1. Mother's milk microbiota is associated with the developing gut microbial consortia in very-low-birth-weight infants.
- Author
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Shama S, Asbury MR, Kiss A, Bando N, Butcher J, Comelli EM, Copeland JK, Greco A, Kothari A, Sherman PM, Stintzi A, Taibi A, Tomlinson C, Unger S, Wang PW, and O'Connor DL
- Subjects
- Humans, Female, Infant, Newborn, Microbial Consortia, Breast Feeding, Adult, Male, Bacteria classification, Bacteria genetics, Bacteria isolation & purification, Infant, Premature, Mothers, Milk, Human microbiology, Infant, Very Low Birth Weight, Gastrointestinal Microbiome physiology, Feces microbiology
- Abstract
Mother's milk contains diverse bacterial communities, although their impact on microbial colonization in very-low-birth-weight (VLBW, <1,500 g) infants remains unknown. Here, we examine relationships between the microbiota in preterm mother's milk and the VLBW infant gut across initial hospitalization (n = 94 mother-infant dyads, 422 milk-stool pairs). Shared zero-radius operational taxonomic units (zOTUs) between milk-stool pairs account for ∼30%-40% of zOTUs in the VLBW infant's gut. We show dose-response relationships between intakes of several genera from milk and their concentrations in the infant's gut. These relationships and those related to microbial sharing change temporally and are modified by in-hospital feeding practices (especially direct breastfeeding) and maternal-infant antibiotic use. Correlations also exist between milk and stool microbial consortia, suggesting that multiple milk microbes may influence overall gut communities together. These results highlight that the mother's milk microbiota may shape the gut colonization of VLBW infants by delivering specific bacteria and through intricate microbial interactions., Competing Interests: Declaration of interests E.M.C. acknowledges research support from Lallemand Health Solutions and Ocean Spray and consultant fees, speaker, and/or travel support from Danone, Nestlé, and Lallemand Health Solutions. P.M.S. is a stockholder and an advisory board member for Antibe Therapeutics Inc. A.S. is a co-founder of MedBiome, a clinical microbiomics company., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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