9 results on '"Morace, Roberta"'
Search Results
2. Surgery after intracranial investigation with subdural electrodes in patients with drug-resistant focal epilepsy: outcome and complications
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Morace, Roberta, Di Gennaro, Giancarlo, Picardi, Angelo, Quarato, Pier Paolo, Sparano, Antonio, Mascia, Addolorata, Meldolesi, Giulio Nicolò, Grammaldo, Liliana Graciela, De Risi, Marco, and Esposito, Vincenzo
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- 2012
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3. Long-term seizure outcome in frontal lobe epilepsy surgery.
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Morace, Roberta, Casciato, Sara, Quarato, Pier Paolo, Mascia, Addolorata, D'Aniello, Alfredo, Grammaldo, Liliana G., De Risi, Marco, Di Gennaro, Giancarlo, and Esposito, Vincenzo
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TEMPORAL lobectomy , *EPILEPSY , *TUMOR grading , *FRONTAL lobe , *ENCEPHALITIS , *SCALP , *MAGNETIC resonance imaging - Abstract
Abstract Purpose The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery. Method This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001–2014), followed up for at least 2 years (mean: 8.7 years). All patients underwent noninvasive presurgical evaluation and/or invasive electroencephalography (EEG) monitoring when nonconcordant data were obtained or epileptogenic zone was hypothesized to be close to the eloquent cortex. Electroclinical, neuroimaging, surgical data, and histology were compared to seizure outcome. Results Mean epilepsy duration was 19 years; mean age at surgery was 31.6 years. Preoperative magnetic resonance imaging (MRI) showed a frontal lesion in 86.4 % of cases. Scalp video-electroencephalography (VEEG) monitoring detected a focal ictal onset in 90% of cases. Twenty-seven patients (61.4%) underwent invasive recordings. Resections involved dorsolateral (47.7%), medial (9%), orbital (13.6%), and rolandic (13.6%) region. Lobectomy within functional boundaries was performed in the remaining 7 cases (16%). Transient and permanent neurological deficits were observed in 2 and 3 cases, respectively. Histology revealed focal cortical dysplasia (45.5%), World Health Organization (WHO) I–II grade tumors (15.9%), gliosis (22.7%), vascular malformations (4.5%), Rasmussen encephalitis (6.8%), and normal tissue (4.5%). At last observation 68.1% of patients were in Engel's class I, 11.4% in class II, 9% in class III, and 11.4% in class IV. A favorable outcome was associated with focal ictal scalp EEG onset (p = 0.0357). Conclusion Surgery is a safe treatment option in drug-resistant FLE with a satisfying long-term outcome. These data highlight the importance of an appropriate selection of potential surgical candidates. Highlights • Surgery is a safe option in drug-resistant FLE with a satisfying long-term outcome. • The presence of focal lesions predicts favorable outcome. • Focal ictal scalp EEG onset is associated with a favorable long-term outcome. [ABSTRACT FROM AUTHOR]
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- 2019
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4. Surgery after intracranial investigation with subdural electrodes in patients with drug-resistant focal epilepsy: outcome and complications
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Morace, Roberta, Giancarlo, Gennaro, Di Gennaro, G., Angelo, Picardi, Pier Paolo Quarato, Antonio, Sparano, Addolorata, Mascia, Giulio Nicolò Meldolesi, Liliana Graciela Grammaldo, Marco, Risi, De Risi, M., and Esposito, Vincenzo
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Drug Resistance ,Subdural Space ,Electroencephalography ,Neurosurgical Procedures ,Temporal lobe ,Lesion ,Epilepsy ,Young Adult ,Postoperative Complications ,Seizures ,Monitoring, Intraoperative ,epilepsy surgery ,extratemporal epilepsy ,subdural electrodes ,outcome ,medicine ,Image Processing, Computer-Assisted ,Humans ,Epilepsy surgery ,Subdural space ,Child ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Electrodes, Implanted ,medicine.anatomical_structure ,Treatment Outcome ,Surgery, Computer-Assisted ,Female ,Neurology (clinical) ,Neurosurgery ,Epilepsies, Partial ,medicine.symptom ,business - Abstract
Video–EEG monitoring with intracranial subdural electrodes is a useful assessment tool for the localization of the epileptogenic zone in patients with drug-resistant focal epilepsy. We aimed at assessing the morbidity related to electrode implantation and the surgical outcome in patients who underwent epilepsy surgery after intracranial EEG monitoring. All patients (N = 58) admitted to our Epilepsy Surgery Centre for drug-resistant focal epilepsy who underwent resective surgery after intracranial monitoring with subdural electrodes and were followed up for at least 2 years were included in the study. Their mean age was 30.4 years (range 8–60 years), 25 (43 %) were female, and 44 (76 %) had a preoperatively detected structural lesion. The mean duration of invasive recording was 2.3 days (range 1–14 days). Extraoperative ECoG allowed the identification of the epileptogenic focus in all cases. The temporal lobe was involved in 21 (36 %) patients, whereas extratemporal foci were identified in 24 (41 %) patients. Thirteen patients (23 %) had multilobar involvement. Functional brain mapping was performed in 15 (26 %) patients. Transient complications related to electrode implantation occurred in three patients. Among patients with evidence of lesion on preoperative MRI, lesionectomy alone was performed in 12 cases (27 %), while it was combined with tailored cortical resection in the remaining cases. Tailored cortical resection was also performed in patients without evidence of lesion on MRI. After resective surgery, transient neurological deficits occurred in five cases, while another patient experienced permanent lateral homonymous hemianopia. At the last follow-up observation, 34 (57 %) patients were seizure-free (Engel class I). This study suggests that invasive EEG recording with subdural electrodes may be useful and fairly safe for many candidates for epilepsy surgery.
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- 2011
5. Temporal pole abnormalities detected by 3 T MRI in temporal lobe epilepsy due to hippocampal sclerosis: No influence on seizure outcome after surgery.
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Casciato, Sara, Picardi, Angelo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Meldolesi, Giulio Nicolo’, Morace, Roberta, Esposito, Vincenzo, Di Gennaro, Giancarlo, D'Aniello, Alfredo, and Meldolesi, Giulio Nicolo'
- Abstract
Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) detected by using 3 Tesla MRI in the preoperative workup in patients with temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS) who underwent surgery.Methods: We studied 78 consecutive patients with TLE-HS who underwent surgery and were followed up for at least 2 years. Based on findings of pre-surgical 3 Tesla MRI, patients were subdivided in subgroups according to the presence of TB or TA. Subgroups were compared on demographic, clinical, neuropsychological data and seizure outcome.Results: TB was found in 39 (50%) patients, while TA was found in 32 (41%) patients, always ipsilateral to HS, with a considerable degree of overlap (69%) between TB and TA (p=0.01). Patients with temporopolar abnormalities did not significantly differ from those without TB or TA with regard to sex, age, age of epilepsy onset, duration of epilepsy, history of febrile convulsions or birth complications, side of surgery, seizure frequency at surgery, presence of GTCSs, and, in particular, seizure outcome. On the other hand, TB patients show a less frequent family history of epilepsy (p<.05) while age at epilepsy onset showed a trend to be lower in the TB group (p=.09). Patients with temporopolar atrophy did not significantly differ from those without TA on any variable, except for age at epilepsy onset, which was significantly lower for the TA group (p<.05). History of birth complications and longer duration of epilepsy also showed a trend to be associated with TA (p=.08). Multivariate analysis corroborated the association between temporopolar abnormalities and absence of family history of epilepsy and history of birth complications.Conclusions: High-field 3 T MRI in the preoperative workup for epilepsy surgery confirms that temporopolar abnormalities are frequent findings in TLE-HS patients and may be helpful to lateralize the epileptogenic zone. Their presence did not influence seizure outcome. [ABSTRACT FROM AUTHOR]- Published
- 2017
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6. Ictal dancing-like semiology in frontal lobe epilepsy.
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Casciato, Sara, Pruneddu, Gianluca, Morace, Roberta, Esposito, Vincenzo, and Di Gennaro, Giancarlo
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FRONTAL lobe ,SYMPTOMS ,EPILEPSY ,VISUAL memory ,TEMPORAL lobe epilepsy ,EPILEPSY surgery ,ELECTROENCEPHALOGRAPHY ,MOVEMENT disorders ,DISEASE complications - Published
- 2019
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7. Temporal pole abnormalities in temporal lobe epilepsy with hippocampal sclerosis: Clinical significance and seizure outcome after surgery.
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Di Gennaro, Giancarlo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Casciato, Sara, Morace, Roberta, Esposito, Vincenzo, Picardi, Angelo, and D'Aniello, Alfredo
- Abstract
Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) with a long post-surgical follow-up.Methods: We studied 60 consecutive patients with TLE-HS and 1.5 preoperative MRI scans who underwent surgery and were followed up for at least 5 years (mean follow-up 7.3 years). Based on findings of pre-surgical MRI, patients were classified according to the presence of TB or TA. Groups were compared on demographic, clinical, neuropsychological data, and seizure outcome.Results: TB was found in 37 (62%) patients, while TA was found in 35 (58%) patients, always ipsilateral to HS, with a high degree of overlap (83%) between TB and TA (p<0.001). Patients with TB did not differ from those without TB with regard to history of febrile convulsions, GTCSs, age of epilepsy onset, side of surgery, seizure frequency, seizure outcome, and neuropsychological outcome. On the other hand, they were significantly older, had a longer duration of epilepsy, and displayed lower preoperative scores on several neuropsychological tests. Similar findings were observed for TA. Multivariate analysis corroborated the association between temporopolar abnormalities and age at onset, age at surgery (for TB only), and lower preoperative scores on some neuropsychological tests.Conclusions: Temporopolar abnormalities are frequent in patients with TLE-HS. Our data support the hypothesis that TB and TA are caused by seizure-related damages. These abnormalities did not influence seizure outcome, even after a long-term post-surgical follow-up. [ABSTRACT FROM AUTHOR]- Published
- 2015
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8. Very long-term seizure outcome in frontal lobe epilepsy surgery.
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Casciato, Sara, Morace, Roberta, Quarato, Pier Paolo, Mascia, Addolorata, D'Aniello, Alfredo, Grammaldo, Liliana G., Esposito, Vincenzo, and Di Gennaro, Giancarlo
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EPILEPSY surgery , *FRONTAL lobe , *TEMPORAL lobectomy , *SEIZURES (Medicine) - Published
- 2021
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9. Temporal lobe epilepsy surgery in children and adults: A multicenter study
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Barba, Carmen, Cossu, Massimo, Guerrini, Renzo, Di Gennaro, Giancarlo, Villani, Flavio, De Palma, Luca, Grisotto, Laura, Consales, Alessandro, Battaglia, Domenica, Zamponi, Nelia, d’Orio, Piergiorgio, Revay, Martina, Rizzi, Michele, Casciato, Sara, Esposito, Vincenzo, Quarato, Pier Paolo, Di Giacomo, Roberta, Didato, Giuseppe, Pastori, Chiara, Pavia, Giusy Carfi, Pellacani, Simona, Matta, Giulia, Pacetti, Mattia, Tamburrini, Gianpiero, Cesaroni, Elisabetta, Colicchio, Gabriella, Vatti, Giampaolo, Asioli, Sofia, Caulo, Massimo, Marras, Carlo Efisio, Tassi, Laura, D’Aniello, Alfredo, Morace, Roberta, De Curtis, Marco, Deleo, Francesca, Giordano, Flavio, De Benedictis, Alessandro, Prato, Giulia, Perulli, Marco, Barba C., Cossu M., Guerrini R., Di Gennaro G., Villani F., De Palma L., Grisotto L., Consales A., Battaglia D., Zamponi N., d'Orio P., Revay M., Rizzi M., Casciato S., Esposito V., Quarato P.P., Di Giacomo R., Didato G., Pastori C., Carfi Pavia G., Pellacani S., Matta G., Pacetti M., Tamburrini G., Cesaroni E., Colicchio G., Vatti G., Asioli S., Caulo M., Marras C.E., and Tassi L.
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0301 basic medicine ,Male ,Electroencephalography ,Neuropsychological Tests ,Hippocampus ,Neurosurgical Procedures ,Epilepsy ,0302 clinical medicine ,Postoperative Complications ,Cognition ,Epilepsy surgery ,Child ,seizure outcome ,medicine.diagnostic_test ,Age Factors ,Prognosis ,Temporal Lobe ,Malformations of Cortical Development ,Neurology ,Child, Preschool ,epilepsy surgery ,Anticonvulsants ,Female ,Adult ,medicine.medical_specialty ,Referral ,Adolescent ,Temporal lobe ,03 medical and health sciences ,Young Adult ,Settore MED/39 - NEUROPSICHIATRIA INFANTILE ,children ,Internal medicine ,Early Medical Intervention ,medicine ,Humans ,Preschool ,Retrospective Studies ,Hippocampal sclerosis ,Sclerosis ,business.industry ,Magnetic resonance imaging ,Odds ratio ,cognitive outcome ,medicine.disease ,030104 developmental biology ,Epilepsy, Temporal Lobe ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective: To assess seizure and cognitive outcomes and their predictors in children (
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