1. [Percutaneous alcohol injection in hyperparathyroidism. Experience in 11 cases with an 18-month follow-up].
- Author
-
Lemmi A, Baroni M, Malaspina C, Rizzo F, Biscarini G, Filipponi P, and Gubbiotti G
- Subjects
- Adenoma diagnostic imaging, Adenoma drug therapy, Alkaline Phosphatase blood, Calcium blood, Follow-Up Studies, Humans, Hyperparathyroidism blood, Hyperparathyroidism diagnostic imaging, Hyperparathyroidism, Secondary blood, Hyperparathyroidism, Secondary diagnostic imaging, Hyperparathyroidism, Secondary drug therapy, Parathyroid Glands diagnostic imaging, Parathyroid Hormone blood, Parathyroid Neoplasms diagnostic imaging, Parathyroid Neoplasms drug therapy, Phosphorus blood, Time Factors, Ultrasonography, Ethanol administration & dosage, Hyperparathyroidism drug therapy
- Abstract
The authors report the results of US-guided percutaneous ethanol injection into parathyroid glands of 11 patients with primary (2) and secondary (9) hyperparathyroidism. Selection criteria for choosing ethanol treatment were the patient's refuse of surgery and high surgical risks for age or severe chronic intercurrent conditions. At 18 months' follow-up, PTH serum levels had normalized in 2 primary and 2 secondary hyperparathyroidism patients; in all the others but one, PTH levels markedly decreased--always > 50% relative to pretreatment values. Serum calcium and phosphorus levels also decreased, which was not always the case with alkaline phosphatase. After injection, the glands became progressively hyperechoic, gland volume decreased and calcifications appeared. Parenchymal flow disappeared on color-Doppler US images. This study confirms the capabilities of US-guided ethanol injection in hyperfunctioning parathyroids, even though complications may occur and the condition recur. This method is thus suggested as an effective alternative to surgery.
- Published
- 1994