1. Oral Mucosal Epithelial Transplantation and Limbal-Rigid Contact Lens: A Therapeutic Modality for the Treatment of Severe Ocular Surface Disorders.
- Author
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Sotozono C, Inatomi T, Nakamura T, Ueta M, Imai K, Fukuoka H, Komai S, Ishida G, Kitazawa K, Yokoi N, Koizumi N, Kimura Y, Go M, Fukushima M, and Kinoshita S
- Subjects
- Burns, Chemical physiopathology, Cells, Cultured, Combined Modality Therapy, Corneal Diseases physiopathology, Corneal Diseases therapy, Epithelium, Corneal cytology, Epithelium, Corneal transplantation, Eye Burns physiopathology, Humans, Pemphigoid, Benign Mucous Membrane physiopathology, Stem Cell Transplantation, Stevens-Johnson Syndrome physiopathology, Vision Disorders rehabilitation, Visual Acuity physiology, Burns, Chemical therapy, Contact Lenses, Epithelial Cells transplantation, Eye Burns chemically induced, Mouth Mucosa cytology, Pemphigoid, Benign Mucous Membrane therapy, Stevens-Johnson Syndrome therapy
- Abstract
Stevens-Johnson syndrome, ocular cicatricial pemphigoid, and severe thermal or chemical injury are considered severe ocular surface disorders (OSDs) because they affect the entire ocular surface, including corneal and conjunctival epithelial stem cells. In patients with severe OSDs, the long-term prognosis for limbal transplantation is poor, and the related corneal opacity and cicatrization lead to devastating visual impairment. To date, there is no standardized treatment to improve vision in cases with severe OSD. Investigating novel treatment methods for severe OSDs, our group began cultivated oral mucosal epithelial transplantation in 2002 and developed a limbal-supported rigid-type contact lens that can be applied as a nonsurgical treatment. When used in combination, these treatment methods make it possible to successfully restore vision in cases with severe OSDs.
- Published
- 2020
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