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Gene selection is a pivotal process in machine-learning-driven medical diagnostics, where the goal is to identify a subset of genes from microarray expression profiles that can enhance the predictive accuracy of classifiers for disease diagnosis. The two key objectives of gene selection are to reduce the dimensionality of the data and to improve the accuracy of disease diagnosis, which is typically a multi-objective optimization problem. In recent years, multi-objective evolutionary algorithms (MOEAs) have gained wide attention in feature selection research, and several related algorithms have been produced. However, most algorithms tend to get stuck in local optimality when searching for solutions from a high-dimensional space. To solve the gene selection problem effectively, this study introduces a recursive multi-objective differential evolution algorithm with elite recursive strategy (RMODE-E) and a recursive multi-objective differential evolution algorithm with Pareto front recursive strategy (RMODE-P). RMODE-E amalgamates the features selected by the top E elite individuals, RMODE-P consolidates the features selected by the Pareto front set, and the combined features then serve as the foundation for subsequent recursive rounds of searching. The proposed feature subspace combination strategy not only reduces the recursive search space but also improves the capacity to find globally optimal feature subsets. Extensive experiments were conducted to compare our proposed algorithms with eight state-of-the-art evolutionary algorithms to validate their effectiveness. Experimental results demonstrate that RMODE-P has better global search capability as it achieves better best classification accuracy, mean classification accuracy , and minimal gene subset size. [ABSTRACT FROM AUTHOR]

• MMODE is developed as a new hybrid gene selection method for tumor identification. • MMODE combines multi-tasking and multi-objective frameworks. • MMODE uses a new elite strategy and a new guidance strategy. • MMODE selects a few genes and achieves high classification accuracy. A key preprocessing step in tumor recognition based on microarray expression profile data and machine learning is to identify tumor marker genes. Gene selection aims to select the most relevant gene subset from the original ultra-high dimensional microarray expression profile data to improve tumor identification performance. Inspired by evolutionary multitasking (EMT) and multi-objective optimization, this paper puts forward a novel multitasking multi-objective differential evolution gene selection algorithm (MMODE) which uses new elite and guidance strategies to select the best gene subsets. MMODE initializes two different populations according to different filtering criteria to increase the diversity of the search. These two populations guide their respective populations to search in the optimal direction through knowledge transfer in the evolutionary process. In addition, MMODE employs new elite and guidance strategies that enables individuals to narrow the search range and jump out of local optima. The proposed algorithm is validated on 13 publicly available microarray expression datasets in comparison with state-of-the-art gene selection algorithms. The experimental results show that MMODE can find smaller gene subsets and achieve higher classification accuracy compared with other algorithms. [ABSTRACT FROM AUTHOR]