1. Ocular Cicatricial Pemphigoid
- Author
-
Alison V. Crum and Sravanthi Vegunta
- Subjects
Autoimmune disease ,medicine.medical_specialty ,Conjunctiva ,integumentary system ,business.industry ,Symblepharon ,medicine.disease ,Dermatology ,eye diseases ,Entropion ,medicine.anatomical_structure ,Corneal neovascularization ,medicine ,sense organs ,Eyelid ,Bullous pemphigoid ,business ,Trichiasis - Abstract
Mucous membrane pemphigoid is a chronic autoimmune disease that mainly affects mucous membranes. Skin lesions occur in 10–43% of patients. The conjunctiva is involved in about 70% of patients. The component of the disease that affects the conjunctiva, regardless of involvement of nonocular sites, is commonly called ocular cicatricial pemphigoid. It is a bilateral, asymmetric, sight-threatening disease characterized by progressive conjunctival cicatrization associated with trichiasis, eyelid entropion, symblepharon, secondary corneal neovascularization, and scarring. It is characterized by IgG, IgA, or C3 (complement component) deposition in a linear fashion along the epithelial basement membrane zone. The disease usually presents between the ages of 30 and 90 years; it affects males twice as often as females.
- Published
- 2020