6 results on '"Canton, R."'
Search Results
2. Escherichia coli: an old friend with new tidings
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Vila, J., Saez-Lopez, E., Johnson, J. R., Romling, U., Dobrindt, U., Canton, R., Giske, C. G., Naas, T., Carattoli, A., Martinez-Medina, M., Bosch, J., Retamar, P., Rodriguez-Bano, J., Baquero, F., Soto, S. M., [Vila, J.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Saez-Lopez, E.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Bosch, J.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Soto, S. M.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Vila, J.] Univ Barcelona, Hosp Clin, Dept Clin Microbiol, E-08036 Barcelona, Spain, [Bosch, J.] Univ Barcelona, Hosp Clin, Dept Clin Microbiol, E-08036 Barcelona, Spain, [Vila, J.] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI, Madrid 28220, Spain, [Canton, R.] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI, Madrid 28220, Spain, [Rodriguez-Bano, J.] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI, Madrid 28220, Spain, [Johnson, J. R.] VA Med Ctr, Minneapolis, MN USA, [Johnson, J. R.] Univ Minnesota, Minneapolis, MN 55417 USA, [Romling, U.] Karolinska Inst, S-17177 Stockholm, Sweden, [Giske, C. G.] Karolinska Inst, S-17177 Stockholm, Sweden, [Dobrindt, U.] Univ Munster, Inst Hyg, D-48149 Munster, Germany, [Canton, R.] Hosp Univ Ramon y Cajal, Microbiol Serv, E-28034 Madrid, Spain, [Baquero, F.] Hosp Univ Ramon y Cajal, Microbiol Serv, E-28034 Madrid, Spain, [Canton, R.] Inst Invest Sanitaria IRYCIS, E-28034 Madrid, Spain, [Baquero, F.] Inst Invest Sanitaria IRYCIS, E-28034 Madrid, Spain, [Naas, T.] Univ Paris 11, Hop Bicetre, F-94270 Le Kremlin Bicetre, France, [Carattoli, A.] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy, [Martinez-Medina, M.] Univ Girona, Dept Biol, Lab Mol Microbiol, Girona 17004, Spain, [Retamar, P.] Univ Seville, Dept Med, Hosp Univ Virgen Macarena & Virgen del Rocio, Unidad Clin Enfermedades Infecciosas Microbiol &, Seville 41071, Spain, [Rodriguez-Bano, J.] Univ Seville, Dept Med, Hosp Univ Virgen Macarena & Virgen del Rocio, Unidad Clin Enfermedades Infecciosas Microbiol &, Seville 41071, Spain, 'Instituto de Salud Carlos III' of Spain - European Development Regional Fund, Ministerio de Economia y Competitividad, Spanish Network for the Research in Infectious Diseases, Karolinska Institutet's 'Elitforskartjanst' in Molecular Microbiology, German Federal Ministry for Education and Research, and Veterans Affairs
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Cyclic-di-gmp ,Onset neonatal sepsis ,pathogenesis ,Klebsiella-pneumoniae ,Invasive e. coli ,clinical ,Gram-negative organisms ,In-vitro activity ,Carbapenemase-producing enterobacteriaceae ,Spectrum-beta-lactamase ,evolution ,Escherichia coli ,epidemiology ,antimicrobial resistance ,Blood-stream infections ,Comparative genomic analysis - Abstract
Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics are continually changing. Extraintestinal E. coli infections, such as urinary tract infections and neonatal sepsis, represent a huge public health problem. They are caused mainly by specialized extraintestinal pathogenic E. coli (ExPEC) strains that can innocuously colonize human hosts but can also cause disease upon entering a normally sterile body site. The virulence capability of such strains is determined by a combination of distinctive accessory traits, called virulence factors, in conjunction with their distinctive phylogenetic background. It is conceivable that by developing interventions against the most successful ExPEC lineages or their key virulence/colonization factors the associated burden of disease and health care costs could foreseeably be reduced in the future. On the other hand, one important problem worldwide is the increase of antimicrobial resistance shown by bacteria. As underscored in the last WHO global report, within a wide range of infectious agents including E. coli, antimicrobial resistance has reached an extremely worrisome situation that 'threatens the achievements of modern medicine'. In the present review, an update of the knowledge about the pathogenicity, antimicrobial resistance and clinical aspects of this 'old friend' was presented.New knowledgements about pathogenesis, antimicrobial resistance and clinical aspects of Escherichia coli.New knowledgements about pathogenesis, antimicrobial resistance and clinical aspects of Escherichia coli.
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- 2016
3. Emergence of ESBL-producing Escherichia coli ST131-C1-M27 clade colonizing patients in Europe.
- Author
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Merino, Irene, Hernández-García, Marta, Turrientes, María-Carmen, Pérez-Viso, Blanca, López-Fresneña, Nieves, Diaz-Agero, Cristina, Maechler, Friederike, Fankhauser-Rodriguez, Carolina, Kola, Axel, Schrenzel, Jacques, Harbarth, Stephan, Bonten, Marc, Gastmeier, Petra, Canton, R, Ruiz-Garbajosa, P, and R-GNOSIS Study Group
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ESCHERICHIA coli ,BETA lactamases ,PENICILLIN ,COMPETITIVE exclusion (Microbiology) ,EPIDEMIOLOGY ,ANTIBIOTICS ,COMPARATIVE studies ,DNA ,ESCHERICHIA coli diseases ,HOSPITAL care ,HYDROLASES ,RESEARCH methodology ,MEDICAL cooperation ,MICROBIAL sensitivity tests ,POLYMERASE chain reaction ,PROTEINS ,PULSED-field gel electrophoresis ,RESEARCH ,EVALUATION research ,DISEASE prevalence ,GENOTYPES ,PHARMACODYNAMICS - Abstract
Background: The ST131 Escherichia coli clone is associated with the global dissemination of ESBLs. It has been hypothesized that ST131 could take advantage of better colonizing abilities. However, the data on colonization prevalence of ESBL-ST131 in European hospitals are scarce.Objectives: To assess the prevalence of the ST131 clone and its microbiological characteristics among colonizing ESBL-producing E. coli (ESBL-Ec) from hospitalized patients in four European hospitals (Berlin, Geneva, Madrid and Utrecht) during the R-GNOSIS study.Methods: ESBL-Ec isolates (n = 688) were obtained from rectal swabs of hospitalized patients from March 2014 to February 2015 using selective media. The ST131 clone and its subclones were sought using PCR and positive isolates were further studied. blaESBL genes were characterized (PCR and sequencing), antibiotic susceptibility testing was performed, clonal relationships were studied by PFGE and fimH allele and O type (PCR) were assessed.Results: ST131 prevalence was 20.5% (141/688); C1/H30R1 isolates were significantly more prevalent in Geneva (49%) and C2/H30Rx in Madrid (67%). C1/H30R1 isolates showed less resistance to amikacin than C2/H30Rx (4% versus 35%) and all were susceptible to penicillin/inhibitor combinations. CTX-M-15 was the most common enzyme (49%) followed by CTX-M-27 (27%). C1/H30R1 isolates were significantly associated with CTX-M-27 (72%) and all of these isolates belonged to the C1-M27 clade. Moreover, C2/H30Rx isolates and CTX-M-15 were also significantly related (88%).Conclusions: The predominance of C2/H30Rx-CTX-M-15 in Madrid and C1/H30R1-CTX-M-27 in Geneva demonstrates a changing epidemiology of ESBLs in Europe caused by ST131 subclones; in particular, the emergence of the C1-M27 clade in Europe. [ABSTRACT FROM AUTHOR]- Published
- 2018
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4. Risk factors and effectiveness of preventive measures against influenza in the community
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Castilla J, Godoy P, Dominguez A, Martin V, Delgado-Rodriguez M, Martinez-Baz I, Baricot M, Soldevila N, Mayoral J, Astray J, Quintana J, Canton R, Castro A, Gonzalez-Candelas F, Alonso J, Saez M, Tamames S, Pumarola T, and CIBERESP Cases Controls Influenza
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Epidemiology ,vaccine ,public health ,transmission ,influenza ,infection control - Abstract
Please cite this paper as: Castilla etal. (2013) Risk factors and effectiveness of preventive measures against influenza in the community. Influenza and Other Respiratory Viruses 7(2) 177183. Background The role of different risk exposures and preventive measures against influenza has not been well established. Objective The aim of this study was to evaluate risk factors and measures to prevent influenza infection in the community. Methods We conducted a multicenter casecontrol study. Cases were 481 outpatients aged 18years or older with laboratory-confirmed influenza A(H1N1)09 in the 20092010 season in Spain. A control was selected for each case from outpatients from the same area matched by age and date of consultation. Information on risk situations, preventive measures and other variables was obtained by interview and review of the medical record. Results In the multivariate conditional logistic regression analysis, the risk of a diagnosis of influenza increased with the number of cohabitants (compared with
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- 2013
5. Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization
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Godoy P, Castilla J, Delgado-Rodriguez M, Martin V, Soldevila N, Alonso J, Astray J, Baricot M, Canton R, Castro A, Gonzalez-Candelas F, Mayoral J, Quintana J, Pumarola T, Tamames S, Dominguez A, and CIBERESP Cases Controls Pandemic
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Hospitalization ,Handwashing ,Non-pharmacological measures ,Epidemiology ,Prevention ,Case control study ,Transmission ,Influenza ,Hand hygiene - Abstract
Background. The objective of the study was to investigate the effectiveness of non-pharmacological interventions in preventing cases of influenza requiring hospitalization. Methods. We performed a multicenter case-control study in 36 hospitals, in 2010 in Spain. Hospitalized influenza cases confirmed by reverse-transcription polymerase chain reaction and three matched controls (two hospital and one community control) per case Were selected. The use of non-pharmacological measures seven days before the onset of symptoms (frequency of hand washing, use of alcohol-based hand sanitizers and handwashing after touching contaminated surfaces) was collected. Results. We studied 813 cases hospitalized for influenza and 2274 controls. The frequency of hand washing 5-10 times (adjusted odds ratio [aOR] = 0.65) and >10 times (aOR = 0.59) and handwashing after contact with contaminated surfaces (aOR = 0.65) were protective factors and were dose-responsive (p < 0.001). Alcohol-based hand sanitizers were associated with marginal benefits (aOR = 0.82). Conclusions. Frequent handwashing should be recommended to prevent influenza cases requiring hospitalization. (C) 2012 Elsevier Inc. All rights reserved.
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- 2012
6. High genetic diversity among community-associated Staphylococcus aureus in Europe: results from a multicenter study
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Joana, Rolo, Maria, Miragaia, Agata Turlej Rogacka, Joanna, Empel, Ons, Bouchami, Faria, Nuno A., Ana, Tavares, Waleria, Hryniewicz, Fluit, Ad C., De Lencastre, H., Nashev, D., Melter, O., Zemlicková, H., Fridrichova, M., Westh, H., Salmenlinna, S., Lina, G., Spiliopoulou, I., Drougka, E., Kristóf, K., Rozgonyi, F., Raponi, Giammarco, Ghezzi, Maria Cristina, Wulf, M., Codita, I., Ionescu, G., Nica, M., Lísková, A., Ruiz Garbajosa, P., Canton, R., Dominguez, M. a., Petersson, A. c., Walker, R., Anderson, R., and Andrews, J.
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Male ,Epidemiology ,medicine.disease_cause ,Polymerase Chain Reaction ,Staphylococci ,0303 health sciences ,education.field_of_study ,Molecular Epidemiology ,Multidisciplinary ,respiratory system ,Staphylococcal Infections ,Bacterial Pathogens ,Bacterial Typing Techniques ,Electrophoresis, Gel, Pulsed-Field ,Community-Acquired Infections ,Europe ,Infectious Diseases ,Medical Microbiology ,Medicine ,Female ,Research Article ,Skin Infections ,Methicillin-Resistant Staphylococcus aureus ,Staphylococcus aureus ,Science ,Population ,Microbial Sensitivity Tests ,Biology ,Staphylococcal infections ,Microbiology ,Infectious Disease Epidemiology ,03 medical and health sciences ,Arginine catabolic mobile element ,medicine ,Humans ,education ,Microbial Pathogens ,030304 developmental biology ,Genetic diversity ,Population Biology ,030306 microbiology ,SCCmec ,Genetic Variation ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,bacterial infections and mycoses ,Methicillin-resistant Staphylococcus aureus ,Genetics, Population ,Multilocus sequence typing ,Panton–Valentine leukocidin - Abstract
BackgroundSeveral studies have addressed the epidemiology of community-associated Staphylococcus aureus (CA-SA) in Europe; nonetheless, a comprehensive perspective remains unclear. In this study, we aimed to describe the population structure of CA-SA and to shed light on the origin of methicillin-resistant S. aureus (MRSA) in this continent.Methods and findingsA total of 568 colonization and infection isolates, comprising both MRSA and methicillin-susceptible S. aureus (MSSA), were recovered in 16 European countries, from community and community-onset infections. The genetic background of isolates was characterized by molecular typing techniques (spa typing, pulsed-field gel electrophoresis and multilocus sequence typing) and the presence of PVL and ACME was tested by PCR. MRSA were further characterized by SCCmec typing. We found that 59% of all isolates were associated with community-associated clones. Most MRSA were related with USA300 (ST8-IVa and variants) (40%), followed by the European clone (ST80-IVc and derivatives) (28%) and the Taiwan clone (ST59-IVa and related clonal types) (15%). A total of 83% of MRSA carried Panton-Valentine leukocidin (PVL) and 14% carried the arginine catabolic mobile element (ACME). Surprisingly, we found a high genetic diversity among MRSA clonal types (ST-SCCmec), Simpson's index of diversity = 0.852 (0.788-0.916). Specifically, about half of the isolates carried novel associations between genetic background and SCCmec. Analysis by BURP showed that some CA-MSSA and CA-MRSA isolates were highly related, suggesting a probable local acquisition/loss of SCCmec.ConclusionsOur results imply that CA-MRSA origin, epidemiology and population structure in Europe is very dissimilar from that of USA.
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- 2012
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