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Your search keyword '"van Leuken, Jeroen"' showing total 3 results
Start Over Author "van Leuken, Jeroen" Topic epidemiology
3 results on '"van Leuken, Jeroen"'

1. A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics

Author

De Rooij, Myrna M T, Van Leuken, Jeroen P G, Swart, Arno, Kretzschmar, Mirjam E E, Nielen, Mirjam, De Koeijer, Aline A, Janse, Ingmar, Wouters, Inge M, Heederik, Dick J J, One Health Microbieel, dIRAS RA-I&I RA, dFAH AVR, One Health Microbieel, dIRAS RA-I&I RA, and dFAH AVR

Subjects
Coxiella burnetii/physiology, Epidemiology, Review, 0403 veterinary science, 0302 clinical medicine, Models, Multidisciplinary approach, Non-U.S. Gov't, Review Articles, Risk management, biology, airborne exposure, Research Support, Non-U.S. Gov't, risk assessment, 04 agricultural and veterinary sciences, Q Fever/epidemiology, Identification (information), Infectious Diseases, Geography, Coxiella burnetii, epidemiology, Public Health, Risk assessment, spatial analysis, 040301 veterinary sciences, Bioinformatica & Diermodellen, 030231 tropical medicine, Q fever, Research Support, Models, Biological, Airborne transmission, 03 medical and health sciences, Immunology and Microbiology(all), Bio-informatics & Animal models, Journal Article, medicine, Animals, Humans, Epidemiology, Bio-informatics & Animal models, Epidemics, Exposure assessment, Epidemiologie, General Veterinary, General Immunology and Microbiology, business.industry, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, Biological, biology.organism_classification, medicine.disease, veterinary(all), Data science, Epidemiologie, Bioinformatica & Diermodellen, WIAS, business
Abstract

From 2007 through 2010, the Netherlands experienced the largest Q fever epidemic ever reported. This study integrates the outcomes of a multidisciplinary research programme on spatial airborne transmission of Coxiella burnetii and reflects these outcomes in relation to other scientific Q fever studies worldwide. We have identified lessons learned and remaining knowledge gaps. This synthesis was structured according to the four steps of quantitative microbial risk assessment (QMRA): (a) Rapid source identification was improved by newly developed techniques using mathematical disease modelling; (b) source characterization efforts improved knowledge but did not provide accurate C. burnetii emission patterns; (c) ambient air sampling, dispersion and spatial modelling promoted exposure assessment; and (d) risk characterization was enabled by applying refined dose–response analyses. The results may support proper and timely risk assessment and risk management during future outbreaks, provided that accurate and structured data are available and exchanged readily between responsible actors.

Published
2019
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2. Two Community Clusters of Legionnaires' Disease Directly Linked to a Biologic Wastewater Treatment Plant, the Netherlands.

Author

Loenenbach, Anna D., Beulens, Christian, Euser, Sjoerd M., van Leuken, Jeroen P. G., Bom, Ben, van der Hoek, Wim, de Roda Husman, Ana Maria, Ruijs, Wilhelmina L. M., Bartels, Alvin A., Rietveld, Ariene, den Boer, Jeroen W., Brandsema, Petra S., and Husman, Ana Maria de Roda

Subjects
LEGIONELLA pneumophila, WASTEWATER treatment, LEGIONNAIRES' disease, INFECTIOUS disease transmission, EPIDEMIOLOGY
Abstract

A biologic wastewater treatment plant was identified as a common source for 2 consecutive Legionnaires' disease clusters in the Netherlands in 2016 and 2017. Sequence typing and transmission modeling indicated direct and long-distance transmission of Legionella, indicating this source type should also be investigated in sporadic Legionnaires' disease cases. [ABSTRACT FROM AUTHOR]

Published
2018
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3. Characteristics of Hospitalized Acute Q Fever Patients during a Large Epidemic, The Netherlands.

Author

Wielders, Cornelia C. H., Wuister, Annemarie M. H., de Visser, Veerle L., de Jager-Leclercq, Monique G., Groot, Cornelis A. R., Dijkstra, Frederika, van Gageldonk-Lafeber, Arianne B., van Leuken, Jeroen P. G., Wever, Peter C., van der Hoek, Wim, and Schneeberger, Peter M.

Subjects
Q fever, HOSPITAL care, EPIDEMICS, PUBLIC health, EPIDEMIOLOGICAL research, HEALTH risk assessment, THERAPEUTICS
Abstract

Background: From 2007 to 2009, the Netherlands experienced a major Q fever epidemic, with higher hospitalization rates than the 2–5% reported in the literature for acute Q fever pneumonia and hepatitis. We describe epidemiological and clinical features of hospitalized acute Q fever patients and compared patients presenting with Q fever pneumonia with patients admitted for other forms of community-acquired pneumonia (CAP). We also examined whether proximity to infected ruminant farms was a risk factor for hospitalization. Methods: A retrospective cohort study was conducted for all patients diagnosed and hospitalized with acute Q fever between 2007 and 2009 in one general hospital situated in the high incidence area in the south of the Netherlands. Pneumonia severity scores (PSI and CURB-65) of acute Q fever pneumonia patients (defined as infiltrate on a chest x-ray) were compared with data from CAP patients. Hepatitis was defined as a >twofold the reference value for alanine aminotransferase and for bilirubin. Results: Among the 183 hospitalized acute Q fever patients, 86.0% had pneumonia. Elevated liver enzymes (alanine aminotransferase) were found in 32.3% of patients, although hepatitis was not observed in any of them. The most frequent clinical signs upon presentation were fever, cough and dyspnoea. The median duration of admission was five days. Acute Q fever pneumonia patients were younger, had less co-morbidity, and lower PSI and CURB-65 scores than other CAP patients. Anecdotal information from attending physicians suggests that some patients were admitted because of severe subjective dyspnoea, which was not included in the scoring systems. Proximity to an infected ruminant farm was not associated with hospitalization. Conclusion: Hospitalized Dutch acute Q fever patients mostly presented with fever and pneumonia. Patients with acute Q fever pneumonia were hospitalized despite low PSI and CURB-65 scores, presumably because subjective dyspnoea was not included in the scoring systems. [ABSTRACT FROM AUTHOR]

Published
2014
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