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Social comparison is central in human life and can be especially challenging in depression and social anxiety. We assessed event‐related potentials and emotions using a social comparison task in which participants received feedback on both their own and a co‐player's performance, in participants with depression and/or social anxiety (n = 63) and healthy controls (n = 72). Participants reported more negative emotions for downward (being better than the co‐player [participant correct, co‐player wrong]) and upward (being worse than the co‐player [participant wrong, co‐player correct]) comparisons versus even outcomes, with these effects being stronger in depression and social anxiety. At the Medial Frontal Negativity, both controls and depressed participants showed a more negative amplitude for upward comparison versus both the participant and co‐player performing wrong. Socially anxious subjects showed the opposite effect, possibly due to greater expectations about being worse than others. The P300 decreased for downward and upward comparisons compared to even outcomes, which may relate to the higher levels of conflict of social inequality. Depressed and socially anxious subjects showed a blunted P300 increase over time in response to the task outcomes, suggesting deficits in allocating resources for the attention of incoming social information. The LPP showed increased amplitude for downward and upward comparison versus the even outcomes and no group effect. Emotional findings suggest that social comparisons are more difficult for depressed and socially anxious individuals. Event‐related potentials findings may shed light on the neural substrates of these difficulties. This is the first study investigating neural responses to social comparison in participants with symptoms of depression and social anxiety, and healthy controls. Results showed heightened negative emotions and distinct event‐related potentials in participants with these disorders compared to controls. Findings suggest difficulties in dealing with the cognitive and emotional demands of social comparison in depression and social anxiety. [ABSTRACT FROM AUTHOR]

Depression and social anxiety are common disorders that have a profound impact on social functioning. The need for studying the neural substrates of social interactions in mental disorders using interactive tasks has been emphasized. The field of neuroeconomics, which combines neuroscience techniques and behavioral economics multiplayer tasks such as the Ultimatum Game (UG), can contribute in this direction. We assessed emotions, behavior, and Event‐Related Potentials in participants with depression and/or social anxiety symptoms (MD/SA, n = 63, 57 females) and healthy controls (n = 72, 67 females), while they played the UG. In this task, participants received fair, mid‐value, and unfair offers from other players. Mixed linear models were implemented to assess trial level changes in neural activity. The MD/SA group reported higher levels of sadness in response to mid‐value and unfair offers compared to controls. In controls, the Medial Frontal Negativity associated with fair offers increased over time, while this dynamic was not observed in the MD/SA group. The MD/SA group showed a decreased P3/LPP in all offers, compared to controls. These results indicate an enhanced negative emotional response to unfairness in the MD/SA group. Neural results reveal a blunted response over time to positive social stimuli in the MD/SA group. Moreover, between‐group differences in P3/LPP may relate to a reduced saliency of offers and/or to a reduced availability of resources for processing incoming stimuli in the MD/SA group. Findings may shed light into the neural substrates of social difficulties in these disorders. It is crucial to study the neural substrates of social interactions in mental health using interactive tasks that immerse the participant in a social context. The Ultimatum Game was used to assess ERPs to fair, mid‐value, and unfair offers from others in depressed and/or socially anxious volunteers. We found blunted neural responses over time to fair offers as well as reduced availability of resources for processing incoming social stimuli in depression and social anxiety. [ABSTRACT FROM AUTHOR]