1. A human factor VIIa concentrate and its effects in the hemophilic A dog.
- Author
-
Chabbat J, Hampikian-Lenin S, Toully V, Gaillandre A, Péjaudier L, and Steinbuch M
- Subjects
- Animals, Bleeding Time, Blood Pressure drug effects, Blood Proteins analysis, Dogs, Factor VIIa, Hemophilia A blood, Humans, Rabbits, Factor VII therapeutic use, Hemophilia A therapy
- Abstract
Properties of a new concentrate of FVII/FVIIa, obtained by adsorption onto an inorganic adsorbent followed by a chromatographic step onto Q-Sepharose using a by-product of routine fractionation as starting material, are described. This fraction contains only small amounts of the other components of the prothrombin complex but it is enriched in Proteins C and S. This preparation is essentially free of FVIIICag. It has been submitted to animal experiments including those carried out on normal and hemophilic A dogs. A normalization of the buccal bleeding time was seen after injection of a minimal dose of 4 uFVIIa/kg. No adverse reaction was observed at any dose employed. This concentrate might thus be indicated for the treatment of Haemophilia A patients with inhibitors. Its viral inactivation has been achieved.
- Published
- 1989
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