1. Na+-K+-ATPase gene regulation by glucocorticoids in a fetal lung epithelial cell line
- Author
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Chalaka, Sridar, Ingbar, David H., Sharma, Renuka, Zhau, Zhong, and Wendt, Christine H.
- Subjects
Epithelium -- Research ,Promoters (Genetics) -- Research ,Lungs -- Genetic aspects ,Epithelial cells -- Research ,Sodium channels -- Research ,Potassium -- Research ,Adenosine triphosphatase genes -- Research ,Biological sciences - Abstract
The Na+ channel and Na+-K+-ATPase are essential for the perinatal removal of alveolar solute and fluid. It was hypothesized that maternal glucocorticoids (GCs) increased Na+-K+-ATPase gene expression in a fetal lung epithelial cell line because Na+-pump mRNA and activity increase before birth. The results showed that GCs increased Na+-K+-ATPase transcription in a fetal lung epithelial cell line. The findings suggest important therapeutic implications, one of which is optimizing treatment of premature infants by maternal GCs.
- Published
- 1999