Search

Your search keyword '"Şenışık, A. M."' showing total 3 results
Start Over Author "Şenışık, A. M." Topic fdg
3 results on '"Şenışık, A. M."'

2. One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study.

Author

Şenışık, A. M., İçhedef, Ç., Kılçar, A. Y., Uçar, E., Arı, K., Göksoy, D., Parlak, Y., Sayıt Bilgin, Bedriye Elvan, and Teksöz, S.

Subjects
*GLYCINE, *RADIOLABELING, *CHEMOSELECTIVITY, *POSITRON emission tomography, *RADIOPHARMACEUTICALS
Abstract

This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [18F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [18F]FDG solution. The radiolabeled product ([18F]FDG-GlyGly) was obtained with 98.65 ± 0.35% yield without any purification step which makes this method more attractive for 18F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [18F]FDG tagged GlyGly in vivo. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

3. One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

Author

Çiğdem İçhedef, Ahmet Murat Senisik, D. Göksoy, Ayfer Yurt Kilcar, Serap Teksöz, Kadir Ari, Bedriye Elvan Sayit Bilgin, Yasemin Parlak, Eser Uçar, Vocational School of Health Services/Radiotheraphy, Istanbul Kemerburgaz University, Bağcılar, İstanbul 34217, Turkey, Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, İzmir 35100, Turkey, Departmant of Nuclear Medicine, Celal Bayar University, Manisa, 45030, Turkey, and Şenışık, A. M.

Subjects
Biodistribution, FDG, Health, Toxicology and Mutagenesis, Kinetics, One-Step, 010403 inorganic & nuclear chemistry, 01 natural sciences, Imaging, 030218 nuclear medicine & medical imaging, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Succinimide, In vivo, Radiology, Nuclear Medicine and imaging, Spectroscopy, Glycylglycine, Radiochemistry, Public Health, Environmental and Occupational Health, Oxime, Pollution, 0104 chemical sciences, PET, Nuclear Energy and Engineering, chemistry, Yield (chemistry), Radiopharmaceuticals
Abstract

KILCAR, AYFER YURT/0000-0003-0866-7515; Senisik, Ahmet Murat/0000-0002-7781-3355; KILCAR, AYFER YURT/0000-0003-0866-7515; ichedef, cigdem/0000-0002-1586-9521 WOS:000431040600006 This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [F-18]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 A degrees C for 30 min in a vial containing AO-GlyGly and [F-18]FDG solution. The radiolabeled product ([F-18]FDG-GlyGly) was obtained with 98.65 +/- 0.35% yield without any purification step which makes this method more attractive for F-18 radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [F-18]FDG tagged GlyGly in vivo. Ege University Scientific Research Project (Bomova, Izmir, Turkey)Ege University [2012 NBE 004] This study was financially supported by the Ege University Scientific Research Project numbered 2012 NBE 004 (Bomova, Izmir, Turkey).

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results