4 results on '"Verstraeten, Thomas"'
Search Results
2. A systematic review of varicella seroprevalence in European countries before universal childhood immunization: deriving incidence from seroprevalence data
- Author
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BOLLAERTS, Kaatje, Riera-Montes, Margarita, Heininger, Ulrich, HENS, Niel, Souverain, Audrey, Verstraeten, Thomas, Hartwig, Susanne, HENS, Niel, Hartwig, Susanne, BOLLAERTS, Kaatje, Souverain, Audrey, Heininger, Ulrich, Verstraeten, Thomas, and Riera-Montes, Margarita
- Subjects
virus diseases ,chickenpox ,Europe ,immunization ,incidence ,seroepidemiology ,varicella zoster virus - Abstract
Surveillance systems for varicella in Europe are highly heterogeneous or completely absent. We estimated the varicella incidence based on seroprevalence data, as these data are largely available and not biased by under-reporting or underascertainment. We conducted a systematic literature search for varicella serological data in Europe prior to introduction of universal varicella immunization. Age-specific serological data were pooled by country and serological profiles estimated using the catalytic model with piecewise constant force of infection. From the estimated profiles, we derived the annual incidence of varicella infection (/100.000) for six age groups (
- Published
- 2017
3. Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization.
- Author
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Riera-Montes, Margarita, Bollaerts, Kaatje, Heininger, Ulrich, Hens, Niel, Gabutti, Giovanni, Gil, Angel, Nozad, Bayad, Mirinaviciute, Grazina, Flem, Elmira, Souverain, Audrey, Verstraeten, Thomas, and Hartwig, Susanne
- Subjects
CHICKENPOX ,IMMUNIZATION of children ,MEDICAL care ,CHICKENPOX vaccines ,COMPARATIVE studies ,EPIDEMIOLOGICAL research ,HOSPITAL care ,IMMUNIZATION ,RESEARCH methodology ,MEDICAL cooperation ,META-analysis ,PRIMARY health care ,RESEARCH ,SYSTEMATIC reviews ,EVALUATION research ,PATIENTS' attitudes ,PREVENTION ,VACCINES - Abstract
Background: Varicella is generally considered a mild disease. Disease burden is not well known and country-level estimation is challenging. As varicella disease is not notifiable, notification criteria and rates vary between countries. In general, existing surveillance systems do not capture cases that do not seek medical care, and most are affected by underreporting and underascertainment. We aimed to estimate the overall varicella disease burden in Europe to provide critical information to support decision-making regarding varicella vaccination.Methods: We conducted a systematic literature review to identify all available epidemiological data on varicella IgG antibody seroprevalence, primary care and hospitalisation incidence, and mortality. We then developed methods to estimate age-specific varicella incidence and annual number of cases by different levels of severity (cases in the community, health care seekers in primary care and hospitals, and deaths) for all countries belonging to the European Medicines Agency (EMA) region and Switzerland.Results: In the absence of universal varicella immunization, the burden of varicella would be substantial with a total of 5.5 million (95% CI: 4.7-6.4) varicella cases occurring annually across Europe. Variation exists between countries but overall the majority of cases (3 million; 95% CI: 2.7-3.3) would occur in children <5 years. Annually, 3-3.9 million patients would consult a primary care physician, 18,200-23,500 patients would be hospitalised, and 80 varicella-related deaths would occur (95% CI: 19-822).Conclusions: Varicella disease burden is substantial. Most cases occur in children <5 years old but adults require hospitalisation more often and are at higher risk of death. This information should be considered when planning and evaluating varicella control strategies. A better understanding of the driving factors of country-specific differences in varicella transmission and health care utilization is needed. Improving and standardizing varicella surveillance in Europe, as initiated by the European Centre for Disease Prevention and Control (ECDC), is important to improve data quality to facilitate inter-country comparison. [ABSTRACT FROM AUTHOR]- Published
- 2017
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4. Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization
- Author
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Susanne Hartwig, Bayad Nozad, Grazina Mirinaviciute, Niel Hens, Audrey Souverain, Thomas Verstraeten, Kaatje Bollaerts, Margarita Riera-Montes, Elmira Flem, Ulrich Heininger, Giovanni Gabutti, Ángel Gil, HENS, Niel, Mirinaviciute, Grazina, Gabutti, Giovanni, Nozad, Bayad, Hartwig, Susanne, Flem, Elmira, BOLLAERTS, Kaatje, Souverain, Audrey, Heininger, Ulrich, Verstraeten, Thomas, Riera-Montes, Margarita, and Gil, Angel
- Subjects
Adult ,0301 basic medicine ,medicine.medical_specialty ,Pediatrics ,Adolescent ,030106 microbiology ,Socio-culturale ,Disease ,varicella ,disease burden ,Europe ,Varicella ,lcsh:Infectious and parasitic diseases ,Chickenpox Vaccine ,Young Adult ,03 medical and health sciences ,Chickenpox ,0302 clinical medicine ,Seroepidemiologic Studies ,Epidemiology ,Health care ,medicine ,Humans ,Seroprevalence ,lcsh:RC109-216 ,030212 general & internal medicine ,Child ,Disease burden ,Primary Health Care ,business.industry ,Transmission (medicine) ,Incidence (epidemiology) ,Vaccination ,Primary care physician ,Infant ,virus diseases ,Patient Acceptance of Health Care ,Hospitalization ,Infectious Diseases ,Child, Preschool ,Immunization ,Human medicine ,business ,Switzerland ,Research Article - Abstract
Background Varicella is generally considered a mild disease. Disease burden is not well known and country-level estimation is challenging. As varicella disease is not notifiable, notification criteria and rates vary between countries. In general, existing surveillance systems do not capture cases that do not seek medical care, and most are affected by underreporting and underascertainment. We aimed to estimate the overall varicella disease burden in Europe to provide critical information to support decision-making regarding varicella vaccination. Methods We conducted a systematic literature review to identify all available epidemiological data on varicella IgG antibody seroprevalence, primary care and hospitalisation incidence, and mortality. We then developed methods to estimate age-specific varicella incidence and annual number of cases by different levels of severity (cases in the community, health care seekers in primary care and hospitals, and deaths) for all countries belonging to the European Medicines Agency (EMA) region and Switzerland. Results In the absence of universal varicella immunization, the burden of varicella would be substantial with a total of 5.5 million (95% CI: 4.7–6.4) varicella cases occurring annually across Europe. Variation exists between countries but overall the majority of cases (3 million; 95% CI: 2.7–3.3) would occur in children
- Published
- 2017
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