1. [Dynamics of regeneration of epitheliocytes from gastric mucosa at different modes of antirelapse treatment of ulcer disease].
- Author
-
Osadchuk AM, Komarov FI, Osadchuk MA, Islamova EA, and Kvetnoĭ IM
- Subjects
- Adolescent, Adult, Amoxicillin therapeutic use, Clarithromycin therapeutic use, Drug Therapy, Combination, Duodenal Ulcer microbiology, Duodenal Ulcer pathology, Epithelial Cells microbiology, Epithelial Cells pathology, Gastric Mucosa microbiology, Gastric Mucosa pathology, Humans, Ki-67 Antigen metabolism, Middle Aged, Omeprazole therapeutic use, Proto-Oncogene Proteins c-bcl-2 metabolism, Secondary Prevention, Young Adult, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents therapeutic use, Duodenal Ulcer prevention & control, Epithelial Cells drug effects, Gastric Mucosa drug effects, Helicobacter pylori drug effects, Melatonin therapeutic use
- Abstract
Exacerbation of duodenal ulcer disease (DUD) is associated with elevated number of Ki-67 and Bcl-2 positive endtotheliocytes and apoptotic activity. Inhibition of endotheliocyte proliferation and apoptotic activity in gastric mucosa (GM) upon eradication of Hp in DUD patients promotes ulcer healing. Combination of eradication with melaxen therapy substantially enhances efficiency of Hp elimination and reduces cicatrization time. Antirelapse treatment with melaxene and omeprazole normalizes endotheliocyte homeostasis on GM to a greater degree than omeprazole monotherapy.
- Published
- 2010