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Objective: To investigate the expression level of prostaglandin D2 in mouse asthma model. Methods: 24 mice were randomly divided into four groups: normal control group for 2 weeks, normal control group for 4 weeks, asthma model group for 2 weeks and asthma model group for 4 weeks. The mice in asthma model group were sensitized by Ovalbumin (OVA) and aluminum hydroxide (Al (OH)3) suspension and be aerosolized by ova. At the end, the levels of PGD2 in the serum and bronchoalveolar lavage fluid（BALF） samples were detected through ELISA, and the eosinophils of the BALF were counted, and Hematoxylin and eosin (HE) staining was performed to observe the lung tissue pathological changes. Results: Compared with the normal groups, the pathological damage of lung tissues in asthma model group was significantly increased. The eosinophils counting of BALF in asthma group were significantly lower than those in normal group, and the difference was statistically significant (P<0.05). The PGD2 levels in serum and BALF were significantly higher than that in the normal groups, the difference was statistically significant (P<0.01). But, along with the prolonging of duration of asthma, lung tissue damage of asthma model in 4 weeks group was more serious than that of 2 weeks group, and EOS counts were higher in serum and BALF, prostaglandin D2 was increased more significantly, and the difference was statistically significant (P<0.05). But, there was no obvious change between the two normal control groups. Conclusion: The inflammatory mediator, PGD2, has a certain level of expression in the asthma model, and PGD2 level is gradually increased with the prolongation of the duration of asthma. [ABSTRACT FROM AUTHOR]

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