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Start Over Author "Wieringa, J.E." Topic european-union
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1. When direct health-care professional communications have an impact on inappropriate and unsafe use of medicines: A retrospective analysis of determinants of impact of safety warnings

Author

Reber, K.C., Piening, S., Wieringa, J.E., Straus, S.M.J.M., Raine, J.M., de Graeff, Pauline, Haaijer-Ruskamp, F.M., Mol, Peter G. M., Research Programme Marketing, Faculteit Medische Wetenschappen/UMCG, and Methods in Medicines evaluation & Outcomes research (M2O)

Subjects
EUROPEAN-UNION, SAFETY, NETHERLANDS, WARNINGS, ADVERSE DRUG-REACTIONS, SPECIALISTS, REGULATORY ACTION
Abstract

Serious safety issues relating to drugs are communicated to health-care professionals via Direct Health-Care Professional Communications (DHPCs). We explored which characteristics determined the impact of DHPCs issued in the Netherlands for ambulatory-care drugs (2001-2008). With multiple linear regression, we examined the impact on the relative change in new drug use post-DHPC of the following: time to DHPC, trend in use, degree of innovation, specialist drug, first/repeated DHPC, DHPC template, and type of safety issue. DHPCs have less impact on use of specialist drugs than nonspecialist drugs (P

Published
2013

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