5 results on '"Verstraeten, Thomas"'
Search Results
2. Epidemiology of Escherichia coli Bacteremia: A Systematic Literature Review.
- Author
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Bonten, Marc, Johnson, James R, Biggelaar, Anita H J van den, Georgalis, Leonidas, Geurtsen, Jeroen, Palacios, Patricia Ibarra de, Gravenstein, Stefan, Verstraeten, Thomas, Hermans, Peter, and Poolman, Jan T
- Subjects
ESCHERICHIA coli disease prevention ,BACTEREMIA ,ONLINE information services ,META-analysis ,SYSTEMATIC reviews ,AGE distribution ,URINARY tract infections ,CROSS infection ,ESCHERICHIA coli diseases ,DESCRIPTIVE statistics ,COMMUNITY-acquired infections ,MEDLINE ,DISEASE risk factors - Abstract
Background Escherichia coli is the most common cause of bacteremia in high-income countries. To enable the development and implementation of effective prevention strategies, a better understanding of the current epidemiology of invasive E. coli infections is needed. Methods A systematic review of literature published between 1 January 2007 and 31 March 2018 on the burden and epidemiology of E. coli bacteremia in populations that include adults in high-income countries was conducted. Meta-analysis was performed for descriptive purposes. Results During the studied time interval, the estimated incidence rate of E. coli bacteremia was 48 per 100 000 person-years, but this increased considerably with age: rates per 100 000 person-years were >100 in 55-to-75-year-olds and >300 in 75-to-85-year-olds. Overall, E. coli accounted for 27% of documented bacteremia episodes: 18% if hospital acquired, 32% if community-onset healthcare associated, and 33% if community acquired. The estimated case fatality rate was 12%. Approximately 44% of episodes were community acquired, 27% community-onset healthcare associated, and 27% hospital acquired. Urinary tract infection (UTI) was the primary source for 53% of episodes. Conclusions This systematic review confirms the substantial burden of E. coli bacteremia in older adults and justifies the implementation of community-level programs to prevent E. coli bacteremia and ideally UTI in this age group. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. The incidence of medically-attended norovirus gastro-enteritis in Japan: Modelling using a medical care insurance claims database.
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Chang, Chia-Hsien, Sakaguchi, Motonobu, Weil, John, and Verstraeten, Thomas
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NOROVIRUS diseases ,GASTROENTERITIS ,HEALTH insurance claims ,OUTPATIENT services in hospitals ,MEDICAL databases ,PATIENTS - Abstract
Background: The burden of medically-attended acute gastro-enteritis (MA-AGE) that can be attributed to norovirus is not well established in Japan. Using a nationwide database of medical care insurance claims, we estimated the incidence of medically-attended norovirus-attributable gastroenteritis (MA-NGE) in Japan. Methods: The incidences of MA-NGE outpatient consultations or hospitalization in Japan were modelled on seasonal patterns of MA-AGE for unspecified causes derived from the Japan Medical Data Center (JMDC) database for the period July 2007 to June 2015. Results: Mean age-adjusted annual incidence rates (per 10,000 person-years) of MA-NGE associated with outpatient care or hospitalization were 389 (95% CI 269–558) and 13 (95% CI 9–20), respectively. Highest rates were in children under 5 years of age: 1,569 (95% CI 1,325–1,792) for outpatient consultations and 48 (95% CI 39–56) for hospitalizations. Of all gastroenteritis episodes associated with outpatient care or hospitalization, 29% and 31% were attributed to norovirus, respectively. Norovirus was estimated to be responsible for 4,964,000 outpatient visits (95% CI 3,435,000–7,123,000) and 171,000 hospitalizations (95% CI 110,000–251,000) per year across Japan. Conclusions: Incidence rates of MA-AGE are high in Japan, and norovirus-attributable disease is at least as high as in some other developed countries. [ABSTRACT FROM AUTHOR]
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- 2018
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4. A decade of norovirus disease risk among older adults in upper-middle and high income countries: a systematic review.
- Author
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Lindsay, Lisa, Wolter, Joanne, De Coster, Ilse, Damme, Pierre Van, Verstraeten, Thomas, and Van Damme, Pierre
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DATABASES ,EPIDEMICS ,GASTROENTERITIS ,HOSPITAL care ,RNA viruses ,SURVIVAL ,SYSTEMATIC reviews ,DEVELOPED countries ,NOROVIRUS diseases - Abstract
Background: Noroviruses (NoVs) are the most common cause of acute gastroenteritis (AGE) causing both sporadic and outbreak-associated illness. Norovirus (NoV) infections occur across all ages but certain sub-groups are considered at increased risk due to heightened transmission and/or symptom severity. Older adults are potentially at high risk of NoV-associated illness due to frequent outbreaks in long-term care facilities (LTCFs) and severe health outcomes following infection. Elucidation of NoV risk among older adults will support prevention, treatment and control efforts.Methods: We conducted a systematic literature review to summarize the published risk estimates of NoV-associated illness, hospitalization and death among individuals aged 65 years and older. A structured search using defined NoV and gastroenteritis (GE) terms was performed in the PubMed and EMBASE databases of human studies published between January 1, 2003 and May 16, 2013.Results: We identified 39 studies from high income (HI) and upper-middle income (UMI) countries. Thirty-six percent of publications provided risk estimates based on laboratory-confirmed or epidemiologically-linked population-based surveillance data using molecular diagnostic methods. Over the study period, estimated annual NoV rates and extrapolated number of cases among older adults in HI and UMI countries were: 29-120/10,000 or 1.2-4.8 million NoV-associated illnesses; 18-54/10,000 or 723,000-2.2 million NoV-associated outpatient visits; 1-19/10,000 or 40,00-763,000 NoV-associated inpatient visits; 0.04-0.32/10,000 or 2000-13,000 NoV-associated deaths. NoV was responsible for approximately 10-20 % of GE hospitalizations and 10-15 % of all-cause GE deaths among older adults. Older adults experienced a heightened risk of nosocomial infections. Those in LTCFs experience frequent NoV outbreaks and the range in attack rates was 3-45 %, case hospitalization rates 0.5-6 % and case fatality rates 0.3-1.6 %.Conclusions: Older adults are at increased risk of severe NoV-associated health outcomes. NoV-associated hospitalization rates were higher, more severe, resulted in longer stays and incurred greater costs than for younger patients. NoV-associated mortality rates were approximately 200 % higher among individuals 65 years and older compared to <5 years. The burden of NoV among older adults is expected to rise along with societal aging and increased need for institutionalized care. NoV prevention in older adults, including potential vaccination, may significantly impact risk of severe illness. [ABSTRACT FROM AUTHOR]- Published
- 2015
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5. Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization
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Susanne Hartwig, Bayad Nozad, Grazina Mirinaviciute, Niel Hens, Audrey Souverain, Thomas Verstraeten, Kaatje Bollaerts, Margarita Riera-Montes, Elmira Flem, Ulrich Heininger, Giovanni Gabutti, Ángel Gil, HENS, Niel, Mirinaviciute, Grazina, Gabutti, Giovanni, Nozad, Bayad, Hartwig, Susanne, Flem, Elmira, BOLLAERTS, Kaatje, Souverain, Audrey, Heininger, Ulrich, Verstraeten, Thomas, Riera-Montes, Margarita, and Gil, Angel
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Adult ,0301 basic medicine ,medicine.medical_specialty ,Pediatrics ,Adolescent ,030106 microbiology ,Socio-culturale ,Disease ,varicella ,disease burden ,Europe ,Varicella ,lcsh:Infectious and parasitic diseases ,Chickenpox Vaccine ,Young Adult ,03 medical and health sciences ,Chickenpox ,0302 clinical medicine ,Seroepidemiologic Studies ,Epidemiology ,Health care ,medicine ,Humans ,Seroprevalence ,lcsh:RC109-216 ,030212 general & internal medicine ,Child ,Disease burden ,Primary Health Care ,business.industry ,Transmission (medicine) ,Incidence (epidemiology) ,Vaccination ,Primary care physician ,Infant ,virus diseases ,Patient Acceptance of Health Care ,Hospitalization ,Infectious Diseases ,Child, Preschool ,Immunization ,Human medicine ,business ,Switzerland ,Research Article - Abstract
Background Varicella is generally considered a mild disease. Disease burden is not well known and country-level estimation is challenging. As varicella disease is not notifiable, notification criteria and rates vary between countries. In general, existing surveillance systems do not capture cases that do not seek medical care, and most are affected by underreporting and underascertainment. We aimed to estimate the overall varicella disease burden in Europe to provide critical information to support decision-making regarding varicella vaccination. Methods We conducted a systematic literature review to identify all available epidemiological data on varicella IgG antibody seroprevalence, primary care and hospitalisation incidence, and mortality. We then developed methods to estimate age-specific varicella incidence and annual number of cases by different levels of severity (cases in the community, health care seekers in primary care and hospitals, and deaths) for all countries belonging to the European Medicines Agency (EMA) region and Switzerland. Results In the absence of universal varicella immunization, the burden of varicella would be substantial with a total of 5.5 million (95% CI: 4.7–6.4) varicella cases occurring annually across Europe. Variation exists between countries but overall the majority of cases (3 million; 95% CI: 2.7–3.3) would occur in children
- Published
- 2017
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