1. Unconjugated estriol and 15alpha-hydroxyestriol in complicated pregnancies.
- Author
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Notation AD and Tagatz GE
- Subjects
- Antibody Formation, Chromatography, Gas, Chromatography, Liquid, Circadian Rhythm, Diabetic Angiopathies immunology, Diabetic Angiopathies metabolism, Female, Fetal Death immunology, Fetal Death metabolism, Humans, Pregnancy, Pregnancy Complications immunology, Pregnancy in Diabetics immunology, Pregnancy in Diabetics metabolism, Pregnancy, Multiple, Rh-Hr Blood-Group System, Twins, Estriol analogs & derivatives, Estriol metabolism, Pregnancy Complications metabolism
- Abstract
Simultaneous determinations of unconjugated estriol and 15alpha-hydroxyestriol (E4) levels in maternal serum were studied serially to ascertain the relative usefulness of these estrogens as indicators of fetal welfare. Complicated pregnancies included 16 patients with pre-eclampsia and/or hypertension, six patients with severe Rh-isoimmunization, 12 patients with diabetes mellitus, of which four had vascular disease, three patients with fetal death in utero, and three twin pregnancies. Retrospective analysis failed to indicate a clinically useful role for serum E4 determinations in the evaluation of fetal welfare during high-risk pregnancies.
- Published
- 1977
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