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1. European Surveillance System on Contact Allergies (ESSCA)

Author

Dittmar, Daan, Uter, Wolfgang, Bauer, Andrea, Fortina, Anna B, Bircher, Andreas J, Czarnecka-Operacz, Magdalena, Dugonik, Aleksandra, Elsner, Peter, Gallo, Rosella, Ghaffar, Sharizan A, Giménez-Arnau, Anna, Johnston, Graham A, Kręcisz, Beata, Filon, Francesca L, Rustemeyer, Thomas, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Schnuch, Axel, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philipp, Corradin, Maria T, Valiukevičienė, Skaidra, Vok, Marko, Weisshaar, Elke, Wilkinson, Mark, Schuttelaar, Marie L, Aberer W, Ballmer-Weber B, Grabbe J, Beiteke U, Brasch J, Fuchs T, John SM, Mahler V, Pesonen M, Jolanki R, Rantanen T, Armario-Hita JC, Fernández-Redondo V, García-Gavín J, Mercader P, Ruiz I, Silvestre JF, Balato A, Ayala F, Peserico A, Sliuziaviciene G, Kieć-Świerczyńska M, Kmecl T, Pandurovic MK, Kecelj N, Lunder T, Simončič Godnič M, Chowdhury MMU, Cooper SM, English JSC, Cousen P, Horne HL, Gawkrodger DJ, Holden C, Sabroe R, Green CM, King CM, Ormerod AD, Samson JE, Statham B, Stone N, White I., Dittmar, Daan, Uter, Wolfgang, Bauer, Andrea, Fortina, Anna B, Bircher, Andreas J, Czarnecka-Operacz, Magdalena, Dugonik, Aleksandra, Elsner, Peter, Gallo, Rosella, Ghaffar, Sharizan A, Giménez-Arnau, Anna, Johnston, Graham A, Kręcisz, Beata, Filon, Francesca L, Rustemeyer, Thoma, Sadowska-Przytocka, Anna, Sánchez-Pérez, Javier, Schnuch, Axel, Simon, Dagmar, Spiewak, Radoslaw, Spring, Philipp, Corradin, Maria T, Valiukevičienė, Skaidra, Vok, Marko, Weisshaar, Elke, Wilkinson, Mark, Schuttelaar, Marie L, Aberer, W, Ballmer-Weber, B, Grabbe, J, Beiteke, U, Brasch, J, Fuchs, T, John, Sm, Mahler, V, Pesonen, M, Jolanki, R, Rantanen, T, Armario-Hita, Jc, Fernández-Redondo, V, García-Gavín, J, Mercader, P, Ruiz, I, Silvestre, Jf, Balato, A, Ayala, F, Peserico, A, Sliuziaviciene, G, Kieć-Świerczyńska, M, Kmecl, T, Pandurovic, Mk, Kecelj, N, Lunder, T, Simončič Godnič, M, Chowdhury, Mmu, Cooper, Sm, English, Jsc, Cousen, P, Horne, Hl, Gawkrodger, Dj, Holden, C, Sabroe, R, Green, Cm, King, Cm, Ormerod, Ad, Samson, Je, Statham, B, Stone, N, White, I., Dermatology, Public Health Research (PHR), Fortina, Ana B., Bircher, Andreas J., Ghaffar, Sharizan A., Johnston, Graham A., Larese Filon, Francesca., Corradin, Maria T., Schuttelaar, Marie L., Aberer, Werner, Ballmer-Weber, Barbara, Grabbe, Jürgen, Beiteke, Ulrike, Brasch, Jochen, Fuchs, Thoma, John, Swen Malte, Mahler, Vera, Pesonen, Maria, Jolanki, Riitta, Rantanen, Tapio, Armario-Hita, José Carlo, Fernández-Redondo, Virginia, García-Gavín, Juan, Mercader, Pedro, Ruiz, Inmaculada, Silvestre, Juan Fco., Balato, Anna, Ayala, Fabio, Peserico, Andrea, Sliuziaviciene, Gondinga, Kieć-Świerczyńska, Marta, Kmecl, Tanja, Pandurovic, Maja Kalac, Kecelj, Nada, Lunder, Tomaž, Simončič Godnič, Mojca, Chowdhury, Mahbub M. U., Cooper, Susan M., English, John S. C., Cousen, Philippa, Horne, Helen L., Gawkrodger, David J., Holden, Catherine, Sabroe, Ruth, Green, Cathy M., King, Codagh M., Ormerod, Anthony D., Samson, Jane E., Statham, Barry, Stone, Natalie, and White, Ian

Subjects
Allergy, Allergic Contact, Occupational Dermatitis, ANGRY BACK SYNDROME, Dermatitis, SUSCEPTIBILITY, medicine.disease_cause, 030207 dermatology & venereal diseases, 0302 clinical medicine, Allergen, Quality of life, QUALITY-OF-LIFE, Adult Allergens Dermatitis, Allergic Contact Dermatitis, Atopic Europe Humans Middle Aged Patch Tests Population Surveillance Prevalence Retrospective Studies Young Adult, Prevalence, Immunology and Allergy, Medicine, Young adult, 610 Medicine & health, DERMATOLOGY IVDK, education.field_of_study, PATCH-TEST REACTIONS, Patch test, BASE-LINE SERIES, clinical epidemiology, Middle Aged, Patch Tests, DERMATITIS-RESEARCH-GROUP, contact allergy, patch test, polysensitization, Adult, Allergens, Dermatitis, Allergic Contact, Dermatitis, Atopic, Europe, Humans, Retrospective Studies, Young Adult, Population Surveillance, Atopic Europe Humans Middle Aged Patch Tests Population Surveillance Prevalence Retrospective Studies Young Adult, GENETIC-FACTORS, Allergic Contact Dermatitis, INFORMATION-NETWORK, Population, Dermatology, Atopic, 2708, 03 medical and health sciences, P-PHENYLENEDIAMINE, education, business.industry, Retrospective cohort study, Adult Allergens Dermatitis, medicine.disease, 030228 respiratory system, business, Demography
Abstract

Background. Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life.Objectives. To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization.Methods. Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed.Results. A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization.Conclusions. The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Knownrisk factors for polysensitization are confirmed in a European dermatitis population.

Published
2018
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2. Patch test results with fragrance markers of the baseline series - Analysis of the European Surveillance System on Contact Allergies (ESSCA) network 2009-2012

Author

Frosch PJ, Duus Johansen J, Schuttelaar ML, Silvestre JF, Sánchez-Pérez J, Weisshaar E, Uter W, Aberer W, Bircher A, Simon D, Ballmer-Weber B, Spring P, Frosch P, Fuchs T, Brasch J, Bauer A, Elsner P, John SM, Mahler V, Johansen JD, Giménez Arnau A, García-Gavín J, Fernández-Redondo V, Amario-Hita JC, Mercader P, Ruiz I, Jolanki R, Pesonen M, Rantanen T, Ayala F, Balato A, Peserico A, Fortina AB, Filon FL, Corradin MT, Gallo R, Valiukeviciene S, Sliuziaviciene G, Coenraads PJ, Rustemeyer T, Kręcicz B, Kieć-Świerczyńska M, Spiewak R, Sadowska A, Czarnecka-Operacz M, Dugonik A, Pandurovic MK, Kmecl T, Vok M, Godnic S, Mesto N, Lunder T, Green CM, Wilkinson M, Sansom JE, King CM, Horne HL, English JS, Johnston GA, Statham BN, Chowdhury MM, Stone N, Cooper S, Gawkrodger DJ, Sabroe R, Holden C, Ormerod AD., Frosch, Pj, Duus Johansen, J, Schuttelaar, Ml, Silvestre, Jf, Sánchez-Pérez, J, Weisshaar, E, Uter, W, Aberer, W, Bircher, A, Simon, D, Ballmer-Weber, B, Spring, P, Frosch, P, Fuchs, T, Brasch, J, Bauer, A, Elsner, P, John, Sm, Mahler, V, Johansen, Jd, Giménez Arnau, A, García-Gavín, J, Fernández-Redondo, V, Amario-Hita, Jc, Mercader, P, Ruiz, I, Jolanki, R, Pesonen, M, Rantanen, T, Ayala, F, Balato, A, Peserico, A, Fortina, Ab, Filon, Fl, Corradin, Mt, Gallo, R, Valiukeviciene, S, Sliuziaviciene, G, Coenraads, Pj, Rustemeyer, T, Kręcicz, B, Kieć-Świerczyńska, M, Spiewak, R, Sadowska, A, Czarnecka-Operacz, M, Dugonik, A, Pandurovic, Mk, Kmecl, T, Vok, M, Godnic, S, Mesto, N, Lunder, T, Green, Cm, Wilkinson, M, Sansom, Je, King, Cm, Horne, Hl, English, J, Johnston, Ga, Statham, Bn, Chowdhury, Mm, Stone, N, Cooper, S, Gawkrodger, Dj, Sabroe, R, Holden, C, and Ormerod, Ad.

Subjects
Adult, Male, Allergic Contact, Patch Test, Petrolatum, Allergen, Dermatiti, regional difference, Perfume, Europe, contact sensitization, Retrospective Studie, Population Surveillance, Dermatitis, Allergic Contact, contact allergy, fragrance, Prevalence, Immunology and Allergy, Female, patch testing, Human
Published
2015

3. Patch test results with fragrance markers of the baseline series - Analysis of the European Surveillance System on Contact Allergies (ESSCA) network 2009-2012

Author

Frosch, Pj1, 2, Duus Johansen J3, Schuttelaar, Ml4, Silvestre, Jf5, Sánchez Pérez J6, Weisshaar, E7, Uter, W8, ESSCA n. e. t. w. o. r. k. Aberer, W, Bircher, A, Simon, D, Ballmer Weber, B, Spring, P, Frosch, P, Fuchs, T, Brasch, J, Bauer, A, Elsner, P, John, Sm, Mahler, V, Weisshaar, E, Johansen, Jd, Giménez Arnau, A, Sánchez Pérez, J, Silvestre, Jf, García Gavín, J, Fernández Redondo, V, Amario Hita, Jc, Mercader, P, Ruiz, I, Jolanki, R, Pesonen, M, Rantanen, T, Ayala, F, Balato, A, PESERICO STECCHINI NEGRI DE SALVI, Andrea, Fortina, Ab, Filon, Fl, Corradin, Mt, Gallo, R, Valiukeviciene, S, Sliuziaviciene, G, Coenraads, Pj, Schuttelaar, Ml, Rustemeyer, T, Kręcicz, B, Kieć Świerczyńska, M, Spiewak, R, Sadowska, A, Czarnecka Operacz, M, Dugonik, A, Pandurovic, Mk, Kmecl, T, Vok, M, Godnic, S, Mesto, N, Lunder, T, Green, Cm, Wilkinson, M, Sansom, Je, King, Cm, Horne, Hl, English, Js, Johnston, Ga, Statham, Bn, Chowdhury, Mm, Stone, N, Cooper, S, Gawkrodger, Dj, Sabroe, R, Holden, C, Ormerod, A. d., BELLONI FORTINA, Anna, Frosch, Pj, Duus Johansen, J, Schuttelaar, Ml, Silvestre, Jf, Sánchez-Pérez, J, Weisshaar, E, Uter, W, Larese Filon, F., and Essca, Network

Subjects
Adult, Male, contact allergy, contact sensitization, fragrances, patch testing, regional differences, 2708, Immunology and Allergy, Allergic Contact, Petrolatum, Dermatitis, Prevalence, fragrance, Humans, Retrospective Studies, Medicine (all), Allergens, Patch Tests, Dermatitis, Allergic Contact, Europe, Female, Perfume, Population Surveillance, regional difference
Abstract

Contact allergy to fragrances is common, and impairs quality of life, particularly in young women. OBJECTIVE: To provide current results on the prevalences of sensitization to fragrance allergens used as markers in the baseline series of most European countries. METHODS: Data of patients consecutively patch tested between 2009 and 2012 in 12 European countries with fragrance allergens contained in the baseline series were collected by the European Surveillance System on Contact Allergies network and descriptively analysed. Four departments used the TRUE Test(®) system. RESULTS: The 'basic markers' were tested on 51 477 [fragrance mix II (FM II)] to 57 123 [Myroxylon pereirae, balsam of Peru] patients, and yielded positive reactions as follows: fragrance mix I 6.9%, Myroxylon pereirae 5.4%, FM II 3.8%, colophonium 2.6%, and hydroxyisohexyl 3-cyclohexene carboxaldehyde 1.7%, with some regional differences. Prevalences with TRUE Test(®) allergens were lower. Additional fragrances were tested on 3643 (trimethylbenzenepropanol) to 14 071 (oil of turpentine) patients, and yielded between 2.6% (Cananga odorata) and 0.7% (trimethylbenzenepropanol) positive reactions. CONCLUSIONS: Contact allergy to fragrances is common throughout Europe, with regional variation probably being explained by patch test technique, and differences in exposure and referral patterns. The current basic markers of fragrance sensitivity in the baseline series should be supplemented with additional fragrance allergens.

Published
2015

4. Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008

Author

Marielouise Schuttelaar, Magda Czarnecka-Operacz, Tapio Rantanen, Werner Aberer, Thomas Rustemeyer, Andrea Peserico, Pieter Jan Coenraads, Dorota Chomiczewska, Clodagh M. King, Riitta Jolanki, Thomas Fuchs, José Carlos Armario-Hita, Peter J. Frosch, Andreas J. Bircher, Anna Balato, Javier Sánchez-Pérez, Maria Zmudzinska, Juan García-Gavín, Beata Krecisz, C. Green, Fabio Ayala, Virginia Fernández-Redondo, Jeanne D. Johansen, Helen L. Horne, Jochen Brasch, Mahbub M. U. Chowdhury, Wolfgang Uter, Radoslaw Spiewak, Vera Mahler, Maria Pesonen, Mark Wilkinson, Natalie M. Stone, Dagmar Simon, Barbara Ballmer-Weber, J.F. Silvestre, Susan Cooper, Marta Kieć-Swierczyńska, F Larese, Andrea Bauer, John S. C. English, Anthony Ormerod, J.M. Fernández-Vozmediano, David J. Gawkrodger, Aiste Beliauskiene, Jane E. Sansom, Anna Belloni Fortina, Ana Giménez-Arnau, Axel Schnuch, B. N. Statham, Peter Elsner, University of Zurich, Uter, Wolfgang, Public Health Research (PHR), Uter, W, Aberer, W, Armario Hita, Jc, Fernandez Vozmediano, Jm, Ayala, F, Balato, A, Bauer, A, Ballmer Weber, B, Beliauskiene, A, Fortina, Ab, Bircher, A, Brasch, J, Chowdhury, Mm, Coenraads, Pj, Schuttelaar, Ml, Cooper, S, Czarnecka Operacz, M, Zmudzinska, M, Elsner, P, English, J, Frosch, Pj, Fuchs, T, García Gavín, J, Fernández Redondo, V, Gawkrodger, Dj, Giménez Arnau, A, Green, Cm, Horne, Hl, Johansen, Jd, Jolanki, R, Pesonen, M, King, Cm, Krêcisz, B, Chomiczewska, D, Kiec Swierczynska, M, LARESE FILON, Francesca, Mahler, V, Ormerod, Ad, Peserico, A, Rantanen, T, Rustemeyer, T, Sánchez Pérez, J, Sansom, Je, Silvestre, Jf, Simon, D, Spiewak, R, Statham, Bn, Stone, N, Wilkinson, M, Schnuch, A., Armario-Hita, Jc, Fernandez-Vozmediano, Jm, Ballmer-Weber, B, Czarnecka-Operacz, M, García-Gavín, J, Fernández-Redondo, V, Giménez-Arnau, A, Kiec-Swierczynska, M, Larese, F, Sánchez-Pérez, J, Dermatology, and CCA - Innovative therapy

Subjects
Nickel allergy, Male, contact dermatitis, METHYLISOTHIAZOLINONE, health reporting, chemistry.chemical_compound, STANDARD, Epidemiology, Prevalence, Immunology and Allergy, PROTECTION, REGULATORY INTERVENTION, COBALT RELEASE, contact dermatitis, epidemiology, patch test, A MULTICENTER, NICKEL ALLERGY, Incidence, Patch test, 10177 Dermatology Clinic, clinical epidemiology, Patch Tests, clinical epidemiology, contact allergy, health reporting, patch testing, Perfume, SENSITIZATION, Europe, Occupational Diseases, Metals, Dermatitis, Allergic Contact, 2723 Immunology and Allergy, Female, epidemiology, patch test, medicine.medical_specialty, IVDK, 610 Medicine & health, Dermatology, 2708 Dermatology, patch tests, Methylisothiazolinone, Environmental health, contact dermatiti, medicine, Humans, Baseline (configuration management), Allergic contact dermatitis, patch testing, Series (stratigraphy), business.industry, Allergens, medicine.disease, Surgery, chemistry, PHENYLENEDIAMINE, contact allergy, business, Contact dermatitis
Abstract

BACKGROUND: The pattern of contact sensitization to the supposedly most important allergens assembled in the baseline series differs between countries, presumably at least partly because of exposure differences. Objectives. To describe the prevalence of contact sensitization to allergens tested in consecutive patients in the years 2007 and 2008, and to discuss possible differences.METHODS: Data from the 39 departments in 11 European countries comprising the European Surveillance System on Contact Allergy network (www.essca-dc.org) in this period have been pooled and analysed according to common standards.RESULTS: Patch test results with the European baseline series, and country-specific or department-specific additions to it, obtained in 25 181 patients, showed marked international variation. Metals and fragrances are still the most frequent allergens across Europe. Some allergens tested nationally may be useful future additions to the European baseline series, for example methylisothiazolinone, whereas a few long-term components of the European baseline series, namely primin and clioquinol, no longer warrant routine testing.CONCLUSIONS: The present analysis points to 'excess' prevalences of specific contact sensitization in some countries, although interpretation must be cautious if only few, and possibly specialized, centres are representing one country. A comparison as presented may help to target in-depth research into possible causes of 'excess' exposure, and/or consideration of methodological issues, including modifications to the baseline series.

Published
2012
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