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Your search keyword '"Zgradić I"' showing total 3 results
Start Over Author "Zgradić I" Topic estramustine
3 results on '"Zgradić I"'

1. Presence of oestrogen receptors on target cells and antiproliferative activity of estramustine phosphate: positive correlation for human tumours in vitro.

Author

Pavelić J, Zgradić I, and Pavelić K

Subjects
Cell Division drug effects, Cytosol metabolism, DNA, Neoplasm biosynthesis, Dose-Response Relationship, Drug, Female, Humans, Kidney Neoplasms metabolism, Leucine metabolism, Male, Prostatic Neoplasms metabolism, Protein Biosynthesis, RNA, Neoplasm biosynthesis, Thymidine metabolism, Tumor Cells, Cultured metabolism, Uridine metabolism, Uterine Cervical Neoplasms metabolism, Uterine Neoplasms metabolism, Estramustine pharmacology, Receptors, Estrogen analysis, Tumor Cells, Cultured drug effects
Abstract

Incubation with estramustine phosphate for 24 h inhibited DNA, RNA and protein synthesis in primary cultures of human kidney, mammary, prostatic, cervical and endometrial carcinoma. Not only the presence, but also the concentration of oestrogen receptors correlated with estramustine phosphate effects on tumour cell proliferation.

Published
1991
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2. Estramustine phosphate-reduced proliferation of murine and human cell lines and murine transplantable tumors.

Author

Pavelić K, Zgradić I, Osmak M, and Popović M

Subjects
Animals, Carcinoma, Ehrlich Tumor pathology, Cell Division drug effects, Cricetinae, Fibroblasts drug effects, Humans, Kidney cytology, Kidney drug effects, Laryngeal Neoplasms pathology, Leukemia, Myeloid pathology, Mammary Neoplasms, Experimental pathology, Mice, Estramustine pharmacology, Neoplasm Transplantation, Nitrogen Mustard Compounds pharmacology
Abstract

The effect of estramustine phosphate (Estracyt) on the growth of murine aplastic mammary carcinoma, Ehrlich carcinoma, melanoma B-16, and five cell lines: L929 (mouse fibroblasts), BHK (baby hamster kidney), HeLa (human cervical carcinoma), HEp-2 (human laryngeal carcinoma), and K562 (human granulocytic leukemia) was investigated. In vivo, estramustine phosphate inhibits the growth of aplastic mammary carcinoma and Ehrlich carcinoma, but has no effect on melanoma B-16. In cultured aplastic mammary carcinoma, estramustine phosphate decreased the incorporation of 3H-thymidine into DNA. This drug inhibits the population growth of L929, BHK, HEp-2, and K562 cultures, but stimulates the growth of HeLa cells. We conclude that estramustine phosphate retards the growth of various cells, and that studies of other potential fields of application of the drug (aside from prostatic carcinoma) is justified.

Published
1985
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