1. Acridine orange induces translocation of phosphatidylserine to red blood cell surface.
- Author
-
Koshkaryev A, Yedgar S, Relevy H, Fibach E, and Barshtein G
- Subjects
- Anion Exchange Protein 1, Erythrocyte metabolism, Cell Adhesion drug effects, Humans, Acridine Orange pharmacology, Erythrocytes drug effects, Erythrocytes metabolism, Mutagens pharmacology, Phosphatidylserines metabolism
- Abstract
Clustering of band-3 on red blood cell (RBC) surface has been assumed to catalyze RBC phagocytosis. In studying this subject, acridine orange (AO) has commonly been employed on the assumption that it specifically induces band-3 clustering. In the present study, we show that AO strongly induces translocation of phosphatidylserine (PS) to RBC surface. Because surface PS is well known to induce RBC intercellular interaction, these findings suggest that the use of AO as a specific inducer of band-3 clustering is questionable. It is possible that band-3 clustering and PS translocation are interdependent, and this interrelationship has yet to be explored.
- Published
- 2003
- Full Text
- View/download PDF