1. Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED)
- Author
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Catherine John, Nicola F Reeve, Robert C Free, Alexander T Williams, Aliki-Eleni Farmaki, Jane Bethea, Linda M Barton, Nick Shrine, Chiara Batini, Richard Packer, Sarah Terry, Beverley Hargadon, Qingning Wang, Carl A Melbourne, Emma L Adams, Catherine E Bee, Kyla Harrington, José Miola, Nigel J Brunskill, Christopher E Brightling, Julian Barwell, Susan E Wallace, Ron Hsu, David J Shepherd, Edward J Hollox, Louise V Wain, and Martin D Tobin
- Subjects
0303 health sciences ,education.field_of_study ,medicine.medical_specialty ,Data collection ,business.industry ,Population ,medicine.disease ,Precision medicine ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,Cohort ,Health care ,Epidemiology ,medicine ,Multiple morbidities ,030212 general & internal medicine ,education ,business ,Record linkage ,030304 developmental biology - Abstract
EXCEED is a longitudinal population-based cohort which facilitates investigation of genetic, environmental and lifestyle-related determinants of a broad range of diseases and of multiple morbidity through data collected at baseline and via electronic healthcare record linkage. Recruitment has taken place in Leicester, Leicestershire and Rutland since 2013 and is ongoing, with 9,840 participants aged 30-69 to date. The population of Leicester is diverse and additional recruitment from the local South Asian community is ongoing. Participants have consented to follow-up for up to 25 years through electronic health records and additional bespoke data collection is planned. Data available includes baseline demographics, anthropometry, spirometry, lifestyle factors (smoking and alcohol use) and longitudinal health information from primary care records, with additional linkage to other EHR datasets planned. Patients have consented to be contacted for recall-by-genotype and recall-by-phenotype sub-studies, providing an important resource for precision medicine research. We welcome requests for collaboration and data access by contacting the study management team via exceed@le.ac.uk.
- Published
- 2018
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