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4 results on '"Bagnasco F"'

3. Invasive mycoses in children receiving hemopoietic SCT.

Author

Castagnol, E., Faraci, M., Moroni, C., Bandettini, R., Granata, C., Caruso, S., Bagnasco, F., Caviglia, I., Malgorzata, M., Furfaro, E., Natalizia, A. R., de Fazio, V., Morreale, G., Lanino, E., Haupt, R., Dini, G., and Viscoli, C.

Subjects
MYCOSES, CHILDREN, TRANSPLANTATION of organs, tissues, etc., NEUTROPENIA, STEROIDS, GRAFT versus host disease, PEDIATRICS
Abstract

Invasive mycoses represent a rare but severe complication following hemopoietic SCT (HSCT) in children. Their incidence is related to the type of donor, being higher after allogeneic transplant, especially from alternative donors. Moreover, the incidence of invasive mycoses varies in the different post transplant phases. Neutropenia, lymphopenia, GvHD, high-dose steroids or other immunosuppressive drugs represent well-known risk factors. The clinical features of invasive mycoses after HSCT in children are similar to those observed in adults, and the diagnostic tools, including Aspergillus galactomannan antigen detection, are feasible also in pediatrics. Mortality due to invasive mycoses after HSCT in children is high.Bone Marrow Transplantation (2008) 41, S107–S111; doi:10.1038/bmt.2008.67 [ABSTRACT FROM AUTHOR]

Published
2008
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4. Risk of repeated febrile episodes during chemotherapy-induced granulocytopenia in children with cancer: a prospective single center study

Author

Francesca Bagnasco, Silvia Caruso, Riccardo Haupt, Paola Rebora, Maria Grazia Valsecchi, Elio Castagnola, Vincenzo Fontana, Ilaria Caviglia, Bagnasco, F, Haupt, R, Fontana, V, Valsecchi, M, Rebora, P, Caviglia, I, Caruso, S, and Castagnola, E

Subjects
Male, medicine.medical_specialty, Pediatrics, Neutropenia, Pediatric cancer, Adolescent, Fever, Epidemiology, Antineoplastic Agents, Single Center, Risk Factors, hemic and lymphatic diseases, Neoplasms, medicine, Humans, Pharmacology (medical), Prospective Studies, Child, Repeated febrile neutropenia, Pharmacology, business.industry, Lymphoma, Non-Hodgkin, Hazard ratio, Infant, Newborn, Infant, Discontinuous interval of risk, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Prognosis, Confidence interval, Survival Rate, Infectious Diseases, Oncology, Child, Preschool, Female, Heterogeneity, Complication, business, Event dependence, Febrile neutropenia, Agranulocytosis
Abstract

Background: Febrile neutropenia (FN) is a possible complication of antineoplastic chemotherapy. Aim of the study was to estimate the risk of developing fever at the beginning of any neutropenic period based on the previous history of FN. Procedure: The conditional frailty model was used to estimate the risk of developing fever during neutropenia separately for children with acute leukaemia/non-Hodgkin lymphoma (AL/NHL), or solid tumour (ST). The total number of previous FN episodes (PFNE), age, gender, type of tumour, calendar year of granulocytopenic period, phase of treatment, and granulocyte count were included in the model. Results: A total of 901 granulocytopenic periods was observed in 223 children: 306 in 66 AL/NHL and 595 in 157 ST. Fever developed in 328 cases: 125 in 53 AL/NHL and 203 in 92 ST. The PFNE variable was not significantly associated to the risk of fever [hazard ratio (HR) of 0.87, 95% confidence interval (CI) of 0.62-1.22 in children with AL/NHL, and HR of 0.98, 95% CI of 0.70-1.37 in those with ST]. The hazard of FN was significantly affected by the phase of treatment in AL/NHL (P

Published
2012

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