1. Renal tubular epithelial cells response to injury in acute kidney injury.
- Author
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Li ZL, Li XY, Zhou Y, Wang B, Lv LL, and Liu BC
- Subjects
- Humans, Animals, Biomarkers, Fibrosis, Regeneration, Acute Kidney Injury etiology, Acute Kidney Injury pathology, Acute Kidney Injury metabolism, Epithelial Cells metabolism, Kidney Tubules pathology, Kidney Tubules metabolism
- Abstract
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid and significant decrease in renal function that can arise from various etiologies, and is associated with high morbidity and mortality. The renal tubular epithelial cells (TECs) represent the central cell type affected by AKI, and their notable regenerative capacity is critical for the recovery of renal function in afflicted patients. The adaptive repair process initiated by surviving TECs following mild AKI facilitates full renal recovery. Conversely, when injury is severe or persistent, it allows the TECs to undergo pathological responses, abnormal adaptive repair and phenotypic transformation, which will lead to the development of renal fibrosis. Given the implications of TECs fate after injury in renal outcomes, a deeper understanding of these mechanisms is necessary to identify promising therapeutic targets and biomarkers of the repair process in the human kidney., Competing Interests: Declaration of interests The authors confirm that there are no conflicts of interest., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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