15 results on '"LeRoy, Eric"'
Search Results
2. Ebola Hemorrhagic Fever Outbreaks in Gabon, 1994-1997: Epidemiologic and Health Control Issues
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Georges, Alain-Jean, Leroy, Eric M., Renaut, André A., Benissan, Carol Tevi, Nabias, René J., Obiang, Paul I., Lepage, J. P. M., Bertherat, Eric J., Bénoni, David D., Wickings, E. Jean, Amblard, Jacques P., Lansoud-Soukate, Joseph M., Milleliri, J. M., Baize, Sylvain, and Georges-Courbot, Marie-Claude
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- 1999
3. Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon.
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Abbate, Jessica L., Becquart, Pierre, Leroy, Eric, Ezenwa, Vanessa O., and Roche, Benjamin
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EBOLA virus disease ,PLASMODIUM ,EBOLA virus ,BLOOD parasites ,PLASMODIUM falciparum ,PROTOZOA ,RESEARCH ,PHENOMENOLOGICAL biology ,RESEARCH methodology ,EVALUATION research ,MEDICAL cooperation ,MALARIA ,COMPARATIVE studies ,RURAL population ,DISEASE complications - Abstract
An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions. We found a strong positive association, on population and individual levels, between seropositivity for antibodies against Ebola virus and the presence of Plasmodium parasites in the blood. According to a multiple regression model accounting for other key variables, antibodies against Ebola virus emerged as the strongest individual-level risk factor for acquiring malaria. Our results suggest that within-host interactions between malaria parasites and Ebola virus may underlie epidemiologic associations. [ABSTRACT FROM AUTHOR]
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- 2020
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4. Revisiting human T-cell lymphotropic virus types 1 and 2 infections among rural population in Gabon, central Africa thirty years after the first analysis.
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Caron, Melanie, Besson, Guillaume, Padilla, Cindy, Makuwa, Maria, Nkoghe, Dieudonne, Leroy, Eric, and Kazanji, Mirdad
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T cells ,LYMPHOTACTIN ,INFECTION ,SEROPREVALENCE ,PHYLOGENETIC models - Abstract
HTLV-1 infection is considered as highly endemic in central Africa. Thirty years ago, a first epidemiological study was performed in Gabon, central Africa, and revealed that the prevalence varied from 5.0 to 10.5%. To evaluate current distribution of HTLVs in Gabon, 4.381 samples were collected from rural population living in 220 villages distributed within the 9 provinces of country. HTLVs prevalence was determined using two ELISA tests and positive results were confirmed by Western Blot. The overall HTLV-1 seroprevalence was of 7.3% among the rural Gabonese population; with 5.4% for men and 9.0% for women. Prevalence of HTLV-1 differed by province, ranging from 2.3% to 12.5% into the rain forest. Being a woman older than 51 years represented a high risk for HTLV-1 acquisition. Hospitalization, operation/surgery, transfusion and medical abortion or fever, arthritis and abdominal pain are also significant risk factors. In addition, 0.1% of samples were found as HTLV-2 positive, while 12.0% had an indeterminate HTLV serological pattern. HTLV-3 and HTLV-4 were not found. Phylogenetic analysis was performed on 87 samples and demonstrated that HTLV-1 present in Gabon belongs mostly to subtype B, however the rare subtype D was also found. Altogether, our results demonstrate that almost thirty years after the first epidemiological study prevention of HTLVs infection is still an issue in Gabon. [ABSTRACT FROM AUTHOR]
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- 2018
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5. A limited outbreak of Ebola haemorrhagic fever in Etoumbi, Republic of Congo, 2005
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Nkoghe, D., Kone, M. L., Yada, A., and Leroy, Eric
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Epidemiology ,Ebola ,Republic of Congo ,Outbreak ,Haemorrhagic fever - Abstract
Ebolavirus has caused highly lethal outbreaks of haemorrhagic fever in the Congo basin. The 2005 outbreak in the Republic of Congo occurred in the Etoumbi district of Cuvette Ouest Department between April and May. The two index cases were infected while poaching. The sanitary response consisted of active surveillance and contact tracing, public awareness campaigns and community mobilization, case management and safe burial practices, and laboratory confirmation. Twelve cases and ten deaths were reported (lethality 83%). A transmission tree was constructed from a sample collected by a medical team. This outbreak was remarkable by its short duration and limited size. Increased awareness among these previously affected populations and the rapid response of the healthcare system probably contributed to its extinction.
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- 2011
6. Discussions and decisions of the 2012-2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012-June 2013.
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Bukreyev, Alexander, Chandran, Kartik, Dolnik, Olga, Dye, John, Ebihara, Hideki, Leroy, Eric, Mühlberger, Elke, Netesov, Sergey, Patterson, Jean, Paweska, Janusz, Saphire, Erica, Smither, Sophie, Takada, Ayato, Towner, Jonathan, Volchkov, Viktor, Warren, Travis, and Kuhn, Jens
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CLASSIFICATION of viruses ,FILOVIRIDAE ,VIRUSES ,VIROLOGY ,EPIDEMIOLOGY ,PATHOLOGY ,IMMUNOLOGY - Abstract
The International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group prepares proposals on the classification and nomenclature of filoviruses to reflect current knowledge or to correct disagreements with the International Code of Virus Classification and Nomenclature (ICVCN). In recent years, filovirus taxonomy has been corrected and updated, but parts of it remain controversial, and several topics remain to be debated. This article summarizes the decisions and discussion of the currently acting ICTV Filoviridae Study Group since its inauguration in January 2012. [ABSTRACT FROM AUTHOR]
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- 2014
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7. Spatial and Temporal Dynamics of a Mortality Event among Central African Great Apes.
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Cameron, Kenneth N., Reed, Patricia, Morgan, David B., Ondzié, Alain I., Sanz, Crickette M., Kühl, Hjalmar S., Olson, Sarah H., Leroy, Eric, Karesh, William B., and Mundry, Roger
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TROGLODYTES (Bird genus) ,HOMINIDS ,MORTALITY ,EPIDEMICS ,STATISTICAL models - Abstract
In 2006–2007 we observed an unusual mortality event among apes in northern Republic of Congo that, although not diagnostically confirmed, we believe to have been a disease outbreak. In 2007–2011 we conducted ape nest surveys in the region, recording 11,835 G. g. gorilla nests (2,262 groups) and 5,548 P. t. troglodytes nests (2,139 groups). We developed a statistical model to determine likely points of origin of the outbreak to help identify variables associated with disease emergence and spread. We modeled disease spread across the study area, using suitable habitat conditions for apes as proxy for local ape densities. Infectious status outputs from that spread model were then used alongside vegetation, temperature, precipitation and human impact factors as explanatory variables in a Generalized Linear Model framework to explain observed 2007–2011 ape nest trends in the region. The best models predicted emergence in the western region of Odzala-Kokoua National Park and north of the last confirmed Ebola virus disease epizootics. Roads were consistently associated with attenuation of modeled virus spread. As disease is amongst the leading threats to great apes, gaining a better understanding of disease transmission dynamics in these species is imperative. Identifying ecological drivers underpinning a disease emergence event and transmission dynamics in apes is critical to creating better predictive models to guide wildlife management, develop potential protective measures for wildlife and to reduce potential zoonotic transmission to humans. The results of our model represent an important step in understanding variables related to great ape disease ecology in Central Africa. [ABSTRACT FROM AUTHOR]
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- 2016
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8. Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa.
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Boundenga, Larson, Makanga, Boris, Ollomo, Benjamin, Gilabert, Aude, Rougeron, Virginie, Mve-Ondo, Bertrand, Arnathau, Céline, Durand, Patrick, Moukodoum, Nancy Diamella, Okouga, Alain-Prince, Delicat-Loembet, Lucresse, Yacka-Mouele, Lauriane, Rahola, Nil, Leroy, Eric, BA, Cheikh Tidiane, Renaud, Francois, Prugnolle, Franck, and Paupy, Christophe
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HAEMOSPORIDA ,ANTELOPES ,MOLECULAR biology ,ANIMAL diversity ,VERTEBRATE classification - Abstract
Re-examination, using molecular tools, of the diversity of haemosporidian parasites (among which the agents of human malaria are the best known) has generally led to rearrangements of traditional classifications. In this study, we explored the diversity of haemosporidian parasites infecting vertebrate species (particularly mammals, birds and reptiles) living in the forests of Gabon (Central Africa), by analyzing a collection of 492 bushmeat samples. We found that samples from five mammalian species (four duiker and one pangolin species), one bird and one turtle species were infected by haemosporidian parasites. In duikers (from which most of the infected specimens were obtained), we demonstrated the existence of at least two distinct parasite lineages related to Polychromophilus species (i.e., bat haemosporidian parasites) and to sauropsid Plasmodium (from birds and lizards). Molecular screening of sylvatic mosquitoes captured during a longitudinal survey revealed the presence of these haemosporidian parasite lineages also in several Anopheles species, suggesting a potential role in their transmission. Our results show that, differently from what was previously thought, several independent clades of haemosporidian parasites (family Plasmodiidae) infect mammals and are transmitted by anopheline mosquitoes. [ABSTRACT FROM AUTHOR]
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- 2016
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9. Bat Distribution Size or Shape as Determinant of Viral Richness in African Bats.
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Maganga, Gaël D., Bourgarel, Mathieu, Vallo, Peter, Dallo, Thierno D., Ngoagouni, Carine, Drexler, Jan Felix, Drosten, Christian, Nakouné, Emmanuel R., Leroy, Eric M., and Morand, Serge
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COMMUNICABLE diseases ,BIODIVERSITY ,HABITATS ,FRAGMENTED landscapes ,PTEROPODIDAE ,COMPARATIVE studies - Abstract
The rising incidence of emerging infectious diseases (EID) is mostly linked to biodiversity loss, changes in habitat use and increasing habitat fragmentation. Bats are linked to a growing number of EID but few studies have explored the factors of viral richness in bats. These may have implications for role of bats as potential reservoirs. We investigated the determinants of viral richness in 15 species of African bats (8 Pteropodidae and 7 microchiroptera) in Central and West Africa for which we provide new information on virus infection and bat phylogeny. We performed the first comparative analysis testing the correlation of the fragmented geographical distribution (defined as the perimeter to area ratio) with viral richness in bats. Because of their potential effect, sampling effort, host body weight, ecological and behavioural traits such as roosting behaviour, migration and geographical range, were included into the analysis as variables. The results showed that the geographical distribution size, shape and host body weight have significant effects on viral richness in bats. Viral richness was higher in large-bodied bats which had larger and more fragmented distribution areas. Accumulation of viruses may be related to the historical expansion and contraction of bat species distribution range, with potentially strong effects of distribution edges on virus transmission. Two potential explanations may explain these results. A positive distribution edge effect on the abundance or distribution of some bat species could have facilitated host switches. Alternatively, parasitism could play a direct role in shaping the distribution range of hosts through host local extinction by virulent parasites. This study highlights the importance of considering the fragmentation of bat species geographical distribution in order to understand their role in the circulation of viruses in Africa. [ABSTRACT FROM AUTHOR]
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- 2014
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10. Phylogeography, Risk Factors and Genetic History of Hepatitis C Virus in Gabon, Central Africa.
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Njouom, Richard, Caron, Mélanie, Besson, Guillaume, Ndong-Atome, Guy-Roger, Makuwa, Maria, Pouillot, Régis, Nkoghé, Dieudonné, Leroy, Eric, Kazanji, Mirdad, and Bowyer, Sheila Mary
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HEPATITIS C virus ,EPIDEMIOLOGY ,DISEASE prevalence ,GABONESE ,POPULATION ,SEROPREVALENCE ,PHYLOGENY ,IATROGENIC diseases - Abstract
Background: The epidemiological and molecular characteristics of hepatitis C virus (HCV) infection in the general population have been poorly investigated in Africa. The aim of this study was to determine the prevalence, genotype distribution and epidemic history of HCV in the Gabonese general population. Methods/Principal Findings: A total of 4042 sera collected from adults in 220 villages in all nine administrative areas of the country were screened for antibodies to HCV. HCV NS5B region sequencing was performed for molecular characterization and population genetic analyses. Of 4042 tested sera, 455 (11.2%) were positive. The seroprevalence of HCV varied significantly by administrative area, with the highest rate in Ogooué-Lolo province (20.4%) and the lowest in Ogooué-Maritine province (3.7%). History of parenteral injections, past hospital admission and age over 55 years were independent risk factors for HCV infection (p<0.0001). Phylogenetic analyses showed that 91.9% of the strains were genotype 4 (HCV-4), 5.7% genotype 1 and 2.2% genotype 2. HCV-4 strains were highly heterogeneous, with more than eight subtypes; subtype 4e predominated (57.3%). Coalescence analyses indicated that subtype 4e was the oldest, with an estimated most recent common ancestor of 1702 [95% CI, 1418-1884]. The epidemic profile indicated that it spread exponentially during the first part of the 20th century, probably by iatrogenic transmission. Conclusions/Significance: These results confirm the endemicity of HCV subtype 4e in Gabon and show that its spread is due to a cohort effect, with previous, possibly iatrogenic events. More extensive epidemiological studies are needed to better characterize the route of transmission and the dissemination of HCV in Gabon. [ABSTRACT FROM AUTHOR]
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- 2012
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11. Epidemiology of Concomitant Infection Due to Loa loa and Mansonella perstans in Gabon.
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Akue, Jean Paul, Nkoghe, Dieudonné, Padilla, Cindy, Moussavou, Ghislain, Moukana, Hubert, Mbou, Roger Antoine, Ollomo, Benjamin, and Leroy, Eric Maurice
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EPIDEMIOLOGY ,MIXED infections ,SYMPTOMS ,BLOOD parasites ,INFECTION ,EDEMA - Abstract
Background: The filarial parasites Loa loa and Mansonnella perstans are endemic in the central and western African forest block. Loa loa is pathogenic and represents a major obstacle to the control of co-endemic filariae because its treatment can cause fatal complications such as encephalitis. Methodology/Principal Findings: 4392 individuals aged over 15 years were studied both by direct examination and a concentration technique. The overall prevalence rates were 22.4% for Loa loa microfilaremia, 10.2% for M. perstans microfilaremia, and 3.2% for mixed infection. The prevalence of both filariae was higher in the forest ecosystem than in savannah and lakeland (p<0.0001). The intensity of microfilariae (mf) was also higher in the forest ecosystem for both parasites. The prevalence and intensity of microfilaria were both influenced by age and gender. Correlations were found between the prevalence and intensity of Loa loa microfilariae (r = 0.215 p = 0.036), and between the prevalence of Loa loa and the prevalence of individuals with microfilaria >8000 mf/ml (r = 0.624; p<0.0001) and microfilariae >30 000 mf/ml (r = 0.319, p = 0.002). In contrast, the prevalence of pruritis and Calabar swellings correlated negatively with the prevalence of Loa loa microfilaria (r = −0.219, p = 0.032; r = −0.220; p = 0.031, respectively). Pruritis, Calabar swellings and eye worm were not associated with L. loa mf intensity (r = −0.144, p = 0.162; r–0.061, p = 0.558; and r = 0.051, p = 0.624, respectively), or with the prevalence or intensity of M. perstans microfilariae. Conclusions/Significance: This map of the distribution of filariae in Gabon should prove helpful for control programs. Our findings confirm the spatial uniformity of the relationship between parasitological indices. Clinical manifestations point to a relationship between filariae and allergy. Author Summary: Loa loa and Mansonella perstans are blood filarial parasites, endemic in the central and western African forest block, and transmitted by chrysops and culicoides flies, respectively. Loa loa is pathogenic and represents a major obstacle to the control of co-endemic filariae. Treatment of individuals with >8000 Loa loa microfilariae/ml can result in severe adverse reactions. M. perstans is prevalent in the tropics, with undefined clinical symptoms. We screened 4392 individuals for these infections in 212 Gabonese villages. The overall prevalence rates were 22.4% for Loa loa microfilariae, 10.2% for M. perstans, and 3.2% for mixed infection. These rates varied across the different ecosystems: forest, savannah, Lakeland, river (Ogouée), and equator. A correlation was found between the prevalence and intensity of microfilariae, while a negative relationship was found between clinical symptoms (pruritis, Calabar swelling) and the prevalence of Loa loa microfilaremia. This study confirms the spatial uniformity of the relationship between parasitological indices, and provides a map and baseline data for implementation of mass chemotherapy for these infections. [ABSTRACT FROM AUTHOR]
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- 2011
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12. Emergence of Divergent Zaire Ebola Virus Strains in Democratic Republic of the Congo in 2007 and 2008.
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Grard, Gilda, Biek, Roman, Tamfum, Jean-Jacques Muyembe, Fair, Joseph, Wolfe, Nathan, Formenty, Pierre, Paweska, Janusz, and Leroy, Eric
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EBOLA virus ,EPIDEMICS ,VIRAL genomes ,PHYLOGENY ,EPIDEMIOLOGY - Abstract
Background. Zaire ebolavirus was responsible for 2 outbreaks in Democratic Republic of the Congo (DRC), in 1976 and 1995. The virus reemerged in DRC 12 years later, causing 2 successive outbreaks in the Luebo region, Kasai Occidental province, in 2007 and 2008. Methods. Viruses of each outbreak were isolated and the full-length genomes were characterized. Phylogenetic analysis was then undertaken to characterize the relationships with previously described viruses. Results. The 2 Luebo viruses are nearly identical but are not related to lineage A viruses known in DRC or to descendants of the lineage B viruses encountered in the Gabon-Republic of the Congo area, with which they do, however, share a common ancestor. Conclusions. Our findings strongly suggest that the Luebo 2007 outbreak did not result from viral spread from previously identified foci but from an independent viral emergence. The previously identified epidemiological link with migratory bat species known to carry Zaire ebolavirus RNA support the hypothesis of viral spillover from this widely dispersed reservoir. The high level of similarity between the Luebo2007 and Luebo2008 viruses suggests that local wildlife populations (most likely bats) became infected and allowed local viral persistence and reemergence from year to year. [ABSTRACT FROM AUTHOR]
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- 2011
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13. A limited outbreak of Ebola haemorrhagic fever in Etoumbi, Republic of Congo, 2005
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Nkoghe, Dieudonné, Kone, Mamadou Lamine, Yada, Adamou, and Leroy, Eric
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EBOLA virus disease ,HEMORRHAGIC fever ,DISEASE outbreaks ,EPIDEMIOLOGY ,VIRUS disease transmission ,POACHING ,PUBLIC health - Abstract
Abstract: Ebolavirus has caused highly lethal outbreaks of haemorrhagic fever in the Congo basin. The 2005 outbreak in the Republic of Congo occurred in the Etoumbi district of Cuvette Ouest Department between April and May. The two index cases were infected while poaching. The sanitary response consisted of active surveillance and contact tracing, public awareness campaigns and community mobilization, case management and safe burial practices, and laboratory confirmation. Twelve cases and ten deaths were reported (lethality 83%). A transmission tree was constructed from a sample collected by a medical team. This outbreak was remarkable by its short duration and limited size. Increased awareness among these previously affected populations and the rapid response of the healthcare system probably contributed to its extinction. [Copyright &y& Elsevier]
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- 2011
- Full Text
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14. Detection of novel astroviruses among rodents of Gabon, Central Africa.
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Mombo, Illich Manfred, Suquet, Eloïse, Boundenga, Larson, Mveang-Nzoghe, Amandine, Maganga-Mboga, Claude, Arnathau, Céline, Sidobre, Christine, Leroy, Eric M., and Rougeron, Virginie
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ASTROVIRUSES , *VIRUS diseases , *ZOONOSES , *LABORATORY rodents , *ANIMAL species - Abstract
Abstract Astroviruses (AstVs) are mostly responsible for mild to severe gastroenteritis infections in humans and animals. AstVs infect a wide range of host species, have a large genetic diversity with different circulating variants and are thus a high zoonotic risk for human populations. Among these host species, rodents are known to harbor several AstVs variants. Therefore, it is important to identify in rodent species which AstVs are circulating and evaluate their potential zoonotic risk for humans. In this context, this study aimed to screen the presence of AstVs in 267 rodents trapped in 2012 in Franceville and Makokou, two cities in Gabon. RNA extracted from grinded intestines were used for the screening of AstVs by amplification of a conserved region of the RNA dependent RNA polymerase. Results report the identification of AstVs in 12 individuals (4.6% rate), belonging to three different species including Rattus rattus , Mus musculus and Hybomys univittatus. These findings report the first identification of AstVs in R. rattus and H. univittatus. The phylogenetic analyses indicate host specificity of rodents AstVs. The absence of rodent AstVs within the human AstV clade suggests a low rate of interspecies transmission of these viruses and consequently a low zoonotic risk. Highlights • Astroviruses infect Hybomys univittatus, Mus Musculus and Rattus rattus. • Rattus rattus is the predominant species infected by astroviruses. • Astrovirus detected in each rodent are host specific. • None of rodent astroviruses is genetically close to human Astroviruses. [ABSTRACT FROM AUTHOR]
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- 2019
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15. Ebola Virus Disease in the Democratic Republic of Congo.
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Maganga, Gaël D., Kapetshi, Jimmy, Berthet, Nicolas, Kebela Ilunga, Benoît, Kabange, Felix, Mbala Kingebeni, Placide, Mondonge, Vital, Muyembe, Jean-Jacques T., Bertherat, Eric, Briand, Sylvie, Cabore, Joseph, Epelboin, Alain, Formenty, Pierre, Kobinger, Gary, González-Angulo, Licé, Labouba, Ingrid, Manuguerra, Jean-Claude, Okwo-Bele, Jean-Marie, Dye, Christopher, and Leroy, Eric M.
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EBOLA virus disease , *EPIDEMIC research , *NUCLEOTIDE sequence , *EBOLA virus , *EPIDEMIOLOGY , *PUBLIC health - Abstract
The article discusses a study on the outbreak of Ebola virus disease (EVD) in the Democratic Republic of Congo which started on July 26, 2014. Topics mentioned include simultaneous reports of EVD in equatorial and West Africa and whether the two outbreaks where linked, details of genome sequencing which confirmed the Ebola virus as the cause of the outbreak, and similar clinical and epidemiological characteristics of the EVD outbreak in Congo and previous outbreaks in equatorial Africa.
- Published
- 2014
- Full Text
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