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1. [Human intra-intronic minisatellite UPS29 associated with neurological diseases regulates reporter gene EGFP expression depending on cell type].

Author

Sasina LK, Slominskaia NA, Suchkova IO, Pitsik EV, Solov'ev KV, Grudinina NA, Klinskaia TA, and Patkin EL

Subjects
Alleles, Animals, Cells, Cultured, Genes, Reporter, HeLa Cells, Humans, Introns genetics, Mice, Minisatellite Repeats genetics, Organ Specificity, Rats, Epilepsy genetics, ErbB Receptors genetics, GTPase-Activating Proteins genetics, Gene Expression Regulation, Membrane Transport Proteins genetics, Minisatellite Repeats physiology, Parkinson Disease genetics
Abstract

Earlier, it was established that polymorphism of minisatellite UPS29 located in one of introns of human gene CENTB5 (ACAP3) was associated with Parkinson's disease and epilepsy. The main aim of this work was to elucidate if that minisatellite could regulate reporter gene activity, and if such activity was tissue (cell)-specific. To this end there was used transient transfection of HeLa cells, mouse embryonal carcinoma line F9, and rat astrocytes cultures with plasmides which contained reporter gene EGFP under eukaryotic promoter ROSA26 and different allelles of minisatellite UPS29. It was found that UPS29 possessed enhancer-like activity in neuronal type cells.

Published
2010

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