1. Protein Modification Characteristics of the Malaria Parasite Plasmodium falciparum and the Infected Erythrocytes.
- Author
-
Wang J, Jiang N, Sang X, Yang N, Feng Y, Chen R, Wang X, and Chen Q
- Subjects
- Humans, Malaria, Falciparum parasitology, Proteome metabolism, Erythrocytes parasitology, Plasmodium falciparum, Protein Processing, Post-Translational, Protozoan Proteins metabolism
- Abstract
Malaria elimination is still pending on the development of novel tools that rely on a deep understanding of parasite biology. Proteins of all living cells undergo myriad posttranslational modifications (PTMs) that are critical to multifarious life processes. An extensive proteome-wide dissection revealed a fine PTM map of most proteins in both Plasmodium falciparum, the causative agent of severe malaria, and the infected red blood cells. More than two-thirds of proteins of the parasite and its host cell underwent extensive and dynamic modification throughout the erythrocytic developmental stage. PTMs critically modulate the virulence factors involved in the host-parasite interaction and pathogenesis. Furthermore, P. falciparum stabilized the supporting proteins of erythrocyte origin by selective demodification. Collectively, our multiple omic analyses, apart from having furthered a deep understanding of the systems biology of P. falciparum and malaria pathogenesis, provide a valuable resource for mining new antimalarial targets., Competing Interests: Conflict of interest The authors declare no competing interests., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
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