte, B., Chartier-Kastler, E., Chereau, N., Colas, P. -A., Duquesne, I., Genser, L., Petit, G. G., Goumard, C., Hasani, A., Lim, C., Martellotto, S., Melot, C., Menegaux, F., Pinar, U., Pocard, M., Roupret, M., Scatton, O., Seisen, T., Severine, N., Turco, C., Chouillard, E., Beganton, P., Frasca, D., Kerforne, T., Corbiere, L., Gasmi, A., Ghemame, M., Guerin, S., Khene, Z. -E., Livin, M., Mahmoud, F., Maillot, B., Merdrignac, A., Mouriaux, F., Robin, F., Sulpice, L., Vazeux, C., Bertheuil, N., Bonneau, S., Cazemajou, C. T., Cousin, I., Defert, C., Fustec, E., Juricic, M., Lavoue, V., Mevel, G., Timoh, K. N., Renault, A., Violas, P., Schwarz, L., Tuech, J. J., Morichau-Beauchant, T., Sauvat, F., Haddad, E., Vermersch, S., Patrizi, A., Roux, A., Aime, A., Malgras, B., Cherkaoui, Z., D'Urso, A., Felli, E., Gonzalez, C. A., Ignat, M., Mutter, D., Pessaux, P., Vix, M., Gornes, H., Vergriete, K., Berthoumieu, P., Genre, L., Le Gall, H., Pierre, T., Chalhoub, M., Del, M., Martinez, A., Fuchs-Buder, T., Vancon, A., Faya, C. A., Asaph, E., Baruwa, E., Hofman, G., Machemedze, S., Idiata, M. M., Muhemi, R., Ndizeye, O., Nkunzimana, E., O'Connor, J., O'Connor, Z., Tchoba, S., Boumas, N., Devidze, G., Pisarevi, G., Baumgarten, S., Grusser, L., Holzle, F., Kowark, P., Kowark, A., Rossaint, R., Schafer, B., Wallqvist, J., Winnand, P., Ziemann, S., Anthuber, M., Broecheler, T., Edlinger, F., Gosslau, Y., Hyhlik-Duerr, A., Maksymiw, F., Shiban, E., Sommer, F., Sommer, B., Zerwes, S., Beyer, K., Lauscher, J. C., Lee, L. D., Loch, F. N., Schineis, C., Aghalarov, I., Belyaev, O., Braumann, C., Enste, A., Fahlbusch, T., Herzog, T., Horn, J., Jedanowski, J., Knipschild, J., Luu, A. M., Mohan, P. V., Siemen, L., Slobodkin, I., Strotmann, J. J., Uhl, W., Wolf, K., Coburn, M., Egger, E., Eichhorn, K., Enderes, J., Far, F., Franzen, A., Guresir, E., Hadjiathanasiou, A., Kalff, J. C., Kohistani, Z., Manekeller, S., Mustea, A., Probst, C., Randau, T., Recker, F., Schuss, P., Strassberger-Nerschbach, N., Strieth, S., Treede, H., van Beekum, C. J., Vatter, H., Velten, M., Vilz, T. O., Wirtz, D., Wittmann, M., Behr, M., Bulian, D. R., Marche, B., Moczko, T., Otchwemah, R., Schulz, S. -A., Thomaidis, P., Bruns, C., Cursiefen, C., Domrose, C., Fuchs, H., Heindl, L. M., Mallmann, M. R., Mallmann, C., Ratiu, D. A., Canzler, U., Distler, M., Korn, S., Meisel, C., Meusel, M., Petzold, A., Praetorius, C., von Renesse, J., Weitz, J., Wimberger, P., Alkhanji, N., Fung, S., Jaber, K., Knoefel, W. T., Vay, C., Clonda, O., Cottin, T., Juodiene, E., Juodis, D., Petrovic, B., Solodarenko, O., Binder, J., Grutzmann, R., Hackner, D., Junker, S., Arsalan, M., Banek, S., Chun, F., Faqar-Uz-Zaman, S. F., Keese, D., Kluth, L., Rolle, U., Van Linden, A., Walther, T., Bayer, J., Beck, J., Fung, C., Kraus, L. M., Leiber, C., Neidert, N., Sandkamp, R., Schnell, O., Schulte, A., Strahle, J., Jarmusch, S., Novotny, H. F. G., Becker, J., Fulghum, C., Gonschor, B., Herbolzheimer, M., Nicolaiciuc, S., Trulson, A., Vogelsang, H., Zimmermann, B., Akbari, A. A., Boening, A., Edinger, F., Hecker, M., Knitschke, M., Koch, C., Reichert, M., Schmidt, G., Schneck, E., Uhl, E., Nobrega, S. F., Kauffmann, P., Miller, C., Nemeth, M., Sievers, D., Kisser, U., Kleeff, J., Klose, J., Lorenz, K., Papendick, N., Plontke, S., Seiwerth, I., Steer, S., Thomssen, C., Ukkat, J., Dumpies, C. W., Gessner, M., Hanke, J., Klauke, F., Leuschner, S., Mendel, T., Muller, K., Schmidt, B., Schreiter, V., Stosberg, P., Vinz, F., Herbig, B., Sander, J., Schulte, T. M., Betz, C. S., Bewarder, J., Bier, J., Bottcher, A., Burg, S., Busch, C. -J., Bussmann, L., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Konig, D., Kopke, L. -G., Moeckelmann, N., Praetorius, M., Priemel, M., Stadlhofer, R., Stangenberg, M., Uzunoglu, F. G., Wittig, L., Zech, H., Zeller, N., Roux, F., Spaeth, T., Fricker, R., Muller, T., Schroder, L., Alasmari, M., Boeker, C., Hakami, I. A., Mall, J. W., Kyritsis, I., Graeb, C., Huber-Strossner, K., Branzan, D., Doss, M., Gockel, I., Jodicke, C., Osterhoff, G., Pempe, C., Sucher, R., Adler, T., Kelly, K., Merkle, J., Siebert, J., Hirche, C., Kneser, U., Tapking, C., Agrawal, R., Qureischie, H., Croner, R., Koslowski, L., Krause, H., Meyer, F., Turial, S., Al-Nawas, B., Battista, M. J., Goedeke, J., Hasenburg, A., Heider, J., Mueller, L. K., Zeller, S., Jentschura, S. L. P., Kowalewski, K. -F., Kriegmair, M., Mannle, D., Reissfelder, C., Rotter, N., Scherl, C., Seyfried, S., Kirschniak, A., Rolinger, J., Wilhelm, P., Bader, F. G., Ottl, S., Behr, A. V., Diamantis, A., Fichter, A., Grill, F., Heck, M., Jira, D., Kallmayer, M., Koll, F., Luhne, S., Meyer, B., Patachia, R., Pergolini, I., Safi, S., Schaffer, C., Schirren, M., Wegmann, H., Wirth, M., Zhu, Z., Aghamaliyev, U., Almaghrabi, M., Bocker, W., Bruder, J., Frank, K., Herterich, V., Huber, V., Ilmer, M., Kammerlander, C., Neuerburg, C., von Ehrlich-Treuenstatt, V. H., Werner, J., Borner, N., Fegg, F., Hartmann, D., Ladurner, R., Liokatis, P., Patzer, K., Schlager, J. G., Smolka, W., Zimmermann, P., Hatz, R., Steinhart, D., Glowalla, C., Schneidmueller, D., Henkel, K. W., Steiner, M., Holz, K., Knorr, C., Kuehlmann, B., Oikonomou, K., Prantl, L., Flurschutz, R., Honarpisheh, H., Kroger, M., Lepiorz, D., Luths, C., Niemeier, A., Sras, Y., Strate, T., Winter, T., Freiman, T., Gessler, F., Won, S. -Y., Widyaningsih, R., Hoffmann, S., Schafer, R. C., Thiel, J. 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P., Iovino, Claudio, CovidSurg Collaborarive, Frisoni T., Palmerini E., Donati D., Traina F., Solaini L., Pignatti M., Conti A., Internal Medicine, Collaborative, COVIDSurg, Collaborative, GlobalSurg, Apollo - University of Cambridge Repository, COVIDSurg Collaborative, Li, E, Emanuele Cammarata, Sofia Campanella, Daniela Canzonieri, Adriana Cordova, Federico De Michele, Ettore Dinoto, Mara Franza, Leo Licari, Daniele Matta, Domenico Mirabella, Felice Pecoraro, Roberto Pirrello, Pierfrancesco Pugliese, Fernando Rosatti, Giuseppe Salamone, Francesca Toia, Massimiliano Tripoli, Vito Chiantera, Leo Licari, Palmisano, Silvia, de Manzini, Nicolo', Collaborative, Covidsurg, Collaborative, Globalsurg, Faculty of Medicine and Pharmacy, Clinical sciences, Medical Oncology, Basic (bio-) Medical Sciences, Diabetes Pathology & Therapy, Gastroenterology, Fruscio, R, Ornaghi, S, Surgical clinical sciences, COVIDSurg Collaborative (GlobalSurg, Collaborative), Beretta, L, and Aldrighetti, L.

Subjects
Male, pulmonary embolism, Internationality, Settore MED/18 - CHIRURGIA GENERALE, Deep vein, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], infectious diseases, Cardiovascular, SARS‐CoV‐2, surgery, COVID-19, SARS-CoV-2, deep vein thrombosis, venous thromboembolism, Cohort Studies, Postoperative Complications, Anesthesiology, Medicine and Health Sciences, Prospective Studies, 610 Medicine & health, Prospective cohort study, Lung, 11 Medical and Health Sciences, Confounding, Hematology, Middle Aged, Thrombosis, 17 Psychology and Cognitive Sciences, Pulmonary embolism, medicine.anatomical_structure, Cohort, COVID-19/complications, Postoperative Complications/etiology, Original Article, Female, Patient Safety, Life Sciences & Biomedicine, Human, Adult, medicine.medical_specialty, Adolescent, Clinical Sciences, GlobalSurg Collaborative, Venous Thromboembolism/etiology, NO, COVIDSurg Collaborative, Young Adult, Medicine, General & Internal, Age Distribution, Clinical Research, COVID‐19, General & Internal Medicine, medicine, Humans, Sex Distribution, Aged, Science & Technology, business.industry, Prevention, Neurosciences, deep vein thrombosi, Pneumonia, Odds ratio, Original Articles, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Prospective Studie, Good Health and Well Being, Anesthesiology and Pain Medicine, Human medicine, Postoperative Complication, Cohort Studie, business, Venous thromboembolism, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly. ispartof: ANAESTHESIA vol:77 issue:1 pages:28-39 ispartof: location:England status: published

Published
2022

41. Survival and prognostic indicators in downer dairy cows presented to a referring hospital: A retrospective study (1318 cases)

Author

Juan Carlos Arango-Sabogal, Marie Babkine, Maria Puerto-Parada, Marie-Ève Bilodeau, David Francoz, Gilles Fecteau, Sylvain Nichols, and André Desrochers

Subjects
medicine.medical_specialty, Referral, Anemia, Veterinary medicine, Population, Cattle Diseases, nonambulatory, Standard Article, ruminant, FOOD AND FIBER, Tachypnea, Internal medicine, SF600-1100, Odds Ratio, medicine, Animals, education, Dairy cattle, Retrospective Studies, education.field_of_study, General Veterinary, business.industry, Medical record, recumbent, Retrospective cohort study, Odds ratio, Prognosis, medicine.disease, Hospitals, cattle, outcome, Female, Other, medicine.symptom, business
Abstract

Background Downer cow syndrome, a common problem in dairy cattle, represents a diagnostic and therapeutic challenge for the attending veterinarian. Identifying prognostic indicators and assessing the odds of survival may improve the accuracy of the clinician's prognosis at the time of diagnosis. Objective To describe a population of downer dairy cows referred to a hospital and investigate predictors of outcome. Animals Recumbent adult dairy cows (cows unable or unwilling to stand without help) treated at a referral hospital. Methods Data at the time of admission were collected from medical records of downer dairy cows treated at the Centre Hospitalier Universitaire Vétérinaire between 1994 and 2016. Simple and multivariable logistic regression analyses were performed to assess the association of predictors with the outcome. Results Among 1318 cows included, 727 (55%) cows were discharged, and 591 (45%) cows died or were euthanized. Cows with longer time of recumbency before referral (odds ratio [OR] = 3.6), tachycardia (100‐120 beats per minute [bpm], OR = 1.93; >120 bpm, OR = 2.92), tachypnea (OR = 1.76), hypothermia (OR = 2.08), anemia (OR = 3.30), neutropenia (OR = 1.7), high aspartate aminotransferase activity (500‐1000 U/L, OR = 2.16; >1000 U/L, OR = 6.69), and increased serum creatinine concentration (OR = 1.75) had higher odds of nonsurvival. Conclusions and Clinical Importance These findings may help the practitioner to consider treatment options and decide if referral is likely beneficial based on the odds of success. Early recognition of low chance of survival may facilitate an early decision for euthanasia.

Published
2021

42. En face swept-source optical coherence tomography angiography choroidal vasculography (CVG) a tool to discriminate choroidal abnormalities in polypoidal choroidal vasculopathy

Author

Eduardo J. Viteri, Juan D Arias, Andrea T Hoyos, M. Margarita Parra, J. Fernando Arevalo, and Francisco J Arango

Subjects
Male, medicine.medical_specialty, Biomedical Engineering, Optical coherence tomography, Ophthalmology, medicine, Humans, In patient, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, Choroid, business.industry, General Medicine, Optical coherence tomography angiography, Gold standard (test), Middle Aged, Macular degeneration, medicine.disease, Reflectivity, Choroidal Neovascularization, eye diseases, Cross-Sectional Studies, medicine.anatomical_structure, Female, Surgery, sense organs, business, Tomography, Optical Coherence, After treatment
Abstract

BACKGROUND Swept source optical coherence tomography angiography (SS-OCT-A) choroidal vasculography (CVG) is an imaging method which allows the evaluation of deep choroid details, being a promising too in choroidal pathologies as polypoidal choroidal vasculopathy (PCV). RESEARCH DESIGN AND METHODS Cross-sectional study performed at FOSCAL International Clinic in Colombia. CVG features in patients with PCV were evaluated using SS-OCT CVG. RESULTS Twenty-two eyes of 21 patients were included. The mean age was 72.7 ± 6.5 years old (range: 48.6-95.4 years old). Twelve (57.1%) patients were male. The mean number of polyps detected by SS-OCT-A CVG before treatment with anti-VEGF therapy was 2.04 ± 1.18, which decreased after treatment to 1.18 ± 0.71. This result was statistically significant (p

Published
2021

43. Therapeutic plasmapheresis for the treatment of thyrotoxicosis: A retrospective multi‐center study

Author

Alejandro Román-González, Clara María Arango-Toro, Luis Antonio Rodriguez-Arrieta, Carolina Prieto-Saldarriaga, Carlos Esteban Builes-Montaño, Carlos Alfonso Builes-Barrera, and Jose C. Alvarez-Payares

Subjects
Adult, Male, Thyroid Hormones, Pediatrics, medicine.medical_specialty, Adolescent, endocrine system diseases, medicine.medical_treatment, Disease, Young Adult, medicine, Humans, Thyroid storm, Endocrine system, Child, Adverse effect, Retrospective Studies, business.industry, Thyroid, Thyroidectomy, Retrospective cohort study, Plasmapheresis, Hematology, General Medicine, Middle Aged, Propranolol, Thyrotoxicosis, medicine.anatomical_structure, Female, business
Abstract

BACKGROUND AND AIMS Thyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and first-line hyperthyroidism treatment is not always an option. Since the first report in 1970, plasmapheresis is a second-line treatment for severe or otherwise untreatable thyrotoxicosis when rapid euthyroidism is desired. METHODS We present a retrospective study of the experience in treating thyrotoxicosis with plasmapheresis between 2012 and 2020 in two specialized centers in Colombia. We register the demographic and clinical characteristic and compare the thyroid hormones and other biochemical measurements before and after treatment. RESULTS Data from 19 patients was obtained, 58% female with a median age of 35 years (IQR 23.5), and most of them with Graves' disease. The most frequent indication for plasmapheresis was thyroid storm. A median of 4 (IQR 2) sessions lead to a significant reduction in FT4 (P .0001) and TT3 (P

Published
2021

44. Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Author

Yash Patel, Jean Shin, Christoph Abé, Ingrid Agartz, Clara Alloza, Dag Alnæs, Sonia Ambrogi, Linda A. Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa-Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Bandeira, Zeynep Başgöze, Renata Basso Cupertino, Claiton H.D. Bau, Jochen Bauer, Sarah Baumeister, Fabio Bernardoni, Alessandro Bertolino, Caterina del Mar Bonnin, Daniel Brandeis, Silvia Brem, Jason Bruggemann, Robin Bülow, Juan R. Bustillo, Sara Calderoni, Rosa Calvo, Erick J. Canales-Rodríguez, Dara M. Cannon, Susanna Carmona, Vaughan J. Carr, Stanley V. Catts, Sneha Chenji, Qian Hui Chew, David Coghill, Colm G. Connolly, Annette Conzelmann, Alexander R. Craven, Benedicto Crespo-Facorro, Kathryn Cullen, Andreas Dahl, Udo Dannlowski, Christopher G. Davey, Christine Deruelle, Covadonga M. Díaz-Caneja, Katharina Dohm, Stefan Ehrlich, Jeffery Epstein, Tracy Erwin-Grabner, Lisa T. Eyler, Jennifer Fedor, Jacqueline Fitzgerald, William Foran, Judith M. Ford, Lydia Fortea, Paola Fuentes-Claramonte, Janice Fullerton, Lisa Furlong, Louise Gallagher, Bingchen Gao, Si Gao, Jose M. Goikolea, Ian Gotlib, Roberto Goya-Maldonado, Hans J. Grabe, Melissa Green, Eugenio H. Grevet, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Jan Haavik, Tim Hahn, Ben J. Harrison, Walter Heindel, Frans Henskens, Dirk J. Heslenfeld, Eva Hilland, Pieter J. Hoekstra, Sarah Hohmann, Nathalie Holz, Fleur M. Howells, Jonathan C. Ipser, Neda Jahanshad, Babette Jakobi, Andreas Jansen, Joost Janssen, Rune Jonassen, Anna Kaiser, Vasiliy Kaleda, James Karantonis, Joseph A. King, Tilo Kircher, Peter Kochunov, Sheri-Michelle Koopowitz, Mikael Landén, Nils Inge Landrø, Stephen Lawrie, Irina Lebedeva, Beatriz Luna, Astri J. Lundervold, Frank P. MacMaster, Luigi A. Maglanoc, Daniel H. Mathalon, Colm McDonald, Andrew McIntosh, Susanne Meinert, Patricia T. Michie, Philip Mitchell, Ana Moreno-Alcázar, Bryan Mowry, Filippo Muratori, Leila Nabulsi, Igor Nenadić, Ruth O'Gorman Tuura, Jaap Oosterlaan, Bronwyn Overs, Christos Pantelis, Mara Parellada, Jose C. Pariente, Paul Pauli, Giulio Pergola, Francesco Maria Piarulli, Felipe Picon, Fabrizio Piras, Edith Pomarol-Clotet, Clara Pretus, Yann Quidé, Joaquim Radua, J. Antoni Ramos-Quiroga, Paul E. Rasser, Andreas Reif, Alessandra Retico, Gloria Roberts, Susan Rossell, Diego Luiz Rovaris, Katya Rubia, Matthew D. Sacchet, Josep Salavert, Raymond Salvador, Salvador Sarró, Akira Sawa, Ulrich Schall, Rodney Scott, Pierluigi Selvaggi, Tim Silk, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Dan J. Stein, Olaf Steinsträter, Aleks Stolicyn, Yoichiro Takayanagi, Leanne Tamm, Maria Tavares, Alexander Teumer, Katharina Thiel, Sophia I. Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutiérrez, Michela Tosetti, Anne Uhlmann, Tamsyn Van Rheenen, Javier Vazquez-Bourgón, Meike W. Vernooij, Eduard Vieta, Oscar Vilarroya, Cynthia Weickert, Thomas Weickert, Lars T. Westlye, Heather Whalley, David Willinger, Alexandra Winter, Katharina Wittfeld, Tony T. Yang, Yuliya Yoncheva, Jendé L. Zijlmans, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan Buitelaar, Christopher R.K. Ching, Ole A. Andreassen, Elena Pozzi, Dick Veltman, Lianne Schmaal, Theo G.M. van Erp, Jessica Turner, F. Xavier Castellanos, Zdenka Pausova, Paul Thompson, Tomas Paus, Pediatric surgery, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, General Paediatrics, ARD - Amsterdam Reproduction and Development, Paediatrics, Radiology & Nuclear Medicine, Epidemiology, Clinical Cognitive Neuropsychiatry Research Program (CCNP), German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne Universit, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Foundation, Society of Mental Health Research, Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute, European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia, Banaschewski, Tobias, Bandeira, Cibele Edom, Cupertino, Renata, Calderoni, Sara, Cannon, Dara, Carr, Vaughan, Chew, Qian Hui, Coghill, David, Cullen, Kathryn, Dahl, Andreas, Epstein, Jeffery, Foran, William, Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice M., Furlong, Lisa, Gallagher, Louise, Gao, Si, Gotlib, Ian, Haavik, Jan, Henskens, Frans, Hilland, Eva, Hoekstra, Pieter J, Howells, Fleur M, Ipser, Jonathan, Jørgensen, Jes Kristian, Karantonis, James A., Lawrie, Stephen, Research Institute of the Hospital for Sick Children and University of Toronto, University of Toronto, Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada, KG Jebsen Centre for Psychosis Research, University of Oslo (UiO)-Institute of Clinical Medicine-Oslo University Hospital [Oslo], Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Mental Health Sciences Unit, University College of London [London] (UCL), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Clinical and Behavioral Neurology - Neuroscienze e riabilitazione, IRCCS Fondazione Santa Lucia [Roma], Heidelberg University, Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Universität Heidelberg [Heidelberg] = Heidelberg University, Clinical Neuropsychology, IBBA, APH - Mental Health, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Hospital Sant Joan de Déu [Barcelona], and Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM)

Subjects
Bipolar Disorder, Autism Spectrum Disorder, [SDV]Life Sciences [q-bio], Neurogenesis, pathology [Premature Birth], Neurodevelopment, Cortical surface area, pathology [Autism Spectrum Disorder], Cortical growth, methods [Magnetic Resonance Imaging], SDG 3 - Good Health and Well-being, Pregnancy, 130 000 Cognitive Neurology & Memory, Humans, ddc:610, Child, Biological Psychiatry, Cerebral Cortex, pathology [Depressive Disorder, Major], Depressive Disorder, Major, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Infant, Newborn, Magnetic Resonance Imaging, Mental illness, Attention Deficit Disorder with Hyperactivity, Premature Birth, genetics [Autism Spectrum Disorder], Female, Psychiatric disorders, 170 000 Motivational & Cognitive Control
Abstract

[Background]: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life., [Methods]: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed., [Results]: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth., [Conclusions]: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy., This work was supported by the German Research Foundation (DFG Grant Nos. HA7070/2-2, HA7070/3, HA7070/4 [to TH]) and IZKF of the medical faculty of Münster (Grants No. Dan3/012/17 [to UD] and MzH 3/020/20 [to TH]), and NHMRC projects (Grant No. 1064643 [to BJH] and 1024570 [to CGD]). The CIAM study was supported by the University of Cape Town Research Committee, South African National Research Foundation, and the South African Medical Research Council (principal investigator [PI], Fleur M. Howells) and Grant No. R01MH117601 (to NJ). This work was funded by the German Research Foundation (Grant Nos. FOR2107 JA 1890/7-1 and FOR2107 JA 1890/7-2 [to AJ]) and Swinburne University scholarship/Australian Postgraduate Award (to JK). Collection of the COGSBD cohort was funded by the Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L Cooper Foundation, and the Society of Mental Health Research (to JK). This work was funded by the German Research Foundation (Grant Nos. FOR2107 KI588/14-1 and FOR2107 KI588/14-2 [to TK]). The St. Göran study was supported by grants from the Swedish Research Council (Grant No. 2018-02653 [to ML]), the Swedish foundation for Strategic Research (Grant No. KF10-0039 [to ML]), the Swedish Brain foundation (Grant No. FO2020-0261 [to ML]), and the Swedish Government under the LUA/ALF agreement (Grant Nos. ALF 20170019 and ALFGBG-716801 [to ML]). This work was supported by RFBR (Grant No. 20-013-00748 [to IL, AST]) and funded by the Health Research Board (Grant No. HRA_POR/2011/100 [to CM]). The Australian Schizophrenia Research Bank (ASRB) was supported by the NHMRC (Enabling Grant No. 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute. Chief investigators for ASRB were VC, US, RSc, AJ, BM, PTM, SVC, FH, and CPa. This work was supported by Deutsche Forschungsgemeinschaft (Grant Nos. DFG NE 2254/2-1, NE 2254/3-1, NE2254/4-1 [to IN]), the University Research Priority Program “Integrative Human Physiology” at the University of Zurich (to ROT), an NHMRC Senior Principal Research Fellowship (Grant No. 1105825 [to CPa]), an NHMRC L3 Investigator Grant (Grant No. 1196508 [to CPa]), and NHMRC Program Grant (Grant No. 1150083 [to CPa]). ASRB was supported by the NHMRC (Enabling Grant No. 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute. Chief investigators for ASRB were VC, US, RSc, AJ, BM, PTM, SVC, FH, and CPa. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant (Agreement No. 798181 [to GP]). ASRB was supported by the NHMRC (Enabling Grant, ID 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute. Chief investigators for ASRB were VC, US, RSc, AJ, BM, PTM, SVC, FH, and CPa. The Imaging Genetics in Psychosis study was funded by Project Grants from the NHMRC (Grant Nos. APP630471 and APP1081603 [to YQ]) and the Macquarie University’s Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders (Grant No. CE110001021 [to YQ]). This work was supported by the Spanish Ministry of Science, Innovation and Universities/Economy and Competitiveness/Instituto de Salud Carlos III (Grant Nos. PI11/01766 and CPII19/00009 [to JR]), co-financed by European Regional Development Fund funds from the European Commission (“A Way of Making Europe”). ASRB was supported by the NHMRC (Enabling Grant No. 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute. Chief investigators for ASRB were VC, US, RSc, AJ, BM, PTM, SVC, FH, and CPa. SR was supported by an NHMRC Senior Fellowship (Grant No. GNT1154651). Collection of the COGSBD cohort was funded by the Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L Cooper Foundation, and the Society of Mental Health Research (to SR). This work was supported by NIHR; MRC (to KR), NIH (Grant Nos. MH-094268, MH-105660, and MH-107730 [to ASS]). The Neuroimaging of the Children's Attention Project cohort was funded by NHMRC, Australia (Grant No. 1065895). Earlier funding for the cohort as also provided by NHMRC (Grant No. 1008522) and a grant from the Collier Foundation. The ACPU cohort was funded by NHMRC, Australia (Project Grant Nos. 384419 and 569533 [to TS]). This work was supported by research grants from the National Healthcare Group, Singapore (Grant Nos. SIG/05004, SIG/05028, and SIG /1103), and the Singapore Bioimaging Consortium (RP C009/2006 [to KS]), and the Ministry of Health, Czech Republic - conceptual development of research organization (“Institute for Clinical and Experimental Medicine - IKEM, IN 00023001” [to ASk]). This study was supported by the Italian Ministry of Health (Grant No. RC/17-18-19-20-21/A [to GS]) and Ministry of Health of the Czech Republic (Grant No. NU20-04-00393 [to FS]). The Drakenstein Child Health Study (DCHS) cohort is funded by the Bill and Melinda Gates Foundation (Grant No. OPP 1017641) and the South African Medical Research Council. This DCHS contribution was made possible in part by a grant from Carnegie Corporation of New York. The statements made and views expressed are solely the responsibility of the author (DJS). STRADL study was supported and funded by the Wellcome Trust Strategic Award “Stratifying Resilience and Depression Longitudinally” (Grant No. 104036/Z/14/Z), and the Medical Research Council Mental Health Pathfinder Award “Leveraging routinely collected and linked research data to study the causes and consequences of common mental disorders” (MRC, Grant No. MC_PC_17209). Scottish Bipolar Family Study (SBFS) was supported by National Health Service Research Scotland, through the Scottish Mental Health Research Network (www.smhrn.org.uk), who provided assistance with subject recruitment and assessments. SBFS was conducted at the Brain Research Imaging Centre (http://www.bric.ed.ac.uk), which is supported by SINAPSE (Scottish Imaging Network, a Platform for Scientific Excellence, http://www.sinapse.ac.uk). Processing of the datasets used the resources provided by the Edinburgh Compute and Data Facility (http://www.ecdf.ed.ac.uk/) (ASt). TVR was supported by an NHMRC Early Career Fellowship (Grant No. GNT1088785). Collection of the COGSBD cohort was funded by the Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L Cooper Foundation, and the Society of Mental Health Research (to TVR). EV was supported by the Spanish Ministry of Science and Innovation (PI18/00805) integrated into the Plan Nacional de I+D+I and co-financed by the ISCIII-Subdirección General de Evaluación and the FEDER; the Instituto de Salud Carlos III; the CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental); by the CERCA Programme/Generalitat de Catalunya and the Secretaria d’Universitats i Recerca del Departament d’Economia I Coneixement (Grant No. 2017SGR1355). This study was also supported by the Departament de Salut de la Generalitat de Catalunya, Pla Estratègic de Recerca i Innovació en Salut (PERIS) 2016-2020 (Grant No. SLT006/17/00345) and the European Union Horizon 2020 research and innovation program (EU.3.1.1. Understanding health, wellbeing and disease: Grant Nos. 754907 and EU.3.1.3 [to EB]; Treating and managing disease: Grant No. 945151 [to EV]). This study was supported by the National Center for Complementary and Integrative Health (Grant Nos. R21AT009173 and R61AT009864 [to TTY]); by the National Center for Advancing Translational Sciences (CTSI), National Institutes of Health, through UCSF-CTSI (Grant No. UL1TR001872 [to TTY]); by the American Foundation for Suicide Prevention (Grant No. SRG-1-141-18 [to TTY]); by UCSF Research Evaluation and Allocation Committee (REAC) and J. Jacobson Fund (to TTY); by the NIMH (Grant No. R01MH085734 [to TTY]); and by the Brain and Behavior Research Foundation (formerly NARSAD) (to TTY). This work was supported by a personal Veni grant to MH from the Netherlands Organization for Scientific Research (NWO, Grant No. 91619115 [to MH]) and European Community’s Horizon 2020 Programme (H2020/2014 – 2020) (Grant Agreements Nos. 667302 [CoCA], 728018 [Eat2beNICE], and 847879 [PRIME] [to BF]). JBu has been supported by the EU-AIMS (European Autism Interventions) and AIMS-2-TRIALS programmes, which receive support from Innovative Medicines Initiative Joint Undertaking Grant Nos. 115300 and 777394, the resources of which are composed of financial contributions from the European Union’s FP7 and Horizon 2020 Programmes, and from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and AUTISM SPEAKS, Autistica and SFARI; and by the Horizon 2020–supported programme CANDY (Grant No. 847818 [to JBu]). This work is supported by Grant No. NIA T32AG058507 and NIH Grant No. U54EB020403 from the Big Data to Knowledge (BD2K) Program (to CRKC). ENIGMA MDD work is supported by NIH (Grant Nos. U54 EB020403 [to PT], R01 MH116147 [to PT], and R01 MH117601 [to NJ and LS]). LS was supported by an NHMRC Career Development Fellowship (Grant No. 1140764). This work was supported by the National Center for Research Resources at the NIH (Grant Nos. NIH 1 U24 RR021992 [Function Biomedical Informatics Research Network], NIH 1 U24 RR025736-01 [Biomedical Informatics Research Network Coordinating Center; http://www.birncommunity.org]). TGMvE is supported by ENIGMA’s NIH BD2K initiative (Grant No. U54 EB020403), ENIGMA Sex Differences (Grant No. R01MH116147), and ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits (Grant No. R01MH121246). This work was supported by the NIH (Grant No. R01MH121246 [to JT, Calhoun, and TGMvE]). This work was supported in part by NIH (Grant No. U54 EB020403 [to PT]).

Published
2022

45. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19

Author

Eran Hadar, Chiara Benedetto, Agnese Maria Chiara Rapisarda, Renato Augusto Moreira de Sá, Deena Elkafrawi, Daniela Luvero, Noa A Brzezinski Sinai, Alicia Martínez-Varea, Antonio Schiattarella, Anna Nunzia Della Gatta, Giovanni Scambia, Albert Lila, Luciano Di Tizio, Andrea Carosso, Giovanni Nazzaro, G. Schera, Giuseppe Rizzo, Giuseppe Maria Maruotti, Giusella D'Urso, Albaro José Nieto-Calvache, Ilenia Mappa, Ozlem Uyaniklar, Fabio Barra, Gilles Faron, Luigi Nappi, Jacopo Ferrari, Giulio Sozzi, Simone Ferrero, Mirjam Druškovič, Tanja Premru-Srsen, Leonardo Borrello, Fabiana Cecchini D, George Daskalakis, Giuliano Petriglia, Caroline Kadji, Felipe Mercado-Olivares, Zeliha Atak, Aylin Pelin Cil, Claudio Gustavino, Axelle Pintiaux, Pantaleo Greco, Rita Figueiredo, Stefano Cosma, Ludovica Puri, Valentina Esposito, Anupam Parange, Simone Garzon, Alessandra Gatti, Ioannis Kyvernitakis, Roberto Brunelli, Maddalena Morlando, Attilio Di Spiezio Sardo, Ignacio Cueto Hernández, Giuseppe Zoccali, Brian Rodriguez, Antonio Mollo, Flaminia Vena, Cihat Sen, Ciuhodaru Madalina, Felice Sorrentino, Francesca Di Sebastiano, Gennady T. Sukhikh, Ilma Floriana Carbone, Andrea Villasco, Blanka Zlatohlavkova, Gabriele Saccone, Erasmo Huertas, Marcel Malan, Leonardo Gucciardo, Eutalia Esposito, Otto Henrique May Feuerschuette, Sarah Dollinger, María de Los Angeles Anaya Baz, Jun Yoshimatsu, Sifa Turan, Vincente Diago, Alicia Yeliz Aykanat, Ignacio Herraiz, Javier Alfonso Schvartzman, Diego Gazzolo, Natalina Buono, Milan Stanojević, Erich Cosmi, Valentina De Robertis, Elena Costa, Angelo Cagnacci, Eleonora Valori, Nicoletta Biglia, Şerife Özlem Genç, Vincenzo Berghella, Francesco Maria Colaleo, Esther Vanessa Aguilar Galán, Gabriela Loscalzo, Marco Palumbo, Fabrizio Sandri, Irmeli Nupponen, Antonio Lanzone, Juan Antonio De León Luis, Amos Grunebaum, Giuseppe Bifulco, Marinella Lenzi, Serena Xodo, Fulvio Zullo, Ozhan Turan, Josefine Königbauer, Anna Luengo Piqueras, Nicola Volpe, Holger Maul, Chiara Taccaliti, Juan Manuel Burgos-Luna, Giovanni Sisti, Rosanna Esposito, Alfredo Ercoli, Panos Antsaklis, Dolores Esteban Oliva, Aly Youssef, Pedro Viana Pinto, Alberto Galindo, Asim Kurjak, Erhan Okuyan, Roberto Angioli, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Massimo Franchi, Maria Carmela Di Dedda, Giovanni Gerosolima, Francesco D'Antonio, Caroline Daelemans, Quintino Cesare Ianniciello, Pasquale De Franciscis, Maurizio Guida, Maria Cristina Rovellotti, Liana Ples, Frank A. Chervenak, Nicola Colacurci, Lilijana Kornhauser Cerar, Zulfiya Khodjaeva, Valentina Longo, Francesca Stollagli, Daniele Di Mascio, Mariavittoria Locci, Amadeo Sanchez, Angelo Sirico, Stefania Fieni, Rebeca Garrote Molpeceres, Pierluigi Benedetti Panici, Vito Chiantera, Esra Tustas Haberal, Liviu Cojocaru, Maria Elena Flacco, Antonella Cromi, Roberta Granese, Antonio Simone Laganà, Maria Giulia Lombana Marino, Silvia Visentin, Beatrice Bianchi, Roberta Venturella, Federica Laraud, Amanda Bermejo, Reyhan Gündüz, Marina Moucho, Zita Maria Gambacorti-Passerini, Danila Morano, Pedro Arango, Francesca Della Sala, Gaetana Di Donna, Jesús S Jimenez Lopez, Mariano Catello Di Donna, Giuliana Simonazzi, Snezana Zdjelar, Vedran Stefanovic, Cecilia Villalain, Antonio Coviello, Lars Hellmeyer, Antonella Giancotti, Elisa Bevilacqua, Igor Samardjiski, Riccardo Buscemi, Arianna Ramone, Marco Cerbone, Lorenza Driul, Danilo Buca, Tiziana Frusca, Elisa Done, Marco Liberati, José Morales Roselló, Fabio Ghezzi, Lorenzo Vasciaveo, Bernd Froessler, Alejandro Pittaro, Yolanda Cuñarro López, Andrew Carlin, Sakine Rahimli Ocakouglu, Giorgia Gattei, I. Cataneo, María José Suárez, Giada Ameli, Lamberto Manzoli, Kaisa Nelskylä, Ludovico Muzii, Peter Palm, Olus Api, Elisa Cueto, Martina Leombroni, Ksenia A. Gorina, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Children's Hospital, HUS Children and Adolescents, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı, Gündüz, Reyhan, Di Mascio D., Sen C., Saccone G., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., De Los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., De Leon Luis J.A., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Della Gatta A.N., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Fabiana Cecchini D., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Della Sala F., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Vasciaveo L., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Di Tizio L., Gazzolo D., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Pinto P.V., Figueiredo R., Rosello J.M., Loscalzo G., Martinez-Varea A., Diago V., Lopez J.S.J., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., De Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Sinai N.A.B., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Cerar L.K., Druskovie M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Mollo A., Nazzaro G., Locci M., Guida M., Di Spiezio Sardo A., Panici P.B., Berghella V., Flacco M.E., Manzoli L., Bifulco G., Scambia G., Zullo F., D'Antonio F., Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, Stanojevic M, Kurjak A, Chervenak F, Rodríguez Suárez MJ, Gambacorti-Passerini ZM, Baz MLAA, Aguilar Galán EV, López YC, De León Luis JA, Hernández IC, Herraiz I, Villalain C, Venturella R, Rizzo G, Mappa I, Gerosolima G, Hellmeyer L, Königbauer J, Ameli G, Frusca T, Volpe N, Luca Schera GB, Fieni S, Esposito E, Simonazzi G, Di Donna G, Youssef A, Della Gatta AN, Di Donna MC, Chiantera V, Buono N, Sozzi G, Greco P, Morano D, Bianchi B, Lombana Marino MG, Laraud F, Ramone A, Cagnacci A, Barra F, Gustavino C, Ferrero S, Ghezzi F, Cromi A, Laganà AS, Laurita Longo V, Stollagli F, Sirico A, Lanzone A, Driul L, Cecchini D F, Xodo S, Rodriguez B, Mercado-Olivares F, Elkafrawi D, Sisti G, Esposito R, Coviello A, Cerbone M, Morlando M, Schiattarella A, Colacurci N, De Franciscis P, Cataneo I, Lenzi M, Sandri F, Buscemi R, Gattei G, Sala FD, Valori E, Rovellotti MC, Done E, Faron G, Gucciardo L, Esposito V, Vena F, Giancotti A, Brunelli R, Muzii L, Nappi L, Sorrentino F, Vasciaveo L, Liberati M, Buca D, Leombroni M, Di Sebastiano F, Di Tizio L, Gazzolo D, Franchi M, Ianniciello QC, Garzon S, Petriglia G, Borrello L, Nieto-Calvache AJ, Burgos-Luna JM, Kadji C, Carlin A, Bevilacqua E, Moucho M, Pinto PV, Figueiredo R, Roselló JM, Loscalzo G, Martinez-Varea A, Diago V, Jimenez Lopez JS, Aykanat AY, Cosma S, Carosso A, Benedetto C, Bermejo A, May Feuerschuette OH, Uyaniklar O, Ocakouglu SR, Atak Z, Gündüz R, Haberal ET, Froessler B, Parange A, Palm P, Samardjiski I, Taccaliti C, Okuyan E, Daskalakis G, Moreira de Sa RA, Pittaro A, Gonzalez-Duran ML, Guisan AC, Genç ŞÖ, Zlatohlávková B, Piqueras AL, Oliva DE, Cil AP, Api O, Antsaklis P, Ples L, Kyvernitakis I, Maul H, Malan M, Lila A, Granese R, Ercoli A, Zoccali G, Villasco A, Biglia N, Madalina C, Costa E, Daelemans C, Pintiaux A, Cueto E, Hadar E, Dollinger S, Brzezinski Sinai NA, Huertas E, Arango P, Sanchez A, Schvartzman JA, Cojocaru L, Turan S, Turan O, Di Dedda MC, Molpeceres RG, Zdjelar S, Premru-Srsen T, Cerar LK, Druškovič M, De Robertis V, Stefanovic V, Nupponen I, Nelskylä K, Khodjaeva Z, Gorina KA, Sukhikh GT, Maruotti GM, Visentin S, Cosmi E, Ferrari J, Gatti A, Luvero D, Angioli R, Puri L, Palumbo M, D'Urso G, Colaleo F, Chiara Rapisarda AM, Carbone IF, Mollo A, Nazzaro G, Locci M, Guida M, Di Spiezio Sardo A, Panici PB, Berghella V, Flacco ME, Manzoli L, Bifulco G, Scambia G, Zullo F, D'Antonio F, Di Mascio, D., Sen, C., Saccone, G., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., De Los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., De Leon Luis, J. A., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Della Gatta, A. N., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Fabiana Cecchini, D., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Della Sala, F., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Vasciaveo, L., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Di Tizio, L., Gazzolo, D., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Pinto, P. V., Figueiredo, R., Rosello, J. M., Loscalzo, G., Martinez-Varea, A., Diago, V., Lopez, J. S. J., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., De Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Sinai, N. A. B., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Cerar, L. K., Druskovie, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Mollo, A., Nazzaro, G., Locci, M., Guida, M., Di Spiezio Sardo, A., Panici, P. B., Berghella, V., Flacco, M. E., Manzoli, L., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., Di Mascio, Daniele, Sen, Cihat, Saccone, Gabriele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Rodríguez Suárez, María José, Gambacorti-Passerini, Zita Maria, Baz, María de Los Angeles Anaya, Aguilar Galán, Esther Vanessa, López, Yolanda Cuñarro, De León Luis, Juan Antonio, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Luca Schera, Giovanni Battista, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Della Gatta, Anna Nunzia, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Lombana Marino, Maria Giulia, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini D, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado-Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Vasciaveo, Lorenzo, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Di Tizio, Luciano, Gazzolo, Diego, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto-Calvache, Albaro Josè, Burgos-Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Pinto, Pedro Viana, Figueiredo, Rita, Roselló, José Morale, Loscalzo, Gabriela, Martinez-Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, May Feuerschuette, Otto Henrique, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, Moreira de Sa, Renato Augusto, Pittaro, Alejandro, Gonzalez-Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Yapar Eyi, Elif Gül, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski Sinai, Noa A, Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru-Srsen, Tanja, Cerar, Lilijana Kornhauser, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A, Sukhikh, Gennady T, Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Chiara Rapisarda, Agnese Maria, Carbone, Ilma Floriana, Mollo, Antonio, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Di Spiezio Sardo, Attilio, Panici, Pierluigi Benedetti, Berghella, Vincenzo, Flacco, Maria Elena, Manzoli, Lamberto, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, and D'Antonio, Francesco

Subjects
COVID-19 Vaccine, Infectious Disease Transmission, Perinatal Death, Abortion, Clinical Laboratory Technique, Miscarriage, Cohort Studies, 0302 clinical medicine, COVID-19 Testing, Pregnancy, Risk Factors, 3123 Gynaecology and paediatrics, Secondary analysis, Perinatal medicine, Abortion, Spontaneou, Medicine, Vertical, 030212 general & internal medicine, Viral, Pregnancy Complications, Infectious, coronavirus, perinatal morbidity, perinatal mortality, covid-19, Coronavirus, Abortion, Spontaneous, COVID-19, COVID-19 Vaccines, Clinical Laboratory Techniques, Coronavirus Infections, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Infectious Disease Transmission, Vertical, Pandemics, Pneumonia, Viral, Pregnancy Outcome, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Betacoronavirus, Fetal Death, 030219 obstetrics & reproductive medicine, Obstetrics, Infectious, Gestational age, Obstetrics and Gynecology, 3. Good health, Settore MED/40, Gestation, Human, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Coronaviru, Socio-culturale, Intrauterine device, 03 medical and health sciences, PARVOVIRUS B19 INFECTION, Coronavirus, perinatal morbidity, perinatal mortality, Adverse effect, Premature, Fetus, Betacoronaviru, Pandemic, Coronavirus Infection, business.industry, Risk Factor, Spontaneous, MORTALITY, Infant, Odds ratio, Pneumonia, medicine.disease, Newborn, Pregnancy Complications, Pediatrics, Perinatology and Child Health, Pregnancy Complications, Infectiou, Cohort Studie, business
Abstract

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6±9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8–0.9 per week increase; p Conclusions Early gestational age at infection, maternal ventilatory supports and low birthweight are the main determinants of adverse perinatal outcomes in fetuses with maternal COVID-19 infection. Conversely, the risk of vertical transmission seems negligible.

Published
2021

46. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Author

Di Mascio Daniele, Gabriele, Saccone, Cihat, Sen, Daniele Di Mascio, Alberto, Galindo, Amos, Grünebaum, Jun, Yoshimatsu, Milan, Stanojevic, Asım, Kurjak, Frank, Chervenak, María José Rodríguez Suárez, Zita Maria Gambacorti-Passerini, María de Los Angeles Anaya Baz, Esther Vanessa Aguilar Galán, Yolanda Cuñarro López, Juan Antonio De León Luis, Ignacio Cueto Hernández, Ignacio, Herraiz, Cecilia, Villalain, Roberta, Venturella, Rizzo, GIUSEPPE DAVIDE, Ilenia, Mappa, Giovanni, Gerosolima, Lars, Hellmeyer, Josefine, Königbauer, Giada, Ameli, Tiziana, Frusca, Nicola, Volpe, Giovanni Battista Luca Schera, Stefania, Fieni, Eutalia, Esposito, Giuliana, Simonazzi, Gaetana Di Donna, Aly, Youssef, Anna Nunzia Della Gatta, Mariano Catello Di Donna, Vito, Chiantera, Natalina, Buono, Giulio, Sozzi, Pantaleo, Greco, Danila, Morano, Beatrice, Bianchi, Maria Giulia Lombana Marino, Federica, Laraud, Arianna, Ramone, Angelo, Cagnacci, Fabio, Barra, Claudio, Gustavino, Ferrero, Simone, Fabio, Ghezzi, Antonella, Cromi, Antonio Simone Laganà, Valentina Laurita Longo, Francesca, Stollagli, Angelo, Sirico, Antonio, Lanzone, Lorenza, Driul, Fabiana, Cecchini, Serena, Xodo, Brian, Rodriguez, Felipe, Mercado-Olivares, Deena, Elkafrawi, Giovanni, Sisti, Rosanna, Esposito, Antonio, Coviello, Marco, Cerbone, Maddalena, Morlando, Antonio, Schiattarella, Nicola, Colacurci, Pasquale De Franciscis, Ilaria, Cataneo, Marinella, Lenzi, Fabrizio, Sandri, Riccardo, Buscemi, Giorgia, Gattei, Francesca Della Sala, Eleonora, Valori, Maria Cristina Rovellotti, Elisa, Done, Gilles, Faron, Leonardo, Gucciardo, Esposito, Valentina, Flaminia, Vena, Antonella, Giancotti, Roberto, Brunelli, Ludovico, Muzii, Luigi, Nappi, Felice, Sorrentino, Marco, Liberati, Danilo, Buca, Martina, Leombroni, Francesca Di Sebastiano, Massimo, Franchi, Quintino Cesare Ianniciello, Simone, Garzon, Giuliano, Petriglia, Leonardo, Borrello, Albaro Josè Nieto-Calvache, Juan Manuel Burgos-Luna, Caroline, Kadji, Andrew, Carlin, Elisa, Bevilacqua, Marina, Moucho, Pedro, Viana, Rita, Figueiredo, José Morales Roselló, Gabriela, Loscalzo, Alicia, Martinez-Varea, Vincente, Diago, Jesús, S Jimenez Lopez, Alicia Yeliz Aykanat, Cosma, Stefano Domenico, Carosso, ANDREA ROBERTO, Benedetto, Chiara, Amanda, Bermejo, Otto Henrique May Feuerschuette, Ozlem, Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha, Atak, Reyhan, Gündüz, Esra Tustas Haberal, Bernd, Froessler, Anupam, Parange, Peter, Palm, Igor, Samardjiski, Chiara, Taccaliti, Erhan, Okuyan, George, Daskalakis, Renato Augusto Moreira de Sa, Alejandro, Pittaro, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Şerife Özlem Genç, Blanka, Zlatohlávková, Anna Luengo Piqueras, Dolores Esteban Oliva, Aylin Pelin Cil, Olus, Api, Panos, Antsaklis, Liana, Ples, Ioannis, Kyvernitakis, Holger, Maul, Marcel, Malan, Albert, Lila, Roberta, Granese, Alfredo, Ercoli, Giuseppe, Zoccali, Villasco, Andrea, Biglia, Nicoletta, Ciuhodaru, Madalina, Costa, Elena, Caroline, Daelemans, Axelle, Pintiaux, Elif Gül Yapar Eyi, Elisa, Cueto, Eran, Hadar, Sarah, Dollinger, Noa, A Brzezinski-Sinai, Erasmo, Huertas, Pedro, Arango, Amadeo, Sanchez, Javier Alfonso Schvartzman, Liviu, Cojocaru, Sifa, Turan, Ozhan, Turan, Maria Carmela Di Dedda, Rebeca Garrote Molpeceres, Snezana, Zdjelar, Tanja, Premru-Srsen, Lilijana, Kornhauser-Cerar, Mirjam, Druškovič, Valentina De Robertis, Vedran, Stefanovic, Irmeli, Nupponen, Kaisa, Nelskylä, Zulfiya, Khodjaeva, Ksenia, A Gorina, Gennady, T Sukhikh, Giuseppe Maria Maruotti, Silvia, Visentin, Erich, Cosmi, Jacopo, Ferrari, Alessandra, Gatti, Daniela, Luvero, Roberto, Angioli, Ludovica, Puri, Marco, Palumbo, Giusella, D'Urso, Francesco, Colaleo, Agnese Maria Chiara Rapisarda, Ilma Floriana Carbone, Manzoli, Lamberto, Maria Elena Flacco, Giovanni, Nazzaro, Mariavittoria, Locci, Maurizio, Guida, Attilio Di Spiezio Sardo, Pierluigi Benedetti Panici, Asma, Khalil, Vincenzo, Berghella, Giuseppe, Bifulco, Giovanni, Scambia, Fulvio, Zullo, Francesco, D'Antonio, Saccone, Gabriele, Sen, Cihat, Di Mascio, Daniele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Suárez, María José Rodríguez, Gambacorti‐Passerini, Zita Maria, de los Angeles Anaya Baz, María, Galán, Esther Vanessa Aguilar, López, Yolanda Cuñarro, Luis, Juan Antonio De León, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Schera, Giovanni Battista Luca, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Gatta, Anna Nunzia Della, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado‐Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto‐Calvache, Albaro Josè, Burgos‐Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Viana Pinto, Pedro, Figueiredo, Rita, Morales Roselló, José, Loscalzo, Gabriela, Martinez‐Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, Feuerschuette, Otto Henrique May, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Gündüz, Reyhan, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, de Sa, Renato Augusto Moreira, Pittaro, Alejandro, Gonzalez‐Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Eyi, Elif Gül Yapar, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski‐Sinai, Noa A., Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru‐Srsen, Tanja, Kornhauser‐Cerar, Lilijana, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A., Sukhikh, Gennady T., Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Rapisarda, Agnese Maria Chiara, Carbone, Ilma Floriana, Manzoli, Lamberto, Flacco, Maria Elena, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Sardo, Attilio Di Spiezio, Panici, Pierluigi Benedetti, Khalil, Asma, Berghella, Vincenzo, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, D'Antonio, Francesco, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve DoğumAna Bilim Dalı, University of Helsinki, Department of Obstetrics and Gynecology, HUS Gynecology and Obstetrics, HUS Children and Adolescents, Children's Hospital, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Saccone, G., Sen, C., Di Mascio, D., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., de los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., Luis, J. A. D. L., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Gatta, A. N. D., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Cecchini, F., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Sala, F. D., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Viana Pinto, P., Figueiredo, R., Morales Rosello, J., Loscalzo, G., Martinez-Varea, A., Diago, V., Jimenez Lopez, J. S., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., de Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Brzezinski-Sinai, N. A., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Kornhauser-Cerar, L., Druskovic, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Manzoli, L., Flacco, M. E., Nazzaro, G., Locci, M., Guida, M., Sardo, A. D. S., Panici, P. B., Khalil, A., Berghella, V., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., José Rodríguez Suárez, María, Maria Gambacorti-Passerini, Zita, de Los Angeles Anaya Baz, María, Vanessa Aguilar Galán, Esther, Cuñarro López, Yolanda, Antonio De León Luis, Juan, Cueto Hernández, Ignacio, Battista Luca Schera, Giovanni, Nunzia Della Gatta, Anna, Catello Di Donna, Mariano, Giulia Lombana Marino, Maria, Simone Laganà, Antonio, Laurita Longo, Valentina, Mercado-Olivares, Felipe, Della Sala, Francesca, Cristina Rovellotti, Maria, Cesare Ianniciello, Quintino, Josè Nieto-Calvache, Albaro, Manuel Burgos-Luna, Juan, Viana, Pedro, Martinez-Varea, Alicia, S Jimenez Lopez, Jesú, Yeliz Aykanat, Alicia, DI BENEDETTO, Chiara, Henrique May Feuerschuette, Otto, Rahimli Ocakouglu, Sakine, Tustas Haberal, Esra, Augusto Moreira de Sa, Renato, Luisa Gonzalez-Duran, Maria, Concheiro Guisan, Ana, Özlem Genç, Şerife, Luengo Piqueras, Anna, Esteban Oliva, Dolore, Pelin Cil, Aylin, Gül Yapar Eyi, Elif, A Brzezinski-Sinai, Noa, Alfonso Schvartzman, Javier, Carmela Di Dedda, Maria, Garrote Molpeceres, Rebeca, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, A Gorina, Ksenia, T Sukhikh, Gennady, Maruotti, GIUSEPPE MARIA, Maria Chiara Rapisarda, Agnese, Floriana Carbone, Ilma, Elena Flacco, Maria, DI SPIEZIO SARDO, Attilio, Benedetti Panici, Pierluigi, Saccone G., Sen C., Di Mascio D., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., de los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., Luis J.A.D.L., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Gatta A.N.D., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Cecchini F., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Sala F.D., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Viana Pinto P., Figueiredo R., Morales Rosello J., Loscalzo G., Martinez-Varea A., Diago V., Jimenez Lopez J.S., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., de Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Brzezinski-Sinai N.A., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Kornhauser-Cerar L., Druskovic M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Manzoli L., Flacco M.E., Nazzaro G., Locci M., Guida M., Sardo A.D.S., Panici P.B., Khalil A., Berghella V., Bifulco G., Scambia G., Zullo F., D'Antonio F., Mother and Child, Surgical clinical sciences, Obstetrics, and Clinical sciences

Subjects
COVID19, medicine.medical_treatment, coronavirus, COVID-19, infection, pregnancy, SARS-CoV-2, Abortion, infectious diseases, law.invention, Cohort Studies, 0302 clinical medicine, law, 3123 Gynaecology and paediatrics, Pregnancy, Obstetrics and Gynaecology, 030212 general & internal medicine, Pregnancy Complications, Infectious, 030219 obstetrics & reproductive medicine, Radiological and Ultrasound Technology, Transmission (medicine), Obstetrics, Pregnancy Outcome, Obstetrics and Gynecology, Coronavirus, SARS-COV-2, General Medicine, Disease 2019 Covid-19, Intensive care unit, 3. Good health, Hospitalization, Intensive Care Units, Maternal Mortality, Settore MED/40, Radiology Nuclear Medicine and imaging, Gestation, Female, coronavirus, Pandemics, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Respiration, Artificial, Retrospective Studies, SARS-CoV-2, COVID-19, Infant, Newborn, Intensive Care Units,Maternal Mortality, Infection, Cohort study, Adult, medicine.medical_specialty, NO, 03 medical and health sciences, medicine, Humans, Radiology, Nuclear Medicine and imaging, Pandemics, Retrospective Studies, Mechanical ventilation, business.industry, Infant, Newborn, Infant, Retrospective cohort study, medicine.disease, Respiration, Artificial, coronaviru, Reproductive Medicine, business
Abstract

WOS:000613461600006 PubMed ID: 32926494 Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.

Published
2021

47. Omega-3 fatty acids during adolescence prevent schizophrenia-related behavioural deficits: Neurophysiological evidences from the prenatal viral infection with PolyI:C

Author

Karina S. MacDowell, Celso Arango, Ana Romero-Miranda, Manuel Desco, Diego Romero-Miguel, Juan C. Leza, Jose Antonio Garcia-Partida, Esther Berrocoso, Vanessa Gómez-Rangel, Marta Casquero-Veiga, Nicolás Lamanna-Rama, María Luisa Soto-Montenegro, and Sonia Torres-Sanchez

Subjects
Male, medicine.medical_specialty, NF-E2-Related Factor 2, Offspring, Anti-Inflammatory Agents, Hippocampus, Inflammation, Hippocampal formation, medicine.disease_cause, Neuroprotection, Antioxidants, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, Fatty Acids, Omega-3, medicine, Animals, Pharmacology (medical), Rats, Wistar, Biological Psychiatry, Prepulse inhibition, Pharmacology, Kelch-Like ECH-Associated Protein 1, business.industry, medicine.disease, Rats, 030227 psychiatry, Disease Models, Animal, Psychiatry and Mental health, Poly I-C, Endocrinology, Neurology, Virus Diseases, Schizophrenia, Prenatal Exposure Delayed Effects, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, Oxidative stress
Abstract

The likely involvement of inflammation and oxidative stress (IOS) in mental disease has led to advocate anti-oxidant and anti-inflammatory drugs as therapeutic strategies in the treatment of schizophrenia. Since omega-3 fatty acids (ω-3) show anti-inflammatory/neuroprotective properties, we aim to evaluate whether ω-3 treatment during adolescence in the maternal immune stimulation (MIS) animal model of schizophrenia could prevent the brain and behavioural deficits described in adulthood. At gestational day 15, PolyI:C (4 mg/kg) or saline (VH) were injected to pregnant Wistar rats. Male offspring received ω-3 (800 mg/kg) or saline (Sal) daily from postnatal day (PND) 35-49, defining 4 groups: MIS-ω-3; MIS-Sal; VH-ω-3 and VH-Sal. At PND70, rats were submitted to prepulse inhibition test (PPI). FDG-PET and T2-weighted MRI brain studies were performed in adulthood and analyzed by means of SPM12. IOS markers were measured in selected brain areas. MIS-offspring showed a PPI deficit compared with VH-offspring and ω-3 treatment prevented this deficit. Also, ω-3 reduced the brain metabolism in the deep mesencephalic area and prevented the volumetric abnormalities in the hippocampus but not in the ventricles in MIS-offspring. Besides, ω-3 reduced the expression of iNOS and Keap1 and increased the activity/concentration of HO1, NQO1 and GPX. Our study demonstrates that administration of ω-3 during adolescence prevents PPI behavioural deficits and hippocampal volumetric abnormalities, and partially counteracts IOS deficits via iNOS and Nrf2-ARE pathways in the MIS model. This study highlights the need for novel strategies based on anti-inflammatory/anti-oxidant compounds to alter the disease course in high-risk populations at early stages.

Published
2021

48. Heritability of perching behavior and its genetic relationship with incidence of floor eggs in Rhode Island Red chickens

Author

Anna Wolc, Kaylee Rowland, Jack C. M. Dekkers, Janet E. Fulton, Petek Settar, Danny Lubritz, and Jesus Arango

Subjects
Oviposition, Genetic relationship, Biology, QH426-470, Genetic correlation, SF1-1100, 03 medical and health sciences, Behavioral traits, Animal science, Quantitative Trait, Heritable, Genetics, Animals, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 0303 health sciences, Polymorphism, Genetic, Behavior, Animal, Models, Genetic, Incidence (epidemiology), 0402 animal and dairy science, 04 agricultural and veterinary sciences, General Medicine, Heritability, 040201 dairy & animal science, Animal culture, Random regression, Genetic selection, Animal Science and Zoology, Female, Chickens, Research Article
Abstract

Background As cage-free production systems become increasingly popular, behavioral traits such as nesting behavior and temperament have become more important. The objective of this study was to estimate heritabilities for frequency of perching and proportion of floor eggs and their genetic correlation in two Rhode Island Red lines. Results The percent of hens observed perching tended to increase and the proportion of eggs laid on the floor tended to decrease as the test progressed. This suggests the ability of hens to learn to use nests and perches. Under the bivariate repeatability model, estimates of heritability in the two lines were 0.22 ± 0.04 and 0.07 ± 0.05 for the percent of hens perching, and 0.52 ± 0.05 and 0.45 ± 0.05 for the percent of floor eggs. Estimates of the genetic correlation between perching and floor eggs were − 0.26 ± 0.14 and − 0.19 ± 0.27 for the two lines, suggesting that, genetically, there was some tendency for hens that better use perches to also use nests; but the phenotypic correlation was close to zero. Random regression models indicated the presence of a genetic component for learning ability. Conclusions In conclusion, perching and tendency to lay floor eggs were shown to be a learned behavior, which stresses the importance of proper management and training of pullets and young hens. A significant genetic component was found, confirming the possibility to improve nesting behavior for cage-free systems through genetic selection.

Published
2021

49. Acute surgical‐like abdomen as a gastrointestinal manifestation of COVID-19 infection: a case report in Colombia

Author

Fernando Sierra-Arango, Mariana Vásquez-Roldan, Cathalina Vergara-Cabra, and Erika D. Pérez-Riveros

Subjects
Adult, medicine.medical_specialty, Abdominal pain, Pediatrics, Physical examination, Case Report, Disease, RC799-869, Colombia, Surgical pathology, Acute abdomen, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, Medicine, Humans, Abdomen, Acute, medicine.diagnostic_test, business.industry, SARS-CoV-2, Gastroenterology, COVID-19, General Medicine, Hepatology, Diseases of the digestive system. Gastroenterology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Surgical Procedure, Abdomen, 030211 gastroenterology & hepatology, Female, medicine.symptom, business
Abstract

Background The SARS-CoV-2 pandemic is a considerable public health problem, which has caused a burden on health systems in many countries. Despite the existence of multiple studies on the different digestive symptoms and their relationship with this disease, it is still vital to highlight the severity of the different symptoms, the need to diagnose it properly and quickly. Currently in Colombia there are no writings that highlight the above. Case presentation This article reports the case of a 37-year-old female patient, with no important history, who consulted for 10 h of a generalized intense abdominal pain, of sudden onset, associated with multiple stools of diarrheal consistency, and no respiratory symptoms and no epidemiological exposure. Physical examination with intense pain in the colic frame with tenderness. It was decided to rule out surgical pathology and a CT scan was performed finding no evidence of acute intra-abdominal pathology, but with a peripheral alveolar, and ground-glass opacities at lung bases, classic COVID-19 radiological pattern, confirmed by a positive RT-PCR for SARS-CoV-2, leading to consider that the gastrointestinal symptoms were secondary to this infection. Symptomatic management was given with subsequent improvement. Conclusions It is extremely important to present this first case report of a young female COVID-19 patient with an acute abdominal pain as the main clinical manifestation, that almost culminates in a surgical procedure; demonstrating the scope of gastrointestinal symptoms secondary to SARS-CoV-2 infection.

Published
2021

50. The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis

Author

Angela Ibáñez, Leticia León-Quismondo, Manuel Durán-Cutilla, Lucía Albarracin-García, Itziar Leal, Dolores Saiz-González, Marina Díaz-Marsá, Juan C. Leza, Enrique Baca-García, Julia García-Albea, Ana Izquierdo, Maria Cabello, Blanca Mellor-Marsá, Ainoa Muñoz-Sanjose, Roberto Rodriguez-Jimenez, María Fe Bravo-Ortiz, Pilar Lopez-Garcia, Patricia Fernández-Martín, Helena Melero, Jessica Merchán-Naranjo, Roberto Mediavilla-Torres, Norberto Malpica, Karina S. MacDowell, Celso Arango, Natalia E. Fares-Otero, José Luis Ayuso-Mateos, Pablo Puras-Rico, Miriam Ayora, Covadonga M. Díaz-Caneja, Luis Sanchez-Pastor, Mónica Dompablo, and UAM. Departamento de Psiquiatría

Subjects
Adult, Male, Longitudinal study, Psychosis, Adolescent, Medicina, Population, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Intervention (counseling), medicine, Humans, Longitudinal Studies, Functioning, education, Biological Psychiatry, First episode, education.field_of_study, Positive and Negative Syndrome Scale, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Psychotic Disorders, First episode of psychosis, Quality of Life, Female, Network analysis, Observational study, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract

The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this population, This work was supported by the Madrid Regional Government (R&D activities in Biomedicine (grant number S2017/BMD-3740 - AGES-CM 2-CM)) and Structural Funds of the European Union. Ana Izquierdo’s work is supported by the PFIS predoctoral program (FI17/00138) from the Instituto de Salud Carlos III (Spain) and co-funded by the European Union (ERDF/ESF, "A way to make Europe”/ “Investing in your future”) and The Biomedical Research Foundation of La Princesa University Hospital. Angela Ib´a˜nez thanks the support of CIBERSAM and of the Spanish Ministry of Science, Innovation and Universities. Instituto de Salud Carlos III (PI16/00834 and PI19/01295) co-financed by ERDF Funds from the European Commission. Covadonga M. Díaz-Caneja holds a Juan Rod´es Grant from Instituto de Salud Carlos III (JR19/00024). Celso Arango was supported by the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/ 024), co-financed by ERDF Funds from the European Commission, “A way of making Europe”, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union Seventh Framework Program under grant agreements FP7-4-HEALTH-2009-2.2.1-2-241909 (Project EU-GEI), FP7- HEALTH- 2013-2.2.1-2-603196 (Project PSYSCAN) and FP7- HEALTH-2013- 2.2.1-2-602478 (Project METSY); and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No 115916, Project PRISM, and grant agreement No 777394, Project AIMS-2-TRIALS), Fundaci´on Familia Alonso, Fundaci´on Alicia Koplowitz and Fundaci´on Mutua Madrile˜na

Published
2021

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