1. Erythrocyte membrane fatty acid concentrations and myelin integrity in young people at ultra-high risk of psychosis.
- Author
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Collins M, Bartholomeusz C, Mei C, Kerr M, Spark J, Wallis N, Polari A, Baird S, Buccilli K, Dempsey SA, Ferguson N, Formica M, Krcmar M, Quinn AL, Wannan C, Oldham S, Fornito A, Mebrahtu Y, Ruslins A, Street R, Loschiavo K, McGorry PD, Nelson B, and Amminger GP more...
- Subjects
- Humans, Male, Female, Young Adult, Adolescent, Anisotropy, White Matter diagnostic imaging, White Matter pathology, White Matter metabolism, Fatty Acids metabolism, Adult, Diffusion Tensor Imaging, Brain diagnostic imaging, Brain metabolism, Brain pathology, Docosahexaenoic Acids metabolism, Psychiatric Status Rating Scales, Fatty Acids, Unsaturated metabolism, Psychotic Disorders metabolism, Psychotic Disorders diagnostic imaging, Psychotic Disorders pathology, Erythrocyte Membrane metabolism, Myelin Sheath metabolism, Myelin Sheath pathology
- Abstract
Decreased white matter (WM) integrity and disturbance in fatty acid composition have been reported in individuals at ultra-high risk of psychosis (UHR). The current study is the first to investigate both WM integrity and erythrocyte membrane polyunsaturated fatty acid (PUFA) levels as potential risk biomarkers for persistent UHR status, and global functioning in UHR individuals. Forty UHR individuals were analysed at baseline for erythrocyte membrane PUFA concentrates. Tract-based spatial statistics (TBSS) was used to analyse fractional anisotropy (FA) and diffusivity measures. Measures of global functioning and psychiatric symptoms were evaluated at baseline and at 12-months. Fatty acids and WM indices did not predict functional outcomes at baseline or 12-months. Significant differences were found in FA between UHR remitters and non-remitters (individuals who no longer met UHR criteria versus those who continued to meet criteria at 12-months). Docosahexaenoic acid (DHA) was found to be a significant predictor of UHR status at 12-months, as was the interaction between the sum of ώ-3 and whole brain FA, and the interaction between the right anterior limb of the internal capsule and the sum of ώ-3. The results confirm that certain fatty acids have a unique relationship with WM integrity in UHR individuals., Competing Interests: Declaration of competing interest The other authors report no biomedical financial interests or potential conflicts of interest., (Copyright © 2024. Published by Elsevier B.V.) more...
- Published
- 2024
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