1. Missorting of plasma miRNAs in aging and Alzheimer's disease.
- Author
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Čarna M, Novotny JS, Dragišić N, Slavik H, Sheardova K, Geda YE, Vyhnalek M, Laczo J, Hort J, Mao Z, Rissman RA, Hajduch M, Dammer EB, and Stokin GB
- Subjects
- Humans, Aging genetics, MicroRNAs genetics, Alzheimer Disease genetics, Extracellular Vesicles
- Abstract
The observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs in aging are downregulated and predicted to be preferentially targeted to the extracellular vesicle (EV) content. In AD, miRNAs are further downregulated, display altered proportions of motifs relevant to their loading into EVs and secretion propensity, and are forecast to be found exclusively in EVs. The circulating miRNA network in AD, therefore, reflects pathological exacerbation of the aging process whereby physiological suppression of AD pathology by miRNAs becomes insufficient., (© 2023 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.)
- Published
- 2023
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