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Loading of the upper eyelid with palpebral implants made of noble metals is the modern standard of surgical treatment for paralytic lagophthalmos, and is aimed at increasing the mobility of the upper eyelid and normalizing involuntary blinking movements. This review presents the results of morphological studies, including immunohistochemical studies, reflecting the features of biointegration of palpebral implants in uncomplicated and complicated course of the postoperative period, and describes the modern understanding of the causes and immunopathological processes underlying the development of nonspecific inflammatory response, which is one of the most serious complications that often becomes an indication for implant removal.

Unlabelled: The article presents the results of an experimental morphological study of biointegration of different eyelid weight implants used for paralytic lagophthalmos correction., Aim: To investigate biointegration features of gold monolithic and chain implants., Material and Methods: The study enrolled 11 Chinchilla rabbits (22 eyelids). Light and scanning electron microscopy was performed 2 weeks, 1, 2, 3 and 6 months after the implantation., Results: Over the whole follow-up period chain implants capsules remained more integrated with surrounding connective tissue than those of monolithic implants., Conclusion: The obtained results prove better immobilization of a gold chain implant preventing it from dislocation in the late postoperative period.