1. Life-threatening antineutrophil cytoplasmic antibody-associated vasculitis after influenza A H1N1 infection requiring veno-venous extracorporeal membrane oxygenation.
- Author
-
Frantzeskaki FG, Dimopoulos S, Konstantonis D, Katsibri P, Kostopanagiotou K, Theodorakopoulou M, Diakaki C, Dougenis D, Boumpas D, Karabinis A, Armaganidis A, and Tsangaris I
- Subjects
- Adult, Female, Humans, Influenza A Virus, H1N1 Subtype, Young Adult, Antibodies, Antineutrophil Cytoplasmic metabolism, Extracorporeal Membrane Oxygenation methods
- Abstract
Introduction: Antineutrophil cytoplasmic autoantibody-associated vasculitis is an immune-mediated necrotizing vasculitis, affecting small- and medium-sized vessels., Case Report: A 22-year-old female patient with free medical history presented with life-threatening pulmonary hemorrhage due to antineutrophil cytoplasmic autoantibody-associated vasculitis, temporarily associated with influenza A H1N1 infection. Due to rapidly worsening respiratory failure, despite conventional management, veno-venous peripheral extracorporeal membrane oxygenation was initiated and continued for 26 days, with subsequent renal replacement therapy., Discussion: We present a case of severe antineutrophil cytoplasmic autoantibody-associated pulmonary vasculitis, managed with veno-venous extracorporeal membrane oxygenation at the initial phase. Despite the significant challenges raised with the use of extracorporeal membrane oxygenation in pulmonary hemorrhage cases, extracorporeal membrane oxygenation may have a significant impact on outcome in this setting, by providing adequate time for a successful immunosuppressive treatment.
- Published
- 2020
- Full Text
- View/download PDF