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Whereas one mature or two immature infections with Fasciola hepatica, which had been eliminated by anthelmintic treatment, conferred resistance to reinfection in rats, this did not occur with rabbits. The differences between the hosts were shown by the numbers of flukes which developed following challenge ands by the changes in peripheral eosinophil counts and serum glutamic dehydrogenase levels. In contrast, rabbits gave a stronger serological response (ELISA) than rats but this was not affected by treatment or challenge in either host.

Resistance to Fasciola hepatica could be elicited in rats by implanting mature flukes subcutaneously or intraperitoneally in diffusion chambers. A similar resistance occurred even when the implants were removed two weeks before challenge. This excluded the possibility that the continuing presence of the sensitising flukes was necessary for the maintenance of resistance and also showed that the resistance could be elicited by only two weeks exposure to diffusible immunogens emanating from the flukes.