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5 results on '"Cavestro C"'

1. Antiphospholipid antibodies in epilepsy: A systematic review and meta-analysis.

Author

Islam MA, Alam F, Cavestro C, Calcii C, Sasongko TH, Levy RA, and Gan SH

Subjects
Humans, Antibodies, Antiphospholipid immunology, Epilepsy etiology, Epilepsy pathology
Abstract

Background: Autoimmunity is believed to play an important causative role in the pathogenesis of epilepsy. There are evidences for the presence of autoantibodies in patients with epilepsy. To date, many studies have assessed the presence of antiphospholipid antibodies (aPLs) in epilepsy patients, though the relationship has been inconclusive., Aims: The aim of this systematic review and meta-analysis was to evaluate the presence of aPLs in epileptic patients as compared to healthy controls., Methods: Five electronic databases (PubMed, Web of Science, Embase, Scopus and Google Scholar) were searched systematically. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects model. Quality assessment was carried out by using the modified 9-star Newcastle-Ottawa Scale (NOS). L'Abbé plots were generated to visually inspect heterogeneity while publication bias was evaluated via visualization of contour- enhanced funnel plots, and Begg's and Egger's tests., Results: Based on the inclusion criteria, 14 studies were selected involving 1248 epilepsy patients and 800 healthy controls. The majority of epilepsy was categorised as generalised or partial and none had comorbidity with autoimmune diseases. Significant presence of both anticardiolipin (aCL) antibodies (OR: 5.16, 95% CI: 3.21-8.28, p < 0.00001) and anti-β2- glycoprotein I (anti-β2-GPI) antibodies (OR: 2.95, 95% CI: 1.07-8.11, p = 0.04) exhibited comorbid association with epilepsy patients as compared to healthy controls. Subgroup analyses revealed that presence of aCL antibodies was more specifically observed in paediatrics (OR: 4.57, 95% CI: 2.57-8.15, p < 0.00001) than adults (OR: 4.24, 95% CI: 1.80-10.01, p = 0.001). The odds of aCL antibody presence was higher in partial epilepsy patients (OR: 7.88, 95% CI: 3.23-19.24, p < 0.00001) than that of generalised (OR: 3.76, 95% CI: 2.15-6.59, p < 0.00001) and in Asian epileptic patients (OR: 9.56, 95% CI: 2.69-33.95, p = 0.0005) than Europeans (OR: 4.35, 95% CI: 2.74-6.92, p < 0.00001). The presence of anti-β2-GPI antibodies was significant in paediatric (OR: 6.44, 95% CI: 1.39-29.89, p = 0.02) and African population with epilepsies (OR: 10.59, 95% CI: 1.22-92.25, p = 0.03). NOS of the majority of the studies (11/14) indicated a high methodological quality. No substantial heterogeneity was observed either from the quantitative analysis or from the L'Abbé plots while no significant publication bias was detected from funnel plots; Begg's and Egger's tests., Conclusion: Since none of the epilepsy subjects exhibited any comorbid autoimmune disorders, significant presence of aCL and anti-β2-GPI antibodies indicate towards their contribution in immune-mediated general pathogenesis of epilepsy., (Copyright © 2018. Published by Elsevier B.V.)

Published
2018
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2. Chronic alcohol use and first symptomatic epileptic seizures.

Author

Leone M, Tonini C, Bogliun G, Monaco F, Mutani R, Bottacchi E, Gambaro P, Rocci E, Tassinari T, Cavestro C, and Beghi E

Subjects
Adult, Brain Injuries complications, Brain Neoplasms complications, Case-Control Studies, Chronic Disease, Epilepsy diagnosis, Epilepsy epidemiology, Female, Humans, Incidence, Male, Stroke complications, Surveys and Questionnaires, Alcoholism complications, Epilepsy etiology
Abstract

Objective: To establish whether chronic alcoholism and alcohol consumption are risk factors for developing a first symptomatic epileptic seizure., Methods: Multicentre case-control study of 293 patients (160 men, 133 women) with a first seizure symptomatic (either acute or remote) of head trauma, stroke, or brain tumour, matched to 444 hospital controls for centre, sex, age (+/-5 years), and underlying pathology., Results: The risk of first seizure in alcoholics was no higher than in non-alcoholics for men (odds ratio 1.2, 95% confidence interval 0.4 to 3.2) or women (1.5, 0.1 to 54.4). The odds ratio (both sexes) was 1.2 (0.8 to 1.7) for an average intake of absolute alcohol of 1-25 g/day, 0.9 (0.5 to 1.5) for 26-50 g/day, 1.6 (0.8 to 3.0) for 51-100 g/day, and 1.4 (0.5 to 3.5) for >100 g/day., Conclusions: We found no evidence of an association between alcohol use or alcoholism and a first symptomatic seizure.

Published
2002
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3. Psychiatric events in epilepsy

Author

Cornaggia, Cesare Maria, Beghi, Massimiliano, Beghi, Ettore, Cornaggia, C. M., Airoldi, L., Beghi, M., Bogliun, G., Brambilla, E., Fiordelli, E., Mascarini, A., Moltrasio, L., Primati, C., Hauser, W. A., Loeber, J. N., De Boer, H., Thorbecke, R., Steuernagel, E., Wolf, P., Sonnen, A. E. H., Severi, S., Zolo, P., Specchio, L. M., Specchio, N., Pasolini, M. P., Antonini, L., Aguglia, U., Russo, C., Gambardella, A., Giubergia, S., Zagnoni, P. G., Cosottini, Mirco, Zaccara, G., Trio, R., Pisani, F., Russo, M., Oteri, G., Cavestro, C. E., Tonini, C., Avanzini, G., Arienti, F., Defanti, C. A., Tartara, A., Manni, R., Castelnuovo, G., Murelli, R., Galimberti, C. A., Zanotta, N., Di Viesti, P., Zarrelli, M., Apollo, F., Runge, U., de Krom, M. C. T. F. M., van Heijden, C., Griet, J., Brown, S. W., Coyle, H., Lopez Lima, J. M., Beleza, P., Ferreira, E., Talvik, T., Beilmann, A., Belousova, E., Levart, T., Zupancic, N., Gromov, S., Lipatova, L. V., Mikhailov, V., Cornaggia, C, Beghi, M, Beghi, E, and Rest, 1

Subjects
Adult, Male, medicine.medical_specialty, Neurology, Adolescent, Referral, Population, Clinical Neurology, Comorbidity, Anxiety, Epilepsy, medicine, Humans, epilepsy, psychiatry, Occupations, Psychiatry, Prospective cohort study, education, Depression (differential diagnoses), education.field_of_study, Depression, business.industry, Mental Disorders, Case-control study, General Medicine, Case-control, medicine.disease, Psychiatric, Case-Control Studies, Female, Follow-Up Studies, Hospitalization, Socioeconomic Factors, Neurology (clinical), MED/25 - PSICHIATRIA, Case–control, business
Abstract

Psychiatric events are thought to be more frequent in people with epileptic seizures than in the general population. However, inter-ictal psychiatric events attributable to epilepsy remain controversial. The aim of the present study was to evaluate the occurrence of psychiatric events in a population of fairly unselected patients with epilepsy and in the general population, and the correlation between psychiatric complaints and selected demographic and disease characteristics. The survey was part of a multicentre prospective cohort study of everyday life risks conducted in eight European countries and comparing referral children and adults with epilepsy referred to secondary/tertiary centers to age- and sex-matched non-epileptic controls. Nine hundred and fifty-one patients with epilepsy and 909 controls were studied. Each patient and his/her control received a diary to record any accident or illness, with severity, circumstances, causes, consequences, and (for the cases) the possible relation to a seizure. The follow-up period ranged between 1 and 2 years. Fifty-eight psychiatric events occurred in 25 patients (2.6%) and 88 in 19 controls (2.1%). Housewives (9.3%) and unemployed persons (4.1%) were mostly affected. No correlation was found between psychiatric events, demographic and disease characteristics. Our results suggest that people with epilepsy if unselected are not at higher risk for psychiatric disorders than the general population. © 2007 British Epilepsy Association.

Published
2007

4. Accidents in Patients with Epilepsy: Types, Circumstances, and Complications: A European Cohort Study

Author

van den Broek, Mariska, Beghi, Ettore, Cornaggia, C. M., Beghi, M., Bogliun, G., Fiordelli, E., Airoldi, L., Frigeni, B., Mascarini, A., Mapelli, L., Moltrasio, L., Biagi, E., Hauser, W. A., Loeber, J. N., Thorbecke, R., Di Viesti, P., Zarrelli, M., Apollo, F., Giovanni Rotondo, S., Steuernagel, E., Wolf, P., Sonnen, A. E. H., Specchio, L. M., Specchio, N., Boati, E., Defanti, C. A., Pinto, P., Breviario, E., Pasolini, M. P., Antonini, L., Aguglia, U., Russo, C., Gambardella, A., Giubergia, S., Zagnoni, P., Cosottini, Mirco, Zaccara, G., Pisani, F., Oteri, G., Cavestro, C. E., David, A., Tonini, C., Avanzini, G., Arienti, F., Tartara, A., Manni, R., Castelnovo, G., Murelli, R., Galimberti, C. A., Zanotta, N., Runge, U., Dekrom, M. C. T. F. M., Vanheijden, C., Griet, J., van denBroek, M. W. C., Brown, S. W., Coyle, H., Edge, Nr Alderley, Lopes Lima, J. M., Beleza, P., Ferreira, E., Talvik, T., Beilmann, A., Belousova, E., Nikanorowa, M., Ravnik, I. M., Levart, T., Zupancic, N., Gromov, S., Lipatova, L. V., Mikhailov, V., Van den Broek, M, Beghi, E, and Cornaggia, C

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Poison control, Cohort Studies, Epilepsy, Risk Factors, Injury prevention, Accidents, Occupational, Humans, Medicine, Prospective Studies, Preschool, Child, Prospective cohort study, Injuries, business.industry, epilepsy, complications, types, circumstances, Accidents, Accidents, Home, Child, Preschool, Europe, Female, Follow-Up Studies, Hospitalization, Patient Acceptance of Health Care, Wounds and Injuries, Neurology, Neurology (clinical), medicine.disease, Occupational, Relative risk, Cohort, Home, business, Risk assessment, Cohort study
Abstract

Purpose: To investigate the risk of accidents in a cohort of patients with epilepsy and in matched nonepilepsy controls. by type, circumstances, and complications. Methods: A total of 95 1 children and adults with idiopathic, cryptogenic, or remote symptomatic epilepsy and 904 matched controls seen in secondary and tertiary centers in eight European Countries (England. Estonia, Germany, Italy, the Netherlands, Portugal. Russia. and Slovenia) were followed Lip prospectively for 17,484 and 17.206 person-months and asked to report any accident requiring medical attention. its site, and complications. Risk assessment was done by using actuarial methods, relative risks (RRs). and 95% confidence intervals (CIs). Results: During the study period, 199 (21%) patients and 123 (14%) controls reported all accident (p < 0.0001); 24% were seizure related. The Cumulative probability of accidents at 12 and 24 months was 17 and 27% in the cases and 12 and 17% in the controls. The risk was highest for concussions (RR, 2.6; 95% Cl, 1.2-5.8), abrasions (RR, 2.1; 95% Cl, 1.1-4.0), and Wounds (RR, 1.9; Cl, 1.2-3.1). Domestic accidents prevailed in both groups, followed by street and work accidents, and were more common among cases. Compared with controls, patients with epilepsy reported more hospitalization, complications, and medical action. Disease characteristics associated with an increased risk of accidents included generalized epilepsy (conclusions), active epilepsy, and at least monthly seizures (abrasions). Most risks decreased, becoming nonsignificant after excluding, seizure-related events. Conclusions: Patients with epilepsy are at higher risk of accidents and their complications. However, the risk was substantially lower after exclusion of seizure-related events

Published
2004

5. Treatment of first tonic-clonic seizure does not affect mortality: long-term follow-up of a randomised clinical trial

Author

Leone, Ma, Vallalta, R, Solari, A, Beghi, E, Hauser, Wa, Fratiglioni, L, Bogliun, G, DEL FELICE, Alessandra, Aloisi, P, Marelli, A, Porto, C, Fusi, L, Francesconi, C, Gambaro, P, Basso, P, Freschi, R, Meregalli, S, Boati, E, Mamoli, A, Gavalotti, B, Camerlingo, M, Rottoli, Mr, Bottacchi, E, Carenini, L, Sironi, L, Casara, Gl, Vecchi, M, Covezzi, E, Tortorici, G, Franzoni, E, Marchiani, V, Moscano, F, Giuliani, G, Angeleri, Va, Polonara, S, Terziani, S, Quattrini, A, Ortenzi, A, Paggi, A, Iemolo, F, Geda, C, Ferrari, Gf, Binetti, Ma, Martini, A, Perenchio, Mt, Malvezzi, L, Tabladon, G, Severi, S, Zolo, P, Montano, V, Fassio, F, Vignolo, L, Pasolini, Mp, Antonini, L, De Maria, G, Rossi, G, Tonini, C, Cittani, D, Zagnoni, Pg, Clerici, D, Romeo, A, Viri, M, Lodi, M, Mazza, S, Vaccario, Ml, De Mattei, M, Cremo, R, Zaina, P, Gentile, S, Lovera, N, Piazza, D, Ravetti, C, Cavestro, C, Rosettani, P., Leone MA, Vallalta R, Solari A, Beghi E, FIRST Group [.., Franzoni E, and ]

Subjects
Male, Time Factors, long-term follow-up, Electroencephalography, law.invention, Epilepsy, Randomized controlled trial, law, Recurrence, Risk Factors, Young adult, Family history, Child, first tonic-clonic seizure, medicine.diagnostic_test, treatment, clinical trial, Middle Aged, Magnetic Resonance Imaging, first tonic–clonic seizure, seizure, Settore MED/26 - NEUROLOGIA, Psychiatry and Mental health, Treatment Outcome, Child, Preschool, Anticonvulsants, Female, Adult, medicine.medical_specialty, Adolescent, antiepileptic treatment, Neurological examination, Young Adult, Seizures, Internal medicine, medicine, Humans, business.industry, medicine.disease, mortality, Surgery, Clinical trial, tonic-clonic seizure, Etiology, Neurology (clinical), business, Tomography, X-Ray Computed, Follow-Up Studies
Abstract

Information on the effects of early treatment of seizures on mortality is scarce. The authors assessed the survival of patients with a first generalised tonic-clonic seizure, randomised to immediate treatment (treated) versus treatment only in the event of seizure recurrence (untreated), over a 20-year period. METHODS: The authors followed 419 patients. The median follow-up was 19.7 years (range 0.2-21.5) for a total of 7867 person-years. RESULTS: 40 persons (9.6%) died during follow-up, 19 (8.9%) treated and 21 (10.3.%) untreated. The probability of surviving was 100% at 1 year, 97% (95% CI 95% to 99%) at 5 years, 94% (91-97) at 10 years and 91% (87-95) at 20 years in treated patients and 100%, 98% (95-100), 97% (94-99) and 89% (85-94), respectively, in untreated patients (p=0.7). After adjustment for treatment of first seizure and putative risk factors (gender, age, seizure type, previous uncertain seizures, family history of seizures, pre-, peri- and postnatal risk factors, remote aetiological factors for epilepsy, abnormal neurological examination, CT or MRI abnormalities, EEG abnormalities and acute treatment), only the presence of aetiological factors for epilepsy predicted a higher mortality (HR 3.4, 95% CI 2.5 to 4.3%; p

Published
2011

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