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In order to solve the problem in predicting and warning the response of an in-service long piled wharf when a ship berths to it, and to improve the efficiency of monitoring and assessing the structural damage of a long piled wharf, a three -dimensional finite element model of a long piled beam-slab wharf considering pile-soil interaction was established based on an example of a long piled wharf using Midas/GTS NX software. The structural failure mode of a long piled wharf when a ship is berthing was studied and the response surface parameters were determined. The response surface equations for the structural response of a long piled wharf was established. Goodness-of-fit test, F-test and t-test were carried out to verify the accuracy of the equations and the significance of various influencing factors on the response of different structures was also analyzed. Finally, the predicted results of the structural response of a long piled wharf were evaluated through error analysis. The results of the study can be useful for the response prediction of long piled wharf structures. [ABSTRACT FROM AUTHOR]