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Your search keyword '"Otte, Matthias"' showing total 3 results
Start Over Author "Otte, Matthias" Topic enzyme models
3 results on '"Otte, Matthias"'

1. A Copper Cage‐Complex as Mimic of the pMMO CuC Site.

Author

Bete, Sarah C., May, Leander K., Woite, Philipp, Roemelt, Michael, and Otte, Matthias

Subjects
OXIDATION of water, COPPER, CATALYTIC oxidation, OXIDATION states, COPPER analysis, BIOMIMETIC synthesis, UBIQUINONES
Abstract

The active site of particulate methane monooxygenase (pMMO) and its mechanism of action are not known. Recently, the CuC site emerged as a potential active site, but to date it lacks any study on biomimetic resemblance of the coordination environment provided by the enzyme. Here, the synthesis of a cage ligand providing such an environment is reported. Copper is incorporated, and coordination occurs by the two imidazole and one carboxylate group offered by the ligand. Depending on the oxidation state, it can adopt different coordination modes, as evidenced by the solid‐state structures and computational investigation. The copper(I) state readily reacts with dioxygen and thereby undergoes CH activation. Moreover, the catalytic aerobic oxidation of hydroquinones as ubiquinol mimics is shown. Clean one‐electron oxidation occurs under mild conditions and EPR analysis of the copper(II) state in the presence of water reveals striking similarities to the data obtained from pMMO. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Mimicry of the 2-His-1-Carboxylate Facial Triad Using Bulky N,N,O-Ligands: Non-Heme Iron Complexes Featuring a Single Facial Ligand and Easily Exchangeable Co-Ligands

Author

Folkertsma, Emma, De Waard, Esther F., Korpershoek, Gerda, Van Schaik, Arnoldus J., Solozabal Mirón, Naiara, Borrmann, Mandy, Nijsse, Sjoerd, Moelands, Marcel, Lutz, Martin, Otte, Matthias, Moret, Marc-etienne, Klein Gebbink, Robertus J. M., Crystal and Structural Chemistry, Organic Chemistry and Catalysis, Sub Organic Chemistry and Catalysis, Sub Chem Biol & Organic Chem begr 1-6-12, and Sub Crystal and Structural Chemistry

Subjects
N,O ligands, Enzyme models, Metalloenzymes, Iron, Taverne, Epoxidation, Non-heme iron
Abstract

Mononuclear iron(II) complexes with facially coordinating N,N,O-ligands were synthesized as accurate structural mimics of the 2-His-1-carboxylate facial triad found in mononuclear non-heme iron enzymes. Mimicking of the facial triad is achieved by designing sterically demanding ligands providing two histidine-like benzimidazole moieties and a coordinating carboxylate or ester moiety. The new methyl-substituted analogue of the bis(benzimidazolyl)propionate ligand, BMBMeIP and its ester analogue, BMBMeIPnPr are designed to prevent the formation of previously reported coordinatively saturated FeL2 type complexes. The crystal structure of [Fe(BMBMeIPnPr)(OTf)2] shows a facial N,N,O-coordination that is very similar to the structure of the enzyme active sites. Both [Fe(BMBMeIPnPr)(OTf)2] and [Fe(BMBMeIP)(OTf)(MeCN)n] catalyze the epoxidation of olefins using H2O2, reaching turnover numbers up to 5.8 per iron. These results represent the first examples of iron complexes bearing a single facial and rigid N,N,O-coordinating ligand and three readily available coordination sites showing catalytic activity in oxidation reactions.

Published
2016

3. Mimicry of the 2-His-1-Carboxylate Facial Triad Using Bulky N,N,O-Ligands: Non-Heme Iron Complexes Featuring a Single Facial Ligand and Easily Exchangeable Co-Ligands (Eur. J. Inorg. Chem. 9/2016).

Author

Folkertsma, Emma, de Waard, Esther F., Korpershoek, Gerda, van Schaik, Arnoldus J., Solozabal Mirón, Naiara, Borrmann, Mandy, Nijsse, Sjoerd, Moelands, Marcel A. H., Lutz, Martin, Otte, Matthias, Moret, Marc-Etienne, and Klein Gebbink, Robertus J. M.

Subjects
INORGANIC chemistry periodicals, INORGANIC compounds
Abstract

The front cover of the March 2016 issue of the "European Journal of Inorganic Chemistry" is presented.

Published
2016
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