4 results on '"Pagano, Maria Teresa"'
Search Results
2. Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers
- Author
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Pagano, MARIA TERESA, Daniela, Peruzzu, Busani, Luca, Marina, Pierdominici, Anna, Ruggieri, Andrea, Antinori, Gianpiero, D'Offizi, Nicola, Petrosillo, Fabrizio, Palmieri, Pierluca, Piselli, Cicalini, Stefania, Stefania, Notari, Nicastri, Emanuele, Chiara, Agrati, Ippolito, Giuseppe, Vaia, Francesco, Maria Cristina Gagliardi, Capobianchi, Maria Rosaria, Ortona, Elena, Manuela, Macchione, Rachele Di Lorenzo, Marta, Camici, Roberta, Gagliardini, Vita, Serena, Maffongelli, Gaetano, Eugenia, Milozzi, Francesca, Faraglia, Cerva, Carlotta, Silvia, Mosti, Davide Roberto Donno, Pierangelo, Chinello, Bordoni, Veronica, Alessandra, Sacchi, Tartaglia, Eleonora, Rita, Casetti, Grassi, Germana, Eleonora, Cimini, Maria Luisa Dupuis, Anticoli, Simona, Fecchi, Katia, Bellenghi, Maria, Puglisi, Rossella, Gianfranco, Mattia, Giada Pontecorvi and, Pagano, M. T., Peruzzu, D., Busani, L., Pierdominici, M., Ruggieri, A., Antinori, A., D'Offizi, G., Petrosillo, N., Palmieri, F., Piselli, P., Cicalini, S., Notari, S., Nicastri, E., Agrati, C., Ippolito, G., Vaia, F., Gagliardi, M. C., Capobianchi, M. R., Ortona, E., Macchione, M., Di Lorenzo, R., Camici, M., Gagliardini, R., Vita, S., Maffongelli, G., Milozzi, E., Faraglia, F., Cerva, C., Mosti, S., Donno, D. R., Chinello, P., Bordoni, V., Sacchi, A., Tartaglia, E., Casetti, R., Grassi, G., Cimini, E., Dupuis, M. L., Anticoli, S., Fecchi, K., Bellenghi, M., Puglisi, R., Mattia, G., and Pontecorvi, G.
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Adult ,Male ,ARDS ,medicine.medical_specialty ,Angiotensins ,Physiology ,Angiotensin1-7 ,Respiratory monitoring ,Gender Studies ,Angiotensin ,Endocrinology ,Internal medicine ,Medicine ,QP1-981 ,Humans ,Testosterone ,Respiratory system ,angiotensin1-7 ,biomarkers ,COVID-19 ,estrogen ,gender ,sex ,testosterone ,Respiratory Distress Syndrome ,Sex Characteristics ,Estradiol ,business.industry ,SARS-CoV-2 ,Research ,Gender ,Biomarker ,Middle Aged ,medicine.disease ,Estrogen ,Hospitalization ,Respiratory failure ,Absolute neutrophil count ,Biomarker (medicine) ,Sex ,Female ,Angiotensin-Converting Enzyme 2 ,business ,Respiratory Insufficiency ,Biomarkers ,Hormone ,Human - Abstract
Background Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim of this study was to identify sex-specific biomarkers of severity and progression of acute respiratory distress syndrome (ARDS) in COVID-19. Methods Plasma levels of sex hormones (testosterone and 17β-estradiol), sex-hormone dependent circulating molecules (ACE2 and Angiotensin1-7) and other known biomarkers for COVID-19 severity were measured in male and female COVID-19 patients at admission to hospital. The association of plasma biomarker levels with ARDS severity at admission and with the occurrence of respiratory deterioration during hospitalization was analysed in aggregated and sex disaggregated form. Results Our data show that some biomarkers could be predictive both for males and female patients and others only for one sex. Angiotensin1-7 plasma levels and neutrophil count predicted the outcome of ARDS only in females, whereas testosterone plasma levels and lymphocytes counts only in males. Conclusions Sex is a biological variable affecting the choice of the correct biomarker that might predict worsening of COVID-19 to severe respiratory failure. The definition of sex specific biomarkers can be useful to alert patients to be safely discharged versus those who need respiratory monitoring.
- Published
- 2021
3. Vitamin D and Sex Differences in COVID-19.
- Author
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Pagano, Maria Teresa, Peruzzu, Daniela, Ruggieri, Anna, Ortona, Elena, and Gagliardi, Maria Cristina
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VITAMIN D ,COVID-19 ,VITAMIN D receptors ,CALCIUM supplements ,ESTROGEN ,COVID-19 pandemic - Published
- 2020
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4. The Sex-Related Interplay between TME and Cancer: On the Critical Role of Estrogen, MicroRNAs and Autophagy.
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Matarrese, Paola, Mattia, Gianfranco, Pagano, Maria Teresa, Pontecorvi, Giada, Ortona, Elena, Malorni, Walter, and Carè, Alessandra
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AUTOPHAGY ,ESTROGEN ,MICRORNA ,SEX hormones ,TUMORS - Abstract
Simple Summary: Autophagy is a complex cell process that allow the cell to survive in unfavorable conditions, e.g., in the lack of nutritional elements coming from the environment. Here we focused on the role played by autophagy in the crosstalk between the microenvironment surrounding the tumor and cancer cells. This environment is in fact known as pivotal in determining the growth or the inhibition of a tumor. Cancer progression and response to therapy significantly differ between women and men and the microenvironment, in particular sex hormones and microRNAs, appears a critical factor. Four representative types of cancer, i.e., colon cancer, melanoma, lymphoma, and lung cancer showing sex/gender specificities have been described herein. We underscore that the use of a "gender tailored" approach could provide a better comprehension of the cellular and molecular mechanisms of cancer growth control contributing to the development of novel therapeutic approaches towards an increasingly personalized medicine. The interplay between cancer cells and the tumor microenvironment (TME) has a fundamental role in tumor progression and response to therapy. The plethora of components constituting the TME, such as stroma, fibroblasts, endothelial and immune cells, as well as macromolecules, e.g., hormones and cytokines, and epigenetic factors, such as microRNAs, can modulate the survival or death of cancer cells. Actually, the TME can stimulate the genetically regulated programs that the cell puts in place under stress: apoptosis or, of interest here, autophagy. However, the implication of autophagy in tumor growth appears still undefined. Autophagy mainly represents a cyto-protective mechanism that allows cell survival but, in certain circumstances, also leads to the blocking of cell cycle progression, possibly leading to cell death. Since significant sex/gender differences in the incidence, progression and response to cancer therapy have been widely described in the literature, in this review, we analyzed the roles played by key components of the TME, e.g., estrogen and microRNAs, on autophagy regulation from a sex/gender-based perspective. We focused our attention on four paradigmatic and different forms of cancers—colon cancer, melanoma, lymphoma, and lung cancer—concluding that sex-specific differences may exert a significant impact on TME/cancer interaction and, thus, tumor growth. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
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