1. Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.
- Author
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Fujii Y, Tanaka T, Harada C, Hirai T, and Kamei C
- Subjects
- Animals, Cetirizine administration & dosage, Cetirizine pharmacology, Diphenhydramine administration & dosage, Diphenhydramine pharmacology, Electroencephalography drug effects, Histamine H1 Antagonists administration & dosage, Injections, Intraperitoneal, Ketotifen administration & dosage, Ketotifen pharmacology, Loratadine administration & dosage, Loratadine pharmacology, Male, Pyrilamine administration & dosage, Pyrilamine pharmacology, Rats, Rats, Wistar, Amygdala physiology, Epilepsy chemically induced, Histamine H1 Antagonists pharmacology, Kindling, Neurologic drug effects
- Abstract
The epileptogenic activities induced by histamine H(1) antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H(1) antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.
- Published
- 2003
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