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Start Over Descriptor "DRD2 signaling" Topic executive function
2 results on '"DRD2 signaling"'

1. Dopamine D1, but not D2, signaling protects mental representations from distracting bottom-up influences.

Author

Bensmann W, Zink N, Arning L, Beste C, and Stock AK

Subjects
Adolescent, Adult, Electroencephalography, Female, Humans, Male, Motor Cortex metabolism, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Receptors, Dopamine D1 genetics, Receptors, Dopamine D2 genetics, Subliminal Stimulation, Young Adult, Attention physiology, Conflict, Psychological, Event-Related Potentials, P300 physiology, Executive Function physiology, Motor Cortex physiology, Psychomotor Performance physiology, Receptors, Dopamine D1 metabolism, Receptors, Dopamine D2 metabolism, Signal Transduction physiology
Abstract

Goal-directed behavior is affected by subliminally and consciously induced conflicts. Both seem to be modulated by catecholamines, especially dopamine. On the basis of cognitive theoretical and neurobiological considerations, we investigated the effects of dopamine D1 and D2 signaling with the help of unweighted polygenic scores in n = 207 healthy young human subjects. We used a task that combines subliminal primes with conscious flankers to induce conflicts. Dopamine D1 scores were formed based on DRD1 rs4532, CALY rs2298122 and TH rs10770141 single nucleotide polymorphisms (SNPs), while dopamine D2 scores were formed based on DRD2 rs6277 and NPY2R rs2234759 SNPs. We used EEG recordings and source localization analyses to identify differentially modulated neurophysiological sub-processes and functional neuroanatomical structures. Increased dopamine D1 signaling was associated with decreases in consciously induced conflicts. This decrease was due to enhanced stimulus-response mapping in the premotor cortex (BA6), as reflected by an increased P3 amplitude in incongruent trials. Attentional processes remained unaffected by dopamine D1 signaling. The effect of dopamine D2 signaling on conscious conflicts did not reach significance. Subliminally induced conflicts were neither modulated by dopamine D1, nor by dopamine D2 signaling. Our findings suggest that dopamine D1 signaling benefits consciously induced conflicts, presumably by improving the suppression of distracting information via gain control-initiated increases in top-down control processes associated with pre-motor regions. Dopamine D2 signaling does not seem to mediate behavioral differences. Probably, this is because the D2 state facilitates switching between (conflicting) top-down-selected mental representations, but not necessarily between top-down processes and bottom-up distractor information., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2020
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2. Dopamine D1, but not D2, signaling protects mental representations from distracting bottom-up influences

Author

Christian Beste, Larissa Arning, Ann-Kathrin Stock, Nicolas Zink, and Wiebke Bensmann

Subjects
Adult, Male, Multifactorial Inheritance, Adolescent, Conflict, Cognitive Neuroscience, Dopamine, Gain control, Electroencephalography, Subliminal Stimulation, Polymorphism, Single Nucleotide, Subliminal, 050105 experimental psychology, lcsh:RC321-571, Premotor cortex, Conflict, Psychological, 03 medical and health sciences, Executive Function, Young Adult, 0302 clinical medicine, Dopamine receptor D2, medicine, Humans, 0501 psychology and cognitive sciences, Attention, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, medicine.diagnostic_test, Receptors, Dopamine D2, Receptors, Dopamine D1, 05 social sciences, Subliminal stimuli, Motor Cortex, Cognition, DRD2 signaling, Neurophysiology, Event-Related Potentials, P300, medicine.anatomical_structure, Neurology, DRD1, Mental representation, Female, Psychology, Neuroscience, 030217 neurology & neurosurgery, Psychomotor Performance, medicine.drug, Signal Transduction
Abstract

Goal-directed behavior is affected by subliminally and consciously induced conflicts. Both seem to be modulated by catecholamines, especially dopamine. On the basis of cognitive theoretical and neurobiological considerations, we investigated the effects of dopamine D1 and D2 signaling with the help of unweighted polygenic scores in n = 207 healthy young human subjects. We used a task that combines subliminal primes with conscious flankers to induce conflicts. Dopamine D1 scores were formed based on DRD1 rs4532, CALY rs2298122 and TH rs10770141 single nucleotide polymorphisms (SNPs), while dopamine D2 scores were formed based on DRD2 rs6277 and NPY2R rs2234759 SNPs. We used EEG recordings and source localization analyses to identify differentially modulated neurophysiological sub-processes and functional neuroanatomical structures. Increased dopamine D1 signaling was associated with decreases in consciously induced conflicts. This decrease was due to enhanced stimulus-response mapping in the premotor cortex (BA6), as reflected by an increased P3 amplitude in incongruent trials. Attentional processes remained unaffected by dopamine D1 signaling. The effect of dopamine D2 signaling on conscious conflicts did not reach significance. Subliminally induced conflicts were neither modulated by dopamine D1, nor by dopamine D2 signaling. Our findings suggest that dopamine D1 signaling benefits consciously induced conflicts, presumably by improving the suppression of distracting information via gain control-initiated increases in top-down control processes associated with pre-motor regions. Dopamine D2 signaling does not seem to mediate behavioral differences. Probably, this is because the D2 state facilitates switching between (conflicting) top-down-selected mental representations, but not necessarily between top-down processes and bottom-up distractor information.

Published
2020

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